Q13451 (FKBP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP5
Short name=PPIase FKBP5
EC=5.2.1.8

Alternative name(s):
51 kDa FK506-binding protein
Short name=51 kDa FKBP
Short name=FKBP-51
54 kDa progesterone receptor-associated immunophilin
Androgen-regulated protein 6
FF1 antigen
FK506-binding protein 5
Short name=FKBP-5
FKBP54
Short name=p54
HSP90-binding immunophilin
Rotamase

Gene names

Name:	FKBP5
Synonyms:	AIG6, FKBP51

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by FK506 but not cyclosporin.
Subunit structure	Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid.
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Widely expressed, enriched in testis compared to other tissues.
Induction	By androgen.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.6 Ref.7
Sequence similarities	Contains 2 PPIase FKBP-type domains. Contains 3 TPR repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat TPR repeat
Molecular function	Chaperone Isomerase Rotamase
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from Biological aspect of Ancestor. Source: RefGenome nucleus Inferred from direct assay. Source: HPA
Molecular function	FK506 binding Inferred from Biological aspect of Ancestor. Source: RefGenome heat shock protein binding Inferred from physical interaction. Source: UniProtKB peptidyl-prolyl cis-trans isomerase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 457

457

Peptidyl-prolyl cis-trans isomerase FKBP5

PRO_0000075324

Regions

Domain

42 – 130

89

PPIase FKBP-type 1

Domain

157 – 243

87

PPIase FKBP-type 2

Repeat

268 – 301

34

TPR 1

Repeat

317 – 350

34

TPR 2

Repeat

351 – 384

34

TPR 3

Amino acid modifications

Modified residue

1

1

N-acetylmethionine Ref.8

Modified residue

13

1

Phosphoserine Ref.6

Modified residue

445

1

Phosphoserine Ref.7

Secondary structure

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457

Helix Strand Turn

Details...

Beta strand

34 – 36

3

Beta strand

52 – 60

9

Beta strand

77 – 80

4

Helix

88 – 94

7

Beta strand

102 – 107

6

Helix

109 – 111

3

Turn

112 – 116

5

Turn

119 – 121

3

Beta strand

128 – 138

11

Beta strand

144 – 154

11

Beta strand

167 – 176

10

Beta strand

179 – 189

11

Helix

193 – 196

4

Helix

200 – 206

7

Beta strand

214 – 219

6

Helix

221 – 223

3

Helix

231 – 233

3

Beta strand

241 – 251

11

Helix

256 – 258

3

Helix

261 – 280

20

Helix

284 – 298

15

Helix

306 – 329

24

Helix

333 – 346

14

Helix

351 – 363

13

Helix

367 – 378

12

Helix

387 – 411

25

Sequences

	Sequence		Length	Mass (Da)
	Q13451 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 18A86608C6891A73	FASTA	457	51,212
	10 20 30 40 50 60 MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK 70 80 90 100 110 120 LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP 130 140 150 160 170 180 KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM 190 200 210 220 230 240 FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE 250 260 270 280 290 300 LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM 310 320 330 340 350 360 EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA 370 380 390 400 410 420 QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD 430 440 450 AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition." Baughman G., Wiederrecht G.J., Chang F., Martin M.M., Bourgeois S. Biochem. Biophys. Res. Commun. 232:437-443(1997) [PubMed: 9125197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymus.
[2]	"Identification of AIG6 as an androgen response gene in human prostate cancer cell line LNCaP." Zhang J.S., Smith D.I. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor." Nair S.C., Rimerman R.A., Toran E.J., Chen S., Prapapanich V., Butts R.N., Smith D.F. Mol. Cell. Biol. 17:594-603(1997) [PubMed: 9001212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-457.
[5]	"FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts." Smith D.F., Albers M.W., Schreiber S.L., Leach K.L., Deibel M.R. Jr. J. Biol. Chem. 268:24270-24273(1993) [PubMed: 7693698] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes." Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J. Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed: 12538866] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U71321 mRNA. Translation: AAC51189.1.
AF194172 mRNA. Translation: AAL54872.1.
BC042605 mRNA. Translation: AAH42605.1.
U42031 mRNA. Translation: AAA86245.1.

IPI

IPI00218775.

PIR

JC5422.

RefSeq

NP_001139247.1. NM_001145775.1.
NP_001139248.1. NM_001145776.1.
NP_004108.1. NM_004117.3.

UniGene

Hs.407190.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KT0	X-ray	2.70	A	1-457	[»]
3O5D	X-ray	4.00	A/B	1-260	[»]
3O5E	X-ray	1.60	A	1-140	[»]
3O5F	X-ray	1.65	A	1-140	[»]
3O5G	X-ray	2.00	A	16-140	[»]
3O5I	X-ray	1.80	A/B	16-140	[»]
3O5J	X-ray	1.70	A	16-140	[»]
3O5K	X-ray	2.70	A/B/C/D	16-140	[»]
3O5L	X-ray	1.30	A	16-140	[»]
3O5M	X-ray	1.60	A/B	16-140	[»]
3O5O	X-ray	1.15	A	16-140	[»]
3O5P	X-ray	1.00	A	16-140	[»]
3O5Q	X-ray	0.96	A	16-140	[»]
3O5R	X-ray	1.10	A	16-140	[»]

ProteinModelPortal

Q13451.

SMR

Q13451. Positions 13-412.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-27597N.

IntAct

Q13451. 8 interactions.

MINT

MINT-1142816.

STRING

Q13451.

PTM databases

PhosphoSite

Q13451.

Polymorphism databases

DMDM

2851536.

Proteomic databases

PRIDE

Q13451.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000337746; ENSP00000338160; ENSG00000096060.
ENST00000357266; ENSP00000349811; ENSG00000096060.

GeneID

2289.

KEGG

hsa:2289.

UCSC

uc003okx.1. human.

Organism-specific databases

CTD

2289.

GeneCards

GC06M035541.

H-InvDB

HIX0005809.

HGNC

HGNC:3721. FKBP5.

HPA

CAB009315.
HPA031092.
HPA031093.

MIM

602623. gene.

neXtProt

NX_Q13451.

PharmGKB

PA28162.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG10953.

HOGENOM

HBG521626.

HOVERGEN

HBG051624.

InParanoid

Q13451.

OMA

QYGFGEA.

OrthoDB

EOG4FTW0G.

PhylomeDB

Q13451.

Gene expression databases

ArrayExpress

Q13451.

Bgee

Q13451.

CleanEx

HS_FKBP5.

Genevestigator

Q13451.

GermOnline

ENSG00000096060. Homo sapiens.

Family and domain databases

InterPro

IPR023114. Elongated_TPR_rpt_dom.
IPR001179. PPIase_FKBP_dom.
IPR001440. TPR-1.
IPR013026. TPR-contain.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]

Gene3D

G3DSA:1.10.150.160. Elongated_TPR_rpt_dom. 1 hit.
G3DSA:1.25.40.10. TPR-like_helical. 1 hit.

KO

K09571.

Pfam

PF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 2 hits.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

9303.

SOURCE

Search...

Entry information

Entry name

FKBP5_HUMAN

Accession

Primary (citable) accession number: Q13451

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1998
Last modified:	January 25, 2012
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.