FK506-binding protein 5 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q13451 (FKBP5_HUMAN)

Last modified November 25, 2008. Version 86. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    FK506-binding protein 5
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase
    51 kDa FK506-binding protein
    FKBP-51
    54 kDa progesterone receptor-associated immunophilin
    FKBP54
      Short name=P54
    FF1 antigen
    HSP90-binding immunophilin
    Androgen-regulated protein 6

Gene names

Name:	FKBP5
Synonyms:	AIG6, FKBP51

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by FK506 but not cyclosporin.
Subunit structure	Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid.
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Widely expressed, enriched in testis compared to other tissues.
Induction	By androgen.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Contains 2 PPIase FKBP-type domains. Contains 3 TPR repeats.

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Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat TPR repeat
Molecular function	Chaperone Isomerase Rotamase
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	protein folding Ref.4 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FK506 binding Ref.4 Traceable author statement. Source: ProtInc peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
CHUK	O15111	1	EBI-306914,EBI-81249

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 457

457

FK506-binding protein 5

PRO_0000075324

Regions

Domain

42 – 130

PPIase FKBP-type 1

Domain

157 – 243

PPIase FKBP-type 2

Repeat

268 – 301

TPR 1

Repeat

317 – 350

TPR 2

Repeat

351 – 384

TPR 3

Amino acid modifications

Modified residue

Phosphoserine

Modified residue

445

Phosphoserine

Secondary structure

457

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q13451-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 18A86608C6891A73
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FASTA

457

51,212

        10         20         30         40         50         60 
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK 

        70         80         90        100        110        120 
LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP 

       130        140        150        160        170        180 
KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM 

       190        200        210        220        230        240 
FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE 

       250        260        270        280        290        300 
LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM 

       310        320        330        340        350        360 
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA 

       370        380        390        400        410        420 
QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD 

       430        440        450 
AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition." Baughman G., Wiederrecht G.J., Chang F., Martin M.M., Bourgeois S. Biochem. Biophys. Res. Commun. 232:437-443(1997) [PubMed: 9125197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymus.
[2]	"Identification of AIG6 as an androgen response gene in human prostate cancer cell line LNCaP." Zhang J.S., Smith D.I. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor." Nair S.C., Rimerman R.A., Toran E.J., Chen S., Prapapanich V., Butts R.N., Smith D.F. Mol. Cell. Biol. 17:594-603(1997) [PubMed: 9001212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-457.
[5]	"FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts." Smith D.F., Albers M.W., Schreiber S.L., Leach K.L., Deibel M.R. Jr. J. Biol. Chem. 268:24270-24273(1993) [PubMed: 7693698] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, MASS SPECTROMETRY.
[8]	"Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes." Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J. Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed: 12538866] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U71321 mRNA. Translation: AAC51189.1.
AF194172 mRNA. Translation: AAL54872.1.
BC042605 mRNA. Translation: AAH42605.1.
U42031 mRNA. Translation: AAA86245.1.

PIR

JC5422.

RefSeq

NP_004108.1.

UniGene

Hs.407190

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KT0	X-ray	2.70	A	1-457	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:27597N.

IntAct

Q13451.

PTM databases

PhosphoSite

Q13451.

Genome annotation databases

Ensembl

ENSG00000096060. Homo sapiens. [Contig view]

GeneID

2289.

KEGG

hsa:2289.

Organism-specific databases

H-InvDB

HIX0005809.

HGNC

HGNC:3721. FKBP5.

HPA

CAB009315.

MIM

602623. gene.

PharmGKB

PA28162.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q13451.

HOVERGEN

Q13451.

Gene expression databases

ArrayExpress

Q13451.

CleanEx

HS_FKBP5.

GermOnline

ENSG00000096060. Homo sapiens.

Family and domain databases

InterPro

IPR001179. PPIase_FKBP.
IPR001440. TPR-1.
IPR011990. TPR-like_helical.
IPR013026. TPR_region.
[Graphical view]

Gene3D

G3DSA:1.25.40.10. TPR-like_helical. 1 hit.

PANTHER

PTHR10516. PPIase_FKBP. 1 hit.

Pfam

PF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 2 hits.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

9303.

SOURCE

Search...

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Entry information

Entry name

FKBP5_HUMAN

Accession

Primary (citable) accession number: Q13451

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1998
Last modified:	November 25, 2008
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents