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Q13487 (SNPC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
snRNA-activating protein complex subunit 2

Short name=SNAPc subunit 2
Alternative name(s):
Proximal sequence element-binding transcription factor subunit delta
Short name=PSE-binding factor subunit delta
Short name=PTF subunit delta
Small nuclear RNA-activating complex polypeptide 2
snRNA-activating protein complex 45 kDa subunit
Short name=SNAPc 45 kDa subunit
Gene names
Name:SNAPC2
Synonyms:SNAP45
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Subunit structure

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC2 interacts with TBP and SNAPC4. Ref.6 Ref.7

Subcellular location

Nucleus.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334snRNA-activating protein complex subunit 2
PRO_0000072020

Natural variations

Natural variant1181L → V. Ref.3 Ref.4
Corresponds to variant rs475002 [ dbSNP | Ensembl ].
VAR_011806

Sequences

Sequence LengthMass (Da)Tools
Q13487 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 441894AF6E1F4083

FASTA33435,556
        10         20         30         40         50         60 
MKPPPRRRAA PARYLGEVTG PATWSAREKR QLVRLLQARQ GQPEPDATEL ARELRGRSEA 

        70         80         90        100        110        120 
EIRVFLQQLK GRVAREAIQK VHPGGLQGPR RREAQPPAPI EVWTDLAEKI TGPLEEALAV 

       130        140        150        160        170        180 
AFSQVLTIAA TEPVTLLHSK PPKPTQARGK PLLLSAPGGQ EDPAPEIPSS APAAPSSAPR 

       190        200        210        220        230        240 
TPDPAPEKPS ESSAGPSTEE DFAVDFEKIY KYLSSVSRSG RSPELSAAES AVVLDLLMSL 

       250        260        270        280        290        300 
PEELPLLPCT ALVEHMTETY LRLTAPQPIP AGGSLGPAAE GDGAGSKAPE ETPPATEKAE 

       310        320        330 
HSELKSPWQA AGICPLNPFL VPLELLGRAA TPAR 

« Hide

References

« Hide 'large scale' references
[1]"The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein."
Sadowski C.L., Henry R.W., Kobayashi R., Hernandez N.
Proc. Natl. Acad. Sci. U.S.A. 93:4289-4293(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Teratocarcinoma.
[2]"Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein."
Yoon J.B., Roeder R.G.
Mol. Cell. Biol. 16:1-9(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-118.
Tissue: Lung.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-118.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1."
Wong M.W., Henry R.W., Ma B., Kobayashi R., Klages N., Matthias P., Strubin M., Hernandez N.
Mol. Cell. Biol. 18:368-377(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNAPC4.
[7]"The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition."
Hinkley C.S., Hirsch H.A., Gu L., LaMere B., Henry R.W.
J. Biol. Chem. 278:18649-18657(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TBP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U44898 mRNA. Translation: AAB06230.1.
U44755 mRNA. Translation: AAC50359.1.
AK314878 mRNA. Translation: BAG37393.1.
CH471139 Genomic DNA. Translation: EAW68957.1.
CH471139 Genomic DNA. Translation: EAW68958.1.
BC011868 mRNA. Translation: AAH11868.1.
PIRJC6082.
RefSeqNP_003074.1. NM_003083.3.
UniGeneHs.631860.

3D structure databases

ProteinModelPortalQ13487.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112502. 4 interactions.
DIPDIP-505N.
STRING9606.ENSP00000221573.

PTM databases

PhosphoSiteQ13487.

Polymorphism databases

DMDM8134714.

Proteomic databases

PaxDbQ13487.
PRIDEQ13487.

Protocols and materials databases

DNASU6618.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221573; ENSP00000221573; ENSG00000104976.
GeneID6618.
KEGGhsa:6618.
UCSCuc002miw.2. human.

Organism-specific databases

CTD6618.
GeneCardsGC19P007985.
HGNCHGNC:11135. SNAPC2.
HPAHPA049843.
MIM605076. gene.
neXtProtNX_Q13487.
PharmGKBPA35983.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41796.
HOGENOMHOG000132929.
HOVERGENHBG079198.
InParanoidQ13487.
KOK15209.
OMAWMDLAEK.
OrthoDBEOG7VTDP4.
PhylomeDBQ13487.
TreeFamTF336993.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ13487.
BgeeQ13487.
CleanExHS_SNAPC2.
GenevestigatorQ13487.

Family and domain databases

InterProIPR021281. SnAPC_su2-like.
[Graphical view]
PANTHERPTHR15132. PTHR15132. 1 hit.
PfamPF11035. SnAPC_2_like. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSNAPC2.
GenomeRNAi6618.
NextBio25771.
PROQ13487.
SOURCESearch...

Entry information

Entry nameSNPC2_HUMAN
AccessionPrimary (citable) accession number: Q13487
Secondary accession number(s): B2RBZ6, D6W663, Q13486
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM