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Protein

Interleukin-18 receptor 1

Gene

IL18R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

GO - Molecular functioni

  • interleukin-18 receptor activity Source: Ensembl
  • interleukin-1 receptor activity Source: InterPro
  • receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-449147. Signaling by Interleukins.
SIGNORiQ13478.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor 1
Short name:
IL-18R-1
Short name:
IL-18R1
Alternative name(s):
CD218 antigen-like family member A
CDw218a
IL1 receptor-related protein
Short name:
IL-1Rrp
Short name:
IL1R-rp
CD_antigen: CD218a
Gene namesi
Name:IL18R1
Synonyms:IL1RRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5988. IL18R1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 329308ExtracellularSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Topological domaini351 – 541191CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 541523Interleukin-18 receptor 1PRO_0000015448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi140 ↔ 185PROSITE-ProRule annotation
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi237 ↔ 298PROSITE-ProRule annotation
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13478.
PaxDbiQ13478.
PRIDEiQ13478.

PTM databases

iPTMnetiQ13478.
PhosphoSiteiQ13478.

Expressioni

Tissue specificityi

Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.

Gene expression databases

BgeeiQ13478.
CleanExiHS_IL18R1.
ExpressionAtlasiQ13478. baseline and differential.
GenevisibleiQ13478. HS.

Organism-specific databases

HPAiHPA007615.

Interactioni

Subunit structurei

Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta.

Binary interactionsi

WithEntry#Exp.IntActNotes
IL18Q141162EBI-9817499,EBI-3910835

Protein-protein interaction databases

BioGridi114337. 2 interactions.
IntActiQ13478. 1 interaction.
STRINGi9606.ENSP00000233957.

Structurei

Secondary structure

1
541
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 316Combined sources
Beta strandi36 – 394Combined sources
Turni43 – 475Combined sources
Beta strandi55 – 595Combined sources
Beta strandi76 – 794Combined sources
Beta strandi82 – 876Combined sources
Helixi90 – 923Combined sources
Beta strandi94 – 1007Combined sources
Beta strandi103 – 11210Combined sources
Beta strandi116 – 1205Combined sources
Helixi122 – 1243Combined sources
Beta strandi125 – 1317Combined sources
Beta strandi134 – 1396Combined sources
Turni143 – 1453Combined sources
Helixi146 – 1483Combined sources
Beta strandi149 – 1568Combined sources
Beta strandi166 – 1683Combined sources
Beta strandi170 – 1745Combined sources
Helixi177 – 1793Combined sources
Beta strandi181 – 19111Combined sources
Beta strandi194 – 20714Combined sources
Beta strandi216 – 2194Combined sources
Beta strandi221 – 2266Combined sources
Beta strandi233 – 2419Combined sources
Beta strandi246 – 2505Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi266 – 2705Combined sources
Turni272 – 2743Combined sources
Beta strandi276 – 2849Combined sources
Turni290 – 2923Combined sources
Beta strandi296 – 3027Combined sources
Beta strandi305 – 31410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WO3X-ray3.10B/D/F/H/J/L20-329[»]
3WO4X-ray3.10B20-329[»]
4R6UX-ray2.80A/C19-329[»]
ProteinModelPortaliQ13478.
SMRiQ13478. Positions 20-318, 373-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12189Ig-like C2-type 1Add
BLAST
Domaini133 – 21280Ig-like C2-type 2Add
BLAST
Domaini220 – 31293Ig-like C2-type 3Add
BLAST
Domaini373 – 523151TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH1W. Eukaryota.
ENOG410ZKHN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ13478.
KOiK05173.
OMAiFTRGMII.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ13478.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNCRELPLTL WVLISVSTAE SCTSRPHITV VEGEPFYLKH CSCSLAHEIE
60 70 80 90 100
TTTKSWYKSS GSQEHVELNP RSSSRIALHD CVLEFWPVEL NDTGSYFFQM
110 120 130 140 150
KNYTQKWKLN VIRRNKHSCF TERQVTSKIV EVKKFFQITC ENSYYQTLVN
160 170 180 190 200
STSLYKNCKK LLLENNKNPT IKKNAEFEDQ GYYSCVHFLH HNGKLFNITK
210 220 230 240 250
TFNITIVEDR SNIVPVLLGP KLNHVAVELG KNVRLNCSAL LNEEDVIYWM
260 270 280 290 300
FGEENGSDPN IHEEKEMRIM TPEGKWHASK VLRIENIGES NLNVLYNCTV
310 320 330 340 350
ASTGGTDTKS FILVRKADMA DIPGHVFTRG MIIAVLILVA VVCLVTVCVI
360 370 380 390 400
YRVDLVLFYR HLTRRDETLT DGKTYDAFVS YLKECRPENG EEHTFAVEIL
410 420 430 440 450
PRVLEKHFGY KLCIFERDVV PGGAVVDEIH SLIEKSRRLI IVLSKSYMSN
460 470 480 490 500
EVRYELESGL HEALVERKIK IILIEFTPVT DFTFLPQSLK LLKSHRVLKW
510 520 530 540
KADKSLSYNS RFWKNLLYLM PAKTVKPGRD EPEVLPVLSE S
Length:541
Mass (Da):62,304
Last modified:November 1, 1996 - v1
Checksum:i7173DB9C7EA71D32
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti210 – 2101R → H.
Corresponds to variant rs11465635 [ dbSNP | Ensembl ].
VAR_053379
Natural varianti232 – 2321N → K.
Corresponds to variant rs11465644 [ dbSNP | Ensembl ].
VAR_053380
Natural varianti310 – 3101S → N.
Corresponds to variant rs11465648 [ dbSNP | Ensembl ].
VAR_053381
Natural varianti317 – 3171Missing .1 Publication
VAR_014955
Natural varianti423 – 4231G → R.
Corresponds to variant rs12619169 [ dbSNP | Ensembl ].
VAR_053382

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43672 mRNA. Translation: AAC50390.1.
AK313967 mRNA. Translation: BAG36682.1.
AC007248 Genomic DNA. Translation: AAY15048.1.
BC069575 mRNA. Translation: AAH69575.1.
BC093975 mRNA. Translation: AAH93975.1.
BC093977 mRNA. Translation: AAH93977.1.
CCDSiCCDS2060.1.
RefSeqiNP_001269328.1. NM_001282399.1.
NP_003846.1. NM_003855.3.
UniGeneiHs.469521.

Genome annotation databases

EnsembliENST00000233957; ENSP00000233957; ENSG00000115604.
ENST00000409599; ENSP00000387211; ENSG00000115604.
ENST00000410040; ENSP00000386663; ENSG00000115604.
GeneIDi8809.
KEGGihsa:8809.
UCSCiuc002tbw.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43672 mRNA. Translation: AAC50390.1.
AK313967 mRNA. Translation: BAG36682.1.
AC007248 Genomic DNA. Translation: AAY15048.1.
BC069575 mRNA. Translation: AAH69575.1.
BC093975 mRNA. Translation: AAH93975.1.
BC093977 mRNA. Translation: AAH93977.1.
CCDSiCCDS2060.1.
RefSeqiNP_001269328.1. NM_001282399.1.
NP_003846.1. NM_003855.3.
UniGeneiHs.469521.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WO3X-ray3.10B/D/F/H/J/L20-329[»]
3WO4X-ray3.10B20-329[»]
4R6UX-ray2.80A/C19-329[»]
ProteinModelPortaliQ13478.
SMRiQ13478. Positions 20-318, 373-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114337. 2 interactions.
IntActiQ13478. 1 interaction.
STRINGi9606.ENSP00000233957.

PTM databases

iPTMnetiQ13478.
PhosphoSiteiQ13478.

Proteomic databases

MaxQBiQ13478.
PaxDbiQ13478.
PRIDEiQ13478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233957; ENSP00000233957; ENSG00000115604.
ENST00000409599; ENSP00000387211; ENSG00000115604.
ENST00000410040; ENSP00000386663; ENSG00000115604.
GeneIDi8809.
KEGGihsa:8809.
UCSCiuc002tbw.6. human.

Organism-specific databases

CTDi8809.
GeneCardsiIL18R1.
HGNCiHGNC:5988. IL18R1.
HPAiHPA007615.
MIMi604494. gene.
neXtProtiNX_Q13478.
PharmGKBiPA29804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH1W. Eukaryota.
ENOG410ZKHN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113032.
HOVERGENiHBG052098.
InParanoidiQ13478.
KOiK05173.
OMAiFTRGMII.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ13478.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-HSA-449147. Signaling by Interleukins.
SIGNORiQ13478.

Miscellaneous databases

GeneWikiiIL18R1.
GenomeRNAii8809.
PROiQ13478.
SOURCEiSearch...

Gene expression databases

BgeeiQ13478.
CleanExiHS_IL18R1.
ExpressionAtlasiQ13478. baseline and differential.
GenevisibleiQ13478. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP."
    Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.
    J. Biol. Chem. 271:3967-3970(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-317 DEL.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: PROTEIN SEQUENCE OF 19-29; 55-58; 59-71; 211-221; 222-231; 269-275; 276-280; 319-315 AND 524-535, CHARACTERIZATION.

Entry informationi

Entry nameiIL18R_HUMAN
AccessioniPrimary (citable) accession number: Q13478
Secondary accession number(s): B2R9Y5, Q52LC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.