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Q13467

- FZD5_HUMAN

UniProt

Q13467 - FZD5_HUMAN

Protein

Frizzled-5

Gene

FZD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. protein binding Source: UniProtKB
    4. protein kinase binding Source: BHF-UCL
    5. ubiquitin protein ligase binding Source: UniProtKB
    6. Wnt-activated receptor activity Source: BHF-UCL
    7. Wnt-protein binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: RefGenome
    2. anterior/posterior axis specification, embryo Source: BHF-UCL
    3. apoptotic process Source: RefGenome
    4. apoptotic process involved in morphogenesis Source: Ensembl
    5. axonogenesis Source: RefGenome
    6. brain development Source: RefGenome
    7. canonical Wnt signaling pathway Source: BHF-UCL
    8. cell maturation Source: Ensembl
    9. cellular response to molecule of bacterial origin Source: BHF-UCL
    10. embryonic axis specification Source: BHF-UCL
    11. embryonic camera-type eye development Source: RefGenome
    12. gonad development Source: RefGenome
    13. labyrinthine layer blood vessel development Source: RefGenome
    14. negative regulation of cell proliferation Source: Ensembl
    15. neuron differentiation Source: UniProtKB
    16. positive regulation of interferon-gamma production Source: BHF-UCL
    17. positive regulation of JUN kinase activity Source: Ensembl
    18. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    19. post-embryonic camera-type eye development Source: RefGenome
    20. Spemann organizer formation Source: BHF-UCL
    21. T cell differentiation in thymus Source: RefGenome
    22. Wnt signaling pathway involved in dorsal/ventral axis specification Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200716. regulation of FZD by ubiquitination.
    SignaLinkiQ13467.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-5
    Short name:
    Fz-5
    Short name:
    hFz5
    Alternative name(s):
    FzE5
    Gene namesi
    Name:FZD5
    Synonyms:C2orf31
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4043. FZD5.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
    Note: Localized at the plasma membrane and also found at the Golgi.By similarity

    GO - Cellular componenti

    1. cell projection Source: RefGenome
    2. cell surface Source: BHF-UCL
    3. clathrin-coated endocytic vesicle membrane Source: Reactome
    4. cytoplasm Source: RefGenome
    5. early endosome Source: Ensembl
    6. Golgi membrane Source: UniProtKB-SubCell
    7. integral component of membrane Source: UniProtKB-KW
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 585559Frizzled-5PRO_0000012990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi41 ↔ 87PROSITE-ProRule annotation
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 116PROSITE-ProRule annotation
    Disulfide bondi105 ↔ 147PROSITE-ProRule annotation
    Disulfide bondi109 ↔ 133PROSITE-ProRule annotation
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ13467.
    PaxDbiQ13467.
    PRIDEiQ13467.

    PTM databases

    PhosphoSiteiQ13467.

    Expressioni

    Gene expression databases

    BgeeiQ13467.
    CleanExiHS_FZD5.
    GenevestigatoriQ13467.

    Organism-specific databases

    HPAiHPA052361.
    HPA053811.

    Interactioni

    Subunit structurei

    Interacts with GOPC.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SCYL2Q6P3W74EBI-3913027,EBI-1046810

    Protein-protein interaction databases

    BioGridi113609. 9 interactions.
    IntActiQ13467. 11 interactions.
    MINTiMINT-7005936.
    STRINGi9606.ENSP00000354607.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13467.
    SMRiQ13467. Positions 33-149, 197-536.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 238212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini337 – 35822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini380 – 40223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 44926CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini471 – 50030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini522 – 58564CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei501 – 52121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 150123FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi525 – 5306Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
    Motifi583 – 5853PDZ-binding

    Domaini

    The PDZ-binding motif mediates interaction with GOPC.By similarity
    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiQ13467.
    KOiK02375.
    OMAiAATYHKQ.
    OrthoDBiEOG7M3J01.
    PhylomeDBiQ13467.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026547. FZD5.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF29. PTHR11309:SF29. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q13467-1 [UniParc]FASTAAdd to Basket

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    MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH    50
    MPNQFNHDTQ DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK 100
    PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG RDAEVLCMDY 150
    NRSEATTAPP RPFPAKPTLP GPPGAPASGG ECPAGGPFVC KCREPFVPIL 200
    KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG LWSVLCFIST 250
    STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 300
    EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN 350
    EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL 400
    RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI 450
    GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGHD TGQPRAKPEY 500
    WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR PRRGHKSGGA 550
    MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV 585
    Length:585
    Mass (Da):64,507
    Last modified:October 17, 2006 - v2
    Checksum:iAC3AB2CD912C1B0A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881S → T in AAC50385. (PubMed:8626800)Curated
    Sequence conflicti262 – 2632ER → DT in AAC50385. (PubMed:8626800)Curated
    Sequence conflicti345 – 3451G → A in AAC50385. (PubMed:8626800)Curated
    Sequence conflicti357 – 3571A → G in AAC50385. (PubMed:8626800)Curated
    Sequence conflicti384 – 3841D → G in BAF83075. (PubMed:15815621)Curated
    Sequence conflicti402 – 4021G → R in AAC50385. (PubMed:8626800)Curated
    Sequence conflicti504 – 5041M → V in BAG37738. (PubMed:15815621)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti216 – 2161P → L.
    Corresponds to variant rs35994626 [ dbSNP | Ensembl ].
    VAR_049291

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43318 mRNA. Translation: AAC50385.1.
    AB043702 mRNA. Translation: BAB60959.1.
    AK290386 mRNA. Translation: BAF83075.1.
    AK315338 mRNA. Translation: BAG37738.1.
    AC096772 Genomic DNA. Translation: AAY24058.1.
    CCDSiCCDS33366.1.
    RefSeqiNP_003459.2. NM_003468.3.
    UniGeneiHs.17631.

    Genome annotation databases

    EnsembliENST00000295417; ENSP00000354607; ENSG00000163251.
    GeneIDi7855.
    KEGGihsa:7855.
    UCSCiuc002vcj.3. human.

    Polymorphism databases

    DMDMi116242481.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43318 mRNA. Translation: AAC50385.1 .
    AB043702 mRNA. Translation: BAB60959.1 .
    AK290386 mRNA. Translation: BAF83075.1 .
    AK315338 mRNA. Translation: BAG37738.1 .
    AC096772 Genomic DNA. Translation: AAY24058.1 .
    CCDSi CCDS33366.1.
    RefSeqi NP_003459.2. NM_003468.3.
    UniGenei Hs.17631.

    3D structure databases

    ProteinModelPortali Q13467.
    SMRi Q13467. Positions 33-149, 197-536.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113609. 9 interactions.
    IntActi Q13467. 11 interactions.
    MINTi MINT-7005936.
    STRINGi 9606.ENSP00000354607.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q13467.

    Polymorphism databases

    DMDMi 116242481.

    Proteomic databases

    MaxQBi Q13467.
    PaxDbi Q13467.
    PRIDEi Q13467.

    Protocols and materials databases

    DNASUi 7855.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295417 ; ENSP00000354607 ; ENSG00000163251 .
    GeneIDi 7855.
    KEGGi hsa:7855.
    UCSCi uc002vcj.3. human.

    Organism-specific databases

    CTDi 7855.
    GeneCardsi GC02M208594.
    HGNCi HGNC:4043. FZD5.
    HPAi HPA052361.
    HPA053811.
    MIMi 601723. gene.
    neXtProti NX_Q13467.
    PharmGKBi PA28460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257258.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi Q13467.
    KOi K02375.
    OMAi AATYHKQ.
    OrthoDBi EOG7M3J01.
    PhylomeDBi Q13467.
    TreeFami TF317907.

    Enzyme and pathway databases

    Reactomei REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
    REACT_172761. Ca2+ pathway.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200716. regulation of FZD by ubiquitination.
    SignaLinki Q13467.

    Miscellaneous databases

    ChiTaRSi FZD5. human.
    GeneWikii FZD5.
    GenomeRNAii 7855.
    NextBioi 30293.
    PROi Q13467.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q13467.
    CleanExi HS_FZD5.
    Genevestigatori Q13467.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR026547. FZD5.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF29. PTHR11309:SF29. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
      Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
      J. Biol. Chem. 271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    2. "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region."
      Saitoh T., Hirai M., Katoh M.
      Int. J. Oncol. 19:105-110(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen and Umbilical cord blood.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
      Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
      Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-331.
      Tissue: Esophageal carcinoma.
    6. "A member of the Frizzled protein family mediating axis induction by Wnt-5A."
      He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H.
      Science 275:1652-1654(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: COUPLING TO BETA-CATENIN PATHWAY.
    7. "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein."
      Hsieh J.C., Rattner A., Smallwood P.M., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. Cited for: UBIQUITINATION BY ZNRF3.
    9. "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors."
      Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M., Clevers H.
      Nature 488:665-669(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY RNF43.

    Entry informationi

    Entry nameiFZD5_HUMAN
    AccessioniPrimary (citable) accession number: Q13467
    Secondary accession number(s): A8K2X1, B2RCZ1, Q53R22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3