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Q13487

- SNPC2_HUMAN

UniProt

Q13487 - SNPC2_HUMAN

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Protein

snRNA-activating protein complex subunit 2

Gene

SNAPC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. gene expression Source: Reactome
  2. snRNA transcription Source: ProtInc
  3. transcription from RNA polymerase III promoter Source: Reactome
  4. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 2
Short name:
SNAPc subunit 2
Alternative name(s):
Proximal sequence element-binding transcription factor subunit delta
Short name:
PSE-binding factor subunit delta
Short name:
PTF subunit delta
Small nuclear RNA-activating complex polypeptide 2
snRNA-activating protein complex 45 kDa subunit
Short name:
SNAPc 45 kDa subunit
Gene namesi
Name:SNAPC2
Synonyms:SNAP45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11135. SNAPC2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334snRNA-activating protein complex subunit 2PRO_0000072020Add
BLAST

Proteomic databases

MaxQBiQ13487.
PaxDbiQ13487.
PRIDEiQ13487.

PTM databases

PhosphoSiteiQ13487.

Expressioni

Gene expression databases

BgeeiQ13487.
CleanExiHS_SNAPC2.
ExpressionAtlasiQ13487. baseline.
GenevestigatoriQ13487.

Organism-specific databases

HPAiHPA049843.

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.2 Publications

Protein-protein interaction databases

BioGridi112502. 4 interactions.
DIPiDIP-505N.
STRINGi9606.ENSP00000221573.

Structurei

3D structure databases

ProteinModelPortaliQ13487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG41796.
GeneTreeiENSGT00390000017407.
HOGENOMiHOG000132929.
HOVERGENiHBG079198.
InParanoidiQ13487.
KOiK15209.
OMAiWMDLAEK.
OrthoDBiEOG7VTDP4.
PhylomeDBiQ13487.
TreeFamiTF336993.

Family and domain databases

InterProiIPR021281. SnAPC_su2-like.
[Graphical view]
PANTHERiPTHR15132. PTHR15132. 1 hit.
PfamiPF11035. SnAPC_2_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13487-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL
60 70 80 90 100
ARELRGRSEA EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI
110 120 130 140 150
EVWTDLAEKI TGPLEEALAV AFSQVLTIAA TEPVTLLHSK PPKPTQARGK
160 170 180 190 200
PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR TPDPAPEKPS ESSAGPSTEE
210 220 230 240 250
DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL PEELPLLPCT
260 270 280 290 300
ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
310 320 330
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR
Length:334
Mass (Da):35,556
Last modified:November 1, 1996 - v1
Checksum:i441894AF6E1F4083
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181L → V.2 Publications
Corresponds to variant rs475002 [ dbSNP | Ensembl ].
VAR_011806

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44898 mRNA. Translation: AAB06230.1.
U44755 mRNA. Translation: AAC50359.1.
AK314878 mRNA. Translation: BAG37393.1.
CH471139 Genomic DNA. Translation: EAW68957.1.
CH471139 Genomic DNA. Translation: EAW68958.1.
BC011868 mRNA. Translation: AAH11868.1.
CCDSiCCDS12190.1.
PIRiJC6082.
RefSeqiNP_003074.1. NM_003083.3.
UniGeneiHs.631860.

Genome annotation databases

EnsembliENST00000221573; ENSP00000221573; ENSG00000104976.
GeneIDi6618.
KEGGihsa:6618.
UCSCiuc002miw.2. human.

Polymorphism databases

DMDMi8134714.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44898 mRNA. Translation: AAB06230.1 .
U44755 mRNA. Translation: AAC50359.1 .
AK314878 mRNA. Translation: BAG37393.1 .
CH471139 Genomic DNA. Translation: EAW68957.1 .
CH471139 Genomic DNA. Translation: EAW68958.1 .
BC011868 mRNA. Translation: AAH11868.1 .
CCDSi CCDS12190.1.
PIRi JC6082.
RefSeqi NP_003074.1. NM_003083.3.
UniGenei Hs.631860.

3D structure databases

ProteinModelPortali Q13487.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112502. 4 interactions.
DIPi DIP-505N.
STRINGi 9606.ENSP00000221573.

PTM databases

PhosphoSitei Q13487.

Polymorphism databases

DMDMi 8134714.

Proteomic databases

MaxQBi Q13487.
PaxDbi Q13487.
PRIDEi Q13487.

Protocols and materials databases

DNASUi 6618.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221573 ; ENSP00000221573 ; ENSG00000104976 .
GeneIDi 6618.
KEGGi hsa:6618.
UCSCi uc002miw.2. human.

Organism-specific databases

CTDi 6618.
GeneCardsi GC19P007985.
HGNCi HGNC:11135. SNAPC2.
HPAi HPA049843.
MIMi 605076. gene.
neXtProti NX_Q13487.
PharmGKBi PA35983.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41796.
GeneTreei ENSGT00390000017407.
HOGENOMi HOG000132929.
HOVERGENi HBG079198.
InParanoidi Q13487.
KOi K15209.
OMAi WMDLAEK.
OrthoDBi EOG7VTDP4.
PhylomeDBi Q13487.
TreeFami TF336993.

Enzyme and pathway databases

Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

GeneWikii SNAPC2.
GenomeRNAii 6618.
NextBioi 25771.
PROi Q13487.
SOURCEi Search...

Gene expression databases

Bgeei Q13487.
CleanExi HS_SNAPC2.
ExpressionAtlasi Q13487. baseline.
Genevestigatori Q13487.

Family and domain databases

InterProi IPR021281. SnAPC_su2-like.
[Graphical view ]
PANTHERi PTHR15132. PTHR15132. 1 hit.
Pfami PF11035. SnAPC_2_like. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein."
    Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N.
    Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Teratocarcinoma.
  2. "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."
    Yoon J.B., Roeder R.G.
    Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118.
    Tissue: Lung.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-118.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1."
    Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P., Strubin M., Hernandez N.
    Mol. Cell. Biol. 18:368-377(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNAPC4.
  7. "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
    Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
    J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TBP.

Entry informationi

Entry nameiSNPC2_HUMAN
AccessioniPrimary (citable) accession number: Q13487
Secondary accession number(s): B2RBZ6, D6W663, Q13486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3