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Protein

NGFI-A-binding protein 1

Gene

NAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138386-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NGFI-A-binding protein 1
Alternative name(s):
EGR-1-binding protein 1
Transcriptional regulatory protein p54
Gene namesi
Name:NAB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7626. NAB1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4664.
OpenTargetsiENSG00000138386.
PharmGKBiPA31431.

Polymorphism and mutation databases

BioMutaiNAB1.
DMDMi90109928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000770381 – 486NGFI-A-binding protein 1Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei172PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei328PhosphoserineCombined sources1
Cross-linki333Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)4 Publications
Cross-linki333Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei407PhosphoserineBy similarity1
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)3 Publications
Cross-linki480Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ13506.
MaxQBiQ13506.
PaxDbiQ13506.
PeptideAtlasiQ13506.
PRIDEiQ13506.

PTM databases

iPTMnetiQ13506.
PhosphoSitePlusiQ13506.

Expressioni

Tissue specificityi

Isoform Short is found in myeloid leukemia cell line KG-1.

Gene expression databases

BgeeiENSG00000138386.
CleanExiHS_NAB1.
ExpressionAtlasiQ13506. baseline and differential.
GenevisibleiQ13506. HS.

Organism-specific databases

HPAiHPA002738.

Interactioni

Subunit structurei

Homomultimers may associate with EGR1 bound to DNA.By similarity

Protein-protein interaction databases

BioGridi110746. 15 interactors.
IntActiQ13506. 5 interactors.
STRINGi9606.ENSP00000336894.

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi193 – 209Combined sources17
Helixi215 – 224Combined sources10
Helixi227 – 232Combined sources6
Helixi234 – 237Combined sources4
Helixi243 – 252Combined sources10
Beta strandi255 – 257Combined sources3
Helixi272 – 286Combined sources15
Helixi288 – 291Combined sources4
Helixi294 – 310Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUFNMR-A189-317[»]
ProteinModelPortaliQ13506.
SMRiQ13506.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13506.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 82NCD1Add BLAST79
Regioni221 – 310NCD2Add BLAST90
Regioni307 – 338Necessary for nuclear localizationBy similarityAdd BLAST32

Domaini

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Sequence similaritiesi

Belongs to the NAB family.Curated

Phylogenomic databases

eggNOGiKOG3835. Eukaryota.
ENOG410YKFH. LUCA.
GeneTreeiENSGT00390000006330.
HOGENOMiHOG000026777.
HOVERGENiHBG003127.
InParanoidiQ13506.
OMAiHIFEMSD.
OrthoDBiEOG091G0NQE.
PhylomeDBiQ13506.
TreeFamiTF315501.

Family and domain databases

InterProiIPR006986. Nab1_C.
IPR006989. NAB_co-repressor_dom.
IPR006988. Nab_N.
[Graphical view]
PfamiPF04902. Nab1. 1 hit.
PF04904. NCD1. 1 hit.
PF04905. NCD2. 1 hit.
[Graphical view]
ProDomiPD342192. Nab_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q13506-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAALPRTLG ELQLYRILQK ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL
60 70 80 90 100
EIMALVGMAS KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP
110 120 130 140 150
EGSPTWLGIS CSSYERSSNA REPHLKIPKC AATTCVQSLG QGKSDVVGSL
160 170 180 190 200
ALQSVGESRL WQGHHATESE HSLSPADLGS PASPKESSEA LDAAAALSVA
210 220 230 240 250
ECVERMAPTL PKSDLNEVKE LLKTNKKLAK MIGHIFEMND DDPHKEEEIR
260 270 280 290 300
KYSAIYGRFD SKRKDGKHLT LHELTVNEAA AQLCVKDNAL LTRRDELFAL
310 320 330 340 350
ARQISREVTY KYTYRTTKSK CGERDELSPK RIKVEDGFPD FQDSVQTLFQ
360 370 380 390 400
QARAKSEELA ALSSQQPEKV MAKQMEFLCN QAGYERLQHA ERRLSAGLYR
410 420 430 440 450
QSSEEHSPNG LTSDNSDGQG ERPLNLRMPN LQNRQPHHFV VDGELSRLYP
460 470 480
SEAKSHSSES LGILKDYPHS AFTLEKKVIK TEPEDSR
Length:487
Mass (Da):54,401
Last modified:March 7, 2006 - v2
Checksum:i385B16391D670059
GO
Isoform Short (identifier: Q13506-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-364: Missing.

Show »
Length:458
Mass (Da):51,233
Checksum:iC639C90F4EF5657E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129K → N in AAC50588 (PubMed:8668170).Curated1
Sequence conflicti366Missing in AAC50588 (PubMed:8668170).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003384336 – 364Missing in isoform Short. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47007 mRNA. Translation: AAC50588.1.
AF045451 mRNA. Translation: AAC25085.1.
AF045452 mRNA. Translation: AAC25086.1.
AC006460 Genomic DNA. Translation: AAX93076.1.
BC035724 mRNA. Translation: AAH35724.1.
AF052744 Genomic DNA. Translation: AAC28325.1.
CCDSiCCDS2307.1. [Q13506-1]
RefSeqiNP_001308241.1. NM_001321312.1. [Q13506-1]
NP_001308242.1. NM_001321313.1. [Q13506-1]
NP_001308243.1. NM_001321314.1.
NP_001308244.1. NM_001321315.1.
NP_005957.2. NM_005966.3. [Q13506-1]
XP_005246639.1. XM_005246582.1. [Q13506-1]
XP_005246640.1. XM_005246583.1. [Q13506-1]
XP_011509521.1. XM_011511219.2. [Q13506-1]
XP_016859659.1. XM_017004170.1. [Q13506-1]
XP_016859665.1. XM_017004176.1. [Q13506-1]
UniGeneiHs.107474.

Genome annotation databases

EnsembliENST00000337386; ENSP00000336894; ENSG00000138386. [Q13506-1]
ENST00000409581; ENSP00000387089; ENSG00000138386. [Q13506-1]
GeneIDi4664.
KEGGihsa:4664.
UCSCiuc002usb.4. human. [Q13506-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47007 mRNA. Translation: AAC50588.1.
AF045451 mRNA. Translation: AAC25085.1.
AF045452 mRNA. Translation: AAC25086.1.
AC006460 Genomic DNA. Translation: AAX93076.1.
BC035724 mRNA. Translation: AAH35724.1.
AF052744 Genomic DNA. Translation: AAC28325.1.
CCDSiCCDS2307.1. [Q13506-1]
RefSeqiNP_001308241.1. NM_001321312.1. [Q13506-1]
NP_001308242.1. NM_001321313.1. [Q13506-1]
NP_001308243.1. NM_001321314.1.
NP_001308244.1. NM_001321315.1.
NP_005957.2. NM_005966.3. [Q13506-1]
XP_005246639.1. XM_005246582.1. [Q13506-1]
XP_005246640.1. XM_005246583.1. [Q13506-1]
XP_011509521.1. XM_011511219.2. [Q13506-1]
XP_016859659.1. XM_017004170.1. [Q13506-1]
XP_016859665.1. XM_017004176.1. [Q13506-1]
UniGeneiHs.107474.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUFNMR-A189-317[»]
ProteinModelPortaliQ13506.
SMRiQ13506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110746. 15 interactors.
IntActiQ13506. 5 interactors.
STRINGi9606.ENSP00000336894.

PTM databases

iPTMnetiQ13506.
PhosphoSitePlusiQ13506.

Polymorphism and mutation databases

BioMutaiNAB1.
DMDMi90109928.

Proteomic databases

EPDiQ13506.
MaxQBiQ13506.
PaxDbiQ13506.
PeptideAtlasiQ13506.
PRIDEiQ13506.

Protocols and materials databases

DNASUi4664.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337386; ENSP00000336894; ENSG00000138386. [Q13506-1]
ENST00000409581; ENSP00000387089; ENSG00000138386. [Q13506-1]
GeneIDi4664.
KEGGihsa:4664.
UCSCiuc002usb.4. human. [Q13506-1]

Organism-specific databases

CTDi4664.
DisGeNETi4664.
GeneCardsiNAB1.
HGNCiHGNC:7626. NAB1.
HPAiHPA002738.
MIMi600800. gene.
neXtProtiNX_Q13506.
OpenTargetsiENSG00000138386.
PharmGKBiPA31431.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3835. Eukaryota.
ENOG410YKFH. LUCA.
GeneTreeiENSGT00390000006330.
HOGENOMiHOG000026777.
HOVERGENiHBG003127.
InParanoidiQ13506.
OMAiHIFEMSD.
OrthoDBiEOG091G0NQE.
PhylomeDBiQ13506.
TreeFamiTF315501.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138386-MONOMER.

Miscellaneous databases

ChiTaRSiNAB1. human.
EvolutionaryTraceiQ13506.
GeneWikiiNAB1.
GenomeRNAii4664.
PROiQ13506.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138386.
CleanExiHS_NAB1.
ExpressionAtlasiQ13506. baseline and differential.
GenevisibleiQ13506. HS.

Family and domain databases

InterProiIPR006986. Nab1_C.
IPR006989. NAB_co-repressor_dom.
IPR006988. Nab_N.
[Graphical view]
PfamiPF04902. Nab1. 1 hit.
PF04904. NCD1. 1 hit.
PF04905. NCD2. 1 hit.
[Graphical view]
ProDomiPD342192. Nab_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNAB1_HUMAN
AccessioniPrimary (citable) accession number: Q13506
Secondary accession number(s): O75383
, O75384, Q6GTU1, Q9UEV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.