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Protein

Non-receptor tyrosine-protein kinase TNK1

Gene

TNK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei148 – 1481ATPPROSITE-ProRule annotationBy similarity
Active sitei245 – 2451Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi122 – 1309ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • hormone receptor binding Source: GO_Central
  • non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
  • protein tyrosine kinase activity Source: UniProtKB
  • signal transducer activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-receptor tyrosine-protein kinase TNK1 (EC:2.7.10.2)
Alternative name(s):
CD38 negative kinase 1
Gene namesi
Name:TNK1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11940. TNK1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Ensembl
  • extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36630.

Polymorphism and mutation databases

BioMutaiTNK1.
DMDMi116242821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 666666Non-receptor tyrosine-protein kinase TNK1PRO_0000088173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei255 – 2551Phosphoserine2 Publications
Modified residuei502 – 5021Phosphoserine5 Publications
Modified residuei514 – 5141Phosphothreonine2 Publications
Modified residuei519 – 5191Phosphoserine1 Publication
Modified residuei582 – 5821Phosphoserine1 Publication
Isoform 2Curated (identifier: Q13470-2)
Modified residuei411 – 4111Phosphoserine2 Publications

Post-translational modificationi

Autophosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13470.
PaxDbiQ13470.
PRIDEiQ13470.

PTM databases

PhosphoSiteiQ13470.

Expressioni

Tissue specificityi

Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.2 Publications

Gene expression databases

BgeeiQ13470.
CleanExiHS_TNK1.
ExpressionAtlasiQ13470. baseline and differential.
GenevisibleiQ13470. HS.

Organism-specific databases

HPAiHPA012065.
HPA056452.

Interactioni

Subunit structurei

Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SFNP319472EBI-1383444,EBI-476295

Protein-protein interaction databases

BioGridi114253. 12 interactions.
IntActiQ13470. 12 interactions.
MINTiMINT-3975658.
STRINGi9606.ENSP00000312309.

Structurei

3D structure databases

ProteinModelPortaliQ13470.
SMRiQ13470. Positions 107-441.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 377262Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini381 – 44464SH3Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi511 – 57363Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.Sequence Analysis

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000231055.
HOVERGENiHBG055513.
InParanoidiQ13470.
KOiK08885.
OMAiLLQEAWP.
OrthoDBiEOG71G9T3.
PhylomeDBiQ13470.
TreeFamiTF316643.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q13470-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG
60 70 80 90 100
MGRPAQRRLS EALKRLRSGP KSKNWVYKIL GGFAPEHKEP TLPSDSPRHL
110 120 130 140 150
PEPEGGLKCL IPEGAVCRGE LLGSGCFGVV HRGLWTLPSG KSVPVAVKSL
160 170 180 190 200
RVGPEGPMGT ELGDFLREVS VMMNLEHPHV LRLHGLVLGQ PLQMVMELAP
210 220 230 240 250
LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG LVHRDLATRN
260 270 280 290 300
LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF
310 320 330 340 350
SSASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR
360 370 380 390 400
ALYSLALRCW APHPADRPSF SHLEGLLQEA GPSEACCVRD VTEPGALRME
410 420 430 440 450
TGDPITVIEG SSSFHSPDST IWKGQNGRTF KVGSFPASAV TLADAGGLPA
460 470 480 490 500
TRPVHRGTPA RGDQHPGSID GDRKKANLWD APPARGQRRN MPLERMKGIS
510 520 530 540 550
RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP PLSSSSPQPS
560 570 580 590 600
QPSRERLPWP KRKPPHNHPM GMPGARKAAA LSGGLLSDPE LQRKIMEVEL
610 620 630 640 650
SVHGVTHQEC QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCWRILEH
660
YQWDLSAASR YVLARP
Length:666
Mass (Da):72,468
Last modified:October 17, 2006 - v3
Checksum:iAA7FBEF6CC778181
GO
Isoform 2Curated (identifier: Q13470-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-415: Missing.

Note: No experimental confirmation available.2 Publications
Show »
Length:661
Mass (Da):71,922
Checksum:i73FF2816065327CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361E → G in AAC50427 (PubMed:8632913).Curated
Sequence conflicti65 – 651R → S in AAC50427 (PubMed:8632913).Curated
Sequence conflicti94 – 941S → T in AAC50427 (PubMed:8632913).Curated
Sequence conflicti118 – 1181R → K in AAC99412 (Ref. 2) Curated
Sequence conflicti252 – 2521L → Q in AAC50427 (PubMed:8632913).Curated
Sequence conflicti288 – 2881A → T in AAC50427 (PubMed:8632913).Curated
Sequence conflicti325 – 3251A → P in AAC50427 (PubMed:8632913).Curated
Sequence conflicti347 – 3482LC → PS in AAC50427 (PubMed:8632913).Curated
Sequence conflicti391 – 3911V → A in AAC50427 (PubMed:8632913).Curated
Sequence conflicti424 – 4241G → D in AAC50427 (PubMed:8632913).Curated
Sequence conflicti443 – 4431A → T in AAC50427 (PubMed:8632913).Curated
Sequence conflicti561 – 5611K → E in AAC50427 (PubMed:8632913).Curated
Sequence conflicti604 – 6041G → W in AAC50427 (PubMed:8632913).Curated
Sequence conflicti622 – 6221V → A in AAC50427 (PubMed:8632913).Curated
Sequence conflicti635 – 6351H → L in AAC50427 (PubMed:8632913).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti278 – 2781V → I.1 Publication
Corresponds to variant rs55939858 [ dbSNP | Ensembl ].
VAR_041863
Natural varianti339 – 3391R → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041864
Natural varianti514 – 5141T → K.1 Publication
Corresponds to variant rs55641092 [ dbSNP | Ensembl ].
VAR_041865
Natural varianti539 – 5391R → C.1 Publication
Corresponds to variant rs36046975 [ dbSNP | Ensembl ].
VAR_041866
Natural varianti546 – 5461S → C.1 Publication
Corresponds to variant rs56093628 [ dbSNP | Ensembl ].
VAR_041867
Natural varianti598 – 5981V → M.3 Publications
Corresponds to variant rs6503018 [ dbSNP | Ensembl ].
VAR_041868

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei411 – 4155Missing in isoform 2. 1 PublicationVSP_051663

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43408 mRNA. Translation: AAC50427.1.
AF097738 Genomic DNA. Translation: AAC99412.1.
BC035782 mRNA. Translation: AAH35782.1.
CCDSiCCDS45602.1. [Q13470-2]
CCDS58510.1. [Q13470-1]
RefSeqiNP_001238831.1. NM_001251902.1. [Q13470-1]
NP_003976.2. NM_003985.4. [Q13470-2]
XP_011522347.1. XM_011524045.1. [Q13470-2]
UniGeneiHs.203420.
Hs.739114.

Genome annotation databases

EnsembliENST00000570896; ENSP00000458834; ENSG00000174292. [Q13470-2]
ENST00000576812; ENSP00000459799; ENSG00000174292.
GeneIDi8711.
KEGGihsa:8711.
UCSCiuc002ggi.4. human. [Q13470-1]
uc002ggj.4. human. [Q13470-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43408 mRNA. Translation: AAC50427.1.
AF097738 Genomic DNA. Translation: AAC99412.1.
BC035782 mRNA. Translation: AAH35782.1.
CCDSiCCDS45602.1. [Q13470-2]
CCDS58510.1. [Q13470-1]
RefSeqiNP_001238831.1. NM_001251902.1. [Q13470-1]
NP_003976.2. NM_003985.4. [Q13470-2]
XP_011522347.1. XM_011524045.1. [Q13470-2]
UniGeneiHs.203420.
Hs.739114.

3D structure databases

ProteinModelPortaliQ13470.
SMRiQ13470. Positions 107-441.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114253. 12 interactions.
IntActiQ13470. 12 interactions.
MINTiMINT-3975658.
STRINGi9606.ENSP00000312309.

Chemistry

BindingDBiQ13470.
ChEMBLiCHEMBL5334.
GuidetoPHARMACOLOGYi2245.

PTM databases

PhosphoSiteiQ13470.

Polymorphism and mutation databases

BioMutaiTNK1.
DMDMi116242821.

Proteomic databases

MaxQBiQ13470.
PaxDbiQ13470.
PRIDEiQ13470.

Protocols and materials databases

DNASUi8711.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570896; ENSP00000458834; ENSG00000174292. [Q13470-2]
ENST00000576812; ENSP00000459799; ENSG00000174292.
GeneIDi8711.
KEGGihsa:8711.
UCSCiuc002ggi.4. human. [Q13470-1]
uc002ggj.4. human. [Q13470-2]

Organism-specific databases

CTDi8711.
GeneCardsiGC17P007284.
HGNCiHGNC:11940. TNK1.
HPAiHPA012065.
HPA056452.
MIMi608076. gene.
neXtProtiNX_Q13470.
PharmGKBiPA36630.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000231055.
HOVERGENiHBG055513.
InParanoidiQ13470.
KOiK08885.
OMAiLLQEAWP.
OrthoDBiEOG71G9T3.
PhylomeDBiQ13470.
TreeFamiTF316643.

Miscellaneous databases

ChiTaRSiTNK1. human.
GenomeRNAii8711.
NextBioi32671.
PROiQ13470.
SOURCEiSearch...

Gene expression databases

BgeeiQ13470.
CleanExiHS_TNK1.
ExpressionAtlasiQ13470. baseline and differential.
GenevisibleiQ13470. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells."
    Hoehn G.T., Stokland T., Amin S., Ramirez M., Hawkins A.L., Griffin C.A., Small D., Civin C.I.
    Oncogene 12:903-913(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-598, TISSUE SPECIFICITY, CHROMOSOMAL LOCATION.
    Tissue: Umbilical cord bloodImported.
  2. "Genomic structure and chromosomal mapping of the human non-receptor tyrosine kinase gene, Tnk1."
    Hoehn G.T., Felschow D.M., Civin C.I.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MET-598.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: OvaryImported.
  4. "Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1."
    Felschow D.M., Civin C.I., Hoehn G.T.
    Biochem. Biophys. Res. Commun. 273:294-301(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION, INTERACTION WITH PLCG1.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: FUNCTION.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-255; SER-502; THR-514 AND SER-582, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502 AND SER-519, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-502, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502 AND THR-514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-278; LYS-339; LYS-514; CYS-539; CYS-546 AND MET-598.

Entry informationi

Entry nameiTNK1_HUMAN
AccessioniPrimary (citable) accession number: Q13470
Secondary accession number(s): O95364, Q8IYI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 17, 2006
Last modified: July 22, 2015
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.