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Protein

Mediator of RNA polymerase II transcription subunit 21

Gene

MED21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.2 Publications

GO - Molecular functioni

  • DNA-directed 5'-3' RNA polymerase activity Source: ProtInc
  • RNA polymerase II transcription cofactor activity Source: GO_Central
  • transcription coactivator activity Source: MGI
  • ubiquitin protein ligase activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 21
Alternative name(s):
Mediator complex subunit 21
RNA polymerase II holoenzyme component SRB7
Short name:
RNAPII complex component SRB7
Short name:
hSrb7
Gene namesi
Name:MED21
Synonyms:SRB7, SURB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000152944.8
HGNCiHGNC:11473 MED21
MIMi603800 gene
neXtProtiNX_Q13503

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152944
PharmGKBiPA162395485

Polymorphism and mutation databases

DMDMi7531204

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963751 – 144Mediator of RNA polymerase II transcription subunit 21Add BLAST144

Proteomic databases

EPDiQ13503
MaxQBiQ13503
PaxDbiQ13503
PeptideAtlasiQ13503
PRIDEiQ13503
TopDownProteomicsiQ13503

PTM databases

iPTMnetiQ13503
PhosphoSitePlusiQ13503

Expressioni

Gene expression databases

BgeeiENSG00000152944
CleanExiHS_MED21
ExpressionAtlasiQ13503 baseline and differential
GenevisibleiQ13503 HS

Organism-specific databases

HPAiHPA017177

Interactioni

Subunit structurei

Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.By similarity8 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114807, 117 interactors
CORUMiQ13503
DIPiDIP-31471N
IntActiQ13503, 35 interactors
STRINGi9606.ENSP00000282892

Structurei

3D structure databases

ProteinModelPortaliQ13503
SMRiQ13503
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 21 family.Curated

Phylogenomic databases

eggNOGiKOG1510 Eukaryota
ENOG4111I75 LUCA
GeneTreeiENSGT00390000014557
HOGENOMiHOG000006767
HOVERGENiHBG009229
InParanoidiQ13503
KOiK15152
PhylomeDBiQ13503

Family and domain databases

InterProiView protein in InterPro
IPR037212 Med7/Med21-like
IPR021384 Mediator_Med21
PANTHERiPTHR13381 PTHR13381, 1 hit
PfamiView protein in Pfam
PF11221 Med21, 1 hit
SUPFAMiSSF140718 SSF140718, 1 hit

Sequencei

Sequence statusi: Complete.

Q13503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFNNIQT AINKDQPANP
60 70 80 90 100
TEEYAQLFAA LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA
110 120 130 140
ATCLEDVVYR GDMLLEKIQS ALADIAQSQL KTRSGTHSQS LPDS
Length:144
Mass (Da):15,564
Last modified:November 1, 1996 - v1
Checksum:iF786169620EDC126
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104L → V in AAB06944 (PubMed:8609996).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46837 mRNA Translation: AAA98511.1
U52960 mRNA Translation: AAB06944.1
CR456999 mRNA Translation: CAG33280.1
AK311838 mRNA Translation: BAG34780.1
CH471094 Genomic DNA Translation: EAW96545.1
BC008380 mRNA Translation: AAH08380.1
CCDSiCCDS8711.1
PIRiS68454
RefSeqiNP_004255.2, NM_004264.4
UniGeneiHs.286145

Genome annotation databases

EnsembliENST00000282892; ENSP00000282892; ENSG00000152944
GeneIDi9412
KEGGihsa:9412
UCSCiuc001rhp.3 human

Similar proteinsi

Entry informationi

Entry nameiMED21_HUMAN
AccessioniPrimary (citable) accession number: Q13503
Secondary accession number(s): B2R4I3, Q6IB05, Q92811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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