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Reviewed, UniProtKB/Swiss-Prot Q13490 (BIRC2_HUMAN)

Last modified June 16, 2009. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Baculoviral IAP repeat-containing protein 2
Alternative name(s):
    Inhibitor of apoptosis protein 2
      Short name=HIAP-2
      Short name=HIAP2
    C-IAP1
    TNFR2-TRAF-signaling complex protein 2
    IAP homolog B
    RING finger protein 48
Gene names
Name: BIRC2
Synonyms: API1, IAP2, MIHB, RNF48
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).

Subunit structure

Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.

Subcellular location

Cytoplasm Potential.

Tissue specificity

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Sequence similarities

Belongs to the IAP family.

Contains 3 BIR repeats.

Contains 1 CARD domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical term3D-structure
Gene Ontology (GO)
   Biological processapoptosis

Inferred from electronic annotation. Source: UniProtKB-KW

cell surface receptor linked signal transduction Ref.1

Traceable author statement. Source: ProtInc

positive regulation of I-kappaB kinase/NF-kappaB cascade

Inferred from expression pattern. Source: UniProtKB

   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618Baculoviral IAP repeat-containing protein 2
PRO_0000122347

Regions

Repeat46 – 11368BIR 1
Repeat184 – 25067BIR 2
Repeat269 – 33668BIR 3
Domain453 – 54391CARD
Zinc finger571 – 60636RING-type

Sites

Metal binding3061Zinc By similarity
Metal binding3091Zinc By similarity
Metal binding3261Zinc By similarity
Metal binding3331Zinc By similarity

Natural variations

Natural variant4531M → I: dbSNP rs34749508. Ref.4
VAR_049535
Natural variant4531M → V Ref.4
VAR_025016
Natural variant5061A → V Ref.4
VAR_025017
Natural variant5491P → S Ref.4
VAR_025018

Experimental info

Sequence conflict1571S → P in AAC50372. Ref.2
Sequence conflict3081C → G in AAC50372. Ref.2
Sequence conflict4141Q → L in AAC50372. Ref.2
Sequence conflict5141L → W in AAC50372. Ref.2

Secondary structure

....................... 618
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q13490-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: C1778D328063586D

FASTA61869,900
        10         20         30         40         50         60 
MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV 

        70         80         90        100        110        120 
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 

       130        140        150        160        170        180 
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA 

       190        200        210        220        230        240 
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH 

       250        260        270        280        290        300 
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR 

       310        320        330        340        350        360 
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL 

       370        380        390        400        410        420 
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT 

       430        440        450        460        470        480 
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD 

       490        500        510        520        530        540 
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF 

       550        560        570        580        590        600 
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR 

       610 
KCPICRGIIK GTVRTFLS 

« Hide

References

« Hide 'large scale' references
[1]"The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins."
Rothe M., Pan M.-G., Henzel W.J., Ayres T.M., Goeddel D.V.
Cell 83:1243-1252(1995) [PubMed: 8548810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."
Liston P., Roy N., Tamai K., Lefebvre C., Baird S., Cherton-Horvat G., Farahani R., McLean M., Ikeda J., Mackenzie A., Korneluk R.G.
Nature 379:349-353(1996) [PubMed: 8552191] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[3]"Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors."
Uren A.G., Pakusch M., Hawkins C.J., Puls K.L., Vaux D.L.
Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996) [PubMed: 8643514] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal liver.
[4]NIEHS SNPs program
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-453; VAL-506 AND SER-549.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis and Uterus.
[6]"Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat."
Hinds M.G., Norton R.S., Vaux D.L., Day C.L.
Nat. Struct. Biol. 6:648-651(1999) [PubMed: 10404221] [Abstract]
Cited for: STRUCTURE BY NMR OF 266-363.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

L49431 mRNA. Translation: AAC41942.1.
U45879 mRNA. Translation: AAC50372.1.
U37547 mRNA. Translation: AAC50508.1.
DQ068066 Genomic DNA. Translation: AAY46158.1.
BC016174 mRNA. Translation: AAH16174.1.
BC028578 mRNA. Translation: AAH28578.1.
IPIIPI00013418.
PIRS68450.
RefSeqNP_001157.1.
UniGeneHs.696238

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1QBHNMR-A266-363[»]
3D9TX-ray1.50A/B260-352[»]
3D9UX-ray2.30A260-352[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ13490. 15 interactions.

Protein family/group databases

MEROPSI32.002.

PTM databases

PhosphoSiteQ13490.

Proteomic databases

PRIDEQ13490.

Genome annotation databases

EnsemblENSG00000110330. Homo sapiens. [Contig view]
GeneID329.
KEGGhsa:329.

Organism-specific databases

GeneCardsGC11P101723.
H-InvDBHIX0010063.
HGNCHGNC:590. BIRC2.
HPAHPA005513.
MIM601712. gene.
PharmGKBPA25359.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ13490.
HOVERGENQ13490.
OMAQ13490. MNTPVIK.

Enzyme and pathway databases

Pathway_Interaction_DBnfkappabcanonicalpathway. Canonical NF-kappaB pathway.
caspase_pathway. Caspase cascade in apoptosis.
p75ntrpathway. p75(NTR)-mediated signaling.
tnfpathway. TNF receptor signaling pathway.
ReactomeREACT_578. Apoptosis.

Gene expression databases

ArrayExpressQ13490.
BgeeQ13490.
CleanExHS_BIRC2.
GermOnlineENSG00000110330. Homo sapiens.

Family and domain databases

InterProIPR001315. CARD.
IPR011029. DEATH-like.
IPR001370. Prot_inh_I32_IAP.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
Gene3DG3DSA:1.10.533.10. DEATH_like. 1 hit.
PfamPF00653. BIR. 3 hits.
PF00619. CARD. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00238. BIR. 3 hits.
SM00114. CARD. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS01282. BIR_REPEAT_1. 3 hits.
PS50143. BIR_REPEAT_2. 3 hits.
PS50209. CARD. 1 hit.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio1355.
PMAP-CutDBQ13490.
SOURCESearch...

Entry information

Entry nameBIRC2_HUMAN
AccessionPrimary (citable) accession number: Q13490
Secondary accession number(s): Q16516, Q4TTG0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents