Q13487 (SNPC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
snRNA-activating protein complex subunit 2
Short name=SNAPc subunit 2

Alternative name(s):
Proximal sequence element-binding transcription factor subunit delta
Short name=PSE-binding factor subunit delta
Short name=PTF subunit delta
Small nuclear RNA-activating complex polypeptide 2
snRNA-activating protein complex 45 kDa subunit
Short name=SNAPc 45 kDa subunit

Gene names

Name:	SNAPC2
Synonyms:	SNAP45

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Subunit structure	Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4. Ref.6 Ref.7
Subcellular location	Nucleus.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	snRNA transcription Traceable author statement Ref.2. Source: ProtInc transcription from RNA polymerase II promoter Traceable author statement Ref.2. Source: ProtInc transcription from RNA polymerase III promoter Traceable author statement. Source: Reactome
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	sequence-specific DNA binding transcription factor activity Traceable author statement PubMed 7715707Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	snRNA-activating protein complex subunit 2		PRO_0000072020
Natural variations
	Natural variant	118	1	L → V. Ref.3 Ref.4 Corresponds to variant rs475002 [ dbSNP | Ensembl ].		VAR_011806

Sequences

	Sequence		Length	Mass (Da)
	Q13487 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 441894AF6E1F4083	FASTA	334	35,556
	10 20 30 40 50 60 MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA 70 80 90 100 110 120 EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV 130 140 150 160 170 180 AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR 190 200 210 220 230 240 TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL 250 260 270 280 290 300 PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE 310 320 330 HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein." Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N. Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Teratocarcinoma.
[2]	"Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein." Yoon J.B., Roeder R.G. Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118. Tissue: Lung.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-118.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1." Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P., Strubin M., Hernandez N. Mol. Cell. Biol. 18:368-377(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SNAPC4.
[7]	"The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition." Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W. J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TBP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U44898 mRNA. Translation: AAB06230.1. U44755 mRNA. Translation: AAC50359.1. AK314878 mRNA. Translation: BAG37393.1. CH471139 Genomic DNA. Translation: EAW68957.1. CH471139 Genomic DNA. Translation: EAW68958.1. BC011868 mRNA. Translation: AAH11868.1.
IPI	IPI00013406.
PIR	JC6082.
RefSeq	NP_003074.1. NM_003083.3.
UniGene	Hs.631860.
3D structure databases
ProteinModelPortal	Q13487.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-505N.
STRING	9606.ENSP00000221573.
PTM databases
PhosphoSite	Q13487.
Polymorphism databases
DMDM	8134714.
Proteomic databases
PaxDb	Q13487.
PRIDE	Q13487.
Protocols and materials databases
DNASU	6618.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221573; ENSP00000221573; ENSG00000104976.
GeneID	6618.
KEGG	hsa:6618.
UCSC	uc002miw.2. human.
Organism-specific databases
CTD	6618.
GeneCards	GC19P007985.
HGNC	HGNC:11135. SNAPC2.
MIM	605076. gene.
neXtProt	NX_Q13487.
PharmGKB	PA35983.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41796.
HOGENOM	HOG000132929.
HOVERGEN	HBG079198.
InParanoid	Q13487.
KO	K15209.
OMA	PKPTQAR.
OrthoDB	EOG43R3PD.
PhylomeDB	Q13487.
Enzyme and pathway databases
Reactome	REACT_1788. Transcription. REACT_71. Gene Expression.
Gene expression databases
Bgee	Q13487.
CleanEx	HS_SNAPC2.
Genevestigator	Q13487.
GermOnline	ENSG00000104976. Homo sapiens.
Family and domain databases
InterPro	IPR021281. SnAPC_su2-like. [Graphical view]
PANTHER	PTHR15132. PTHR15132. 1 hit.
Pfam	PF11035. SnAPC_2_like. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6618.
NextBio	25771.
SOURCE	Search...

Entry information

Entry name

SNPC2_HUMAN

Accession

Primary (citable) accession number: Q13487
Secondary accession number(s): B2RBZ6, D6W663, Q13486

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.