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Protein

snRNA-activating protein complex subunit 2

Gene

SNAPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • snRNA transcription Source: ProtInc
  • snRNA transcription from RNA polymerase II promoter Source: Reactome
  • transcription from RNA polymerase III promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 2
Short name:
SNAPc subunit 2
Alternative name(s):
Proximal sequence element-binding transcription factor subunit delta
Short name:
PSE-binding factor subunit delta
Short name:
PTF subunit delta
Small nuclear RNA-activating complex polypeptide 2
snRNA-activating protein complex 45 kDa subunit
Short name:
SNAPc 45 kDa subunit
Gene namesi
Name:SNAPC2
Synonyms:SNAP45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104976.11.
HGNCiHGNC:11135. SNAPC2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104976.
PharmGKBiPA35983.

Polymorphism and mutation databases

BioMutaiSNAPC2.
DMDMi8134714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720201 – 334snRNA-activating protein complex subunit 2Add BLAST334

Proteomic databases

EPDiQ13487.
MaxQBiQ13487.
PaxDbiQ13487.
PeptideAtlasiQ13487.
PRIDEiQ13487.

PTM databases

iPTMnetiQ13487.
PhosphoSitePlusiQ13487.

Expressioni

Gene expression databases

BgeeiENSG00000104976.
CleanExiHS_SNAPC2.
ExpressionAtlasiQ13487. baseline and differential.
GenevisibleiQ13487. HS.

Organism-specific databases

HPAiHPA049843.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.2 Publications

Protein-protein interaction databases

BioGridi112502. 6 interactors.
CORUMiQ13487.
DIPiDIP-505N.
IntActiQ13487. 1 interactor.
STRINGi9606.ENSP00000221573.

Structurei

3D structure databases

ProteinModelPortaliQ13487.
SMRiQ13487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IX3I. Eukaryota.
ENOG410YPM6. LUCA.
GeneTreeiENSGT00390000017407.
HOGENOMiHOG000132929.
HOVERGENiHBG079198.
InParanoidiQ13487.
KOiK15209.
OMAiVEHMTET.
OrthoDBiEOG091G0O5J.
PhylomeDBiQ13487.
TreeFamiTF336993.

Family and domain databases

InterProiView protein in InterPro
IPR021281. SnAPC_su2-like.
PANTHERiPTHR15132. PTHR15132. 1 hit.
PfamiView protein in Pfam
PF11035. SnAPC_2_like. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL
60 70 80 90 100
ARELRGRSEA EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI
110 120 130 140 150
EVWTDLAEKI TGPLEEALAV AFSQVLTIAA TEPVTLLHSK PPKPTQARGK
160 170 180 190 200
PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR TPDPAPEKPS ESSAGPSTEE
210 220 230 240 250
DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL PEELPLLPCT
260 270 280 290 300
ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
310 320 330
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR
Length:334
Mass (Da):35,556
Last modified:November 1, 1996 - v1
Checksum:i441894AF6E1F4083
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011806118L → V2 PublicationsCorresponds to variant dbSNP:rs475002Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44898 mRNA. Translation: AAB06230.1.
U44755 mRNA. Translation: AAC50359.1.
AK314878 mRNA. Translation: BAG37393.1.
CH471139 Genomic DNA. Translation: EAW68957.1.
CH471139 Genomic DNA. Translation: EAW68958.1.
BC011868 mRNA. Translation: AAH11868.1.
CCDSiCCDS12190.1.
PIRiJC6082.
RefSeqiNP_003074.1. NM_003083.3.
UniGeneiHs.631860.

Genome annotation databases

EnsembliENST00000221573; ENSP00000221573; ENSG00000104976.
GeneIDi6618.
KEGGihsa:6618.
UCSCiuc002miw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNPC2_HUMAN
AccessioniPrimary (citable) accession number: Q13487
Secondary accession number(s): B2RBZ6, D6W663, Q13486
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot