Q13491 (GPM6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuronal membrane glycoprotein M6-b
Short name=M6b

Gene names

Name:	GPM6B
Synonyms:	M6B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Ref.10
Subunit structure	Interacts with SERT. Ref.9
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: Colocalizes with SERT at the plasma membrane By similarity.
Tissue specificity	Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.
Sequence similarities	Belongs to the myelin proteolipid protein family.
Sequence caution	The sequence AAB16888.1 differs from that shown. Reason: Erroneous initiation. The sequence AAC19165.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Osteogenesis Protein transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW extracellular matrix assembly Inferred from mutant phenotype Ref.10. Source: UniProtKB negative regulation of protein localization to cell surface Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of serotonin uptake Inferred from sequence or structural similarity. Source: UniProtKB nervous system development Non-traceable author statement Ref.1. Source: UniProtKB ossification Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of bone mineralization Inferred from mutant phenotype Ref.10. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of actin cytoskeleton organization Inferred from mutant phenotype Ref.10. Source: UniProtKB regulation of focal adhesion assembly Inferred from mutant phenotype Ref.10. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB membrane raft Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13491-1)

Also known as: A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13491-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MKPAMETAAEENTEQSQERK → M

Isoform 3 (identifier: Q13491-3)

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: K → KVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSP

Isoform 4 (identifier: Q13491-4)

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: K → KVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSP
     240-265: LIYMMATTYNYAVLKFKSREDCCTKF → IHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT

Note: Contains a phosphoserine at position 318.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Neuronal membrane glycoprotein M6-b		PRO_0000159021
Regions
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
Amino acid modifications
	Modified residue	257	1	Phosphoserine By similarity
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 20	20	MKPAM…SQERK → M in isoform 2.		VSP_003326
	Alternative sequence	20	1	K → KVNSRAEMEIGRYHWMYPGS KNHQYHPVPTLGDRASPLSS P in isoform 3 and isoform 4.		VSP_041121
	Alternative sequence	240 – 265	26	LIYMM…CCTKF → IHFLMILSSNWAYLKDASKM QAYQDIKAKEEQELQDIQSR SKEQLNSYT in isoform 4.		VSP_043247

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (A) [UniParc]. Last modified April 3, 2002. Version 2. Checksum: 560AB12DD2B5AE75	FASTA	265	28,989
	10 20 30 40 50 60 MKPAMETAAE ENTEQSQERK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA 70 80 90 100 110 120 GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH 130 140 150 160 170 180 GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT 190 200 210 220 230 240 GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL 250 260 IYMMATTYNY AVLKFKSRED CCTKF
	Isoform 2 (B) [UniParc]. Checksum: 9DA14EFDF2CFB81F	FASTA	246	26,830
	10 20 30 40 50 60 MGCFECCIKC LGGVPYASLV ATILCFSGVA LFCGCGHVAL AGTVAILEQH FSTNASDHAL 70 80 90 100 110 120 LSEVIQLMQY VIYGIASFFF LYGIILLAEG FYTTSAVKEL HGEFKTTACG RCISGMFVFL 130 140 150 160 170 180 TYVLGVAWLG VFGFSAVPVF MFYNIWSTCE VIKSPQTNGT TGVEQICVDI RQYGIIPWNA 190 200 210 220 230 240 FPGKICGSAL ENICNTNEFY MSYHLFIVAC AGAGATVIAL LIYMMATTYN YAVLKFKSRE DCCTKF
	Isoform 3 [UniParc]. Checksum: 69BE0DAA9B35C3A0	FASTA	305	33,538
	10 20 30 40 50 60 MKPAMETAAE ENTEQSQERK VNSRAEMEIG RYHWMYPGSK NHQYHPVPTL GDRASPLSSP 70 80 90 100 110 120 GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA GTVAILEQHF STNASDHALL 130 140 150 160 170 180 SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH GEFKTTACGR CISGMFVFLT 190 200 210 220 230 240 YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT GVEQICVDIR QYGIIPWNAF 250 260 270 280 290 300 PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL IYMMATTYNY AVLKFKSRED CCTKF
	Isoform 4 [UniParc]. Checksum: 58E2FC71DEA76C7A	FASTA	328	36,220
	10 20 30 40 50 60 MKPAMETAAE ENTEQSQERK VNSRAEMEIG RYHWMYPGSK NHQYHPVPTL GDRASPLSSP 70 80 90 100 110 120 GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA GTVAILEQHF STNASDHALL 130 140 150 160 170 180 SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH GEFKTTACGR CISGMFVFLT 190 200 210 220 230 240 YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT GVEQICVDIR QYGIIPWNAF 250 260 270 280 290 300 PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALI HFLMILSSNW AYLKDASKMQ 310 320 AYQDIKAKEE QELQDIQSRS KEQLNSYT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chromosomal mapping of the human M6 genes." Olinsky S., Loop B.T., Dekosky A., Ripepi B., Weng W., Cummins J., Wenger S.L., Yan Y., Lagenaur C., Narayanan V. Genomics 33:532-536(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Spinal cord.
[2]	"Mutation analysis of the M6b gene in patients with Rett syndrome." Narayanan V., Olinsky S.L., Dahle E., Naidu S., Zoghbi H.Y. Am. J. Med. Genet. 78:165-168(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
[3]	"Cloning of human full-length m6b1 gene." Xia J.-H., Liu C.-Y., Ruan Q.-G., Fu J.-J., Deng H.-X. Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Molecular cloning of a splicing form of M6b." Liu C.-Y., Cui F., Fu J.-J., Xia J.-H. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[6]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain.
[9]	"Membrane glycoprotein M6B interacts with the human serotonin transporter." Fjorback A.W., Muller H.K., Wiborg O. J. Mol. Neurosci. 37:191-200(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SERT.
[10]	"GPM6B regulates osteoblast function and induction of mineralization by controlling cytoskeleton and matrix vesicle release." Drabek K., van de Peppel J., Eijken M., van Leeuwen J.P. J. Bone Miner. Res. 26:2045-2051(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-318 (ISOFORM 4), MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U45955 mRNA. Translation: AAB16888.1. Different initiation. AF037347 , AF037341, AF037342, AF037343, AF037344, AF037345, AF037346 Genomic DNA. Translation: AAC19165.1. Different initiation. AF037347 , AF037340, AF037342, AF037343, AF037344, AF037345, AF037346 Genomic DNA. Translation: AAC19166.1. AF016004 mRNA. Translation: AAC28560.1. AF047197 , AF047191, AF047192, AF047193, AF047194, AF047195, AF047196 Genomic DNA. Translation: AAD13718.1. AK095657 mRNA. Translation: BAC04600.1. AC003035 Genomic DNA. No translation available. AC003037 Genomic DNA. No translation available. CH471074 Genomic DNA. Translation: EAW98845.1. CH471074 Genomic DNA. Translation: EAW98846.1. BC008151 mRNA. Translation: AAH08151.1. BC047295 mRNA. Translation: AAH47295.1.
IPI	IPI00013421. IPI00187158. IPI00384484. IPI00411643.
RefSeq	NP_001001994.1. NM_001001994.1. NP_001001995.1. NM_001001995.1. NP_001001996.1. NM_001001996.1. NP_005269.1. NM_005278.3.
UniGene	Hs.495710.
3D structure databases
ProteinModelPortal	Q13491.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13491. 2 interactions.
STRING	9606.ENSP00000316861.
PTM databases
PhosphoSite	Q13491.
Polymorphism databases
DMDM	20141466.
Proteomic databases
PaxDb	Q13491.
PRIDE	Q13491.
Protocols and materials databases
DNASU	2824.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316715; ENSP00000316861; ENSG00000046653. ENST00000355135; ENSP00000347258; ENSG00000046653. ENST00000356942; ENSP00000349420; ENSG00000046653. ENST00000454189; ENSP00000389915; ENSG00000046653.
GeneID	2824.
KEGG	hsa:2824.
UCSC	uc004cvw.3. human. uc004cvy.2. human. uc004cvz.2. human. uc004cwa.2. human.
Organism-specific databases
CTD	2824.
GeneCards	GC0XM013698.
HGNC	HGNC:4461. GPM6B.
HPA	HPA002913.
MIM	300051. gene.
neXtProt	NX_Q13491.
PharmGKB	PA28844.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300631.
HOGENOM	HOG000231338.
HOVERGEN	HBG000096.
OMA	KECLNSY.
Gene expression databases
ArrayExpress	Q13491.
Bgee	Q13491.
CleanEx	HS_GPM6B.
Genevestigator	Q13491.
GermOnline	ENSG00000046653. Homo sapiens.
Family and domain databases
InterPro	IPR001614. Myelin_PLP. IPR018237. Myelin_PLP_CS. [Graphical view]
PANTHER	PTHR11683. PTHR11683. 1 hit.
Pfam	PF01275. Myelin_PLP. 1 hit. [Graphical view]
PRINTS	PR00214. MYELINPLP.
SMART	SM00002. PLP. 1 hit. [Graphical view]
PROSITE	PS00575. MYELIN_PLP_1. 1 hit. PS01004. MYELIN_PLP_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPM6B. human.
GenomeRNAi	2824.
NextBio	11135.
SOURCE	Search...

Entry information

Entry name

GPM6B_HUMAN

Accession

Primary (citable) accession number: Q13491
Secondary accession number(s): O76077, Q86X43, Q8N956

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 3, 2002
Last modified:	May 29, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.