ID   SNPC2_HUMAN             Reviewed;         334 AA.
AC   Q13487; B2RBZ6; D6W663; Q13486;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 171.
DE   RecName: Full=snRNA-activating protein complex subunit 2;
DE            Short=SNAPc subunit 2;
DE   AltName: Full=Proximal sequence element-binding transcription factor subunit delta;
DE            Short=PSE-binding factor subunit delta;
DE            Short=PTF subunit delta;
DE   AltName: Full=Small nuclear RNA-activating complex polypeptide 2;
DE   AltName: Full=snRNA-activating protein complex 45 kDa subunit;
DE            Short=SNAPc 45 kDa subunit;
GN   Name=SNAPC2; Synonyms=SNAP45;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Teratocarcinoma;
RX   PubMed=8633057; DOI=10.1073/pnas.93.9.4289;
RA   Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N.;
RT   "The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein
RT   complex is required for RNA polymerase II and III snRNA gene transcription
RT   and interacts with the TATA box binding protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8524284; DOI=10.1128/mcb.16.1.1;
RA   Yoon J.B., Roeder R.G.;
RT   "Cloning of two proximal sequence element-binding transcription factor
RT   subunits (gamma and delta) that are required for transcription of small
RT   nuclear RNA genes by RNA polymerases II and III and interact with the TATA-
RT   binding protein.";
RL   Mol. Cell. Biol. 16:1-9(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-118.
RC   TISSUE=Lung;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-118.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH SNAPC4.
RX   PubMed=9418884; DOI=10.1128/mcb.18.1.368;
RA   Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P.,
RA   Strubin M., Hernandez N.;
RT   "The large subunit of basal transcription factor SNAPc is a Myb domain
RT   protein that interacts with Oct-1.";
RL   Mol. Cell. Biol. 18:368-377(1998).
RN   [7]
RP   INTERACTION WITH TBP.
RX   PubMed=12621023; DOI=10.1074/jbc.m204247200;
RA   Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.;
RT   "The small nuclear RNA-activating protein 190 Myb DNA binding domain
RT   stimulates TATA box-binding protein-TATA box recognition.";
RL   J. Biol. Chem. 278:18649-18657(2003).
CC   -!- FUNCTION: Part of the SNAPc complex required for the transcription of
CC       both RNA polymerase II and III small-nuclear RNA genes. Binds to the
CC       proximal sequence element (PSE), a non-TATA-box basal promoter element
CC       common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA
CC       TATA box.
CC   -!- SUBUNIT: Part of the SNAPc complex composed of 5 subunits: SNAPC1,
CC       SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and
CC       SNAPC4. {ECO:0000269|PubMed:12621023, ECO:0000269|PubMed:9418884}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; U44898; AAB06230.1; -; mRNA.
DR   EMBL; U44755; AAC50359.1; -; mRNA.
DR   EMBL; AK314878; BAG37393.1; -; mRNA.
DR   EMBL; CH471139; EAW68957.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW68958.1; -; Genomic_DNA.
DR   EMBL; BC011868; AAH11868.1; -; mRNA.
DR   CCDS; CCDS12190.1; -.
DR   PIR; JC6082; JC6082.
DR   RefSeq; NP_003074.1; NM_003083.3.
DR   AlphaFoldDB; Q13487; -.
DR   SMR; Q13487; -.
DR   BioGRID; 112502; 10.
DR   CORUM; Q13487; -.
DR   DIP; DIP-505N; -.
DR   IntAct; Q13487; 3.
DR   MINT; Q13487; -.
DR   STRING; 9606.ENSP00000221573; -.
DR   iPTMnet; Q13487; -.
DR   PhosphoSitePlus; Q13487; -.
DR   BioMuta; SNAPC2; -.
DR   DMDM; 8134714; -.
DR   EPD; Q13487; -.
DR   jPOST; Q13487; -.
DR   MassIVE; Q13487; -.
DR   MaxQB; Q13487; -.
DR   PaxDb; 9606-ENSP00000221573; -.
DR   PeptideAtlas; Q13487; -.
DR   ProteomicsDB; 59480; -.
DR   Pumba; Q13487; -.
DR   Antibodypedia; 12285; 159 antibodies from 23 providers.
DR   DNASU; 6618; -.
DR   Ensembl; ENST00000221573.11; ENSP00000221573.5; ENSG00000104976.13.
DR   GeneID; 6618; -.
DR   KEGG; hsa:6618; -.
DR   MANE-Select; ENST00000221573.11; ENSP00000221573.5; NM_003083.4; NP_003074.1.
DR   UCSC; uc002miw.3; human.
DR   AGR; HGNC:11135; -.
DR   CTD; 6618; -.
DR   DisGeNET; 6618; -.
DR   GeneCards; SNAPC2; -.
DR   HGNC; HGNC:11135; SNAPC2.
DR   HPA; ENSG00000104976; Low tissue specificity.
DR   MIM; 605076; gene.
DR   neXtProt; NX_Q13487; -.
DR   OpenTargets; ENSG00000104976; -.
DR   PharmGKB; PA35983; -.
DR   VEuPathDB; HostDB:ENSG00000104976; -.
DR   eggNOG; ENOG502S260; Eukaryota.
DR   GeneTree; ENSGT00390000017407; -.
DR   HOGENOM; CLU_048442_0_0_1; -.
DR   InParanoid; Q13487; -.
DR   OMA; EPKSAWQ; -.
DR   OrthoDB; 5363345at2759; -.
DR   PhylomeDB; Q13487; -.
DR   TreeFam; TF336993; -.
DR   PathwayCommons; Q13487; -.
DR   Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes.
DR   Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
DR   Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter.
DR   SignaLink; Q13487; -.
DR   BioGRID-ORCS; 6618; 770 hits in 1174 CRISPR screens.
DR   ChiTaRS; SNAPC2; human.
DR   GeneWiki; SNAPC2; -.
DR   GenomeRNAi; 6618; -.
DR   Pharos; Q13487; Tdark.
DR   PRO; PR:Q13487; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q13487; Protein.
DR   Bgee; ENSG00000104976; Expressed in right uterine tube and 120 other cell types or tissues.
DR   ExpressionAtlas; Q13487; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0016604; C:nuclear body; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; TAS:ProtInc.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; NAS:ARUK-UCL.
DR   GO; GO:0009301; P:snRNA transcription; TAS:ProtInc.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR   GO; GO:0006383; P:transcription by RNA polymerase III; TAS:ProtInc.
DR   InterPro; IPR021281; SNAPC2.
DR   PANTHER; PTHR15132; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR15132:SF1; SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF11035; SNAPC2; 1.
DR   Genevisible; Q13487; HS.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..334
FT                   /note="snRNA-activating protein complex subunit 2"
FT                   /id="PRO_0000072020"
FT   REGION          137..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..186
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         118
FT                   /note="L -> V (in dbSNP:rs475002)"
FT                   /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.4"
FT                   /id="VAR_011806"
SQ   SEQUENCE   334 AA;  35556 MW;  441894AF6E1F4083 CRC64;
     MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA
     EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV
     AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR
     TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL
     PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
     HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR
//