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Q13507

- TRPC3_HUMAN

UniProt

Q13507 - TRPC3_HUMAN

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Protein

Short transient receptor potential channel 3

Gene

TRPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.4 Publications

GO - Molecular functioni

  1. calcium channel activity Source: ProtInc
  2. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  3. store-operated calcium channel activity Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Reactome
  2. blood coagulation Source: Reactome
  3. calcium ion transmembrane transport Source: UniProtKB
  4. calcium ion transport Source: ProtInc
  5. ion transmembrane transport Source: Reactome
  6. phototransduction Source: ProtInc
  7. platelet activation Source: Reactome
  8. positive regulation of calcium ion transport into cytosol Source: UniProtKB
  9. positive regulation of cardiac muscle hypertrophy in response to stress Source: BHF-UCL
  10. response to ATP Source: UniProtKB
  11. response to calcium ion Source: UniProtKB
  12. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Protein family/group databases

TCDBi1.A.4.1.4. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 3
Short name:
TrpC3
Alternative name(s):
Transient receptor protein 3
Short name:
TRP-3
Short name:
hTrp-3
Short name:
hTrp3
Gene namesi
Name:TRPC3
Synonyms:TRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12335. TRPC3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 369369CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Topological domaini391 – 41828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence AnalysisAdd
BLAST
Topological domaini440 – 45112CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei452 – 47221HelicalSequence AnalysisAdd
BLAST
Topological domaini473 – 52351ExtracellularSequence AnalysisAdd
BLAST
Transmembranei524 – 54421HelicalSequence AnalysisAdd
BLAST
Topological domaini545 – 56723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence AnalysisAdd
BLAST
Topological domaini589 – 63749ExtracellularSequence AnalysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence AnalysisAdd
BLAST
Topological domaini659 – 836178CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37008.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Short transient receptor potential channel 3PRO_0000215310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi404 – 4041N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ13507.
PRIDEiQ13507.

Expressioni

Tissue specificityi

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Gene expression databases

BgeeiQ13507.
CleanExiHS_TRPC3.
ExpressionAtlasiQ13507. baseline and differential.
GenevestigatoriQ13507.

Organism-specific databases

HPAiHPA037969.

Interactioni

Subunit structurei

Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITPR3Q145735EBI-520807,EBI-351055
MX1P205912EBI-520807,EBI-929476
Plcg1P106862EBI-520807,EBI-520788From a different organism.

Protein-protein interaction databases

BioGridi113073. 8 interactions.
DIPiDIP-34311N.
IntActiQ13507. 3 interactions.
STRINGi9606.ENSP00000368966.

Structurei

3D structure databases

ProteinModelPortaliQ13507.
SMRiQ13507. Positions 29-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 5530ANK 1Add
BLAST
Repeati61 – 9030ANK 2Add
BLAST
Repeati92 – 11827ANK 3Add
BLAST
Repeati147 – 17630ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni765 – 78521Binds to IP3R3Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ13507.
KOiK04966.
OMAiLRRKTVM.
OrthoDBiEOG77HDD1.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005459. TRPC3_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF8. PTHR10117:SF8. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13507-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MREKGRRQAV RGPAFMFNDR GTSLTAEEER FLDAAEYGNI PVVRKMLEES
60 70 80 90 100
KTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK
110 120 130 140 150
GYVRIVEAIL NHPGFAASKR LTLSPCEQEL QDDDFYAYDE DGTRFSPDIT
160 170 180 190 200
PIILAAHCQK YEVVHMLLMK GARIERPHDY FCKCGDCMEK QRHDSFSHSR
210 220 230 240 250
SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL
260 270 280 290 300
SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLEVHRH KASLSRVKLA
310 320 330 340 350
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF
360 370 380 390 400
LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT
410 420 430 440 450
TLPNITVTDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR
460 470 480 490 500
EYILQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SYVQESDLSE
510 520 530 540 550
VTLPPEIQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES
560 570 580 590 600
FGPLQISLGR TVKDIFKFMV LFIMVFFAFM IGMFILYSYY LGAKVNAAFT
610 620 630 640 650
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL
660 670 680 690 700
LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS
710 720 730 740 750
PKSFVYFIMR IVNFPKCRRR RLQKDIEMGM GNSKSRLNLF TQSNSRVFES
760 770 780 790 800
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS
810 820 830
SLRYELLEDK SQATEELAIL IHKLSEKLNP SMLRCE
Length:836
Mass (Da):96,009
Last modified:May 3, 2011 - v3
Checksum:i4179CB3DA8B3F508
GO
Isoform 2 (identifier: Q13507-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSTKVRKCKE...SPSLRRMTVM

Show »
Length:921
Mass (Da):105,538
Checksum:i8D7E0D144EF4BE51
GO
Isoform 3 (identifier: Q13507-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEGSPSLRRMTVM

Show »
Length:848
Mass (Da):97,355
Checksum:i1DBC92BC941DF416
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti525 – 5251I → L in BAF76424. 1 PublicationCurated
Sequence conflicti662 – 6621Y → C in BAF76424. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSTKVRKCKEQARVTFPAPE EEEDEGEDEGAEPQRRRRGW RGVNGGLEPRSAPSQREPHG YCPPPFSHGPDLSMEGSPSL RRMTVM in isoform 2. 1 PublicationVSP_042446
Alternative sequencei1 – 11M → MEGSPSLRRMTVM in isoform 3. 4 PublicationsVSP_042445

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47050 mRNA. Translation: AAC51653.1.
Y13758 mRNA. Translation: CAA74083.1.
AY865574 mRNA. Translation: AAW62292.1.
AB255424 mRNA. Translation: BAF76424.1.
AC079341 Genomic DNA. No translation available.
AC108930 Genomic DNA. No translation available.
BC093682 mRNA. Translation: AAH93682.1.
BC093684 mRNA. Translation: AAH93684.1.
X89068 mRNA. Translation: CAA61448.1.
CCDSiCCDS3725.1. [Q13507-3]
CCDS47130.1. [Q13507-2]
RefSeqiNP_001124170.1. NM_001130698.1. [Q13507-2]
NP_003296.1. NM_003305.2. [Q13507-3]
UniGeneiHs.150981.

Genome annotation databases

EnsembliENST00000264811; ENSP00000264811; ENSG00000138741. [Q13507-3]
ENST00000379645; ENSP00000368966; ENSG00000138741. [Q13507-2]
GeneIDi7222.
KEGGihsa:7222.
UCSCiuc003ief.2. human. [Q13507-3]
uc003ieg.2. human. [Q13507-2]
uc011cgl.1. human. [Q13507-1]

Polymorphism databases

DMDMi332278239.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47050 mRNA. Translation: AAC51653.1 .
Y13758 mRNA. Translation: CAA74083.1 .
AY865574 mRNA. Translation: AAW62292.1 .
AB255424 mRNA. Translation: BAF76424.1 .
AC079341 Genomic DNA. No translation available.
AC108930 Genomic DNA. No translation available.
BC093682 mRNA. Translation: AAH93682.1 .
BC093684 mRNA. Translation: AAH93684.1 .
X89068 mRNA. Translation: CAA61448.1 .
CCDSi CCDS3725.1. [Q13507-3 ]
CCDS47130.1. [Q13507-2 ]
RefSeqi NP_001124170.1. NM_001130698.1. [Q13507-2 ]
NP_003296.1. NM_003305.2. [Q13507-3 ]
UniGenei Hs.150981.

3D structure databases

ProteinModelPortali Q13507.
SMRi Q13507. Positions 29-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113073. 8 interactions.
DIPi DIP-34311N.
IntActi Q13507. 3 interactions.
STRINGi 9606.ENSP00000368966.

Chemistry

BindingDBi Q13507.
ChEMBLi CHEMBL2417348.
GuidetoPHARMACOLOGYi 488.

Protein family/group databases

TCDBi 1.A.4.1.4. the transient receptor potential ca(2+) channel (trp-cc) family.

