Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13507

- TRPC3_HUMAN

UniProt

Q13507 - TRPC3_HUMAN

Protein

Short transient receptor potential channel 3

Gene

TRPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 3 (03 May 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.4 Publications

    GO - Molecular functioni

    1. calcium channel activity Source: ProtInc
    2. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. store-operated calcium channel activity Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. blood coagulation Source: Reactome
    3. calcium ion transmembrane transport Source: UniProtKB
    4. calcium ion transport Source: ProtInc
    5. ion transmembrane transport Source: Reactome
    6. phototransduction Source: ProtInc
    7. platelet activation Source: Reactome
    8. positive regulation of calcium ion transport into cytosol Source: UniProtKB
    9. response to ATP Source: UniProtKB
    10. response to calcium ion Source: UniProtKB
    11. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_169333. TRP channels.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Protein family/group databases

    TCDBi1.A.4.1.4. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 3
    Short name:
    TrpC3
    Alternative name(s):
    Transient receptor protein 3
    Short name:
    TRP-3
    Short name:
    hTrp-3
    Short name:
    hTrp3
    Gene namesi
    Name:TRPC3
    Synonyms:TRP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:12335. TRPC3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37008.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 836836Short transient receptor potential channel 3PRO_0000215310Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi404 – 4041N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ13507.
    PRIDEiQ13507.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

    Gene expression databases

    ArrayExpressiQ13507.
    BgeeiQ13507.
    CleanExiHS_TRPC3.
    GenevestigatoriQ13507.

    Organism-specific databases

    HPAiHPA037969.

    Interactioni

    Subunit structurei

    Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITPR3Q145735EBI-520807,EBI-351055
    MX1P205912EBI-520807,EBI-929476
    Plcg1P106862EBI-520807,EBI-520788From a different organism.

    Protein-protein interaction databases

    BioGridi113073. 8 interactions.
    DIPiDIP-34311N.
    IntActiQ13507. 3 interactions.
    STRINGi9606.ENSP00000368966.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13507.
    SMRiQ13507. Positions 29-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 369369CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini391 – 41828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini440 – 45112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini473 – 52351ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini545 – 56723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini589 – 63749ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini659 – 836178CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei419 – 43921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei568 – 58821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei638 – 65821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati26 – 5530ANK 1Add
    BLAST
    Repeati61 – 9030ANK 2Add
    BLAST
    Repeati92 – 11827ANK 3Add
    BLAST
    Repeati147 – 17630ANK 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni765 – 78521Binds to IP3R3Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254238.
    HOGENOMiHOG000020590.
    HOVERGENiHBG068337.
    InParanoidiQ13507.
    KOiK04966.
    OMAiLRRKTVM.
    OrthoDBiEOG77HDD1.
    TreeFamiTF313147.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005459. TRPC3_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF8. PTHR10117:SF8. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01644. TRPCHANNEL3.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13507-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MREKGRRQAV RGPAFMFNDR GTSLTAEEER FLDAAEYGNI PVVRKMLEES    50
    KTLNVNCVDY MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK 100
    GYVRIVEAIL NHPGFAASKR LTLSPCEQEL QDDDFYAYDE DGTRFSPDIT 150
    PIILAAHCQK YEVVHMLLMK GARIERPHDY FCKCGDCMEK QRHDSFSHSR 200
    SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE KEFKNDYRKL 250
    SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLEVHRH KASLSRVKLA 300
    IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF 350
    LAIGYWIAPC SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT 400
    TLPNITVTDY PKQIFRVKTT QFTWTEMLIM VWVLGMMWSE CKELWLEGPR 450
    EYILQLWNVL DFGMLSIFIA AFTARFLAFL QATKAQQYVD SYVQESDLSE 500
    VTLPPEIQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR IAYILPANES 550
    FGPLQISLGR TVKDIFKFMV LFIMVFFAFM IGMFILYSYY LGAKVNAAFT 600
    TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL 650
    LNMLIAMINS SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS 700
    PKSFVYFIMR IVNFPKCRRR RLQKDIEMGM GNSKSRLNLF TQSNSRVFES 750
    HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS 800
    SLRYELLEDK SQATEELAIL IHKLSEKLNP SMLRCE 836
    Length:836
    Mass (Da):96,009
    Last modified:May 3, 2011 - v3
    Checksum:i4179CB3DA8B3F508
    GO
    Isoform 2 (identifier: Q13507-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSTKVRKCKE...SPSLRRMTVM

    Show »
    Length:921
    Mass (Da):105,538
    Checksum:i8D7E0D144EF4BE51
    GO
    Isoform 3 (identifier: Q13507-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MEGSPSLRRMTVM

    Show »
    Length:848
    Mass (Da):97,355
    Checksum:i1DBC92BC941DF416
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti525 – 5251I → L in BAF76424. 1 PublicationCurated
    Sequence conflicti662 – 6621Y → C in BAF76424. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MSTKVRKCKEQARVTFPAPE EEEDEGEDEGAEPQRRRRGW RGVNGGLEPRSAPSQREPHG YCPPPFSHGPDLSMEGSPSL RRMTVM in isoform 2. 1 PublicationVSP_042446
    Alternative sequencei1 – 11M → MEGSPSLRRMTVM in isoform 3. 4 PublicationsVSP_042445

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47050 mRNA. Translation: AAC51653.1.
    Y13758 mRNA. Translation: CAA74083.1.
    AY865574 mRNA. Translation: AAW62292.1.
    AB255424 mRNA. Translation: BAF76424.1.
    AC079341 Genomic DNA. No translation available.
    AC108930 Genomic DNA. No translation available.
    BC093682 mRNA. Translation: AAH93682.1.
    BC093684 mRNA. Translation: AAH93684.1.
    X89068 mRNA. Translation: CAA61448.1.
    CCDSiCCDS3725.1. [Q13507-3]
    CCDS47130.1. [Q13507-2]
    RefSeqiNP_001124170.1. NM_001130698.1. [Q13507-2]
    NP_003296.1. NM_003305.2. [Q13507-3]
    UniGeneiHs.150981.

    Genome annotation databases

    EnsembliENST00000264811; ENSP00000264811; ENSG00000138741. [Q13507-3]
    ENST00000379645; ENSP00000368966; ENSG00000138741. [Q13507-2]
    GeneIDi7222.
    KEGGihsa:7222.
    UCSCiuc003ief.2. human. [Q13507-3]
    uc003ieg.2. human. [Q13507-2]
    uc011cgl.1. human. [Q13507-1]

    Polymorphism databases

    DMDMi332278239.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47050 mRNA. Translation: AAC51653.1 .
    Y13758 mRNA. Translation: CAA74083.1 .
    AY865574 mRNA. Translation: AAW62292.1 .
    AB255424 mRNA. Translation: BAF76424.1 .
    AC079341 Genomic DNA. No translation available.
    AC108930 Genomic DNA. No translation available.
    BC093682 mRNA. Translation: AAH93682.1 .
    BC093684 mRNA. Translation: AAH93684.1 .
    X89068 mRNA. Translation: CAA61448.1 .
    CCDSi CCDS3725.1. [Q13507-3 ]
    CCDS47130.1. [Q13507-2 ]
    RefSeqi NP_001124170.1. NM_001130698.1. [Q13507-2 ]
    NP_003296.1. NM_003305.2. [Q13507-3 ]
    UniGenei Hs.150981.

    3D structure databases

    ProteinModelPortali Q13507.
    SMRi Q13507. Positions 29-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113073. 8 interactions.
    DIPi DIP-34311N.
    IntActi Q13507. 3 interactions.
    STRINGi 9606.ENSP00000368966.

    Chemistry

    ChEMBLi CHEMBL2417348.
    GuidetoPHARMACOLOGYi 488.

    Protein family/group databases

    TCDBi 1.A.4.1.4. the transient receptor potential ca(2+) channel (trp-cc) family.

    Polymorphism databases

    DMDMi 332278239.

    Proteomic databases

    PaxDbi Q13507.
    PRIDEi Q13507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264811 ; ENSP00000264811 ; ENSG00000138741 . [Q13507-3 ]
    ENST00000379645 ; ENSP00000368966 ; ENSG00000138741 . [Q13507-2 ]
    GeneIDi 7222.
    KEGGi hsa:7222.
    UCSCi uc003ief.2. human. [Q13507-3 ]
    uc003ieg.2. human. [Q13507-2 ]
    uc011cgl.1. human. [Q13507-1 ]

    Organism-specific databases

    CTDi 7222.
    GeneCardsi GC04M122800.
    HGNCi HGNC:12335. TRPC3.
    HPAi HPA037969.
    MIMi 602345. gene.
    neXtProti NX_Q13507.
    PharmGKBi PA37008.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254238.
    HOGENOMi HOG000020590.
    HOVERGENi HBG068337.
    InParanoidi Q13507.
    KOi K04966.
    OMAi LRRKTVM.
    OrthoDBi EOG77HDD1.
    TreeFami TF313147.

    Enzyme and pathway databases

    Reactomei REACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_169333. TRP channels.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Miscellaneous databases

    ChiTaRSi TRPC3. human.
    GeneWikii TRPC3.
    GenomeRNAii 7222.
    NextBioi 28283.
    PROi Q13507.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13507.
    Bgeei Q13507.
    CleanExi HS_TRPC3.
    Genevestigatori Q13507.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005459. TRPC3_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF8. PTHR10117:SF8. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01644. TRPCHANNEL3.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry."
      Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L.
      Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION.
      Tissue: Embryonic kidney.
    2. "Coassembly of TRP and TRPL produces a distinct store-operated conductance."
      Xu X.-Z.S., Li H.-S., Guggino W.B., Montell C.
      Cell 89:1155-1164(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel."
      Yildirim E., Kawasaki B.T., Birnbaumer L.
      Proc. Natl. Acad. Sci. U.S.A. 102:3307-3311(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Molecular cloning of novel TRPC3 isoform."
      Yamazaki D., Yamamura H., Ohya S., Asai K., Imaizumi Y.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-735 (ISOFORMS 1/2/3).
      Tissue: Fetal brain.
    8. "The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry."
      Vannier B., Zhu X., Brown D., Birnbaumer L.
      J. Biol. Chem. 273:8675-8679(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-404, MEMBRANE TOPOLOGY.
    9. "Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry."
      Zhu X., Jiang M., Birnbaumer L.
      J. Biol. Chem. 273:133-142(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Functional interaction between InsP3 receptors and store-operated Htrp3 channels."
      Kiselyov K., Xu X., Mozhayeva G., Kuo T., Pessah I., Mignery G., Zhu X., Birnbaumer L., Muallem S.
      Nature 396:478-482(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITPR1.
    11. "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol."
      Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G.
      Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry."
      Boulay G., Brown D.M., Qin N., Jiang M., Dietrich A., Zhu M.X., Chen Z., Birnbaumer M., Mikoshiba K., Birnbaumer L.
      Proc. Natl. Acad. Sci. U.S.A. 96:14955-14960(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITPR3.
    13. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
      Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
      J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MX1.
    14. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
      Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
      Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF24.
    15. "S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle."
      Woo J.S., Hwang J.H., Ko J.K., Weisleder N., Kim do H., Ma J., Lee E.H.
      Biochem. J. 427:125-134(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH JPH2, FUNCTION.
    16. "The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas."
      Mio K., Ogura T., Kiyonaka S., Hiroaki Y., Tanimura Y., Fujiyoshi Y., Mori Y., Sato C.
      J. Mol. Biol. 367:373-383(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ELECTRON MICROSCOPY (15 ANGSTROM), MEMBRANE TOPOLOGY.

    Entry informationi

    Entry nameiTRPC3_HUMAN
    AccessioniPrimary (citable) accession number: Q13507
    Secondary accession number(s): A7VJS1
    , E9PCJ9, O00593, Q15660, Q52M35, Q5G1L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 143 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3