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Q13467

- FZD5_HUMAN

UniProt

Q13467 - FZD5_HUMAN

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Protein
Frizzled-5
Gene
FZD5, C2orf31
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: RefGenome
  3. Wnt-activated receptor activity Source: BHF-UCL
  4. Wnt-protein binding Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. protein kinase binding Source: BHF-UCL
  7. ubiquitin protein ligase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. Spemann organizer formation Source: BHF-UCL
  2. T cell differentiation in thymus Source: RefGenome
  3. Wnt signaling pathway involved in dorsal/ventral axis specification Source: BHF-UCL
  4. angiogenesis Source: RefGenome
  5. anterior/posterior axis specification, embryo Source: BHF-UCL
  6. apoptotic process Source: RefGenome
  7. apoptotic process involved in morphogenesis Source: Ensembl
  8. axonogenesis Source: RefGenome
  9. brain development Source: RefGenome
  10. canonical Wnt signaling pathway Source: BHF-UCL
  11. cell maturation Source: Ensembl
  12. cellular response to molecule of bacterial origin Source: BHF-UCL
  13. embryonic axis specification Source: BHF-UCL
  14. embryonic camera-type eye development Source: RefGenome
  15. gonad development Source: RefGenome
  16. labyrinthine layer blood vessel development Source: RefGenome
  17. negative regulation of cell proliferation Source: Ensembl
  18. neuron differentiation Source: UniProtKB
  19. positive regulation of JUN kinase activity Source: Ensembl
  20. positive regulation of interferon-gamma production Source: BHF-UCL
  21. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  22. post-embryonic camera-type eye development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200716. regulation of FZD by ubiquitination.
SignaLinkiQ13467.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-5
Short name:
Fz-5
Short name:
hFz5
Alternative name(s):
FzE5
Gene namesi
Name:FZD5
Synonyms:C2orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4043. FZD5.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity
Note: Localized at the plasma membrane and also found at the Golgi By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 238212Extracellular Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini260 – 27011Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei271 – 29121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini292 – 31524Extracellular Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini337 – 35822Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei359 – 37921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini380 – 40223Extracellular Reviewed prediction
Add
BLAST
Transmembranei403 – 42321Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini424 – 44926Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei450 – 47021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini471 – 50030Extracellular Reviewed prediction
Add
BLAST
Transmembranei501 – 52121Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini522 – 58564Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. cell projection Source: RefGenome
  3. cell surface Source: BHF-UCL
  4. clathrin-coated endocytic vesicle membrane Source: Reactome
  5. cytoplasm Source: RefGenome
  6. early endosome Source: Ensembl
  7. integral component of membrane Source: UniProtKB-KW
  8. perinuclear region of cytoplasm Source: Ensembl
  9. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 585559Frizzled-5
PRO_0000012990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 94 By similarity
Disulfide bondi41 ↔ 87 By similarity
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi78 ↔ 116 By similarity
Disulfide bondi105 ↔ 147 By similarity
Disulfide bondi109 ↔ 133 By similarity
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13467.
PaxDbiQ13467.
PRIDEiQ13467.

PTM databases

PhosphoSiteiQ13467.

Expressioni

Gene expression databases

BgeeiQ13467.
CleanExiHS_FZD5.
GenevestigatoriQ13467.

Organism-specific databases

HPAiHPA052361.
HPA053811.

Interactioni

Subunit structurei

Interacts with GOPC By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
SCYL2Q6P3W74EBI-3913027,EBI-1046810

Protein-protein interaction databases

BioGridi113609. 9 interactions.
IntActiQ13467. 10 interactions.
MINTiMINT-7005936.
STRINGi9606.ENSP00000354607.

Structurei

3D structure databases

ProteinModelPortaliQ13467.
SMRiQ13467. Positions 33-149, 197-536.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 150123FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi525 – 5306Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi583 – 5853PDZ-binding

Domaini

The PDZ-binding motif mediates interaction with GOPC By similarity.
Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
HOGENOMiHOG000233236.
HOVERGENiHBG006977.
InParanoidiQ13467.
KOiK02375.
OMAiAATYHKQ.
OrthoDBiEOG7M3J01.
PhylomeDBiQ13467.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026547. FZD5.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF29. PTHR11309:SF29. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13467-1 [UniParc]FASTAAdd to Basket

« Hide

MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH    50
MPNQFNHDTQ DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK 100
PLPPCRSVCE RAKAGCSPLM RQYGFAWPER MSCDRLPVLG RDAEVLCMDY 150
NRSEATTAPP RPFPAKPTLP GPPGAPASGG ECPAGGPFVC KCREPFVPIL 200
KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG LWSVLCFIST 250
STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 300
EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN 350
EAIAGYAQYF HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL 400
RGFVLGPLVL YLLVGTLFLL AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI 450
GIFTLLYTVP ASIVVACYLY EQHYRESWEA ALTCACPGHD TGQPRAKPEY 500
WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR PRRGHKSGGA 550
MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV 585
Length:585
Mass (Da):64,507
Last modified:October 17, 2006 - v2
Checksum:iAC3AB2CD912C1B0A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161P → L.
Corresponds to variant rs35994626 [ dbSNP | Ensembl ].
VAR_049291

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881S → T in AAC50385. 1 Publication
Sequence conflicti262 – 2632ER → DT in AAC50385. 1 Publication
Sequence conflicti345 – 3451G → A in AAC50385. 1 Publication
Sequence conflicti357 – 3571A → G in AAC50385. 1 Publication
Sequence conflicti384 – 3841D → G in BAF83075. 1 Publication
Sequence conflicti402 – 4021G → R in AAC50385. 1 Publication
Sequence conflicti504 – 5041M → V in BAG37738. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43318 mRNA. Translation: AAC50385.1.
AB043702 mRNA. Translation: BAB60959.1.
AK290386 mRNA. Translation: BAF83075.1.
AK315338 mRNA. Translation: BAG37738.1.
AC096772 Genomic DNA. Translation: AAY24058.1.
CCDSiCCDS33366.1.
RefSeqiNP_003459.2. NM_003468.3.
UniGeneiHs.17631.

Genome annotation databases

EnsembliENST00000295417; ENSP00000354607; ENSG00000163251.
GeneIDi7855.
KEGGihsa:7855.
UCSCiuc002vcj.3. human.

Polymorphism databases

DMDMi116242481.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43318 mRNA. Translation: AAC50385.1 .
AB043702 mRNA. Translation: BAB60959.1 .
AK290386 mRNA. Translation: BAF83075.1 .
AK315338 mRNA. Translation: BAG37738.1 .
AC096772 Genomic DNA. Translation: AAY24058.1 .
CCDSi CCDS33366.1.
RefSeqi NP_003459.2. NM_003468.3.
UniGenei Hs.17631.

3D structure databases

ProteinModelPortali Q13467.
SMRi Q13467. Positions 33-149, 197-536.
ModBasei Search...

Protein-protein interaction databases

BioGridi 113609. 9 interactions.
IntActi Q13467. 10 interactions.
MINTi MINT-7005936.
STRINGi 9606.ENSP00000354607.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q13467.

Polymorphism databases

DMDMi 116242481.

Proteomic databases

MaxQBi Q13467.
PaxDbi Q13467.
PRIDEi Q13467.

Protocols and materials databases

DNASUi 7855.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295417 ; ENSP00000354607 ; ENSG00000163251 .
GeneIDi 7855.
KEGGi hsa:7855.
UCSCi uc002vcj.3. human.

Organism-specific databases

CTDi 7855.
GeneCardsi GC02M208594.
HGNCi HGNC:4043. FZD5.
HPAi HPA052361.
HPA053811.
MIMi 601723. gene.
neXtProti NX_Q13467.
PharmGKBi PA28460.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257258.
HOGENOMi HOG000233236.
HOVERGENi HBG006977.
InParanoidi Q13467.
KOi K02375.
OMAi AATYHKQ.
OrthoDBi EOG7M3J01.
PhylomeDBi Q13467.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_172631. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
REACT_172761. Ca2+ pathway.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200716. regulation of FZD by ubiquitination.
SignaLinki Q13467.

Miscellaneous databases

ChiTaRSi FZD5. human.
GeneWikii FZD5.
GenomeRNAii 7855.
NextBioi 30293.
PROi Q13467.
SOURCEi Search...

Gene expression databases

Bgeei Q13467.
CleanExi HS_FZD5.
Genevestigatori Q13467.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026547. FZD5.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF29. PTHR11309:SF29. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled."
    Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    J. Biol. Chem. 271:4468-4476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region."
    Saitoh T., Hirai M., Katoh M.
    Int. J. Oncol. 19:105-110(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen and Umbilical cord blood.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
    Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
    Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 273-331.
    Tissue: Esophageal carcinoma.
  6. "A member of the Frizzled protein family mediating axis induction by Wnt-5A."
    He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H.
    Science 275:1652-1654(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: COUPLING TO BETA-CATENIN PATHWAY.
  7. "Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein."
    Hsieh J.C., Rattner A., Smallwood P.M., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. Cited for: UBIQUITINATION BY ZNRF3.
  9. "Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors."
    Koo B.K., Spit M., Jordens I., Low T.Y., Stange D.E., van de Wetering M., van Es J.H., Mohammed S., Heck A.J., Maurice M.M., Clevers H.
    Nature 488:665-669(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY RNF43.

Entry informationi

Entry nameiFZD5_HUMAN
AccessioniPrimary (citable) accession number: Q13467
Secondary accession number(s): A8K2X1, B2RCZ1, Q53R22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi