Q13507 (TRPC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 3
Short name=TrpC3

Alternative name(s):
Transient receptor protein 3
Short name=TRP-3
Short name=hTrp-3
Short name=hTrp3

Gene names

Name:	TRPC3
Synonyms:	TRP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. Ref.1 Ref.9 Ref.11 Ref.15
Subunit structure	Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca2+ homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation. Ref.10 Ref.12 Ref.13 Ref.14 Ref.15
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. [View classification] Contains 4 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome phototransduction Traceable author statement Ref.2. Source: ProtInc platelet activation Traceable author statement. Source: Reactome positive regulation of calcium ion transport into cytosol Inferred from direct assay PubMed 21062895. Source: UniProtKB response to ATP Inferred from direct assay PubMed 21062895. Source: UniProtKB response to calcium ion Inferred from direct assay PubMed 21062895. Source: UniProtKB
Cellular_component	integral to plasma membrane Inferred from direct assay PubMed 9368034. Source: MGI
Molecular_function	inositol 1,4,5 trisphosphate binding Inferred from direct assay PubMed 14505576. Source: BHF-UCL store-operated calcium channel activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ITPR3	Q14573	5	EBI-520807,EBI-351055
MX1	P20591	2	EBI-520807,EBI-929476
Plcg1	P10686	2	EBI-520807,EBI-520788	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13507-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13507-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSTKVRKCKE...SPSLRRMTVM

Isoform 3 (identifier: Q13507-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEGSPSLRRMTVM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 836	836	Short transient receptor potential channel 3		PRO_0000215310
Regions
	Topological domain	1 – 337	337	Cytoplasmic Potential
	Transmembrane	338 – 358	21	Helical; Potential
	Topological domain	359 – 369	11	Extracellular Potential
	Transmembrane	370 – 390	21	Helical; Potential
	Topological domain	391 – 418	28	Cytoplasmic Potential
	Transmembrane	419 – 439	21	Helical; Potential
	Topological domain	440 – 451	12	Extracellular Potential
	Transmembrane	452 – 472	21	Helical; Potential
	Topological domain	473 – 523	51	Cytoplasmic Potential
	Transmembrane	524 – 544	21	Helical; Potential
	Topological domain	545 – 567	23	Extracellular Potential
	Transmembrane	568 – 588	21	Helical; Potential
	Topological domain	589 – 603	15	Cytoplasmic Potential
	Transmembrane	604 – 624	21	Helical; Potential
	Topological domain	625 – 637	13	Extracellular Potential
	Transmembrane	638 – 658	21	Helical; Potential
	Topological domain	659 – 694	36	Cytoplasmic Potential
	Transmembrane	695 – 714	20	Helical; Potential
	Topological domain	715 – 836	122	Extracellular Potential
	Repeat	26 – 55	30	ANK 1
	Repeat	61 – 90	30	ANK 2
	Repeat	92 – 118	27	ANK 3
	Repeat	147 – 176	30	ANK 4
	Region	765 – 785	21	Binds to IP3R3
Natural variations
	Alternative sequence	1	1	M → MSTKVRKCKEQARVTFPAPE EEEDEGEDEGAEPQRRRRGW RGVNGGLEPRSAPSQREPHG YCPPPFSHGPDLSMEGSPSL RRMTVM in isoform 2.		VSP_042446
	Alternative sequence	1	1	M → MEGSPSLRRMTVM in isoform 3.		VSP_042445
Experimental info
	Sequence conflict	525	1	I → L in BAF76424. Ref.4
	Sequence conflict	662	1	Y → C in BAF76424. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 3, 2011. Version 3. Checksum: 4179CB3DA8B3F508	FASTA	836	96,009
	10 20 30 40 50 60 MREKGRRQAV RGPAFMFNDR GTSLTAEEER FLDAAEYGNI PVVRKMLEES KTLNVNCVDY 70 80 90 100 110 120 MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK GYVRIVEAIL NHPGFAASKR 130 140 150 160 170 180 LTLSPCEQEL QDDDFYAYDE DGTRFSPDIT PIILAAHCQK YEVVHMLLMK GARIERPHDY 190 200 210 220 230 240 FCKCGDCMEK QRHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE 250 260 270 280 290 300 KEFKNDYRKL SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLEVHRH KASLSRVKLA 310 320 330 340 350 360 IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF LAIGYWIAPC 370 380 390 400 410 420 SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT TLPNITVTDY PKQIFRVKTT 430 440 450 460 470 480 QFTWTEMLIM VWVLGMMWSE CKELWLEGPR EYILQLWNVL DFGMLSIFIA AFTARFLAFL 490 500 510 520 530 540 QATKAQQYVD SYVQESDLSE VTLPPEIQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR 550 560 570 580 590 600 IAYILPANES FGPLQISLGR TVKDIFKFMV LFIMVFFAFM IGMFILYSYY LGAKVNAAFT 610 620 630 640 650 660 TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL LNMLIAMINS 670 680 690 700 710 720 SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS PKSFVYFIMR IVNFPKCRRR 730 740 750 760 770 780 RLQKDIEMGM GNSKSRLNLF TQSNSRVFES HSFNSILNQP TRYQQIMKRL IKRYVLKAQV 790 800 810 820 830 DKENDEVNEG ELKEIKQDIS SLRYELLEDK SQATEELAIL IHKLSEKLNP SMLRCE
	Isoform 2 [UniParc]. Checksum: 8D7E0D144EF4BE51	FASTA	921	105,538
	10 20 30 40 50 60 MSTKVRKCKE QARVTFPAPE EEEDEGEDEG AEPQRRRRGW RGVNGGLEPR SAPSQREPHG 70 80 90 100 110 120 YCPPPFSHGP DLSMEGSPSL RRMTVMREKG RRQAVRGPAF MFNDRGTSLT AEEERFLDAA 130 140 150 160 170 180 EYGNIPVVRK MLEESKTLNV NCVDYMGQNA LQLAVGNEHL EVTELLLKKE NLARIGDALL 190 200 210 220 230 240 LAISKGYVRI VEAILNHPGF AASKRLTLSP CEQELQDDDF YAYDEDGTRF SPDITPIILA 250 260 270 280 290 300 AHCQKYEVVH MLLMKGARIE RPHDYFCKCG DCMEKQRHDS FSHSRSRINA YKGLASPAYL 310 320 330 340 350 360 SLSSEDPVLT ALELSNELAK LANIEKEFKN DYRKLSMQCK DFVVGVLDLC RDSEEVEAIL 370 380 390 400 410 420 NGDLESAEPL EVHRHKASLS RVKLAIKYEV KKFVAHPNCQ QQLLTIWYEN LSGLREQTIA 430 440 450 460 470 480 IKCLVVLVVA LGLPFLAIGY WIAPCSRLGK ILRSPFMKFV AHAASFIIFL GLLVFNASDR 490 500 510 520 530 540 FEGITTLPNI TVTDYPKQIF RVKTTQFTWT EMLIMVWVLG MMWSECKELW LEGPREYILQ 550 560 570 580 590 600 LWNVLDFGML SIFIAAFTAR FLAFLQATKA QQYVDSYVQE SDLSEVTLPP EIQYFTYARD 610 620 630 640 650 660 KWLPSDPQII SEGLYAIAVV LSFSRIAYIL PANESFGPLQ ISLGRTVKDI FKFMVLFIMV 670 680 690 700 710 720 FFAFMIGMFI LYSYYLGAKV NAAFTTVEES FKTLFWSIFG LSEVTSVVLK YDHKFIENIG 730 740 750 760 770 780 YVLYGIYNVT MVVVLLNMLI AMINSSYQEI EDDSDVEWKF ARSKLWLSYF DDGKTLPPPF 790 800 810 820 830 840 SLVPSPKSFV YFIMRIVNFP KCRRRRLQKD IEMGMGNSKS RLNLFTQSNS RVFESHSFNS 850 860 870 880 890 900 ILNQPTRYQQ IMKRLIKRYV LKAQVDKEND EVNEGELKEI KQDISSLRYE LLEDKSQATE 910 920 ELAILIHKLS EKLNPSMLRC E
	Isoform 3 [UniParc]. Checksum: 1DBC92BC941DF416	FASTA	848	97,355
	10 20 30 40 50 60 MEGSPSLRRM TVMREKGRRQ AVRGPAFMFN DRGTSLTAEE ERFLDAAEYG NIPVVRKMLE 70 80 90 100 110 120 ESKTLNVNCV DYMGQNALQL AVGNEHLEVT ELLLKKENLA RIGDALLLAI SKGYVRIVEA 130 140 150 160 170 180 ILNHPGFAAS KRLTLSPCEQ ELQDDDFYAY DEDGTRFSPD ITPIILAAHC QKYEVVHMLL 190 200 210 220 230 240 MKGARIERPH DYFCKCGDCM EKQRHDSFSH SRSRINAYKG LASPAYLSLS SEDPVLTALE 250 260 270 280 290 300 LSNELAKLAN IEKEFKNDYR KLSMQCKDFV VGVLDLCRDS EEVEAILNGD LESAEPLEVH 310 320 330 340 350 360 RHKASLSRVK LAIKYEVKKF VAHPNCQQQL LTIWYENLSG LREQTIAIKC LVVLVVALGL 370 380 390 400 410 420 PFLAIGYWIA PCSRLGKILR SPFMKFVAHA ASFIIFLGLL VFNASDRFEG ITTLPNITVT 430 440 450 460 470 480 DYPKQIFRVK TTQFTWTEML IMVWVLGMMW SECKELWLEG PREYILQLWN VLDFGMLSIF 490 500 510 520 530 540 IAAFTARFLA FLQATKAQQY VDSYVQESDL SEVTLPPEIQ YFTYARDKWL PSDPQIISEG 550 560 570 580 590 600 LYAIAVVLSF SRIAYILPAN ESFGPLQISL GRTVKDIFKF MVLFIMVFFA FMIGMFILYS 610 620 630 640 650 660 YYLGAKVNAA FTTVEESFKT LFWSIFGLSE VTSVVLKYDH KFIENIGYVL YGIYNVTMVV 670 680 690 700 710 720 VLLNMLIAMI NSSYQEIEDD SDVEWKFARS KLWLSYFDDG KTLPPPFSLV PSPKSFVYFI 730 740 750 760 770 780 MRIVNFPKCR RRRLQKDIEM GMGNSKSRLN LFTQSNSRVF ESHSFNSILN QPTRYQQIMK 790 800 810 820 830 840 RLIKRYVLKA QVDKENDEVN EGELKEIKQD ISSLRYELLE DKSQATEELA ILIHKLSEKL NPSMLRCE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry." Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E., Birnbaumer L. Cell 85:661-671(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION. Tissue: Embryonic kidney.
[2]	"Coassembly of TRP and TRPL produces a distinct store-operated conductance." Xu X.-Z.S., Li H.-S., Guggino W.B., Montell C. Cell 89:1155-1164(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel." Yildirim E., Kawasaki B.T., Birnbaumer L. Proc. Natl. Acad. Sci. U.S.A. 102:3307-3311(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	"Molecular cloning of novel TRPC3 isoform." Yamazaki D., Yamamura H., Ohya S., Asai K., Imaizumi Y. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[7]	"TRPC1, a human homolog of a Drosophila store-operated channel." Wes P.D., Chevesich J., Jeromin A., Rosenberg C., Stetten G., Montell C. Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-735 (ISOFORMS 1/2/3). Tissue: Fetal brain.
[8]	"The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry." Vannier B., Zhu X., Brown D., Birnbaumer L. J. Biol. Chem. 273:8675-8679(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY.
[9]	"Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry." Zhu X., Jiang M., Birnbaumer L. J. Biol. Chem. 273:133-142(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"Functional interaction between InsP3 receptors and store-operated Htrp3 channels." Kiselyov K., Xu X., Mozhayeva G., Kuo T., Pessah I., Mignery G., Zhu X., Birnbaumer L., Muallem S. Nature 396:478-482(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ITPR1.
[11]	"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol." Hofmann T., Obukhov A.G., Schaefer M., Harteneck C., Gudermann T., Schultz G. Nature 397:259-263(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry." Boulay G., Brown D.M., Qin N., Jiang M., Dietrich A., Zhu M.X., Chen Z., Birnbaumer M., Mikoshiba K., Birnbaumer L. Proc. Natl. Acad. Sci. U.S.A. 96:14955-14960(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ITPR3.
[13]	"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC." Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G. J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MX1.
[14]	"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC." Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G. Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RNF24.
[15]	"S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle." Woo J.S., Hwang J.H., Ko J.K., Weisleder N., Kim do H., Ma J., Lee E.H. Biochem. J. 427:125-134(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH JPH2, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U47050 mRNA. Translation: AAC51653.1. Y13758 mRNA. Translation: CAA74083.1. AY865574 mRNA. Translation: AAW62292.1. AB255424 mRNA. Translation: BAF76424.1. AC079341 Genomic DNA. No translation available. AC108930 Genomic DNA. No translation available. BC093682 mRNA. Translation: AAH93682.1. BC093684 mRNA. Translation: AAH93684.1. X89068 mRNA. Translation: CAA61448.1.
IPI	IPI00013681. IPI00748783. IPI00966128.
RefSeq	NP_001124170.1. NM_001130698.1. NP_003296.1. NM_003305.2.
UniGene	Hs.150981.
3D structure databases
ProteinModelPortal	Q13507.
SMR	Q13507. Positions 29-172.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-34311N.
IntAct	Q13507. 3 interactions.
STRING	9606.ENSP00000368966.
Protein family/group databases
TCDB	1.A.4.1.4. transient receptor potential Ca2+ channel (TRP-CC) family.
Polymorphism databases
DMDM	12643721.
Proteomic databases
PaxDb	Q13507.
PRIDE	Q13507.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264811; ENSP00000264811; ENSG00000138741. ENST00000379645; ENSP00000368966; ENSG00000138741.
GeneID	7222.
KEGG	hsa:7222.
UCSC	uc011cgl.1. human.
Organism-specific databases
CTD	7222.
GeneCards	GC04M122800.
HGNC	HGNC:12335. TRPC3.
HPA	HPA037969.
MIM	602345. gene.
neXtProt	NX_Q13507.
PharmGKB	PA37008.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254238.
HOGENOM	HOG000020590.
HOVERGEN	HBG068337.
InParanoid	Q13507.
KO	K04966.
OMA	VVHMLLL.
OrthoDB	EOG4V436Z.
Enzyme and pathway databases
Pathway_Interaction_DB	pi3kplctrkpathway. Trk receptor signaling mediated by PI3K and PLC-gamma.
Reactome	REACT_111045. Developmental Biology. REACT_111102. Signal Transduction. REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q13507.
Bgee	Q13507.
CleanEx	HS_TRPC3.
Genevestigator	Q13507.
GermOnline	ENSG00000138741. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005459. TRPC3_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF8. PTHR10117:SF8. 1 hit.
Pfam	PF00023. Ank. 1 hit. PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01644. TRPCHANNEL3.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRPC3. human.
GenomeRNAi	7222.
NextBio	28283.
SOURCE	Search...

Entry information

Entry name

TRPC3_HUMAN

Accession

Primary (citable) accession number: Q13507
Secondary accession number(s): A7VJS1 , E9PCJ9, O00593, Q15660, Q52M35, Q5G1L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.