Q13508 (NAR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 106.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ecto-ADP-ribosyltransferase 3 EC=2.4.2.31 Alternative name(s): Mono(ADP-ribosyl)transferase 3 NAD(P)(+)--arginine ADP-ribosyltransferase 3 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 389 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine. NADP+ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine. |
| Subcellular location | |
| Tissue specificity | Testis specific. |
| Sequence similarities | Belongs to the Arg-specific ADP-ribosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Signal |
| Ligand | NAD NADP |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond GPI-anchor Glycoprotein Lipoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein ADP-ribosylation Traceable author statement. Source: ProtInc |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membraneTraceable author statement. Source: ProtInc |
| Molecular function | NAD(P)+-protein-arginine ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC NAD+ ADP-ribosyltransferase activityTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] Note: Experimental confirmation may be lacking for some isoforms. | ||||||
| Isoform 3 (identifier: Q13508-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 1 (identifier: Q13508-2) The sequence of this isoform differs from the canonical sequence as follows: 324-346: GMKIPEPFPLPEDKSQGNINNPT → A | ||||||
| Isoform 2 (identifier: Q13508-3) The sequence of this isoform differs from the canonical sequence as follows: 324-334: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 26 | 26 | Potential | ||||||||
| Chain | 27 – 362 | 336 | Ecto-ADP-ribosyltransferase 3 | PRO_0000019325 | |||||||
| Propeptide | 363 – 389 | 27 | Removed in mature form By similarity | PRO_0000019326 | |||||||
Regions | |||||||||||
| Repeat | 283 – 292 | 10 | 1 | ||||||||
| Repeat | 293 – 302 | 10 | 2 | ||||||||
| Repeat | 303 – 312 | 10 | 3 | ||||||||
| Region | 283 – 312 | 30 | 3 X 10 AA tandem repeats of [GS]-E-K-N-[QW]-K-L-E-D-H | ||||||||
Sites | |||||||||||
| Active site | 229 | 1 | By similarity | ||||||||
| Binding site | 101 | 1 | NAD By similarity | ||||||||
| Binding site | 163 | 1 | NAD By similarity | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 362 | 1 | GPI-anchor amidated serine By similarity | ||||||||
| Glycosylation | 248 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 43 ↔ 256 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 324 – 346 | 23 | GMKIP…INNPT → A in isoform 1. | VSP_003375 | |||||||
| Alternative sequence | 324 – 334 | 11 | Missing in isoform 2. | VSP_003374 | |||||||
| Natural variant | 363 | 1 | S → L. Ref.3 Ref.5 Ref.6 Corresponds to variant rs1128864 [ dbSNP | Ensembl ]. | VAR_060072 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 357 | 1 | S → C in CAA65096. Ref.2 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human testis specifically expresses a homologue of the rodent T lymphocytes RT6 mRNA." Levy I., Wu Y.-Q., Roeckel N., Bulle F., Pawlak A., Siegrist S., Mattei M.-G., Guellaen G. FEBS Lett. 382:276-280(1996) [PubMed: 8605984] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis. |
| [2] | "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins." Koch-Nolte F., Haag F., Braren R., Kuehl M., Hoovers J., Balasubramanian S., Bazan J.F., Thiele H.-G. Genomics 39:370-376(1997) [PubMed: 9119374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-363. |
| [4] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-363. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT LEU-363. Tissue: Skeletal muscle. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U47054 mRNA. Translation: AAB01894.1. X95827 Genomic DNA. Translation: CAA65096.1. BT007249 mRNA. Translation: AAP35913.1. CR541664 mRNA. Translation: CAG46465.1. CH471057 Genomic DNA. Translation: EAX05765.1. BC008397 mRNA. Translation: AAH08397.1. BC017913 mRNA. Translation: AAH17913.1. |
| IPI | IPI00013682. IPI00220292. IPI00220293. |
| PIR | S62906. |
| RefSeq | NP_001123488.1. NM_001130016.1. NP_001123489.1. NM_001130017.1. NP_001170.2. NM_001179.4. |
| UniGene | Hs.24976. |
3D structure databases | |
| ProteinModelPortal | Q13508. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q13508. 1 interaction. |
| STRING | Q13508. |
Polymorphism databases | |
| DMDM | 22261808. |
Proteomic databases | |
| PeptideAtlas | Q13508. |
| PRIDE | Q13508. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000355810; ENSP00000348064; ENSG00000156219. |
| GeneID | 419. |
| KEGG | hsa:419. |
| UCSC | uc003hjk.1. human. uc003hjn.1. human. uc003hjo.1. human. |
Organism-specific databases | |
| CTD | 419. |
| GeneCards | GC04P076932. |
| HGNC | HGNC:725. ART3. |
| HPA | HPA011268. |
| MIM | 603086. gene. |
| neXtProt | NX_Q13508. |
| PharmGKB | PA25016. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG10783. |
| HOVERGEN | HBG006445. |
| InParanoid | Q13508. |
| OMA | EYLKCTD. |
| PhylomeDB | Q13508. |
Gene expression databases | |
| ArrayExpress | Q13508. |
| Bgee | Q13508. |
| CleanEx | HS_ART3. |
| Genevestigator | Q13508. |
| GermOnline | ENSG00000156219. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000768. ART. [Graphical view] |
| KO | K00775. |
| PANTHER | PTHR10339. ART. 1 hit. |
| Pfam | PF01129. ART. 1 hit. [Graphical view] |
| PRINTS | PR00970. RIBTRNSFRASE. |
| PROSITE | PS01291. ART. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 1771. |
| SOURCE | Search... |
Entry information
| Entry name | NAR3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13508 Secondary accession number(s): Q53XW3 Q96HL1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with