Reviewed,
UniProtKB/Swiss-Prot Q13489 (BIRC3_HUMAN)
Last modified
November 25, 2008.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Baculoviral IAP repeat-containing protein 3 Alternative name(s): Inhibitor of apoptosis protein 1 Short name=HIAP-1 Short name=HIAP1 C-IAP2 TNFR2-TRAF-signaling complex protein 1 IAP homolog C Apoptosis inhibitor 2 Short name=API2 RING finger protein 49 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 604 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). |
| Subunit structure | Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. |
| Subcellular location | CytoplasmPotential. |
| Tissue specificity | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. |
| Involvement in disease | A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. |
| Sequence similarities | Belongs to the IAP family. Contains 3 BIR repeats. Contains 1 CARD domain. Contains 1 RING-type zinc finger. |
Ontologies
Keywords | |
|---|---|
| Biological process | Apoptosis |
| Cellular component | Cytoplasm |
| Coding sequence diversity | Chromosomal rearrangement Polymorphism |
| Domain | Repeat Zinc-finger |
| Ligand | Metal-binding Zinc |
| Technical term | 3D-structure |
Gene Ontology (GO) | |
| Biological process | anti-apoptosis Ref.2 Traceable author statement. Source: ProtInc cell surface receptor linked signal transduction Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | cytoplasm Inferred from direct assay. Source: UniProtKB nucleusInferred from direct assay. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB ubiquitin-protein ligase activityInferred from direct assay. Source: UniProtKB zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| DIABLO | Q9NR28 | 1 | EBI-517709,EBI-517508 | |
| TRAF2 | Q12933 | 2 | EBI-517709,EBI-355744 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 604 | 604 | Baculoviral IAP repeat-containing protein 3 | PRO_0000122349 | |||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||
| Repeat | 29 – 96 | 68 | BIR 1 | ||||||||||||||||||||||||
| Repeat | 169 – 235 | 67 | BIR 2 | ||||||||||||||||||||||||
| Repeat | 255 – 322 | 68 | BIR 3 | ||||||||||||||||||||||||
| Domain | 439 – 529 | 91 | CARD | ||||||||||||||||||||||||
| Zinc finger | 557 – 592 | 36 | RING-type | ||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||
| Site | 442 – 443 | 2 | Breakpoint for translocation to form BIRC3-MALT1 | ||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||
| Natural variant | 260 | 1 | K → R: dbSNP rs2276113. | VAR_021069 | |||||||||||||||||||||||
| Natural variant | 401 | 1 | R → K: dbSNP rs17881197. | VAR_021070 | |||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||
| Sequence conflict | 18 | 1 | N → Y in AAC83232. Ref.4 | ||||||||||||||||||||||||
| Sequence conflict | 119 | 1 | N → H in AAC50371. Ref.2 | ||||||||||||||||||||||||
| Sequence conflict | 153 | 1 | D → E in AAC50371. Ref.2 | ||||||||||||||||||||||||
| Sequence conflict | 163 | 1 | H → P Ref.2 | ||||||||||||||||||||||||
| Sequence conflict | 165 | 1 | A → P Ref.2 | ||||||||||||||||||||||||
| Sequence conflict | 191 | 1 | K → R in AAC50371. Ref.2 | ||||||||||||||||||||||||
| Sequence conflict | 364 | 1 | F → L in AAC50371. Ref.2 | ||||||||||||||||||||||||
| Sequence conflict | 552 | 1 | Q → P in AAC50371. Ref.2 | ||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||
| Helix | 250 – 252 | 3 | |||||||||||||||||||||||||
| Helix | 255 – 260 | 6 | |||||||||||||||||||||||||
| Helix | 261 – 264 | 4 | |||||||||||||||||||||||||
| Helix | 273 – 278 | 6 | |||||||||||||||||||||||||
| Beta strand | 281 – 285 | 5 | |||||||||||||||||||||||||
| Turn | 286 – 288 | 3 | |||||||||||||||||||||||||
| Beta strand | 289 – 292 | 4 | |||||||||||||||||||||||||
| Turn | 293 – 295 | 3 | |||||||||||||||||||||||||
| Beta strand | 298 – 301 | 4 | |||||||||||||||||||||||||
| Helix | 308 – 315 | 8 | |||||||||||||||||||||||||
| Helix | 320 – 334 | 15 | |||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins." Rothe M., Pan M.-G., Henzel W.J., Ayres T.M., Goeddel D.V. Cell 83:1243-1252(1995) [PubMed: 8548810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes." Liston P., Roy N., Tamai K., Lefebvre C., Baird S., Cherton-Horvat G., Farahani R., McLean M., Ikeda J., Mackenzie A., Korneluk R.G. Nature 379:349-353(1996) [PubMed: 8552191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [3] | "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors." Uren A.G., Pakusch M., Hawkins C.J., Puls K.L., Vaux D.L. Proc. Natl. Acad. Sci. U.S.A. 93:4974-4978(1996) [PubMed: 8643514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver. |
| [4] | "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes." Horrevoets A.J.G., Fontijn R.D., van Zonneveld A.J., de Vries C.J.M., ten Cate J.W., Pannekoek H. Blood 93:3418-3431(1999) [PubMed: 10233894] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [5] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S., Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-260 AND LYS-401. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph. |
| [7] | "Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type." Baens M., Steyls A., Dierlamm J., De Wolf-Peeters C., Marynen P. Genes Chromosomes Cancer 29:281-291(2000) [PubMed: 11066071] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 362-441. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L49432 mRNA. Translation: AAC41943.1. U45878 mRNA. Translation: AAC50371.1. U37546 mRNA. Translation: AAC50507.1. AF070674 mRNA. Translation: AAC83232.1. AY764389 Genomic DNA. Translation: AAU88144.1. BC037420 mRNA. Translation: AAH37420.1. AF178945 Genomic DNA. Translation: AAG09369.1. | |||||||||||||||||||||||||
| PIR | S68449. | ||||||||||||||||||||||||
| RefSeq | NP_001156.1. NP_892007.1. | ||||||||||||||||||||||||
| UniGene | Hs.127799 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | Q13489. | ||||||||||||||||||||||||
Protein family/group databases | |||||||||||||||||||||||||
| MEROPS | I32.003. | ||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||
| PhosphoSite | Q13489. | ||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||
| NIEHS-SNPs | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSG00000023445. Homo sapiens. [Contig view] | ||||||||||||||||||||||||
| GeneID | 330. | ||||||||||||||||||||||||
| KEGG | hsa:330. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| H-InvDB | HIX0026135. | ||||||||||||||||||||||||
| HGNC | HGNC:591. BIRC3. | ||||||||||||||||||||||||
| HPA | HPA002317. | ||||||||||||||||||||||||
| MIM | 601721. gene. | ||||||||||||||||||||||||
| PharmGKB | PA25360. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
| GeneCards | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | Q13489. | ||||||||||||||||||||||||
| HOVERGEN | Q13489. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | Q13489. | ||||||||||||||||||||||||
| CleanEx | HS_BIRC3. | ||||||||||||||||||||||||
| GermOnline | ENSG00000023445. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR001315. CARD. IPR011029. DEATH_like. IPR001370. Prot_inh_I32_IAP. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 1 hit. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00653. BIR. 3 hits. PF00619. CARD. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SMART | SM00238. BIR. 3 hits. SM00114. CARD. 1 hit. SM00184. RING. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS01282. BIR_REPEAT_1. 3 hits. PS50143. BIR_REPEAT_2. 3 hits. PS50209. CARD. 1 hit. PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| NextBio | 1359. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | BIRC3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q13489 Secondary accession number(s): Q16628, Q9HC27, Q9UP46 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


