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Q13459 (MYO9B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-IXb
Alternative name(s):
Unconventional myosin-9b
Gene names
Name:MYO9B
Synonyms:MYR5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2157 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho.

Subcellular location

Cytoplasmcell cortex. Cytoplasmperinuclear region. Cytoplasmcytoskeleton. Note: In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region.

Tissue specificity

Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.

Involvement in disease

Celiac disease 4 (CELIAC4) [MIM:609753]: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.6

Sequence similarities

Contains 4 IQ domains.

Contains 1 myosin head-like domain.

Contains 1 phorbol-ester/DAG-type zinc finger.

Contains 1 Ras-associating domain.

Contains 1 Rho-GAP domain.

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).

Sequence caution

The sequence AAC50402.1 differs from that shown. Reason: The C-terminal sequence from position 1917 onwards appears to be not correctly spliced.

The sequence BAA92132.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Repeat
Zinc-finger
   LigandActin-binding
ATP-binding
Calmodulin-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionGTPase activation
Motor protein
Myosin
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRho protein signal transduction

Inferred by curator Ref.4. Source: UniProtKB

actin filament-based movement

Traceable author statement Ref.1. Source: UniProtKB

establishment of cell polarity

Inferred from electronic annotation. Source: Ensembl

lamellipodium morphogenesis

Inferred from electronic annotation. Source: Ensembl

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

monocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

regulation of small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

   Cellular_componentactin cytoskeleton

Traceable author statement Ref.1. Source: ProtInc

cell cortex

Inferred from direct assay Ref.1. Source: UniProtKB

cytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

cytosol

Traceable author statement. Source: Reactome

filamentous actin

Inferred from direct assay PubMed 16338935PubMed 16616011Ref.1. Source: UniProtKB

filopodium tip

Inferred from electronic annotation. Source: Ensembl

lamellipodium

Inferred from electronic annotation. Source: Ensembl

myosin complex

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from direct assay Ref.1. Source: UniProtKB

ruffle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionADP binding

Inferred from direct assay PubMed 16338935. Source: UniProtKB

ATP binding

Inferred from direct assay PubMed 16338935. Source: UniProtKB

ATPase activity

Inferred from direct assay PubMed 16338935. Source: UniProtKB

Rho GTPase activator activity

Inferred from direct assay PubMed 15644318Ref.4. Source: UniProtKB

actin binding

Inferred from direct assay PubMed 16338935PubMed 16616011Ref.4. Source: UniProtKB

actin-dependent ATPase activity

Inferred from electronic annotation. Source: Ensembl

calmodulin binding

Inferred from direct assay PubMed 16338935Ref.4. Source: UniProtKB

microfilament motor activity

Inferred from direct assay PubMed 11901422PubMed 16616011Ref.4. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ARFGEF1Q9Y6D62EBI-6251250,EBI-1044254

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q13459-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q13459-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2021-2022: PP → QY
     2023-2157: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.18
Chain2 – 21572156Unconventional myosin-IXb
PRO_0000123469

Regions

Domain2 – 939938Myosin head-like
Domain15 – 114100Ras-associating
Domain957 – 97721IQ 1
Domain979 – 100022IQ 2
Domain1001 – 102323IQ 3
Domain1024 – 105330IQ 4
Domain1703 – 1888186Rho-GAP
Nucleotide binding239 – 2468ATP Potential
Zinc finger1632 – 168150Phorbol-ester/DAG-type
Region844 – 85512Actin-binding
Region940 – 1044105Neck or regulatory domain
Region1045 – 21571113Tail
Coiled coil1046 – 107126 Potential
Coiled coil1880 – 190122 Potential
Coiled coil1959 – 198931 Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.18
Modified residue7161Phosphoserine Ref.11
Modified residue12421Phosphoserine By similarity
Modified residue12671Phosphoserine Ref.9 Ref.14 Ref.17
Modified residue12711Phosphothreonine Ref.9 Ref.14 Ref.17
Modified residue12901Phosphoserine Ref.8 Ref.9 Ref.10 Ref.11 Ref.13 Ref.15 Ref.17
Modified residue13231Phosphoserine Ref.15
Modified residue13461Phosphothreonine Ref.15
Modified residue13541Phosphoserine Ref.11 Ref.17
Modified residue14051Phosphoserine Ref.10
Modified residue19921Phosphoserine Ref.11 Ref.13 Ref.14 Ref.17

Natural variations

Alternative sequence2021 – 20222PP → QY in isoform Short.
VSP_003361
Alternative sequence2023 – 2157135Missing in isoform Short.
VSP_003362

Experimental info

Sequence conflict237 – 2382IS → YP in AAC50402. Ref.1
Sequence conflict2761G → C in AAC50402. Ref.1
Sequence conflict10111S → A in AAC50402. Ref.1
Sequence conflict16931V → A in AAC50402. Ref.1
Sequence conflict19461L → P in BAA92132. Ref.4
Sequence conflict2039 – 20446TVAAPP → PWPPLH in AAC26597. Ref.3
Sequence conflict20481P → L in AAC26597. Ref.3
Sequence conflict20661P → S in AAC26597. Ref.3
Sequence conflict2156 – 21572NG → MAESHS in AAC26597. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified March 8, 2011. Version 3.
Checksum: A3E72CAB759CD5FD

FASTA2,157243,401
        10         20         30         40         50         60 
MSVKEAGSSG RREQAAYHLH IYPQLSTTES QASCRVTATK DSTTSDVIKD AIASLRLDGT 

        70         80         90        100        110        120 
KCYVLVEVKE SGGEEWVLDA NDSPVHRVLL WPRRAQDEHP QEDGYYFLLQ ERNADGTIKY 

       130        140        150        160        170        180 
VHMQLVAQAT ATRRLVERGL LPRQQADFDD LCNLPELTEG NLLKNLKHRF LQQKIYTYAG 

       190        200        210        220        230        240 
SILVAINPFK FLPIYNPKYV KMYENQQLGK LEPHVFALAD VAYYTMLRKR VNQCIVISGE 

       250        260        270        280        290        300 
SGSGKTQSTN FLIHCLTALS QKGYASGVER TILGAGPVLE AFGNAKTAHN NNSSRFGKFI 

       310        320        330        340        350        360 
QVSYLESGIV RGAVVEKYLL EKSRLVSQEK DERNYHVFYY LLLGVSEEER QEFQLKQPED 

       370        380        390        400        410        420 
YFYLNQHNLK IEDGEDLKHD FERLKQAMEM VGFLPATKKQ IFAVLSAILY LGNVTYKKRA 

       430        440        450        460        470        480 
TGREEGLEVG PPEVLDTLSQ LLKVKREILV EVLTKRKTVT VNDKLILPYS LSEAITARDS 

       490        500        510        520        530        540 
MAKSLYSALF DWIVLRINHA LLNKKDVEEA VSCLSIGVLD IFGFEDFERN SFEQFCINYA 

       550        560        570        580        590        600 
NEQLQYYFNQ HIFKLEQEEY QGEGITWHNI GYTDNVGCIH LISKKPTGLF YLLDEESNFP 

       610        620        630        640        650        660 
HATSQTLLAK FKQQHEDNKY FLGTPVMEPA FIIQHFAGKV KYQIKDFREK NMDYMRPDIV 

       670        680        690        700        710        720 
ALLRGSDSSY VRELIGMDPV AVFRWAVLRA AIRAMAVLRE AGRLRAERAE KAAGMSSPGA 

       730        740        750        760        770        780 
QSHPEELPRG ASTPSEKLYR DLHNQMIKSI KGLPWQGEDP RSLLQSLSRL QKPRAFILKS 

       790        800        810        820        830        840 
KGIKQKQIIP KNLLDSKSLK LIISMTLHDR TTKSLLHLHK KKKPPSISAQ FQTSLNKLLE 

       850        860        870        880        890        900 
ALGKAEPFFI RCIRSNAEKK ELCFDDELVL QQLRYTGMLE TVRIRRSGYS AKYTFQDFTE 

       910        920        930        940        950        960 
QFQVLLPKDA QPCREVISTL LEKMKIDKRN YQIGKTKVFL KETERQALQE TLHREVVRKI 

       970        980        990       1000       1010       1020 
LLLQSWFRMV LERRHFLQMK RAAVTIQACW RSYRVRRALE RTQAAVYLQA SWRGYWQRKL 

      1030       1040       1050       1060       1070       1080 
YRHQKQSIIR LQSLCRGHLQ RKSFSQMISE KQKAEEKERE ALEAARAGAE EGGQGQAAGG 

      1090       1100       1110       1120       1130       1140 
QQVAEQGPEP AEDGGHLASE PEVQPSDRSP LEHSSPEKEA PSPEKTLPPQ KTVAAESHEK 

      1150       1160       1170       1180       1190       1200 
VPSSREKRES RRQRGLEHVK FQNKHIQSCK EESALREPSR RVTQEQGVSL LEDKKESRED 

      1210       1220       1230       1240       1250       1260 
ETLLVVETEA ENTSQKQPTE QPQAMAVGKV SEETEKTLPS GSPRPGQLER PTSLALDSRV 

      1270       1280       1290       1300       1310       1320 
SPPAPGSAPE TPEDKSKPCG SPRVQEKPDS PGGSTQIQRY LDAERLASAV ELWRGKKLVA 

      1330       1340       1350       1360       1370       1380 
AASPSAMLSQ SLDLSDRHRA TGAALTPTEE RRTSFSTSDV SKLLPSLAKA QPAAETTDGE 

      1390       1400       1410       1420       1430       1440 
RSAKKPAVQK KKPGDASSLP DAGLSPGSQV DSKSTFKRLF LHKTKDKKYS LEGAEELENA 

      1450       1460       1470       1480       1490       1500 
VSGHVVLEAT TMKKGLEAPS GQQHRHAAGE KRTKEPGGKG KKNRNVKIGK ITVSEKWRES 

      1510       1520       1530       1540       1550       1560 
VFRQITNANE LKYLDEFLLN KINDLRSQKT PIESLFIEAT EKFRSNIKTM YSVPNGKIHV 

      1570       1580       1590       1600       1610       1620 
GYKDLMENYQ IVVSNLATER GQKDTNLVLN LFQSLLDEFT RGYTKNDFEP VKQSKAQKKK 

      1630       1640       1650       1660       1670       1680 
RKQERAVQEH NGHVFASYQV SIPQSCEQCL SYIWLMDKAL LCSVCKMTCH KKCVHKIQSH 

      1690       1700       1710       1720       1730       1740 
CSYTYGRKGE PGVEPGHFGV CVDSLTSDKA SVPIVLEKLL EHVEMHGLYT EGLYRKSGAA 

      1750       1760       1770       1780       1790       1800 
NRTRELRQAL QTDPAAVKLE NFPIHAITGV LKQWLRELPE PLMTFAQYGD FLRAVELPEK 

      1810       1820       1830       1840       1850       1860 
QEQLAAIYAV LEHLPEANHN SLERLIFHLV KVALLEDVNR MSPGALAIIF APCLLRCPDN 

      1870       1880       1890       1900       1910       1920 
SDPLTSMKDV LKITTCVEML IKEQMRKYKV KMEEISQLEA AESIAFRRLS LLRQNAPWPL 

      1930       1940       1950       1960       1970       1980 
KLGFSSPYEG VLNKSPKTRD IQEEELEVLL EEEAAGGDED REKEILIERI QSIKEEKEDI 

      1990       2000       2010       2020       2030       2040 
TYRLPELDPR GSDEENLDSE TSASTESLLE ERAGRGASEG PPAPALPCPG APTPSPLPTV 

      2050       2060       2070       2080       2090       2100 
AAPPRRRPSS FVTVRVKTPR RTPIMPTANI KLPPGLPSHL PRWAPGAREA AAPVRRREPP 

      2110       2120       2130       2140       2150 
ARRPDQIHSV YITPGADLPV QGALEPLEED GQPPGAKRRY SDPPTYCLPP ASGQTNG 

« Hide

Isoform Short [UniParc].

Checksum: D0E47A7EAF86A929
Show »

FASTA2,022229,143

References

« Hide 'large scale' references
[1]"Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail."
Wirth J.A., Jensen K.A., Post P.L., Bement W.M., Mooseker M.S.
J. Cell Sci. 109:653-661(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG/SHORT).
Tissue: Liver and Small intestine.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing."
Grewal P.K., Jones A.-M., Maconochie M., Lemmers R.J.F., Frants R.R., Hewitt J.E.
Gene 240:389-398(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[4]"Human myosin-IXb is a mechanochemically active motor and a GAP for rho."
Post P.L., Bokoch G.M., Mooseker M.S.
J. Cell Sci. 111:941-950(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1940-2157 (ISOFORM LONG).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1828-2022 (ISOFORM SHORT).
Tissue: Placenta.
[6]"Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect."
Monsuur A.J., de Bakker P.I., Alizadeh B.Z., Zhernakova A., Bevova M.R., Strengman E., Franke L., van't Slot R., van Belzen M.J., Lavrijsen I.C., Diosdado B., Daly M.J., Mulder C.J., Mearin M.L., Meijer J.W., Meijer G.A., van Oort E., Wapenaar M.C., Koeleman B.P., Wijmenga C.
Nat. Genet. 37:1341-1344(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH CELIAC DISEASE 4.
[7]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: T-cell.
[9]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1267; THR-1271 AND SER-1290, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1290 AND SER-1405, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-716; SER-1290; SER-1354 AND SER-1992, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1290 AND SER-1992, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1267; THR-1271 AND SER-1992, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1290; SER-1323 AND THR-1346, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1267; THR-1271; SER-1290; SER-1354 AND SER-1992, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Wikipedia

MYO9B entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U42391 mRNA. Translation: AAC50402.1. Sequence problems.
AC020913 Genomic DNA. No translation available.
AC020908 Genomic DNA. No translation available.
AF143684 mRNA. Translation: AAF00119.1.
AF020267 mRNA. Translation: AAC26597.1.
AK002201 mRNA. Translation: BAA92132.1. Different initiation.
RefSeqNP_004136.2. NM_004145.3.
UniGeneHs.123198.

3D structure databases

ProteinModelPortalQ13459.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110734. 6 interactions.
IntActQ13459. 8 interactions.
MINTMINT-1419073.
STRING9606.ENSP00000380444.

PTM databases

PhosphoSiteQ13459.

Polymorphism databases

DMDM325511388.

Proteomic databases

PaxDbQ13459.
PRIDEQ13459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397274; ENSP00000380444; ENSG00000099331. [Q13459-2]
ENST00000595618; ENSP00000471457; ENSG00000099331. [Q13459-2]
GeneID4650.
KEGGhsa:4650.
UCSCuc002nfi.3. human. [Q13459-2]
uc002nfj.1. human. [Q13459-1]

Organism-specific databases

CTD4650.
GeneCardsGC19P017186.
HGNCHGNC:7609. MYO9B.
HPACAB037190.
HPA042043.
MIM602129. gene.
609753. phenotype.
neXtProtNX_Q13459.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000113707.
HOVERGENHBG052558.
InParanoidQ13459.
KOK10360.
OrthoDBEOG7CK35Z.
PhylomeDBQ13459.
TreeFamTF319651.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressQ13459.
BgeeQ13459.
CleanExHS_MYO9B.
GenevestigatorQ13459.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR000048. IQ_motif_EF-hand-BS.
IPR028557. MYO9B.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PANTHERPTHR13140:SF184. PTHR13140:SF184. 1 hit.
PfamPF00612. IQ. 4 hits.
PF00063. Myosin_head. 1 hit.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00109. C1. 1 hit.
SM00015. IQ. 4 hits.
SM00242. MYSc. 1 hit.
SM00314. RA. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEPS50096. IQ. 3 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYO9B. human.
GeneWikiMYO9B.
GenomeRNAi4650.
NextBio17928.
PROQ13459.
SOURCESearch...

Entry information

Entry nameMYO9B_HUMAN
AccessionPrimary (citable) accession number: Q13459
Secondary accession number(s): O75314, Q9NUJ2, Q9UHN0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM