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Protein

DNA-directed RNA polymerase subunit alpha

Gene

rpoA

Organism
Rhodopseudomonas palustris (strain BisB5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Enzyme and pathway databases

BioCyciRPAL316057:G1G68-3199-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit alphaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit alphaUniRule annotation
Alternative name(s):
RNA polymerase subunit alphaUniRule annotation
Transcriptase subunit alphaUniRule annotation
Gene namesi
Name:rpoAUniRule annotation
Ordered Locus Names:RPD_3160
OrganismiRhodopseudomonas palustris (strain BisB5)
Taxonomic identifieri316057 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002645351 – 339DNA-directed RNA polymerase subunit alphaAdd BLAST339

Interactioni

Subunit structurei

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi316057.RPD_3160

Structurei

3D structure databases

ProteinModelPortaliQ134V3
SMRiQ134V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 235Alpha N-terminal domain (alpha-NTD)UniRule annotationAdd BLAST235
Regioni251 – 339Alpha C-terminal domain (alpha-CTD)UniRule annotationAdd BLAST89

Domaini

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.UniRule annotation

Sequence similaritiesi

Belongs to the RNA polymerase alpha chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CTF Bacteria
COG0202 LUCA
HOGENOMiHOG000218481
KOiK03040
OMAiLMKFRNF
OrthoDBiPOG091H001Z

Family and domain databases

Gene3Di2.170.120.12, 1 hit
3.30.1360.10, 2 hits
HAMAPiMF_00059 RNApol_bact_RpoA, 1 hit
InterProiView protein in InterPro
IPR011262 DNA-dir_RNA_pol_insert
IPR011263 DNA-dir_RNA_pol_RpoA/D/Rpb3
IPR011773 DNA-dir_RpoA
IPR036603 RBP11-like
IPR011260 RNAP_asu_C
IPR036643 RNApol_insert_sf
PANTHERiPTHR32108 PTHR32108, 1 hit
PfamiView protein in Pfam
PF01000 RNA_pol_A_bac, 1 hit
PF03118 RNA_pol_A_CTD, 1 hit
PF01193 RNA_pol_L, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001179 RNAP_asu_C, 1 hit
SMARTiView protein in SMART
SM00662 RPOLD, 1 hit
SUPFAMiSSF55257 SSF55257, 2 hits
SSF56553 SSF56553, 1 hit
TIGRFAMsiTIGR02027 rpoA, 1 hit

Sequencei

Sequence statusi: Complete.

Q134V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIQKNWQEL IRPNKLQVSP GSDATRFATL VAEPLERGFG QTLGNALRRV
60 70 80 90 100
LLSSLQGAAV QSVQIDGVLH EFSSIAGVRE DVTDIVLNIK DISLKMQGEG
110 120 130 140 150
PKRMVVKKQG PGVVTAGDIQ TVGDIVVLNP DLQICTLDEG AEIRMEFTVN
160 170 180 190 200
TGKGYVAAER NRPEDAPIGL IPVDSLYSPV RKVSYKVENT REGQILDYDK
210 220 230 240 250
LTMTVETNGA LTPDDAVAFA ARILQDQLNV FVNFEEPRKE VTQEIIPDLA
260 270 280 290 300
FNPAFLKKVD ELELSVRSAN CLKNDNIVYI GDLVQKSEAE MLRTPNFGRK
310 320 330
SLNEIKEVLA QMGLHLGMEV PGWPPENIDE LAKRFEDHY
Length:339
Mass (Da):37,554
Last modified:October 31, 2006 - v1
Checksum:i838D83125E906027
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000283 Genomic DNA Translation: ABE40386.1
RefSeqiWP_011503560.1, NC_007958.1

Genome annotation databases

EnsemblBacteriaiABE40386; ABE40386; RPD_3160
KEGGirpd:RPD_3160

Entry informationi

Entry nameiRPOA_RHOPS
AccessioniPrimary (citable) accession number: Q134V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 31, 2006
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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