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Q13470

- TNK1_HUMAN

UniProt

Q13470 - TNK1_HUMAN

Protein

Non-receptor tyrosine-protein kinase TNK1

Gene

TNK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.2 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei148 – 1481ATPBy similarityPROSITE-ProRule annotation
    Active sitei245 – 2451Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi122 – 1309ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein tyrosine kinase activity Source: UniProtKB
    5. signal transducer activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of cell growth Source: Ensembl
    2. negative regulation of Ras protein signal transduction Source: Ensembl
    3. peptidyl-tyrosine phosphorylation Source: GOC
    4. protein autophosphorylation Source: UniProtKB
    5. protein phosphorylation Source: ProtInc
    6. signal transduction Source: GOC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-receptor tyrosine-protein kinase TNK1 (EC:2.7.10.2)
    Alternative name(s):
    CD38 negative kinase 1
    Gene namesi
    Name:TNK1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11940. TNK1.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. cytoplasm Source: UniProtKB
    3. cytosol Source: Ensembl
    4. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36630.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 666666Non-receptor tyrosine-protein kinase TNK1PRO_0000088173Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei60 – 601Phosphoserine1 Publication
    Modified residuei255 – 2551Phosphoserine2 Publications
    Modified residuei502 – 5021Phosphoserine5 Publications
    Modified residuei514 – 5141Phosphothreonine2 Publications
    Modified residuei519 – 5191Phosphoserine1 Publication
    Modified residuei582 – 5821Phosphoserine1 Publication

    Post-translational modificationi

    Autophosphorylated on tyrosine residues.6 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13470.
    PaxDbiQ13470.
    PRIDEiQ13470.

    PTM databases

    PhosphoSiteiQ13470.

    Expressioni

    Tissue specificityi

    Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.2 Publications

    Gene expression databases

    ArrayExpressiQ13470.
    BgeeiQ13470.
    CleanExiHS_TNK1.
    GenevestigatoriQ13470.

    Organism-specific databases

    HPAiHPA012065.
    HPA056452.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.1 Publication

    Protein-protein interaction databases

    BioGridi114253. 5 interactions.
    IntActiQ13470. 4 interactions.
    MINTiMINT-3975658.
    STRINGi9606.ENSP00000312309.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13470.
    SMRiQ13470. Positions 107-441.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini116 – 377262Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini381 – 44464SH3Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi511 – 57363Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.Sequence Analysis

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000231055.
    HOVERGENiHBG055513.
    InParanoidiQ13470.
    KOiK08885.
    OMAiVRDVTEP.
    OrthoDBiEOG71G9T3.
    PhylomeDBiQ13470.
    TreeFamiTF316643.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q13470-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG    50
    MGRPAQRRLS EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL 100
    PEPEGGLKCL IPEGAVCRGE LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL 150
    RVGPEGPMGT ELGDFLREVS VMMNLEHPHV LRLHGLVLGQ PLQMVMELAP 200
    LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG LVHRDLATRN 250
    LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF 300
    SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR 350
    ALYSLALRCW APHPADRPSF SHLEGLLQEA GPSEACCVRD VTEPGALRME 400
    TGDPITVIEG SSSFHSPDST IWKGQNGRTF KVGSFPASAV TLADAGGLPA 450
    TRPVHRGTPA RGDQHPGSID GDRKKANLWD APPARGQRRN MPLERMKGIS 500
    RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP PLSSSSPQPS 550
    QPSRERLPWP KRKPPHNHPM GMPGARKAAA LSGGLLSDPE LQRKIMEVEL 600
    SVHGVTHQEC QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCWRILEH 650
    YQWDLSAASR YVLARP 666
    Length:666
    Mass (Da):72,468
    Last modified:October 17, 2006 - v3
    Checksum:iAA7FBEF6CC778181
    GO
    Isoform 2Curated (identifier: Q13470-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         411-415: Missing.

    Note: No experimental confirmation available. Contains a phosphoserine at position 411.

    Show »
    Length:661
    Mass (Da):71,922
    Checksum:i73FF2816065327CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361E → G in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti65 – 651R → S in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti94 – 941S → T in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti118 – 1181R → K in AAC99412. 1 PublicationCurated
    Sequence conflicti252 – 2521L → Q in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti288 – 2881A → T in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti325 – 3251A → P in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti347 – 3482LC → PS in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti391 – 3911V → A in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti424 – 4241G → D in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti443 – 4431A → T in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti561 – 5611K → E in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti604 – 6041G → W in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti622 – 6221V → A in AAC50427. (PubMed:8632913)Curated
    Sequence conflicti635 – 6351H → L in AAC50427. (PubMed:8632913)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti278 – 2781V → I.1 Publication
    Corresponds to variant rs55939858 [ dbSNP | Ensembl ].
    VAR_041863
    Natural varianti339 – 3391R → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041864
    Natural varianti514 – 5141T → K.1 Publication
    Corresponds to variant rs55641092 [ dbSNP | Ensembl ].
    VAR_041865
    Natural varianti539 – 5391R → C.1 Publication
    Corresponds to variant rs36046975 [ dbSNP | Ensembl ].
    VAR_041866
    Natural varianti546 – 5461S → C.1 Publication
    Corresponds to variant rs56093628 [ dbSNP | Ensembl ].
    VAR_041867
    Natural varianti598 – 5981V → M.3 Publications
    Corresponds to variant rs6503018 [ dbSNP | Ensembl ].
    VAR_041868

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei411 – 4155Missing in isoform 2. 1 PublicationVSP_051663

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43408 mRNA. Translation: AAC50427.1.
    AF097738 Genomic DNA. Translation: AAC99412.1.
    BC035782 mRNA. Translation: AAH35782.1.
    CCDSiCCDS45602.1. [Q13470-2]
    CCDS58510.1. [Q13470-1]
    RefSeqiNP_001238831.1. NM_001251902.1. [Q13470-1]
    NP_003976.2. NM_003985.4. [Q13470-2]
    UniGeneiHs.203420.
    Hs.739114.

    Genome annotation databases

    EnsembliENST00000570896; ENSP00000458834; ENSG00000174292. [Q13470-2]
    ENST00000576812; ENSP00000459799; ENSG00000174292. [Q13470-1]
    GeneIDi8711.
    KEGGihsa:8711.
    UCSCiuc002ggi.4. human. [Q13470-1]
    uc002ggj.4. human. [Q13470-2]

    Polymorphism databases

    DMDMi116242821.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43408 mRNA. Translation: AAC50427.1 .
    AF097738 Genomic DNA. Translation: AAC99412.1 .
    BC035782 mRNA. Translation: AAH35782.1 .
    CCDSi CCDS45602.1. [Q13470-2 ]
    CCDS58510.1. [Q13470-1 ]
    RefSeqi NP_001238831.1. NM_001251902.1. [Q13470-1 ]
    NP_003976.2. NM_003985.4. [Q13470-2 ]
    UniGenei Hs.203420.
    Hs.739114.

    3D structure databases

    ProteinModelPortali Q13470.
    SMRi Q13470. Positions 107-441.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114253. 5 interactions.
    IntActi Q13470. 4 interactions.
    MINTi MINT-3975658.
    STRINGi 9606.ENSP00000312309.

    Chemistry

    BindingDBi Q13470.
    ChEMBLi CHEMBL5334.
    GuidetoPHARMACOLOGYi 2245.

    PTM databases

    PhosphoSitei Q13470.

    Polymorphism databases

    DMDMi 116242821.

    Proteomic databases

    MaxQBi Q13470.
    PaxDbi Q13470.
    PRIDEi Q13470.

    Protocols and materials databases

    DNASUi 8711.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000570896 ; ENSP00000458834 ; ENSG00000174292 . [Q13470-2 ]
    ENST00000576812 ; ENSP00000459799 ; ENSG00000174292 . [Q13470-1 ]
    GeneIDi 8711.
    KEGGi hsa:8711.
    UCSCi uc002ggi.4. human. [Q13470-1 ]
    uc002ggj.4. human. [Q13470-2 ]

    Organism-specific databases

    CTDi 8711.
    GeneCardsi GC17P007284.
    HGNCi HGNC:11940. TNK1.
    HPAi HPA012065.
    HPA056452.
    MIMi 608076. gene.
    neXtProti NX_Q13470.
    PharmGKBi PA36630.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000231055.
    HOVERGENi HBG055513.
    InParanoidi Q13470.
    KOi K08885.
    OMAi VRDVTEP.
    OrthoDBi EOG71G9T3.
    PhylomeDBi Q13470.
    TreeFami TF316643.

    Miscellaneous databases

    GenomeRNAii 8711.
    NextBioi 32671.
    PROi Q13470.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13470.
    Bgeei Q13470.
    CleanExi HS_TNK1.
    Genevestigatori Q13470.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells."
      Hoehn G.T., Stokland T., Amin S., Ramirez M., Hawkins A.L., Griffin C.A., Small D., Civin C.I.
      Oncogene 12:903-913(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-598, TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
      Tissue: Umbilical cord bloodImported.
    2. "Genomic structure and chromosomal mapping of the human non-receptor tyrosine kinase gene, Tnk1."
      Hoehn G.T., Felschow D.M., Civin C.I.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-598.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: OvaryImported.
    4. "Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1."
      Felschow D.M., Civin C.I., Hoehn G.T.
      Biochem. Biophys. Res. Commun. 273:294-301(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION, INTERACTION WITH PLCG1.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: FUNCTION.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-255; SER-502; THR-514 AND SER-582, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502 AND SER-519, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-502, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502 AND THR-514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-278; LYS-339; LYS-514; CYS-539; CYS-546 AND MET-598.

    Entry informationi

    Entry nameiTNK1_HUMAN
    AccessioniPrimary (citable) accession number: Q13470
    Secondary accession number(s): O95364, Q8IYI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3