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Reviewed, UniProtKB/Swiss-Prot Q13507 (TRPC3_HUMAN)

Last modified November 24, 2009. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Short transient receptor potential channel 3
      Short name=TrpC3
Alternative name(s):
    Transient receptor protein 3
      Short name=TRP-3
      Short name=hTrp-3
      Short name=hTrp3
Gene names
Name: TRPC3
Synonyms: TRP3
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length848 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Ref.6 Ref.8

Subunit structure

Interacts with TRPC1. Interacts with ITPR3. Interacts with MX1 and RNF24. Ref.7 Ref.9 Ref.10 Ref.11

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Sequence similarities

Belongs to the transient receptor family. STrpC subfamily.

Contains 5 ANK repeats.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

ITPR3Q145733EBI-520807,EBI-351055
MX1P205912EBI-520807,EBI-929476
Plcg1P106861EBI-520807,EBI-520788From a different organism.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 848848Short transient receptor potential channel 3
PRO_0000215310

Regions

Topological domain1 – 349349Cytoplasmic Potential
Transmembrane350 – 37021 Potential
Topological domain371 – 38111Extracellular Potential
Transmembrane382 – 40221 Potential
Topological domain403 – 43028Cytoplasmic Potential
Transmembrane431 – 45121 Potential
Topological domain452 – 46312Extracellular Potential
Transmembrane464 – 48421 Potential
Topological domain485 – 53551Cytoplasmic Potential
Transmembrane536 – 55621 Potential
Topological domain557 – 57923Extracellular Potential
Transmembrane580 – 60021 Potential
Topological domain601 – 61515Cytoplasmic Potential
Transmembrane616 – 63621 Potential
Topological domain637 – 64913Extracellular Potential
Transmembrane650 – 67021 Potential
Topological domain671 – 70636Cytoplasmic Potential
Transmembrane707 – 72620 Potential
Topological domain727 – 848122Extracellular Potential
Repeat38 – 6730ANK 1
Repeat73 – 10230ANK 2
Repeat104 – 13027ANK 3
Repeat159 – 18830ANK 4
Repeat561 – 59030ANK 5
Region777 – 79721Binds to IP3R3

Experimental info

Sequence conflict739 – 7424EMGM → GNGEW in CAA61448. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Q13507-1 [UniParc].

Last modified January 1, 1998. Version 2.
Checksum: 1DBC92BC941DF416

FASTA84897,355
        10         20         30         40         50         60 
MEGSPSLRRM TVMREKGRRQ AVRGPAFMFN DRGTSLTAEE ERFLDAAEYG NIPVVRKMLE 

        70         80         90        100        110        120 
ESKTLNVNCV DYMGQNALQL AVGNEHLEVT ELLLKKENLA RIGDALLLAI SKGYVRIVEA 

       130        140        150        160        170        180 
ILNHPGFAAS KRLTLSPCEQ ELQDDDFYAY DEDGTRFSPD ITPIILAAHC QKYEVVHMLL 

       190        200        210        220        230        240 
MKGARIERPH DYFCKCGDCM EKQRHDSFSH SRSRINAYKG LASPAYLSLS SEDPVLTALE 

       250        260        270        280        290        300 
LSNELAKLAN IEKEFKNDYR KLSMQCKDFV VGVLDLCRDS EEVEAILNGD LESAEPLEVH 

       310        320        330        340        350        360 
RHKASLSRVK LAIKYEVKKF VAHPNCQQQL LTIWYENLSG LREQTIAIKC LVVLVVALGL 

       370        380        390        400        410        420 
PFLAIGYWIA PCSRLGKILR SPFMKFVAHA ASFIIFLGLL VFNASDRFEG ITTLPNITVT 

       430        440        450        460        470        480 
DYPKQIFRVK TTQFTWTEML IMVWVLGMMW SECKELWLEG PREYILQLWN VLDFGMLSIF 

       490        500        510        520        530        540 
IAAFTARFLA FLQATKAQQY VDSYVQESDL SEVTLPPEIQ YFTYARDKWL PSDPQIISEG 

       550        560        570        580        590        600 
LYAIAVVLSF SRIAYILPAN ESFGPLQISL GRTVKDIFKF MVLFIMVFFA FMIGMFILYS 

       610        620        630        640        650        660 
YYLGAKVNAA FTTVEESFKT LFWSIFGLSE VTSVVLKYDH KFIENIGYVL YGIYNVTMVV 

       670        680        690        700        710        720 
VLLNMLIAMI NSSYQEIEDD SDVEWKFARS KLWLSYFDDG KTLPPPFSLV PSPKSFVYFI 

       730        740        750        760        770        780 
MRIVNFPKCR RRRLQKDIEM GMGNSKSRLN LFTQSNSRVF ESHSFNSILN QPTRYQQIMK 

       790        800        810        820        830        840 
RLIKRYVLKA QVDKENDEVN EGELKEIKQD ISSLRYELLE DKSQATEELA ILIHKLSEKL 


NPSMLRCE

« Hide

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References

« Hide 'large scale' references
[1]"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
Cell 85:661-671(1996) [PubMed: 8646775] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryonic kidney.
[2]"Coassembly of TRP and TRPL produces a distinct store-operated conductance."
Xu X.-Z.S., Li H.-S., Guggino W.B., Montell C.
Cell 89:1155-1164(1997) [PubMed: 9215637] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"TRPC1, a human homolog of a Drosophila store-operated channel."
Wes P.D., Chevesich J., Jeromin A., Rosenberg C., Stetten G., Montell C.
Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995) [PubMed: 7568191] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 632-747.
Tissue: Fetal brain.
[5]"The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry."
Vannier B., Zhu X., Brown D., Birnbaumer L.
J. Biol. Chem. 273:8675-8679(1998) [PubMed: 9535843] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry."
Zhu X., Jiang M., Birnbaumer L.
J. Biol. Chem. 273:133-142(1998) [PubMed: 9417057] [Abstract]
Cited for: FUNCTION.
[7]"Functional interaction between InsP3 receptors and store-operated Htrp3 channels."
Kiselyov K., Xu X., Mozhayeva G., Kuo T., Pessah I., Mignery G., Zhu X., Birnbaumer L., Muallem S.
Nature 396:478-482(1998) [PubMed: 9853757] [Abstract]
Cited for: INTERACTION WITH IP3 RECEPTOR.
[8]"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."
Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G.
Nature 397:259-263(1999) [PubMed: 9930701] [Abstract]
Cited for: FUNCTION.
[9]"Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry."
Boulay G., Brown D.M., Qin N., Jiang M., Dietrich A., Zhu M.X., Chen Z., Birnbaumer M., Mikoshiba K., Birnbaumer L.
Proc. Natl. Acad. Sci. U.S.A. 96:14955-14960(1999) [PubMed: 10611319] [Abstract]
Cited for: INTERACTION WITH IP3 RECEPTOR.
[10]"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
J. Biol. Chem. 280:19393-19400(2005) [PubMed: 15757897] [Abstract]
Cited for: INTERACTION WITH MX1.
[11]"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
Cell Calcium 43:432-443(2008) [PubMed: 17850865] [Abstract]
Cited for: INTERACTION WITH RNF24.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U47050 mRNA. Translation: AAC51653.1.
Y13758 mRNA. Translation: CAA74083.1.
BC093682 mRNA. Translation: AAH93682.1.
BC093684 mRNA. Translation: AAH93684.1.
X89068 mRNA. Translation: CAA61448.1.
IPIIPI00748783.
RefSeqNP_001124170.1.
NP_003296.1.
UniGeneHs.150981

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ13507. 3 interactions.
STRINGQ13507.

Protein family/group databases

TCDB1.A.4.1.4. transient receptor potential Ca2+ channel (TRP-CC) family.

PTM databases

PhosphoSiteQ13507.

Proteomic databases

PRIDEQ13507.

Genome annotation databases

EnsemblENST00000264811; ENSP00000264811; ENSG00000138741; Homo sapiens. [Genome view]
ENST00000379645; ENSP00000368966; ENSG00000138741; Homo sapiens. [Genome view]
GeneID7222.
KEGGhsa:7222.
UCSCuc003ief.1. human.

Organism-specific databases

CTD7222.
GeneCardsGC04M123079.
H-InvDBHIX0031423.
HGNCHGNC:12335. TRPC3.
MIM602345. gene.
PharmGKBPA37008.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ13507.

Enzyme and pathway databases

Pathway_Interaction_DBpi3kplctrkpathway. Trk receptor signaling mediated by PI3K and PLC-gamma.

Gene expression databases

ArrayExpressQ13507.
BgeeQ13507.
CleanExHS_TRPC3.
GenevestigatorQ13507.
GermOnlineENSG00000138741. Homo sapiens.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans.
IPR002153. Trans_rcpt.
IPR013555. TRP_2.
IPR004729. TRP_channel.
IPR005459. TRP_channel3.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 4 hits.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTSM00248. ANK. 3 hits.
[Graphical view]
TIGRFAMsTIGR00870. trp. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio28283.
SOURCESearch...

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Entry information

Entry nameTRPC3_HUMAN
AccessionPrimary (citable) accession number: Q13507
Secondary accession number(s): O00593, Q15660, Q52M35
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 24, 2009
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents