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Q13477

- MADCA_HUMAN

UniProt

Q13477 - MADCA_HUMAN

Protein

Mucosal addressin cell adhesion molecule 1

Gene

MADCAM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

    GO - Biological processi

    1. aging Source: Ensembl
    2. cell adhesion Source: ProtInc
    3. embryo development Source: Ensembl
    4. extracellular matrix organization Source: Reactome
    5. immune response Source: ProtInc
    6. keratinocyte differentiation Source: Ensembl
    7. leukocyte migration Source: Ensembl
    8. positive regulation of leukocyte migration Source: Ensembl
    9. regulation of immune response Source: Reactome
    10. signal transduction Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_13552. Integrin cell surface interactions.
    SignaLinkiQ13477.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucosal addressin cell adhesion molecule 1
    Short name:
    MAdCAM-1
    Short name:
    hMAdCAM-1
    Gene namesi
    Name:MADCAM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6765. MADCAM1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30522.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 382364Mucosal addressin cell adhesion molecule 1PRO_0000014853Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 94
    Disulfide bondi51 ↔ 98
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi134 ↔ 204

    Post-translational modificationi

    The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13477.
    PRIDEiQ13477.

    Expressioni

    Tissue specificityi

    Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ13477.
    BgeeiQ13477.
    CleanExiHS_MADCAM1.
    GenevestigatoriQ13477.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    BioGridi113825. 1 interaction.
    STRINGi9606.ENSP00000215637.

    Structurei

    Secondary structure

    1
    382
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 306
    Beta strandi33 – 386
    Beta strandi43 – 497
    Beta strandi52 – 543
    Beta strandi57 – 626
    Turni64 – 674
    Beta strandi69 – 8315
    Helixi86 – 883
    Beta strandi90 – 989
    Beta strandi101 – 11313
    Beta strandi116 – 12510
    Beta strandi131 – 14010
    Turni144 – 1463
    Beta strandi147 – 1537
    Beta strandi167 – 1715
    Beta strandi175 – 1773
    Beta strandi180 – 19011
    Beta strandi200 – 21011
    Beta strandi213 – 22311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BQSX-ray2.20A23-231[»]
    1GSMX-ray1.90A19-224[»]
    4HBQX-ray1.40A/B23-171[»]
    A/B180-224[»]
    4HC1X-ray2.87A/B23-171[»]
    A/B180-224[»]
    4HCRX-ray2.30A/B23-225[»]
    4HD9X-ray1.70A23-225[»]
    ProteinModelPortaliQ13477.
    SMRiQ13477. Positions 23-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13477.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 317299ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini339 – 38244CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 11290Ig-like 1Add
    BLAST
    Domaini113 – 231119Ig-like 2Add
    BLAST
    Repeati228 – 23141; truncated
    Repeati232 – 23982
    Repeati240 – 24783
    Repeati248 – 25584
    Repeati256 – 26385
    Repeati264 – 27186

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni226 – 31792Mucin-likeAdd
    BLAST
    Regioni228 – 271445.5 X 8 AA tandem repeats of [PS]-P-D-T-T-S-[QP]-EAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26033.
    HOGENOMiHOG000060103.
    HOVERGENiHBG108114.
    InParanoidiQ13477.
    KOiK06779.
    OMAiQAGPTQG.
    OrthoDBiEOG7FR7HJ.
    TreeFamiTF337571.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR015169. Adhes-Ig-like.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    PfamiPF09085. Adhes-Ig_like. 1 hit.
    [Graphical view]
    ProDomiPD336606. Adhes-Ig-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q13477-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA    50
    CADRGASVQW RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG 100
    RTFQHTVQLL VYAFPDQLTV SPAALVPGDP EVACTAHKVT PVDPNALSFS 150
    LLVGGQELEG AQALGPEVQE EEEEPQGDED VLFRVTERWR LPPLGTPVPP 200
    ALYCQATMRL PGLELSHRQA IPVLHSPTSP EPPDTTSPES PDTTSPESPD 250
    TTSQEPPDTT SPEPPDKTSP EPAPQQGSTH TPRSPGSTRT RRPEISQAGP 300
    TQGEVIPTGS SKPAGDQLPA ALWTSSAVLG LLLLALPTYH LWKRCRHLAE 350
    DDTHPPASLR LLPQVSAWAG LRGTGQVGIS PS 382
    Length:382
    Mass (Da):40,155
    Last modified:December 16, 2008 - v2
    Checksum:i9DCA60C30BA61E62
    GO
    Isoform 2 (identifier: Q13477-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-334: VLHSPTSPEP...SSAVLGLLLL → A

    Show »
    Length:271
    Mass (Da):28,705
    Checksum:i3613F1F208F9F31D
    GO
    Isoform 3 (identifier: Q13477-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-310: VLHSPTSPEP...TQGEVIPTGS → A

    Note: No experimental confirmation available.

    Show »
    Length:295
    Mass (Da):31,109
    Checksum:iF635D6F54504D68D
    GO
    Isoform 4 (identifier: Q13477-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         18-112: Missing.
         223-310: VLHSPTSPEP...TQGEVIPTGS → A

    Show »
    Length:200
    Mass (Da):21,247
    Checksum:i84204D98FC1FC7C7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti240 – 2401S → P in AAB02194. (PubMed:8609404)Curated
    Sequence conflicti240 – 2401S → P in AAC51354. (PubMed:9162097)Curated
    Sequence conflicti242 – 2421D → N in AAB02194. (PubMed:8609404)Curated
    Sequence conflicti242 – 2421D → N in AAC51354. (PubMed:9162097)Curated
    Sequence conflicti254 – 2541Q → P in AAC13661. (PubMed:8989586)Curated

    Polymorphismi

    The number of repeats in the mucin domain varies between 5 and 8 repeats.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti253 – 2531S → SPESPDTTSQEPPDTTSQEP PDTTS.3 Publications
    VAR_047901
    Natural varianti300 – 3001P → H.
    Corresponds to variant rs3745925 [ dbSNP | Ensembl ].
    VAR_017580

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 11295Missing in isoform 4. 1 PublicationVSP_047694Add
    BLAST
    Alternative sequencei223 – 334112VLHSP…GLLLL → A in isoform 2. CuratedVSP_050014Add
    BLAST
    Alternative sequencei223 – 31088VLHSP…IPTGS → A in isoform 3 and isoform 4. 2 PublicationsVSP_043202Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43628 mRNA. Translation: AAB02194.1.
    U80016
    , U80012, U80013, U80014, U80015 Genomic DNA. Translation: AAC51354.1.
    U82483 mRNA. Translation: AAC13661.1.
    AY732484 mRNA. Translation: AAV33123.1.
    AC005775 Genomic DNA. Translation: AAC62844.1.
    CH471242 Genomic DNA. Translation: EAW61195.1.
    BC137506 mRNA. Translation: AAI37507.1.
    BC137507 mRNA. Translation: AAI37508.1.
    BC144065 mRNA. Translation: AAI44066.1.
    BC142629 mRNA. Translation: AAI42630.1.
    CCDSiCCDS12028.1. [Q13477-1]
    CCDS12029.1. [Q13477-3]
    RefSeqiNP_570116.2. NM_130760.2. [Q13477-1]
    NP_570118.1. NM_130762.2. [Q13477-3]
    UniGeneiHs.102598.

    Genome annotation databases

    EnsembliENST00000215637; ENSP00000215637; ENSG00000099866. [Q13477-1]
    ENST00000346144; ENSP00000304247; ENSG00000099866. [Q13477-3]
    ENST00000382683; ENSP00000372130; ENSG00000099866. [Q13477-4]
    GeneIDi8174.
    KEGGihsa:8174.
    UCSCiuc002los.3. human. [Q13477-1]
    uc002lot.3. human. [Q13477-3]

    Polymorphism databases

    DMDMi218511712.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43628 mRNA. Translation: AAB02194.1 .
    U80016
    , U80012 , U80013 , U80014 , U80015 Genomic DNA. Translation: AAC51354.1 .
    U82483 mRNA. Translation: AAC13661.1 .
    AY732484 mRNA. Translation: AAV33123.1 .
    AC005775 Genomic DNA. Translation: AAC62844.1 .
    CH471242 Genomic DNA. Translation: EAW61195.1 .
    BC137506 mRNA. Translation: AAI37507.1 .
    BC137507 mRNA. Translation: AAI37508.1 .
    BC144065 mRNA. Translation: AAI44066.1 .
    BC142629 mRNA. Translation: AAI42630.1 .
    CCDSi CCDS12028.1. [Q13477-1 ]
    CCDS12029.1. [Q13477-3 ]
    RefSeqi NP_570116.2. NM_130760.2. [Q13477-1 ]
    NP_570118.1. NM_130762.2. [Q13477-3 ]
    UniGenei Hs.102598.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BQS X-ray 2.20 A 23-231 [» ]
    1GSM X-ray 1.90 A 19-224 [» ]
    4HBQ X-ray 1.40 A/B 23-171 [» ]
    A/B 180-224 [» ]
    4HC1 X-ray 2.87 A/B 23-171 [» ]
    A/B 180-224 [» ]
    4HCR X-ray 2.30 A/B 23-225 [» ]
    4HD9 X-ray 1.70 A 23-225 [» ]
    ProteinModelPortali Q13477.
    SMRi Q13477. Positions 23-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113825. 1 interaction.
    STRINGi 9606.ENSP00000215637.

    Chemistry

    BindingDBi Q13477.
    ChEMBLi CHEMBL4467.

    Polymorphism databases

    DMDMi 218511712.

    Proteomic databases

    PaxDbi Q13477.
    PRIDEi Q13477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000215637 ; ENSP00000215637 ; ENSG00000099866 . [Q13477-1 ]
    ENST00000346144 ; ENSP00000304247 ; ENSG00000099866 . [Q13477-3 ]
    ENST00000382683 ; ENSP00000372130 ; ENSG00000099866 . [Q13477-4 ]
    GeneIDi 8174.
    KEGGi hsa:8174.
    UCSCi uc002los.3. human. [Q13477-1 ]
    uc002lot.3. human. [Q13477-3 ]

    Organism-specific databases

    CTDi 8174.
    GeneCardsi GC19P000499.
    H-InvDB HIX0014553.
    HGNCi HGNC:6765. MADCAM1.
    MIMi 102670. gene.
    neXtProti NX_Q13477.
    PharmGKBi PA30522.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26033.
    HOGENOMi HOG000060103.
    HOVERGENi HBG108114.
    InParanoidi Q13477.
    KOi K06779.
    OMAi QAGPTQG.
    OrthoDBi EOG7FR7HJ.
    TreeFami TF337571.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_13552. Integrin cell surface interactions.
    SignaLinki Q13477.

    Miscellaneous databases

    EvolutionaryTracei Q13477.
    GeneWikii Addressin.
    GenomeRNAii 8174.
    NextBioi 30850.
    PROi Q13477.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13477.
    Bgeei Q13477.
    CleanExi HS_MADCAM1.
    Genevestigatori Q13477.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR015169. Adhes-Ig-like.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    Pfami PF09085. Adhes-Ig_like. 1 hit.
    [Graphical view ]
    ProDomi PD336606. Adhes-Ig-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts."
      Leung E., Greene J., Ni J., Raymond L.G., Lehnert K., Langley R., Krissansen G.W.
      Immunol. Cell Biol. 74:490-496(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences."
      Shyjan A.M., Bertagnolli M., Kenney C.J., Briskin M.J.
      J. Immunol. 156:2851-2857(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ALPHA-4/BETA-7 INTEGRIN, TISSUE SPECIFICITY, VARIANT PRO-GLU-SER-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-253 INS.
      Tissue: Lymph node.
    3. "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene."
      Leung E., Berg R.W., Langley R., Greene J., Raymond L.A., Augustus M., Ni J., Carter K.C., Spurr N., Choo K.H.A., Krissansen G.W.
      Immunogenetics 46:111-119(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), VARIANT PRO-GLU-SER-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-253 INS.
      Tissue: Placenta.
    4. "Novel splicing variants of some human genes."
      Wang P.Z., Wang F., Chang Q.S., Wang X.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT PRO-GLU-SER-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-GLN-GLU-PRO-PRO-ASP-THR-THR-SER-253 INS.
      Tissue: Brain.
    8. "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition."
      Tan K., Casasnovas J.M., Liu J.H., Briskin M.J., Springer T.A., Wang J.H.
      Structure 6:793-801(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 23-231.
    9. "A reassessment of the MAdCAM-1 structure and its role in integrin recognition."
      Dando J., Wilkinson K.W., Ortlepp S., King D.J., Brady R.L.
      Acta Crystallogr. D 58:233-241(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-224.

    Entry informationi

    Entry nameiMADCA_HUMAN
    AccessioniPrimary (citable) accession number: Q13477
    Secondary accession number(s): A5PKV4
    , B2RPL9, O60222, O75867, Q5UGI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3