Baculoviral IAP repeat-containing protein 2

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Reviewed, UniProtKB/Swiss-Prot Q13490 (BIRC2_HUMAN)

Last modified June 16, 2009. Version 95. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Baculoviral IAP repeat-containing protein 2
Alternative name(s):
    Inhibitor of apoptosis protein 2
      Short name=HIAP-2
      Short name=HIAP2
    C-IAP1
    TNFR2-TRAF-signaling complex protein 2
    IAP homolog B
    RING finger protein 48

Gene names

Name:	BIRC2
Synonyms:	API1, IAP2, MIHB, RNF48

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	618 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Subunit structure	Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
Sequence similarities	Belongs to the IAP family. Contains 3 BIR repeats. Contains 1 CARD domain. Contains 1 RING-type zinc finger.

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Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW cell surface receptor linked signal transduction Ref.1 Traceable author statement. Source: ProtInc positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from expression pattern. Source: UniProtKB
Cellular component	cytosol Inferred from Experiment. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
CASP3	P42574	1	EBI-514538,EBI-524064
CASP7	P55210	2	EBI-514538,EBI-523958
CASP9	P55211	1	EBI-514538,EBI-516799
DIABLO	Q9NR28	2	EBI-514538,EBI-517508
MAP3K14	Q99558	1	EBI-514538,EBI-358011
TRAF2	Q12933	3	EBI-514538,EBI-355744

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 618

618

Baculoviral IAP repeat-containing protein 2

PRO_0000122347

Regions

Repeat

46 – 113

BIR 1

Repeat

184 – 250

BIR 2

Repeat

269 – 336

BIR 3

Domain

453 – 543

CARD

Zinc finger

571 – 606

RING-type

Sites

Metal binding

306

Zinc By similarity

Metal binding

309

Zinc By similarity

Metal binding

326

Zinc By similarity

Metal binding

333

Zinc By similarity

Natural variations

Natural variant

453

M → I: dbSNP rs34749508. Ref.4

VAR_049535

Natural variant

453

M → V Ref.4

VAR_025016

Natural variant

506

A → V Ref.4

VAR_025017

Natural variant

549

P → S Ref.4

VAR_025018

Experimental info

Sequence conflict

157

S → P in AAC50372. Ref.2

Sequence conflict

308

C → G in AAC50372. Ref.2

Sequence conflict

414

Q → L in AAC50372. Ref.2

Sequence conflict

514

L → W in AAC50372. Ref.2

Secondary structure

618

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q13490-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: C1778D328063586D
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FASTA

618

69,900

        10         20         30         40         50         60 
MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV 

        70         80         90        100        110        120 
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 

       130        140        150        160        170        180 
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA 

       190        200        210        220        230        240 
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH 

       250        260        270        280        290        300 
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR 

       310        320        330        340        350        360 
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL 

       370        380        390        400        410        420 
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT 

       430        440        450        460        470        480 
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD 

       490        500        510        520        530        540 
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF 

       550        560        570        580        590        600 
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR 

       610 
KCPICRGIIK GTVRTFLS

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins." Rothe M., Pan M.-G., Henzel W.J., Ayres T.M., Goeddel D.V. Cell 83:1243-1252(1995) [PubMed: 8548810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes." Liston P., Roy N., Tamai K., Lefebvre C., Baird S., Cherton-Horvat G., Farahani R., McLean M., Ikeda J., Mackenzie A., Korneluk R.G. Nature 379:349-353(1996) [PubMed: 8552191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors." Uren A.G., Pakusch M., Hawkins C.J., Puls K.L., Vaux D.L. Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996) [PubMed: 8643514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver.
[4]	NIEHS SNPs program Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-453; VAL-506 AND SER-549.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis and Uterus.
[6]	"Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat." Hinds M.G., Norton R.S., Vaux D.L., Day C.L. Nat. Struct. Biol. 6:648-651(1999) [PubMed: 10404221] [Abstract] Cited for: STRUCTURE BY NMR OF 266-363.
+	Additional computationally mapped references.

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Web resources

NIEHS-SNPs

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Cross-references

Sequence databases

L49431 mRNA. Translation: AAC41942.1.
U45879 mRNA. Translation: AAC50372.1.
U37547 mRNA. Translation: AAC50508.1.
DQ068066 Genomic DNA. Translation: AAY46158.1.
BC016174 mRNA. Translation: AAH16174.1.
BC028578 mRNA. Translation: AAH28578.1.

IPI

IPI00013418.

PIR

S68450.

RefSeq

NP_001157.1.

UniGene

Hs.696238

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QBH	NMR	-	A	266-363	[»]
3D9T	X-ray	1.50	A/B	260-352	[»]
3D9U	X-ray	2.30	A	260-352	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13490. 15 interactions.

Protein family/group databases

MEROPS

I32.002.

PTM databases

PhosphoSite

Q13490.

Proteomic databases

PRIDE

Q13490.

Genome annotation databases

Ensembl

ENSG00000110330. Homo sapiens. [Contig view]

GeneID

329.

KEGG

hsa:329.

Organism-specific databases

GeneCards

GC11P101723.

H-InvDB

HIX0010063.

HGNC

HGNC:590. BIRC2.

HPA

HPA005513.

MIM

601712. gene.

PharmGKB

PA25359.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q13490.

HOVERGEN

Q13490.

OMA

Q13490. MNTPVIK.

Enzyme and pathway databases

Pathway_Interaction_DB

nfkappabcanonicalpathway. Canonical NF-kappaB pathway.
caspase_pathway. Caspase cascade in apoptosis.
p75ntrpathway. p75(NTR)-mediated signaling.
tnfpathway. TNF receptor signaling pathway.

Reactome

REACT_578. Apoptosis.

Gene expression databases

ArrayExpress

Q13490.

Bgee

Q13490.

CleanEx

HS_BIRC2.

GermOnline

ENSG00000110330. Homo sapiens.

Family and domain databases

InterPro

IPR001315. CARD.
IPR011029. DEATH-like.
IPR001370. Prot_inh_I32_IAP.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]

Gene3D

G3DSA:1.10.533.10. DEATH_like. 1 hit.

Pfam

PF00653. BIR. 3 hits.
PF00619. CARD. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]

SMART

SM00238. BIR. 3 hits.
SM00114. CARD. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]

PROSITE

PS01282. BIR_REPEAT_1. 3 hits.
PS50143. BIR_REPEAT_2. 3 hits.
PS50209. CARD. 1 hit.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

1355.

PMAP-CutDB

Q13490.

SOURCE

Search...

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Entry information

Entry name

BIRC2_HUMAN

Accession

Primary (citable) accession number: Q13490
Secondary accession number(s): Q16516, Q4TTG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Experimental info

Secondary structure

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents