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Q13487

- SNPC2_HUMAN

UniProt

Q13487 - SNPC2_HUMAN

Protein

snRNA-activating protein complex subunit 2

Gene

SNAPC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. snRNA transcription Source: ProtInc
    3. transcription from RNA polymerase III promoter Source: Reactome
    4. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    snRNA-activating protein complex subunit 2
    Short name:
    SNAPc subunit 2
    Alternative name(s):
    Proximal sequence element-binding transcription factor subunit delta
    Short name:
    PSE-binding factor subunit delta
    Short name:
    PTF subunit delta
    Small nuclear RNA-activating complex polypeptide 2
    snRNA-activating protein complex 45 kDa subunit
    Short name:
    SNAPc 45 kDa subunit
    Gene namesi
    Name:SNAPC2
    Synonyms:SNAP45
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11135. SNAPC2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35983.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334snRNA-activating protein complex subunit 2PRO_0000072020Add
    BLAST

    Proteomic databases

    MaxQBiQ13487.
    PaxDbiQ13487.
    PRIDEiQ13487.

    PTM databases

    PhosphoSiteiQ13487.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13487.
    BgeeiQ13487.
    CleanExiHS_SNAPC2.
    GenevestigatoriQ13487.

    Organism-specific databases

    HPAiHPA049843.

    Interactioni

    Subunit structurei

    Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.2 Publications

    Protein-protein interaction databases

    BioGridi112502. 4 interactions.
    DIPiDIP-505N.
    STRINGi9606.ENSP00000221573.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG41796.
    HOGENOMiHOG000132929.
    HOVERGENiHBG079198.
    InParanoidiQ13487.
    KOiK15209.
    OMAiWMDLAEK.
    OrthoDBiEOG7VTDP4.
    PhylomeDBiQ13487.
    TreeFamiTF336993.

    Family and domain databases

    InterProiIPR021281. SnAPC_su2-like.
    [Graphical view]
    PANTHERiPTHR15132. PTHR15132. 1 hit.
    PfamiPF11035. SnAPC_2_like. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13487-1 [UniParc]FASTAAdd to Basket

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    MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL    50
    ARELRGRSEA EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI 100
    EVWTDLAEKI TGPLEEALAV AFSQVLTIAA TEPVTLLHSK PPKPTQARGK 150
    PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR TPDPAPEKPS ESSAGPSTEE 200
    DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL PEELPLLPCT 250
    ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE 300
    HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR 334
    Length:334
    Mass (Da):35,556
    Last modified:November 1, 1996 - v1
    Checksum:i441894AF6E1F4083
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181L → V.2 Publications
    Corresponds to variant rs475002 [ dbSNP | Ensembl ].
    VAR_011806

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44898 mRNA. Translation: AAB06230.1.
    U44755 mRNA. Translation: AAC50359.1.
    AK314878 mRNA. Translation: BAG37393.1.
    CH471139 Genomic DNA. Translation: EAW68957.1.
    CH471139 Genomic DNA. Translation: EAW68958.1.
    BC011868 mRNA. Translation: AAH11868.1.
    CCDSiCCDS12190.1.
    PIRiJC6082.
    RefSeqiNP_003074.1. NM_003083.3.
    UniGeneiHs.631860.

    Genome annotation databases

    EnsembliENST00000221573; ENSP00000221573; ENSG00000104976.
    GeneIDi6618.
    KEGGihsa:6618.
    UCSCiuc002miw.2. human.

    Polymorphism databases

    DMDMi8134714.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44898 mRNA. Translation: AAB06230.1 .
    U44755 mRNA. Translation: AAC50359.1 .
    AK314878 mRNA. Translation: BAG37393.1 .
    CH471139 Genomic DNA. Translation: EAW68957.1 .
    CH471139 Genomic DNA. Translation: EAW68958.1 .
    BC011868 mRNA. Translation: AAH11868.1 .
    CCDSi CCDS12190.1.
    PIRi JC6082.
    RefSeqi NP_003074.1. NM_003083.3.
    UniGenei Hs.631860.

    3D structure databases

    ProteinModelPortali Q13487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112502. 4 interactions.
    DIPi DIP-505N.
    STRINGi 9606.ENSP00000221573.

    PTM databases

    PhosphoSitei Q13487.

    Polymorphism databases

    DMDMi 8134714.

    Proteomic databases

    MaxQBi Q13487.
    PaxDbi Q13487.
    PRIDEi Q13487.

    Protocols and materials databases

    DNASUi 6618.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221573 ; ENSP00000221573 ; ENSG00000104976 .
    GeneIDi 6618.
    KEGGi hsa:6618.
    UCSCi uc002miw.2. human.

    Organism-specific databases

    CTDi 6618.
    GeneCardsi GC19P007985.
    HGNCi HGNC:11135. SNAPC2.
    HPAi HPA049843.
    MIMi 605076. gene.
    neXtProti NX_Q13487.
    PharmGKBi PA35983.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41796.
    HOGENOMi HOG000132929.
    HOVERGENi HBG079198.
    InParanoidi Q13487.
    KOi K15209.
    OMAi WMDLAEK.
    OrthoDBi EOG7VTDP4.
    PhylomeDBi Q13487.
    TreeFami TF336993.

    Enzyme and pathway databases

    Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

    Miscellaneous databases

    GeneWikii SNAPC2.
    GenomeRNAii 6618.
    NextBioi 25771.
    PROi Q13487.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13487.
    Bgeei Q13487.
    CleanExi HS_SNAPC2.
    Genevestigatori Q13487.

    Family and domain databases

    InterProi IPR021281. SnAPC_su2-like.
    [Graphical view ]
    PANTHERi PTHR15132. PTHR15132. 1 hit.
    Pfami PF11035. SnAPC_2_like. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein."
      Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N.
      Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Teratocarcinoma.
    2. "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."
      Yoon J.B., Roeder R.G.
      Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118.
      Tissue: Lung.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-118.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1."
      Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P., Strubin M., Hernandez N.
      Mol. Cell. Biol. 18:368-377(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNAPC4.
    7. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
      Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
      J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TBP.

    Entry informationi

    Entry nameiSNPC2_HUMAN
    AccessioniPrimary (citable) accession number: Q13487
    Secondary accession number(s): B2RBZ6, D6W663, Q13486
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3