Polymorphism databases

DMDMi 332278239.

Proteomic databases

PaxDbi Q13507.
PRIDEi Q13507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264811 ; ENSP00000264811 ; ENSG00000138741 . [Q13507-3 ]
ENST00000379645 ; ENSP00000368966 ; ENSG00000138741 . [Q13507-2 ]
GeneIDi 7222.
KEGGi hsa:7222.
UCSCi uc003ief.2. human. [Q13507-3 ]
uc003ieg.2. human. [Q13507-2 ]
uc011cgl.1. human. [Q13507-1 ]

Organism-specific databases

CTDi 7222.
GeneCardsi GC04M122800.
HGNCi HGNC:12335. TRPC3.
HPAi HPA037969.
MIMi 602345. gene.
neXtProti NX_Q13507.
PharmGKBi PA37008.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254238.
GeneTreei ENSGT00760000119180.
HOGENOMi HOG000020590.
HOVERGENi HBG068337.
InParanoidi Q13507.
KOi K04966.
OMAi LRRKTVM.
OrthoDBi EOG77HDD1.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSi TRPC3. human.
GeneWikii TRPC3.
GenomeRNAii 7222.
NextBioi 28283.
PROi Q13507.
SOURCEi Search...

Gene expression databases

Bgeei Q13507.
CleanExi HS_TRPC3.
ExpressionAtlasi Q13507. baseline and differential.
Genevestigatori Q13507.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005459. TRPC3_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF8. PTHR10117:SF8. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01644. TRPCHANNEL3.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
    Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
    Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION.
    Tissue: Embryonic kidney.
  2. "Coassembly of TRP and TRPL produces a distinct store-operated conductance."
    Xu X.-Z.S., Li H.-S., Guggino W.B., Montell C.
    Cell 89:1155-1164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel."
    Yildirim E., Kawasaki B.T., Birnbaumer L.
    Proc. Natl. Acad. Sci. U.S.A. 102:3307-3311(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  4. "Molecular cloning of novel TRPC3 isoform."
    Yamazaki D., Yamamura H., Ohya S., Asai K., Imaizumi Y.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-735 (ISOFORMS 1/2/3).
    Tissue: Fetal brain.
  8. "The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry."
    Vannier B., Zhu X., Brown D., Birnbaumer L.
    J. Biol. Chem. 273:8675-8679(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-404, MEMBRANE TOPOLOGY.
  9. "Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry."
    Zhu X., Jiang M., Birnbaumer L.
    J. Biol. Chem. 273:133-142(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Functional interaction between InsP3 receptors and store-operated Htrp3 channels."
    Kiselyov K., Xu X., Mozhayeva G., Kuo T., Pessah I., Mignery G., Zhu X., Birnbaumer L., Muallem S.
    Nature 396:478-482(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITPR1.
  11. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."
    Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G.
    Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry."
    Boulay G., Brown D.M., Qin N., Jiang M., Dietrich A., Zhu M.X., Chen Z., Birnbaumer M., Mikoshiba K., Birnbaumer L.
    Proc. Natl. Acad. Sci. U.S.A. 96:14955-14960(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITPR3.
  13. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
    Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
    J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MX1.
  14. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
    Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
    Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF24.
  15. "S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle."
    Woo J.S., Hwang J.H., Ko J.K., Weisleder N., Kim do H., Ma J., Lee E.H.
    Biochem. J. 427:125-134(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH JPH2, FUNCTION.
  16. "The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas."
    Mio K., Ogura T., Kiyonaka S., Hiroaki Y., Tanimura Y., Fujiyoshi Y., Mori Y., Sato C.
    J. Mol. Biol. 367:373-383(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY (15 ANGSTROM), MEMBRANE TOPOLOGY.

Entry informationi

Entry nameiTRPC3_HUMAN
AccessioniPrimary (citable) accession number: Q13507
Secondary accession number(s): A7VJS1
, E9PCJ9, O00593, Q15660, Q52M35, Q5G1L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 3, 2011
Last modified: November 26, 2014
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3