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Protein

snRNA-activating protein complex subunit 2

Gene

SNAPC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  • snRNA transcription Source: ProtInc
  • snRNA transcription by RNA polymerase II Source: Reactome
  • transcription by RNA polymerase II Source: ProtInc
  • transcription by RNA polymerase III Source: ProtInc

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 2
Short name:
SNAPc subunit 2
Alternative name(s):
Proximal sequence element-binding transcription factor subunit delta
Short name:
PSE-binding factor subunit delta
Short name:
PTF subunit delta
Small nuclear RNA-activating complex polypeptide 2
snRNA-activating protein complex 45 kDa subunit
Short name:
SNAPc 45 kDa subunit
Gene namesi
Name:SNAPC2
Synonyms:SNAP45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104976.11
HGNCiHGNC:11135 SNAPC2
MIMi605076 gene
neXtProtiNX_Q13487

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104976
PharmGKBiPA35983

Polymorphism and mutation databases

BioMutaiSNAPC2
DMDMi8134714

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720201 – 334snRNA-activating protein complex subunit 2Add BLAST334

Proteomic databases

EPDiQ13487
MaxQBiQ13487
PaxDbiQ13487
PeptideAtlasiQ13487
PRIDEiQ13487

PTM databases

iPTMnetiQ13487
PhosphoSitePlusiQ13487

Expressioni

Gene expression databases

BgeeiENSG00000104976
CleanExiHS_SNAPC2
ExpressionAtlasiQ13487 baseline and differential
GenevisibleiQ13487 HS

Organism-specific databases

HPAiHPA049843

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4.2 Publications

Protein-protein interaction databases

BioGridi112502, 6 interactors
CORUMiQ13487
DIPiDIP-505N
IntActiQ13487, 1 interactor
STRINGi9606.ENSP00000221573

Structurei

3D structure databases

ProteinModelPortaliQ13487
SMRiQ13487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IX3I Eukaryota
ENOG410YPM6 LUCA
GeneTreeiENSGT00390000017407
HOGENOMiHOG000132929
HOVERGENiHBG079198
InParanoidiQ13487
KOiK15209
OMAiVEHMTET
OrthoDBiEOG091G0O5J
PhylomeDBiQ13487
TreeFamiTF336993

Family and domain databases

InterProiView protein in InterPro
IPR021281 SnAPC_su2-like
PANTHERiPTHR15132 PTHR15132, 1 hit
PfamiView protein in Pfam
PF11035 SnAPC_2_like, 1 hit

Sequencei

Sequence statusi: Complete.

Q13487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL
60 70 80 90 100
ARELRGRSEA EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI
110 120 130 140 150
EVWTDLAEKI TGPLEEALAV AFSQVLTIAA TEPVTLLHSK PPKPTQARGK
160 170 180 190 200
PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR TPDPAPEKPS ESSAGPSTEE
210 220 230 240 250
DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL PEELPLLPCT
260 270 280 290 300
ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE
310 320 330
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR
Length:334
Mass (Da):35,556
Last modified:November 1, 1996 - v1
Checksum:i441894AF6E1F4083
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011806118L → V2 PublicationsCorresponds to variant dbSNP:rs475002Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44898 mRNA Translation: AAB06230.1
U44755 mRNA Translation: AAC50359.1
AK314878 mRNA Translation: BAG37393.1
CH471139 Genomic DNA Translation: EAW68957.1
CH471139 Genomic DNA Translation: EAW68958.1
BC011868 mRNA Translation: AAH11868.1
CCDSiCCDS12190.1
PIRiJC6082
RefSeqiNP_003074.1, NM_003083.3
UniGeneiHs.631860

Genome annotation databases

EnsembliENST00000221573; ENSP00000221573; ENSG00000104976
GeneIDi6618
KEGGihsa:6618
UCSCiuc002miw.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNPC2_HUMAN
AccessioniPrimary (citable) accession number: Q13487
Secondary accession number(s): B2RBZ6, D6W663, Q13486
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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