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Q13492

- PICAL_HUMAN

UniProt

Q13492 - PICAL_HUMAN

Protein

Phosphatidylinositol-binding clathrin assembly protein

Gene

PICALM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei648 – 6492Breakpoint for translocation to form CALM/MLLT10 fusion protein

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. clathrin adaptor activity Source: Alzheimers_University_of_Toronto
    3. clathrin binding Source: UniProtKB
    4. clathrin heavy chain binding Source: BHF-UCL
    5. protein binding Source: BHF-UCL

    GO - Biological processi

    1. axonogenesis Source: Ensembl
    2. cargo loading into vesicle Source: Alzheimers_University_of_Toronto
    3. cell proliferation Source: Alzheimers_University_of_Toronto
    4. clathrin coat assembly Source: BHF-UCL
    5. clathrin-mediated endocytosis Source: Alzheimers_University_of_Toronto
    6. dendrite morphogenesis Source: Ensembl
    7. endosomal transport Source: BHF-UCL
    8. hemopoiesis Source: Ensembl
    9. iron ion homeostasis Source: Alzheimers_University_of_Toronto
    10. iron ion import into cell Source: Alzheimers_University_of_Toronto
    11. negative regulation of gene expression Source: Alzheimers_University_of_Toronto
    12. negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
    13. negative regulation of receptor-mediated endocytosis Source: BHF-UCL
    14. positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
    15. positive regulation of beta-amyloid formation Source: Alzheimers_University_of_Toronto
    16. positive regulation of neuron death Source: Alzheimers_University_of_Toronto
    17. positive regulation of transcription, DNA-templated Source: BHF-UCL
    18. protein complex assembly Source: ProtInc
    19. receptor internalization Source: BHF-UCL
    20. receptor-mediated endocytosis Source: UniProtKB
    21. regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: Alzheimers_University_of_Toronto
    22. regulation of endocytosis Source: BHF-UCL
    23. regulation of protein localization Source: BHF-UCL
    24. synaptic vesicle maturation Source: Alzheimers_University_of_Toronto
    25. vesicle-mediated transport Source: ProtInc

    Keywords - Biological processi

    Endocytosis

    Enzyme and pathway databases

    ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol-binding clathrin assembly protein
    Alternative name(s):
    Clathrin assembly lymphoid myeloid leukemia protein
    Gene namesi
    Name:PICALM
    Synonyms:CALM
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15514. PICALM.

    Subcellular locationi

    Membraneclathrin-coated pit. Golgi apparatus. Cytoplasmic vesicleclathrin-coated vesicle. Nucleus
    Note: Colocalized with clathrin in the Golgi area. Interaction with FAM64A may target PICALM to the nucleus in some cells.

    GO - Cellular componenti

    1. clathrin coat Source: InterPro
    2. clathrin-coated vesicle Source: UniProtKB-SubCell
    3. coated pit Source: UniProtKB
    4. Golgi apparatus Source: UniProtKB-SubCell
    5. intracellular membrane-bounded organelle Source: HPA
    6. membrane Source: UniProtKB
    7. neurofibrillary tangle Source: Alzheimers_University_of_Toronto
    8. neuronal cell body Source: Alzheimers_University_of_Toronto
    9. nucleus Source: BHF-UCL
    10. perinuclear region of cytoplasm Source: Ensembl
    11. postsynaptic membrane Source: BHF-UCL
    12. presynaptic membrane Source: BHF-UCL
    13. vesicle Source: Alzheimers_University_of_Toronto

    Keywords - Cellular componenti

    Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBiPA33287.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 652651Phosphatidylinositol-binding clathrin assembly proteinPRO_0000187062Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ13492.
    PaxDbiQ13492.
    PRIDEiQ13492.

    PTM databases

    PhosphoSiteiQ13492.

    Miscellaneous databases

    PMAP-CutDBQ13492.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined.1 Publication

    Gene expression databases

    ArrayExpressiQ13492.
    BgeeiQ13492.
    CleanExiHS_PICALM.
    GenevestigatoriQ13492.

    Organism-specific databases

    HPAiHPA019053.
    HPA019061.

    Interactioni

    Subunit structurei

    Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with FAM64A; this interaction may change the subcellular location into the nucleus.2 Publications

    Protein-protein interaction databases

    BioGridi113902. 26 interactions.
    IntActiQ13492. 11 interactions.
    MINTiMINT-1636298.
    STRINGi9606.ENSP00000342095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13492.
    SMRiQ13492. Positions 20-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 145132ENTHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni221 – 29474Interaction with FAM64AAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PICALM/SNAP91 family.Curated
    Contains 1 ENTH (epsin N-terminal homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG267212.
    HOVERGENiHBG049391.
    OMAiWNAATMA.
    OrthoDBiEOG76QFM8.
    PhylomeDBiQ13492.
    TreeFamiTF314861.

    Family and domain databases

    Gene3Di1.20.58.150. 1 hit.
    1.25.40.90. 1 hit.
    InterProiIPR011417. ANTH_dom.
    IPR014712. Clathrin_Pinositid-bd_GAT-like.
    IPR008942. ENTH_VHS.
    IPR013809. Epsin-like_N.
    [Graphical view]
    PfamiPF07651. ANTH. 1 hit.
    [Graphical view]
    SMARTiSM00273. ENTH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    PROSITEiPS50942. ENTH. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13492-1) [UniParc]FASTAAdd to Basket

    Also known as: Type I

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN    50
    EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR 100
    NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR 150
    GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL 200
    FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF 250
    LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 300
    TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP 350
    HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT 400
    FHPSVHPMST ASQVASTWGD PFSATVDAVD DAIPSLNPFL TKSSGDVHLS 450
    ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH PSAGLNVDFE SVFGNKSTNV 500
    IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL DSSLANLVGN 550
    LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY 600
    PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ 650
    FM 652
    Length:652
    Mass (Da):70,755
    Last modified:October 17, 2006 - v2
    Checksum:iAC3227E9D32AFEDA
    GO
    Isoform 2 (identifier: Q13492-2) [UniParc]FASTAAdd to Basket

    Also known as: Type II

    The sequence of this isoform differs from the canonical sequence as follows:
         594-613: Missing.

    Show »
    Length:632
    Mass (Da):68,764
    Checksum:iD13D4427A30EE4FD
    GO
    Isoform 3 (identifier: Q13492-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         420-469: Missing.
         593-593: M → MNGMHFPQY

    Note: No experimental confirmation available.

    Show »
    Length:610
    Mass (Da):66,393
    Checksum:i3B0D0AEB901CF85D
    GO
    Isoform 4 (identifier: Q13492-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.
         420-469: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:551
    Mass (Da):59,918
    Checksum:iA39E7E594F66D57F
    GO
    Isoform 5 (identifier: Q13492-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         420-426: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:645
    Mass (Da):70,037
    Checksum:iE4F76B25065B499A
    GO

    Sequence cautioni

    The sequence BAE06099.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321N → D in BAG62035. (PubMed:14702039)Curated
    Sequence conflicti212 – 2121N → H in AAB07762. (PubMed:8643484)Curated
    Sequence conflicti331 – 3311E → G in BAG62035. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581T → P.
    Corresponds to variant rs12800974 [ dbSNP | Ensembl ].
    VAR_028191
    Natural varianti383 – 3831S → F.
    Corresponds to variant rs12222608 [ dbSNP | Ensembl ].
    VAR_028192
    Natural varianti578 – 5781W → C.2 Publications
    Corresponds to variant rs1043858 [ dbSNP | Ensembl ].
    VAR_028193
    Natural varianti579 – 5791Q → E.2 Publications
    Corresponds to variant rs1043859 [ dbSNP | Ensembl ].
    VAR_028194
    Natural varianti641 – 6411F → L.
    Corresponds to variant rs556337 [ dbSNP | Ensembl ].
    VAR_028195

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5151Missing in isoform 4. 1 PublicationVSP_044567Add
    BLAST
    Alternative sequencei420 – 46950Missing in isoform 3 and isoform 4. 2 PublicationsVSP_009607Add
    BLAST
    Alternative sequencei420 – 4267Missing in isoform 5. 1 PublicationVSP_044568
    Alternative sequencei593 – 5931M → MNGMHFPQY in isoform 3. 1 PublicationVSP_009608
    Alternative sequencei594 – 61320Missing in isoform 2. 1 PublicationVSP_004067Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U45976 mRNA. Translation: AAB07762.1.
    AK300275 mRNA. Translation: BAG62035.1.
    AB210017 mRNA. Translation: BAE06099.1. Different initiation.
    AP000767 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW75120.1.
    BC048259 mRNA. Translation: AAH48259.2.
    BC064357 mRNA. Translation: AAH64357.1.
    BC073961 mRNA. Translation: AAH73961.1.
    AF060939 mRNA. Translation: AAC16711.1.
    AF060940 mRNA. Translation: AAC16712.1.
    CCDSiCCDS31653.1. [Q13492-3]
    CCDS55783.1. [Q13492-4]
    CCDS55784.1. [Q13492-5]
    CCDS8272.1. [Q13492-1]
    RefSeqiNP_001008660.1. NM_001008660.2. [Q13492-3]
    NP_001193875.1. NM_001206946.1. [Q13492-5]
    NP_001193876.1. NM_001206947.1. [Q13492-4]
    NP_009097.2. NM_007166.3. [Q13492-1]
    XP_005274388.1. XM_005274331.1. [Q13492-2]
    UniGeneiHs.163893.

    Genome annotation databases

    EnsembliENST00000356360; ENSP00000348718; ENSG00000073921. [Q13492-2]
    ENST00000393346; ENSP00000377015; ENSG00000073921. [Q13492-1]
    ENST00000526033; ENSP00000433846; ENSG00000073921. [Q13492-5]
    ENST00000528398; ENSP00000434884; ENSG00000073921. [Q13492-4]
    ENST00000532317; ENSP00000436958; ENSG00000073921. [Q13492-3]
    GeneIDi8301.
    KEGGihsa:8301.
    UCSCiuc001pbl.3. human. [Q13492-3]
    uc001pbm.3. human. [Q13492-1]

    Polymorphism databases

    DMDMi116242714.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U45976 mRNA. Translation: AAB07762.1 .
    AK300275 mRNA. Translation: BAG62035.1 .
    AB210017 mRNA. Translation: BAE06099.1 . Different initiation.
    AP000767 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW75120.1 .
    BC048259 mRNA. Translation: AAH48259.2 .
    BC064357 mRNA. Translation: AAH64357.1 .
    BC073961 mRNA. Translation: AAH73961.1 .
    AF060939 mRNA. Translation: AAC16711.1 .
    AF060940 mRNA. Translation: AAC16712.1 .
    CCDSi CCDS31653.1. [Q13492-3 ]
    CCDS55783.1. [Q13492-4 ]
    CCDS55784.1. [Q13492-5 ]
    CCDS8272.1. [Q13492-1 ]
    RefSeqi NP_001008660.1. NM_001008660.2. [Q13492-3 ]
    NP_001193875.1. NM_001206946.1. [Q13492-5 ]
    NP_001193876.1. NM_001206947.1. [Q13492-4 ]
    NP_009097.2. NM_007166.3. [Q13492-1 ]
    XP_005274388.1. XM_005274331.1. [Q13492-2 ]
    UniGenei Hs.163893.

    3D structure databases

    ProteinModelPortali Q13492.
    SMRi Q13492. Positions 20-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113902. 26 interactions.
    IntActi Q13492. 11 interactions.
    MINTi MINT-1636298.
    STRINGi 9606.ENSP00000342095.

    PTM databases

    PhosphoSitei Q13492.

    Polymorphism databases

    DMDMi 116242714.

    Proteomic databases

    MaxQBi Q13492.
    PaxDbi Q13492.
    PRIDEi Q13492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356360 ; ENSP00000348718 ; ENSG00000073921 . [Q13492-2 ]
    ENST00000393346 ; ENSP00000377015 ; ENSG00000073921 . [Q13492-1 ]
    ENST00000526033 ; ENSP00000433846 ; ENSG00000073921 . [Q13492-5 ]
    ENST00000528398 ; ENSP00000434884 ; ENSG00000073921 . [Q13492-4 ]
    ENST00000532317 ; ENSP00000436958 ; ENSG00000073921 . [Q13492-3 ]
    GeneIDi 8301.
    KEGGi hsa:8301.
    UCSCi uc001pbl.3. human. [Q13492-3 ]
    uc001pbm.3. human. [Q13492-1 ]

    Organism-specific databases

    CTDi 8301.
    GeneCardsi GC11M085668.
    HGNCi HGNC:15514. PICALM.
    HPAi HPA019053.
    HPA019061.
    MIMi 603025. gene.
    neXtProti NX_Q13492.
    Orphaneti 99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBi PA33287.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267212.
    HOVERGENi HBG049391.
    OMAi WNAATMA.
    OrthoDBi EOG76QFM8.
    PhylomeDBi Q13492.
    TreeFami TF314861.

    Enzyme and pathway databases

    Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    ChiTaRSi PICALM. human.
    GeneWikii PICALM.
    GenomeRNAii 8301.
    NextBioi 31101.
    PMAP-CutDB Q13492.
    PROi Q13492.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13492.
    Bgeei Q13492.
    CleanExi HS_PICALM.
    Genevestigatori Q13492.

    Family and domain databases

    Gene3Di 1.20.58.150. 1 hit.
    1.25.40.90. 1 hit.
    InterProi IPR011417. ANTH_dom.
    IPR014712. Clathrin_Pinositid-bd_GAT-like.
    IPR008942. ENTH_VHS.
    IPR013809. Epsin-like_N.
    [Graphical view ]
    Pfami PF07651. ANTH. 1 hit.
    [Graphical view ]
    SMARTi SM00273. ENTH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    PROSITEi PS50942. ENTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family."
      Dreyling M.H., Martinez-Climent J.A., Zheng M., Mao J., Rowley J.D., Bohlander S.K.
      Proc. Natl. Acad. Sci. U.S.A. 93:4804-4809(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION, TISSUE SPECIFICITY, VARIANTS CYS-578 AND GLU-579.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta.
    3. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: PNS.
    7. "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides."
      Silliman C.C., McGavran L., Wei Q., Miller L.A., Li S., Hunger S.P.
      Leukemia 12:1404-1410(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 575-652 (ISOFORMS 1 AND 2), VARIANTS CYS-578 AND GLU-579.
      Tissue: Bone marrow.
    8. "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic."
      Tebar F., Bohlander S.K., Sorkin A.
      Mol. Biol. Cell 10:2687-2702(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CLATHRIN, SUBCELLULAR LOCATION.
    9. "The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10."
      Archangelo L.F., Glaesner J., Krause A., Bohlander S.K.
      Oncogene 25:4099-4109(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH FAM64A.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPICAL_HUMAN
    AccessioniPrimary (citable) accession number: Q13492
    Secondary accession number(s): B4DTM3
    , E9PN05, F8VPG7, O60700, Q4LE54, Q6GMQ6, Q86XZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3