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Q13472

- TOP3A_HUMAN

UniProt

Q13472 - TOP3A_HUMAN

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Protein
DNA topoisomerase 3-alpha
Gene
TOP3A, TOP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity.2 Publications

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.2 Publications

Cofactori

Magnesium.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei362 – 3621O-(5'-phospho-DNA)-tyrosine intermediate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri658 – 68528C4-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: ProtInc
  3. DNA topoisomerase type I activity Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA topological change Source: UniProtKB
  2. meiotic nuclear division Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Topoisomerase

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_27271. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 3-alpha (EC:5.99.1.2)
Alternative name(s):
DNA topoisomerase III alpha
Gene namesi
Name:TOP3A
Synonyms:TOP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11992. TOP3A.

Subcellular locationi

GO - Cellular componenti

  1. PML body Source: UniProtKB
  2. chromosome Source: InterPro
  3. nucleus Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001DNA topoisomerase 3-alpha
PRO_0000145190Add
BLAST

Proteomic databases

MaxQBiQ13472.
PaxDbiQ13472.
PRIDEiQ13472.

PTM databases

PhosphoSiteiQ13472.

Expressioni

Tissue specificityi

High expression is found in testis, heart, skeletal muscle and pancreas.

Gene expression databases

ArrayExpressiQ13472.
BgeeiQ13472.
CleanExiHS_TOP3A.
GenevestigatoriQ13472.

Organism-specific databases

HPAiCAB002449.
HPA042910.

Interactioni

Subunit structurei

Interacts (via N-terminal region) with BLM; the interaction is direct. Directly interacts with RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.5 Publications

Protein-protein interaction databases

BioGridi113009. 18 interactions.
DIPiDIP-33323N.
IntActiQ13472. 10 interactions.
MINTiMINT-6610291.
STRINGi9606.ENSP00000321636.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 308
Beta strandi35 – 428
Helixi43 – 5412
Beta strandi59 – 613
Beta strandi70 – 778
Beta strandi80 – 889
Beta strandi95 – 984
Helixi100 – 1034
Helixi105 – 1073
Helixi110 – 1145
Beta strandi118 – 1214
Helixi124 – 1263
Helixi127 – 13913
Beta strandi141 – 1477
Helixi151 – 16515
Beta strandi172 – 1754
Helixi183 – 1919
Helixi198 – 22932
Helixi231 – 2344
Helixi245 – 26117
Beta strandi266 – 27611
Beta strandi279 – 2857
Helixi293 – 30412
Beta strandi309 – 32113
Helixi329 – 33810
Helixi344 – 35613
Helixi376 – 3816
Turni382 – 3854
Turni387 – 3893
Helixi390 – 3989
Helixi428 – 44417
Beta strandi449 – 46012
Beta strandi463 – 47412
Helixi476 – 4794
Beta strandi503 – 5119
Helixi520 – 53011
Turni534 – 5374
Helixi538 – 54710
Beta strandi550 – 5534
Beta strandi559 – 5613
Helixi563 – 57311
Helixi583 – 59614
Helixi602 – 62221
Helixi625 – 63511

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CGYX-ray2.85A2-753[»]
4CHTX-ray3.25A2-753[»]
ProteinModelPortaliQ13472.
SMRiQ13472. Positions 21-679.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 179145Toprim
Add
BLAST
Repeati812 – 839281
Add
BLAST
Repeati896 – 923282
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni812 – 9231122 X 27 AA approximate repeats
Add
BLAST

Sequence similaritiesi

Contains 1 Toprim domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0550.
HOGENOMiHOG000184377.
HOVERGENiHBG056668.
InParanoidiQ13472.
KOiK03165.
OMAiLYQICME.
OrthoDBiEOG74R1Q0.
PhylomeDBiQ13472.
TreeFamiTF105287.

Family and domain databases

Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 3 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd.
IPR013498. Topo_IA_Znf.
IPR006171. Toprim_domain.
IPR001878. Znf_CCHC.
IPR010666. Znf_GRF.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF01396. zf-C4_Topoisom. 1 hit.
PF06839. zf-GRF. 2 hits.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q13472-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIFPVARYAL RWLRRPEDRA FSRAAMEMAL RGVRKVLCVA EKNDAAKGIA     50
DLLSNGRMRR REGLSKFNKI YEFDYHLYGQ NVTMVMTSVS GHLLAHDFQM 100
QFRKWQSCNP LVLFEAEIEK YCPENFVDIK KTLERETRQC QALVIWTDCD 150
REGENIGFEI IHVCKAVKPN LQVLRARFSE ITPHAVRTAC ENLTEPDQRV 200
SDAVDVRQEL DLRIGAAFTR FQTLRLQRIF PEVLAEQLIS YGSCQFPTLG 250
FVVERFKAIQ AFVPEIFHRI KVTHDHKDGI VEFNWKRHRL FNHTACLVLY 300
QLCVEDPMAT VVEVRSKPKS KWRPQALDTV ELEKLASRKL RINAKETMRI 350
AEKLYTQGYI SYPRTETNIF PRDLNLTVLV EQQTPDPRWG AFAQSILERG 400
GPTPRNGNKS DQAHPPIHPT KYTNNLQGDE QRLYEFIVRH FLACCSQDAQ 450
GQETTVEIDI AQERFVAHGL MILARNYLDV YPYDHWSDKI LPVYEQGSHF 500
QPSTVEMVDG ETSPPKLLTE ADLIALMEKH GIGTDATHAE HIETIKARMY 550
VGLTPDKRFL PGHLGMGLVE GYDSMGYEMS KPDLRAELEA DLKLICDGKK 600
DKFVVLRQQV QKYKQVFIEA VAKAKKLDEA LAQYFGNGTE LAQQEDIYPA 650
MPEPIRKCPQ CNKDMVLKTK KNGGFYLSCM GFPECRSAVW LPDSVLEASR 700
DSSVCPVCQP HPVYRLKLKF KRGSLPPTMP LEFVCCIGGC DDTLREILDL 750
RFSGGPPRAS QPSGRLQANQ SLNRMDNSQH PQPADSRQTG SSKALAQTLP 800
PPTAAGESNS VTCNCGQEAV LLTVRKEGPN RGRQFFKCNG GSCNFFLWAD 850
SPNPGAGGPP ALAYRPLGAS LGCPPGPGIH LGGFGNPGDG SGSGTSCLCS 900
QPSVTRTVQK DGPNKGRQFH TCAKPREQQC GFFQWVDENT APGTSGAPSW 950
TGDRGRTLES EARSKRPRAS SSDMGSTAKK PRKCSLCHQP GHTRPFCPQN 1000
R 1001
Length:1,001
Mass (Da):112,372
Last modified:November 1, 1997 - v1
Checksum:i06558C749569E0C2
GO
Isoform Short (identifier: Q13472-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:976
Mass (Da):109,341
Checksum:i4AB9262B5DE7D05B
GO
Isoform 3 (identifier: Q13472-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MIFPVARYAL...HDFQMQFRKW → MNLIIICMAR

Note: No experimental confirmation available.

Show »
Length:906
Mass (Da):101,208
Checksum:i60F389C5FF1A92F9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti459 – 4591D → N.
Corresponds to variant rs28671051 [ dbSNP | Ensembl ].
VAR_052588
Natural varianti596 – 5961C → Y.
VAR_007529
Natural varianti742 – 7421D → N.
Corresponds to variant rs9909732 [ dbSNP | Ensembl ].
VAR_052589
Natural varianti773 – 7731N → D.
Corresponds to variant rs9911283 [ dbSNP | Ensembl ].
VAR_052590

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 105105MIFPV…QFRKW → MNLIIICMAR in isoform 3.
VSP_054189Add
BLAST
Alternative sequencei1 – 2525Missing in isoform Short.
VSP_006524Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43431 mRNA. Translation: AAB03694.1.
U43431 mRNA. Translation: AAB03695.1.
HQ205026 Genomic DNA. Translation: ADP90454.1.
HQ205027 Genomic DNA. Translation: ADP90455.1.
HQ205028 Genomic DNA. Translation: ADP90456.1.
HQ205029 Genomic DNA. Translation: ADP90457.1.
HQ205030 Genomic DNA. Translation: ADP90458.1.
HQ205031 Genomic DNA. Translation: ADP90459.1.
HQ205032 Genomic DNA. Translation: ADP90460.1.
HQ205033 Genomic DNA. Translation: ADP90461.1.
HQ205034 Genomic DNA. Translation: ADP90462.1.
HQ205035 Genomic DNA. Translation: ADP90463.1.
HQ205036 Genomic DNA. Translation: ADP90464.1.
HQ205037 Genomic DNA. Translation: ADP90465.1.
HQ205038 Genomic DNA. Translation: ADP90466.1.
HQ205039 Genomic DNA. Translation: ADP90467.1.
HQ205040 Genomic DNA. Translation: ADP90468.1.
HQ205041 Genomic DNA. Translation: ADP90469.1.
HQ205042 Genomic DNA. Translation: ADP90470.1.
HQ205043 Genomic DNA. Translation: ADP90471.1.
HQ205044 Genomic DNA. Translation: ADP90472.1.
HQ205045 Genomic DNA. Translation: ADP90473.1.
HQ205046 Genomic DNA. Translation: ADP90474.1.
HQ205047 Genomic DNA. Translation: ADP90475.1.
HQ205048 Genomic DNA. Translation: ADP90476.1.
HQ205049 Genomic DNA. Translation: ADP90477.1.
HQ205050 Genomic DNA. Translation: ADP90478.1.
HQ205051 Genomic DNA. Translation: ADP90479.1.
HQ205052 Genomic DNA. Translation: ADP90480.1.
HQ205053 Genomic DNA. Translation: ADP90481.1.
HQ205054 Genomic DNA. Translation: ADP90482.1.
HQ205055 Genomic DNA. Translation: ADP90483.1.
HQ205056 Genomic DNA. Translation: ADP90484.1.
HQ205057 Genomic DNA. Translation: ADP90485.1.
HQ205058 Genomic DNA. Translation: ADP90486.1.
HQ205059 Genomic DNA. Translation: ADP90487.1.
HQ205060 Genomic DNA. Translation: ADP90488.1.
HQ205061 Genomic DNA. Translation: ADP90489.1.
HQ205062 Genomic DNA. Translation: ADP90490.1.
HQ205063 Genomic DNA. Translation: ADP90491.1.
HQ205064 Genomic DNA. Translation: ADP90492.1.
HQ205065 Genomic DNA. Translation: ADP90493.1.
AK292926 mRNA. Translation: BAF85615.1.
AK296437 mRNA. Translation: BAG59092.1.
AC127537 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55646.1.
CH471196 Genomic DNA. Translation: EAW55648.1.
CH471196 Genomic DNA. Translation: EAW55649.1.
BC051748 mRNA. Translation: AAH51748.1.
CCDSiCCDS11194.1. [Q13472-1]
RefSeqiNP_004609.1. NM_004618.3. [Q13472-1]
XP_005256833.1. XM_005256776.1. [Q13472-3]
UniGeneiHs.592115.

Genome annotation databases

EnsembliENST00000321105; ENSP00000321636; ENSG00000177302. [Q13472-1]
ENST00000542570; ENSP00000442336; ENSG00000177302.
ENST00000580095; ENSP00000462790; ENSG00000177302. [Q13472-2]
GeneIDi7156.
KEGGihsa:7156.
UCSCiuc002gsx.1. human. [Q13472-1]

Polymorphism databases

DMDMi2501242.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43431 mRNA. Translation: AAB03694.1 .
U43431 mRNA. Translation: AAB03695.1 .
HQ205026 Genomic DNA. Translation: ADP90454.1 .
HQ205027 Genomic DNA. Translation: ADP90455.1 .
HQ205028 Genomic DNA. Translation: ADP90456.1 .
HQ205029 Genomic DNA. Translation: ADP90457.1 .
HQ205030 Genomic DNA. Translation: ADP90458.1 .
HQ205031 Genomic DNA. Translation: ADP90459.1 .
HQ205032 Genomic DNA. Translation: ADP90460.1 .
HQ205033 Genomic DNA. Translation: ADP90461.1 .
HQ205034 Genomic DNA. Translation: ADP90462.1 .
HQ205035 Genomic DNA. Translation: ADP90463.1 .
HQ205036 Genomic DNA. Translation: ADP90464.1 .
HQ205037 Genomic DNA. Translation: ADP90465.1 .
HQ205038 Genomic DNA. Translation: ADP90466.1 .
HQ205039 Genomic DNA. Translation: ADP90467.1 .
HQ205040 Genomic DNA. Translation: ADP90468.1 .
HQ205041 Genomic DNA. Translation: ADP90469.1 .
HQ205042 Genomic DNA. Translation: ADP90470.1 .
HQ205043 Genomic DNA. Translation: ADP90471.1 .
HQ205044 Genomic DNA. Translation: ADP90472.1 .
HQ205045 Genomic DNA. Translation: ADP90473.1 .
HQ205046 Genomic DNA. Translation: ADP90474.1 .
HQ205047 Genomic DNA. Translation: ADP90475.1 .
HQ205048 Genomic DNA. Translation: ADP90476.1 .
HQ205049 Genomic DNA. Translation: ADP90477.1 .
HQ205050 Genomic DNA. Translation: ADP90478.1 .
HQ205051 Genomic DNA. Translation: ADP90479.1 .
HQ205052 Genomic DNA. Translation: ADP90480.1 .
HQ205053 Genomic DNA. Translation: ADP90481.1 .
HQ205054 Genomic DNA. Translation: ADP90482.1 .
HQ205055 Genomic DNA. Translation: ADP90483.1 .
HQ205056 Genomic DNA. Translation: ADP90484.1 .
HQ205057 Genomic DNA. Translation: ADP90485.1 .
HQ205058 Genomic DNA. Translation: ADP90486.1 .
HQ205059 Genomic DNA. Translation: ADP90487.1 .
HQ205060 Genomic DNA. Translation: ADP90488.1 .
HQ205061 Genomic DNA. Translation: ADP90489.1 .
HQ205062 Genomic DNA. Translation: ADP90490.1 .
HQ205063 Genomic DNA. Translation: ADP90491.1 .
HQ205064 Genomic DNA. Translation: ADP90492.1 .
HQ205065 Genomic DNA. Translation: ADP90493.1 .
AK292926 mRNA. Translation: BAF85615.1 .
AK296437 mRNA. Translation: BAG59092.1 .
AC127537 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55646.1 .
CH471196 Genomic DNA. Translation: EAW55648.1 .
CH471196 Genomic DNA. Translation: EAW55649.1 .
BC051748 mRNA. Translation: AAH51748.1 .
CCDSi CCDS11194.1. [Q13472-1 ]
RefSeqi NP_004609.1. NM_004618.3. [Q13472-1 ]
XP_005256833.1. XM_005256776.1. [Q13472-3 ]
UniGenei Hs.592115.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CGY X-ray 2.85 A 2-753 [» ]
4CHT X-ray 3.25 A 2-753 [» ]
ProteinModelPortali Q13472.
SMRi Q13472. Positions 21-679.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113009. 18 interactions.
DIPi DIP-33323N.
IntActi Q13472. 10 interactions.
MINTi MINT-6610291.
STRINGi 9606.ENSP00000321636.

PTM databases

PhosphoSitei Q13472.

Polymorphism databases

DMDMi 2501242.

Proteomic databases

MaxQBi Q13472.
PaxDbi Q13472.
PRIDEi Q13472.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321105 ; ENSP00000321636 ; ENSG00000177302 . [Q13472-1 ]
ENST00000542570 ; ENSP00000442336 ; ENSG00000177302 .
ENST00000580095 ; ENSP00000462790 ; ENSG00000177302 . [Q13472-2 ]
GeneIDi 7156.
KEGGi hsa:7156.
UCSCi uc002gsx.1. human. [Q13472-1 ]

Organism-specific databases

CTDi 7156.
GeneCardsi GC17M018175.
HGNCi HGNC:11992. TOP3A.
HPAi CAB002449.
HPA042910.
MIMi 601243. gene.
neXtProti NX_Q13472.
PharmGKBi PA36673.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0550.
HOGENOMi HOG000184377.
HOVERGENi HBG056668.
InParanoidi Q13472.
KOi K03165.
OMAi LYQICME.
OrthoDBi EOG74R1Q0.
PhylomeDBi Q13472.
TreeFami TF105287.

Enzyme and pathway databases

Reactomei REACT_27271. Meiotic recombination.

Miscellaneous databases

GeneWikii TOP3A.
GenomeRNAii 7156.
NextBioi 28002.
PROi Q13472.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13472.
Bgeei Q13472.
CleanExi HS_TOP3A.
Genevestigatori Q13472.

Family and domain databases

Gene3Di 1.10.460.10. 2 hits.
2.70.20.10. 3 hits.
3.40.50.140. 1 hit.
InterProi IPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd.
IPR013498. Topo_IA_Znf.
IPR006171. Toprim_domain.
IPR001878. Znf_CCHC.
IPR010666. Znf_GRF.
[Graphical view ]
PANTHERi PTHR11390. PTHR11390. 1 hit.
Pfami PF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF01396. zf-C4_Topoisom. 1 hit.
PF06839. zf-GRF. 2 hits.
[Graphical view ]
PRINTSi PR00417. PRTPISMRASEI.
SMARTi SM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view ]
SUPFAMi SSF56712. SSF56712. 1 hit.
PROSITEi PS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human TOP3: a single-copy gene encoding DNA topoisomerase III."
    Hanai R., Caron P.R., Wang J.C.
    Proc. Natl. Acad. Sci. U.S.A. 93:3653-3657(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), FUNCTION, CATALYTIC ACTIVITY.
  2. "Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing."
    Wang W., Shen P., Thiyagarajan S., Lin S., Palm C., Horvath R., Klopstock T., Cutler D., Pique L., Schrijver I., Davis R.W., Mindrinos M., Speed T.P., Scharfe C.
    Nucleic Acids Res. 39:44-58(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3).
    Tissue: Thalamus and Trachea.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Testis.
  7. "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity."
    Yin J., Sobeck A., Xu C., Meetei A.R., Hoatlin M., Li L., Wang W.
    EMBO J. 24:1465-1476(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COMPLEX WITH BLM AND RMI1.
  8. "RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability."
    Xu D., Guo R., Sobeck A., Bachrati C.Z., Yang J., Enomoto T., Brown G.W., Hoatlin M.E., Hickson I.D., Wang W.
    Genes Dev. 22:2843-2855(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RMI COMPLEX.
  9. "BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome."
    Singh T.R., Ali A.M., Busygina V., Raynard S., Fan Q., Du C.-H., Andreassen P.R., Sung P., Meetei A.R.
    Genes Dev. 22:2856-2868(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RMI COMPLEX.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1."
    Yang J., Bachrati C.Z., Ou J., Hickson I.D., Brown G.W.
    J. Biol. Chem. 285:21426-21436(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, COFACTOR, INTERACTION WITH RMI1.
  12. "Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair."
    Wan L., Han J., Liu T., Dong S., Xie F., Chen H., Huang J.
    Proc. Natl. Acad. Sci. U.S.A. 110:10646-10651(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BLM.

Entry informationi

Entry nameiTOP3A_HUMAN
AccessioniPrimary (citable) accession number: Q13472
Secondary accession number(s): A8KA61
, B4DK80, D3DXC7, Q13473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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