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Protein

Interleukin-18 receptor 1

Gene

IL18R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).By similarityCurated1 Publication

GO - Molecular functioni

  • interleukin-18 receptor activity Source: Ensembl
  • interleukin-1 receptor activity Source: InterPro
  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115604-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SIGNORiQ13478.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor 1
Short name:
IL-18R-1
Short name:
IL-18R1
Alternative name(s):
CD218 antigen-like family member A
CDw218a
IL1 receptor-related protein
Short name:
IL-1Rrp
Short name:
IL1R-rp
CD_antigen: CD218a
Gene namesi
Name:IL18R1
Synonyms:IL1RRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5988. IL18R1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 329ExtracellularSequence analysisAdd BLAST308
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351 – 541CytoplasmicSequence analysisAdd BLAST191

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8809.
OpenTargetsiENSG00000115604.
PharmGKBiPA29804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000001544819 – 541Interleukin-18 receptor 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi140 ↔ 185PROSITE-ProRule annotation
Glycosylationi150N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi237 ↔ 298PROSITE-ProRule annotation
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13478.
PaxDbiQ13478.
PeptideAtlasiQ13478.
PRIDEiQ13478.

PTM databases

iPTMnetiQ13478.
PhosphoSitePlusiQ13478.

Expressioni

Tissue specificityi

Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart.1 Publication

Gene expression databases

BgeeiENSG00000115604.
CleanExiHS_IL18R1.
ExpressionAtlasiQ13478. baseline and differential.
GenevisibleiQ13478. HS.

Organism-specific databases

HPAiHPA007615.

Interactioni

Subunit structurei

Heterodimer with IL18RAP; within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).By similarityCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
IL18Q141162EBI-9817499,EBI-3910835

Protein-protein interaction databases

BioGridi114337. 2 interactors.
IntActiQ13478. 1 interactor.
STRINGi9606.ENSP00000233957.

Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 31Combined sources6
Beta strandi36 – 39Combined sources4
Turni43 – 47Combined sources5
Beta strandi55 – 59Combined sources5
Beta strandi76 – 79Combined sources4
Beta strandi82 – 87Combined sources6
Helixi90 – 92Combined sources3
Beta strandi94 – 100Combined sources7
Beta strandi103 – 112Combined sources10
Beta strandi116 – 120Combined sources5
Helixi122 – 124Combined sources3
Beta strandi125 – 131Combined sources7
Beta strandi134 – 139Combined sources6
Turni143 – 145Combined sources3
Helixi146 – 148Combined sources3
Beta strandi149 – 156Combined sources8
Beta strandi166 – 168Combined sources3
Beta strandi170 – 174Combined sources5
Helixi177 – 179Combined sources3
Beta strandi181 – 191Combined sources11
Beta strandi194 – 207Combined sources14
Beta strandi216 – 219Combined sources4
Beta strandi221 – 226Combined sources6
Beta strandi233 – 241Combined sources9
Beta strandi246 – 250Combined sources5
Beta strandi261 – 263Combined sources3
Beta strandi266 – 270Combined sources5
Turni272 – 274Combined sources3
Beta strandi276 – 284Combined sources9
Turni290 – 292Combined sources3
Beta strandi296 – 302Combined sources7
Beta strandi305 – 314Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO3X-ray3.10B/D/F/H/J/L20-329[»]
3WO4X-ray3.10B20-329[»]
4R6UX-ray2.80A/C19-329[»]
ProteinModelPortaliQ13478.
SMRiQ13478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 121Ig-like C2-type 1Add BLAST89
Domaini133 – 212Ig-like C2-type 2Add BLAST80
Domaini220 – 312Ig-like C2-type 3Add BLAST93
Domaini373 – 523TIRPROSITE-ProRule annotationAdd BLAST151

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH1W. Eukaryota.
ENOG410ZKHN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ13478.
KOiK05173.
OMAiFTRGMII.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ13478.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE
60 70 80 90 100
TTTKSWYKSS GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM
110 120 130 140 150
KNYTQKWKLN VIRRNKHSCF TERQVTSKIV EVKKFFQITC ENSYYQTLVN
160 170 180 190 200
STSLYKNCKK LLLENNKNPT IKKNAEFEDQ GYYSCVHFLH HNGKLFNITK
210 220 230 240 250
TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL LNEEDVIYWM
260 270 280 290 300
FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV
310 320 330 340 350
ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI
360 370 380 390 400
YRVDLVLFYR HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL
410 420 430 440 450
PRVLEKHFGY KLCIFERDVV PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN
460 470 480 490 500
EVRYELESGL HEALVERKIK IILIEFTPVT DFTFLPQSLK LLKSHRVLKW
510 520 530 540
KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S
Length:541
Mass (Da):62,304
Last modified:November 1, 1996 - v1
Checksum:i7173DB9C7EA71D32
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053379210R → H.Corresponds to variant rs11465635dbSNPEnsembl.1
Natural variantiVAR_053380232N → K.Corresponds to variant rs11465644dbSNPEnsembl.1
Natural variantiVAR_053381310S → N.Corresponds to variant rs11465648dbSNPEnsembl.1
Natural variantiVAR_014955317Missing .1 Publication1
Natural variantiVAR_053382423G → R.Corresponds to variant rs12619169dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43672 mRNA. Translation: AAC50390.1.
AK313967 mRNA. Translation: BAG36682.1.
AC007248 Genomic DNA. Translation: AAY15048.1.
BC069575 mRNA. Translation: AAH69575.1.
BC093975 mRNA. Translation: AAH93975.1.
BC093977 mRNA. Translation: AAH93977.1.
CCDSiCCDS2060.1.
RefSeqiNP_001269328.1. NM_001282399.1.
NP_003846.1. NM_003855.3.
UniGeneiHs.469521.

Genome annotation databases

EnsembliENST00000233957; ENSP00000233957; ENSG00000115604.
ENST00000409599; ENSP00000387211; ENSG00000115604.
ENST00000410040; ENSP00000386663; ENSG00000115604.
GeneIDi8809.
KEGGihsa:8809.
UCSCiuc002tbw.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43672 mRNA. Translation: AAC50390.1.
AK313967 mRNA. Translation: BAG36682.1.
AC007248 Genomic DNA. Translation: AAY15048.1.
BC069575 mRNA. Translation: AAH69575.1.
BC093975 mRNA. Translation: AAH93975.1.
BC093977 mRNA. Translation: AAH93977.1.
CCDSiCCDS2060.1.
RefSeqiNP_001269328.1. NM_001282399.1.
NP_003846.1. NM_003855.3.
UniGeneiHs.469521.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO3X-ray3.10B/D/F/H/J/L20-329[»]
3WO4X-ray3.10B20-329[»]
4R6UX-ray2.80A/C19-329[»]
ProteinModelPortaliQ13478.
SMRiQ13478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114337. 2 interactors.
IntActiQ13478. 1 interactor.
STRINGi9606.ENSP00000233957.

PTM databases

iPTMnetiQ13478.
PhosphoSitePlusiQ13478.

Proteomic databases

MaxQBiQ13478.
PaxDbiQ13478.
PeptideAtlasiQ13478.
PRIDEiQ13478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233957; ENSP00000233957; ENSG00000115604.
ENST00000409599; ENSP00000387211; ENSG00000115604.
ENST00000410040; ENSP00000386663; ENSG00000115604.
GeneIDi8809.
KEGGihsa:8809.
UCSCiuc002tbw.6. human.

Organism-specific databases

CTDi8809.
DisGeNETi8809.
GeneCardsiIL18R1.
HGNCiHGNC:5988. IL18R1.
HPAiHPA007615.
MIMi604494. gene.
neXtProtiNX_Q13478.
OpenTargetsiENSG00000115604.
PharmGKBiPA29804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1W. Eukaryota.
ENOG410ZKHN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ13478.
KOiK05173.
OMAiFTRGMII.
OrthoDBiEOG091G0GXW.
PhylomeDBiQ13478.
TreeFamiTF325519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115604-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.
SIGNORiQ13478.

Miscellaneous databases

GeneWikiiIL18R1.
GenomeRNAii8809.
PROiQ13478.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115604.
CleanExiHS_IL18R1.
ExpressionAtlasiQ13478. baseline and differential.
GenevisibleiQ13478. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL18R_HUMAN
AccessioniPrimary (citable) accession number: Q13478
Secondary accession number(s): B2R9Y5, Q52LC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.