Ecto-ADP-ribosyltransferase 3 precursor

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Reviewed, UniProtKB/Swiss-Prot Q13508 (NAR3_HUMAN)

Last modified November 3, 2009. Version 89. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Ecto-ADP-ribosyltransferase 3
    EC=2.4.2.31
Alternative name(s):
    NAD(P)(+)--arginine ADP-ribosyltransferase 3
    Mono(ADP-ribosyl)transferase 3

Gene names

Name:	ART3
Synonyms:	TMART

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Catalytic activity	NAD⁺ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine. NADP⁺ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Testis specific.
Sequence similarities	Belongs to the Arg-specific ADP-ribosyltransferase family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
Ligand	NAD NADP
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid ADP-ribosylation Ref.2 Traceable author statement. Source: ProtInc
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Inferred from direct assay. Source: HPA integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc
Molecular function	NAD(P)+-protein-arginine ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC NAD+ ADP-ribosyltransferase activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] Note: Experimental confirmation may be lacking for some isoforms.

Isoform 3 (identifier: Q13508-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q13508-2) The sequence of this isoform differs from the canonical sequence as follows: 324-346: GMKIPEPFPLPEDKSQGNINNPT → A

Isoform 2 (identifier: Q13508-3) The sequence of this isoform differs from the canonical sequence as follows: 324-334: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Potential

Chain

27 – 362

336

Ecto-ADP-ribosyltransferase 3

PRO_0000019325

Propeptide

363 – 389

Removed in mature form By similarity

PRO_0000019326

Regions

Repeat

Repeat

Repeat

Region

3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H

Sites

Active site

229

By similarity

Binding site

101

NAD By similarity

Binding site

163

NAD By similarity

Amino acid modifications

Lipidation

362

GPI-anchor amidated serine By similarity

Glycosylation

248

N-linked (GlcNAc...) Potential

Disulfide bond

43 ↔ 256

By similarity

Natural variations

Alternative sequence

324 – 346

GMKIP…INNPT → A in isoform 1.

VSP_003375

Alternative sequence

324 – 334

Missing in isoform 2.

VSP_003374

Natural variant

363

S → L: dbSNP rs1128864. Ref.4

VAR_060072

Experimental info

Sequence conflict

357

S → C in CAA65096. Ref.2

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Sequences

Sequence		Length	Mass (Da)
Isoform 3 [UniParc]. Last modified August 13, 2002. Version 2. Checksum: EE1311304BB2F41D Show »	FASTA	389	43,923
10 20 30 40 50 60 MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK 70 80 90 100 110 120 ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK 130 140 150 160 170 180 MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF 190 200 210 220 230 240 GHFTLAYSAK PQAANDQLTV LSIYTCLGVD IENFLDKESE RITLIPLNEV FQVSQEGAGN 250 260 270 280 290 300 NLILQSINKT CSHYECAFLG GLKTENCIEN LEYFQPIYVY NPGEKNQKLE DHSEKNWKLE 310 320 330 340 350 360 DHGEKNQKLE DHGVKILEPT QIPGMKIPEP FPLPEDKSQG NINNPTPGPV PVPGPKSHPS 370 380 ASSGKLLLPQ FGMVIILISV SAINLFVAL « Hide
Isoform 1. Checksum: 2741C884A7C685A2 Show »	FASTA	367	41,489
10 20 30 40 50 60 MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK 70 80 90 100 110 120 ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK 130 140 150 160 170 180 MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF 190 200 210 220 230 240 GHFTLAYSAK PQAANDQLTV LSIYTCLGVD IENFLDKESE RITLIPLNEV FQVSQEGAGN 250 260 270 280 290 300 NLILQSINKT CSHYECAFLG GLKTENCIEN LEYFQPIYVY NPGEKNQKLE DHSEKNWKLE 310 320 330 340 350 360 DHGEKNQKLE DHGVKILEPT QIPAPGPVPV PGPKSHPSAS SGKLLLPQFG MVIILISVSA INLFVAL « Hide
Isoform 2. Checksum: 210DDA8EB3ABEA56 Show »	FASTA	378	42,716
10 20 30 40 50 60 MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK 70 80 90 100 110 120 ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK 130 140 150 160 170 180 MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF 190 200 210 220 230 240 GHFTLAYSAK PQAANDQLTV LSIYTCLGVD IENFLDKESE RITLIPLNEV FQVSQEGAGN 250 260 270 280 290 300 NLILQSINKT CSHYECAFLG GLKTENCIEN LEYFQPIYVY NPGEKNQKLE DHSEKNWKLE 310 320 330 340 350 360 DHGEKNQKLE DHGVKILEPT QIPEDKSQGN INNPTPGPVP VPGPKSHPSA SSGKLLLPQF 370 GMVIILISVS AINLFVAL « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human testis specifically expresses a homologue of the rodent T lymphocytes RT6 mRNA." Levy I., Wu Y.-Q., Roeckel N., Bulle F., Pawlak A., Siegrist S., Mattei M.-G., Guellaen G. FEBS Lett. 382:276-280(1996) [PubMed: 8605984] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins." Koch-Nolte F., Haag F., Braren R., Kuehl M., Hoovers J., Balasubramanian S., Bazan J.F., Thiele H.-G. Genomics 39:370-376(1997) [PubMed: 9119374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT LEU-363. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U47054 mRNA. Translation: AAB01894.1. X95827 Genomic DNA. Translation: CAA65096.1. CR541664 mRNA. Translation: CAG46465.1. BC008397 mRNA. Translation: AAH08397.1. BC017913 mRNA. Translation: AAH17913.1.
IPI	IPI00013682. IPI00220292. IPI00220293.
PIR	S62906.
RefSeq	NP_001123488.1. NP_001123489.1. NP_001170.2.
UniGene	Hs.24976
3D structure databases
HSSP	HSSP built from PDB template 1GXY based on UniProtKB P20974.
ModBase	Search...
Protein-protein interaction databases
STRING	Q13508.
Proteomic databases
PeptideAtlas	Q13508.
PRIDE	Q13508.
Genome annotation databases
Ensembl	ENST00000341029; ENSP00000343843; ENSG00000156219; Homo sapiens. [Genome view] ENST00000349321; ENSP00000304313; ENSG00000156219; Homo sapiens. [Genome view] ENST00000355810; ENSP00000348064; ENSG00000156219; Homo sapiens. [Genome view] ENST00000395688; ENSP00000379043; ENSG00000156219; Homo sapiens. [Genome view]
GeneID	419.
KEGG	hsa:419.
UCSC	uc003hjk.1. human. uc003hjn.1. human. uc003hjo.1. human. uc003hjr.1. human.
Organism-specific databases
CTD	419.
GeneCards	GC04P077186.
H-InvDB	HIX0004304.
HGNC	HGNC:725. ART3.
HPA	HPA011268.
MIM	603086. gene.
PharmGKB	PA25016.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q13508.
OMA	EYLKCTD.
Enzyme and pathway databases
BRENDA	2.4.2.31. 247.
Gene expression databases
ArrayExpress	Q13508.
Bgee	Q13508.
CleanEx	HS_ART3.
Genevestigator	Q13508.
GermOnline	ENSG00000156219. Homo sapiens.
Family and domain databases
InterPro	IPR000768. ART. [Graphical view]
PANTHER	PTHR10339. ART. 1 hit.
Pfam	PF01129. ART. 1 hit. [Graphical view]
PRINTS	PR00970. RIBTRNSFRASE.
PROSITE	PS01291. ART. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1771.
SOURCE	Search...

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Entry information

Entry name

NAR3_HUMAN

Accession

Primary (citable) accession number: Q13508
Secondary accession number(s): Q6FHT7

Q96HL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	August 13, 2002
Last modified:	November 3, 2009
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents