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Reviewed, UniProtKB/Swiss-Prot Q13451 (FKBP5_HUMAN)

Last modified November 25, 2008. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    FK506-binding protein 5
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase
    51 kDa FK506-binding protein
    FKBP-51
    54 kDa progesterone receptor-associated immunophilin
    FKBP54
      Short name=P54
    FF1 antigen
    HSP90-binding immunophilin
    Androgen-regulated protein 6
Gene names
Name: FKBP5
Synonyms: AIG6, FKBP51
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by FK506 but not cyclosporin.

Subunit structure

Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid.

Subcellular location

Cytoplasm. Nucleus.

Tissue specificity

Widely expressed, enriched in testis compared to other tissues.

Induction

By androgen.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR.

Sequence similarities

Contains 2 PPIase FKBP-type domains.

Contains 3 TPR repeats.

Ontologies

Keywords

   Cellular componentCytoplasm
Nucleus
   DomainRepeat
TPR repeat
   Molecular functionChaperone
Isomerase
Rotamase
   PTMPhosphoprotein
   Technical term3D-structure

Gene Ontology (GO)

   Biological processprotein folding Ref.4

Traceable author statement. Source: ProtInc

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFK506 binding Ref.4

Traceable author statement. Source: ProtInc

peptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CHUKO151111EBI-306914,EBI-81249

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457FK506-binding protein 5
PRO_0000075324

Regions

Domain42 – 13089PPIase FKBP-type 1
Domain157 – 24387PPIase FKBP-type 2
Repeat268 – 30134TPR 1
Repeat317 – 35034TPR 2
Repeat351 – 38434TPR 3

Amino acid modifications

Modified residue131Phosphoserine
Modified residue4451Phosphoserine

Secondary structure

.................................................... 457
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q13451-1 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 18A86608C6891A73

FASTA45751,212
        10         20         30         40         50         60 
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG DKVYVHYKGK 

        70         80         90        100        110        120 
LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGSAGSLP 

       130        140        150        160        170        180 
KIPSNATLFF EIELLDFKGE DLFEDGGIIR RTKRKGEGYS NPNEGATVEI HLEGRCGGRM 

       190        200        210        220        230        240 
FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE 

       250        260        270        280        290        300 
LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM 

       310        320        330        340        350        360 
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA 

       370        380        390        400        410        420 
QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE HNERDRRIYA NMFKKFAEQD 

       430        440        450 
AKEEANKAMG KKTSEGVTNE KGTDSQAMEE EKPEGHV 

« Hide

References

« Hide 'large scale' references
[1]"Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition."
Baughman G., Wiederrecht G.J., Chang F., Martin M.M., Bourgeois S.
Biochem. Biophys. Res. Commun. 232:437-443(1997) [PubMed: 9125197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
[2]"Identification of AIG6 as an androgen response gene in human prostate cancer cell line LNCaP."
Zhang J.S., Smith D.I.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor."
Nair S.C., Rimerman R.A., Toran E.J., Chen S., Prapapanich V., Butts R.N., Smith D.F.
Mol. Cell. Biol. 17:594-603(1997) [PubMed: 9001212] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-457.
[5]"FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts."
Smith D.F., Albers M.W., Schreiber S.L., Leach K.L., Deibel M.R. Jr.
J. Biol. Chem. 268:24270-24273(1993) [PubMed: 7693698] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, MASS SPECTROMETRY.
Tissue: Epithelium.
[7]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, MASS SPECTROMETRY.
[8]"Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes."
Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J.
Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed: 12538866] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

U71321 mRNA. Translation: AAC51189.1.
AF194172 mRNA. Translation: AAL54872.1.
BC042605 mRNA. Translation: AAH42605.1.
U42031 mRNA. Translation: AAA86245.1.
PIRJC5422.
RefSeqNP_004108.1.
UniGeneHs.407190

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1KT0X-ray2.70A1-457[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:27597N.
IntActQ13451.

PTM databases

PhosphoSiteQ13451.

Genome annotation databases

EnsemblENSG00000096060. Homo sapiens. [Contig view]
GeneID2289.
KEGGhsa:2289.

Organism-specific databases

H-InvDBHIX0005809.
HGNCHGNC:3721. FKBP5.
HPACAB009315.
MIM602623. gene.
PharmGKBPA28162.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ13451.
HOVERGENQ13451.

Gene expression databases

ArrayExpressQ13451.
CleanExHS_FKBP5.
GermOnlineENSG00000096060. Homo sapiens.

Family and domain databases

InterProIPR001179. PPIase_FKBP.
IPR001440. TPR-1.
IPR011990. TPR-like_helical.
IPR013026. TPR_region.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 1 hit.
PANTHERPTHR10516. PPIase_FKBP. 1 hit.
PfamPF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 2 hits.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio9303.
SOURCESearch...

Entry information

Entry nameFKBP5_HUMAN
AccessionPrimary (citable) accession number: Q13451
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: November 25, 2008
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents