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Reviewed, UniProtKB/Swiss-Prot Q13467 (FZD5_HUMAN)

Last modified February 9, 2010. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Frizzled-5
      Short name=Fz-5
      Short name=hFz5
Alternative name(s):
    FzE5
Gene names
Name: FZD5
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.

Subunit structure

Interacts with GOPC By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Note: Localized at the plasma membrane and also found at the Golgi By similarity.

Domain

The PDZ-binding motif mediates interaction with GOPC By similarity.

Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor Fz/Smo family.

Contains 1 FZ (frizzled) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 585559Frizzled-5
PRO_0000012990

Regions

Topological domain27 – 238212Extracellular Potential
Transmembrane239 – 259211 Potential
Topological domain260 – 27011Cytoplasmic Potential
Transmembrane271 – 291212 Potential
Topological domain292 – 31524Extracellular Potential
Transmembrane316 – 336213 Potential
Topological domain337 – 35822Cytoplasmic Potential
Transmembrane359 – 379214 Potential
Topological domain380 – 40223Extracellular Potential
Transmembrane403 – 423215 Potential
Topological domain424 – 44926Cytoplasmic Potential
Transmembrane450 – 470216 Potential
Topological domain471 – 50030Extracellular Potential
Transmembrane501 – 521217 Potential
Topological domain522 – 58564Cytoplasmic Potential
Domain28 – 150123FZ
Motif525 – 5306Lys-Thr-X-X-X-Trp motif
Motif583 – 5853PDZ-binding

Amino acid modifications

Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 94 By similarity
Disulfide bond41 ↔ 87 By similarity
Disulfide bond78 ↔ 116 By similarity
Disulfide bond105 ↔ 147 By similarity
Disulfide bond109 ↔ 133 By similarity

Natural variations

Natural variant2161P → L: dbSNP rs35994626.
VAR_049291

Experimental info

Sequence conflict881S → T in AAC50385. Ref.1
Sequence conflict262 – 2632ER → DT in AAC50385. Ref.1
Sequence conflict3451G → A in AAC50385. Ref.1
Sequence conflict3571A → G in AAC50385. Ref.1
Sequence conflict4021G → R in AAC50385. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q13467-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: AC3AB2CD912C1B0A

FASTA58564,507
        10         20         30         40         50         60 
MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH MPNQFNHDTQ 

        70         80         90        100        110        120 
DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK PLPPCRSVCE RAKAGCSPLM 

       130        140        150        160        170        180 
RQYGFAWPER MSCDRLPVLG RDAEVLCMDY NRSEATTAPP RPFPAKPTLP GPPGAPASGG 

       190        200        210        220        230        240 
ECPAGGPFVC KCREPFVPIL KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG 

       250        260        270        280        290        300 
LWSVLCFIST STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 

       310        320        330        340        350        360 
EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN EAIAGYAQYF 

       370        380        390        400        410        420 
HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL RGFVLGPLVL YLLVGTLFLL 

       430        440        450        460        470        480 
AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI GIFTLLYTVP ASIVVACYLY EQHYRESWEA 

       490        500        510        520        530        540 
ALTCACPGHD TGQPRAKPEY WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR 

       550        560        570        580 
PRRGHKSGGA MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV

« Hide

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References

« Hide 'large scale' references
[1]"A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
J. Biol. Chem. 271:4468-4476(1996) [PubMed: 8626800] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]"Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region."
Saitoh T., Hirai M., Katoh M.
Int. J. Oncol. 19:105-110(2001) [PubMed: 11408929] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed: 9707618] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-331.
Tissue: Oesophageal carcinoma.
[5]"A member of the Frizzled protein family mediating axis induction by Wnt-5A."
He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H.
Science 275:1652-1654(1997) [PubMed: 9054360] [Abstract]
Cited for: COUPLING TO BETA-CATENIN PATHWAY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U43318 mRNA. Translation: AAC50385.1.
AB043702 mRNA. Translation: BAB60959.1.
AC096772 Genomic DNA. Translation: AAY24058.1.
IPIIPI00298743.
RefSeqNP_003459.2.
UniGeneHs.17631

3D structure databases

SMRQ13467. Positions 33-152.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ13467.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ13467.

Proteomic databases

PRIDEQ13467.

Genome annotation databases

EnsemblENST00000295417; ENSP00000354607; ENSG00000163251; Homo sapiens. [Genome view]
GeneID7855.
KEGGhsa:7855.
UCSCuc002vcj.1. human.

Organism-specific databases

CTD7855.
GeneCardsGC02M208338.
HGNCHGNC:4043. FZD5.
MIM601723. gene.
PharmGKBPA28460.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG19110.
HOGENOMHBG447413.
HOVERGENQ13467.
InParanoidQ13467.
OMAHKSGGAM.
OrthoDBEOG9RZ1K6.
PhylomeDBQ13467.

Gene expression databases

ArrayExpressQ13467.
BgeeQ13467.
CleanExHS_FZD5.
GenevestigatorQ13467.
GermOnlineENSG00000163251. Homo sapiens.

Family and domain databases

InterProIPR000539. Frizzled.
IPR020067. Frizzled-like_dom.
IPR000024. Frizzled_Cys-rich.
IPR020068. Frizzled_dom_subgr.
IPR015526. Frizzled_related.
IPR017981. GPCR_2-like.
[Graphical view]
Gene3DG3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHERPTHR11309. Fz_related. 1 hit.
PfamPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSPR00489. FRIZZLED.
SMARTSM00063. FRI. 1 hit.
[Graphical view]
PROSITEPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio30293.
SOURCESearch...

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Entry information

Entry nameFZD5_HUMAN
AccessionPrimary (citable) accession number: Q13467
Secondary accession number(s): Q53R22
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 17, 2006
Last modified: February 9, 2010
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

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List of 7-transmembrane G-linked receptor entries

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents