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Q13451

- FKBP5_HUMAN

UniProt

Q13451 - FKBP5_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP5

Gene

FKBP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by FK506 but not cyclosporin.

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. heat shock protein binding Source: UniProtKB
    3. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

    GO - Biological processi

    1. chaperone-mediated protein folding Source: UniProtKB
    2. protein folding Source: ProtInc
    3. protein peptidyl-prolyl isomerization Source: GOC

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP5 (EC:5.2.1.8)
    Short name:
    PPIase FKBP5
    Alternative name(s):
    51 kDa FK506-binding protein
    Short name:
    51 kDa FKBP
    Short name:
    FKBP-51
    54 kDa progesterone receptor-associated immunophilin
    Androgen-regulated protein 6
    FF1 antigen
    FK506-binding protein 5
    Short name:
    FKBP-5
    FKBP54
    Short name:
    p54
    HSP90-binding immunophilin
    Rotamase
    Gene namesi
    Name:FKBP5
    Synonyms:AIG6, FKBP51
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:3721. FKBP5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: RefGenome
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28162.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Peptidyl-prolyl cis-trans isomerase FKBP5PRO_0000075324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei445 – 4451Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13451.
    PaxDbiQ13451.
    PRIDEiQ13451.

    PTM databases

    PhosphoSiteiQ13451.

    Expressioni

    Tissue specificityi

    Widely expressed, enriched in testis compared to other tissues.

    Inductioni

    By androgen.

    Gene expression databases

    ArrayExpressiQ13451.
    BgeeiQ13451.
    CleanExiHS_FKBP5.
    GenevestigatoriQ13451.

    Organism-specific databases

    HPAiCAB009315.
    HPA031092.
    HPA031093.
    HPA031095.

    Interactioni

    Subunit structurei

    Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK15Q96Q402EBI-306914,EBI-1051975
    CDK9P507504EBI-306914,EBI-1383449
    CHUKO151112EBI-306914,EBI-81249
    STK11Q158313EBI-306914,EBI-306838
    USP49Q70CQ12EBI-306914,EBI-2511022

    Protein-protein interaction databases

    BioGridi108579. 36 interactions.
    DIPiDIP-27597N.
    IntActiQ13451. 109 interactions.
    MINTiMINT-1142816.
    STRINGi9606.ENSP00000338160.

    Structurei

    Secondary structure

    1
    457
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 216
    Beta strandi22 – 243
    Beta strandi26 – 283
    Beta strandi30 – 3910
    Beta strandi42 – 443
    Beta strandi52 – 6110
    Beta strandi66 – 694
    Helixi70 – 734
    Beta strandi77 – 804
    Beta strandi83 – 864
    Helixi88 – 947
    Beta strandi102 – 1076
    Helixi109 – 1113
    Turni112 – 1165
    Turni119 – 1213
    Beta strandi128 – 13811
    Beta strandi144 – 15411
    Beta strandi167 – 17610
    Beta strandi179 – 18911
    Helixi193 – 1964
    Helixi200 – 2067
    Beta strandi214 – 2196
    Helixi221 – 2233
    Helixi231 – 2333
    Beta strandi241 – 25111
    Helixi256 – 2583
    Helixi261 – 28020
    Helixi284 – 29815
    Helixi306 – 32924
    Helixi333 – 34614
    Helixi351 – 36313
    Helixi367 – 37812
    Helixi387 – 41125

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KT0X-ray2.70A1-457[»]
    3O5DX-ray4.00A/B1-260[»]
    3O5EX-ray1.60A1-140[»]
    3O5FX-ray1.65A1-140[»]
    3O5GX-ray2.00A16-140[»]
    3O5IX-ray1.80A/B16-140[»]
    3O5JX-ray1.70A16-140[»]
    3O5KX-ray2.70A/B/C/D16-140[»]
    3O5LX-ray1.30A16-140[»]
    3O5MX-ray1.60A/B16-140[»]
    3O5OX-ray1.15A16-140[»]
    3O5PX-ray1.00A16-140[»]
    3O5QX-ray0.96A16-140[»]
    3O5RX-ray1.10A16-140[»]
    4DRHX-ray2.30A/D1-140[»]
    4DRIX-ray1.45A1-140[»]
    4DRKX-ray1.50A/B16-140[»]
    4DRMX-ray1.48A16-140[»]
    4DRNX-ray1.07A16-140[»]
    4DROX-ray1.10A16-140[»]
    4DRPX-ray1.80A16-140[»]
    4DRQX-ray1.00A16-140[»]
    4JFIX-ray1.05A16-139[»]
    4JFJX-ray1.08A16-140[»]
    4JFKX-ray1.15A16-140[»]
    4JFLX-ray1.20A16-140[»]
    4JFMX-ray1.02A16-140[»]
    ProteinModelPortaliQ13451.
    SMRiQ13451. Positions 13-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13451.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 13089PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini157 – 24387PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati268 – 30134TPR 1Add
    BLAST
    Repeati317 – 35034TPR 2Add
    BLAST
    Repeati351 – 38434TPR 3Add
    BLAST

    Sequence similaritiesi

    Contains 2 PPIase FKBP-type domains.PROSITE-ProRule annotation
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000256916.
    HOVERGENiHBG051624.
    InParanoidiQ13451.
    KOiK09571.
    OMAiHLEGCCG.
    OrthoDBiEOG725DHH.
    PhylomeDBiQ13451.
    TreeFamiTF105292.

    Family and domain databases

    Gene3Di1.10.150.160. 1 hit.
    1.25.40.10. 1 hit.
    InterProiIPR023114. Elongated_TPR_rpt_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 2 hits.
    PF00515. TPR_1. 2 hits.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 2 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13451-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG    50
    DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG 100
    EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDFKGE DLFEDGGIIR 150
    RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI 200
    GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF 250
    EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM 300
    EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN 350
    EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE 400
    HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE 450
    EKPEGHV 457
    Length:457
    Mass (Da):51,212
    Last modified:July 15, 1998 - v2
    Checksum:i18A86608C6891A73
    GO
    Isoform 2 (identifier: Q13451-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-268: YGFGEAGKPK...MDTKEKLEQA → PKNPGRWIPK...SISKNLFKCW
         269-457: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:268
    Mass (Da):30,032
    Checksum:i2B172A6E03570AAD
    GO

    Sequence cautioni

    The sequence BAD93130.1 differs from that shown. Reason: Frameshift at position 29.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei223 – 26846YGFGE…KLEQA → PKNPGRWIPKKNWSRLPLSK RREPYTSRCVSPYAILSISK NLFKCW in isoform 2. 1 PublicationVSP_044820Add
    BLAST
    Alternative sequencei269 – 457189Missing in isoform 2. 1 PublicationVSP_044821Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71321 mRNA. Translation: AAC51189.1.
    AF194172 mRNA. Translation: AAL54872.1.
    AK312422 mRNA. Translation: BAG35332.1.
    AB209893 mRNA. Translation: BAD93130.1. Frameshift.
    AL033519 Genomic DNA. Translation: CAI20256.1.
    AL157823 Genomic DNA. No translation available.
    AL590400 Genomic DNA. No translation available.
    CH471081 Genomic DNA. Translation: EAX03842.1.
    BC042605 mRNA. Translation: AAH42605.1.
    U42031 mRNA. Translation: AAA86245.1.
    CCDSiCCDS4808.1. [Q13451-1]
    CCDS54996.1. [Q13451-2]
    PIRiJC5422.
    RefSeqiNP_001139247.1. NM_001145775.2. [Q13451-1]
    NP_001139248.1. NM_001145776.1. [Q13451-1]
    NP_001139249.1. NM_001145777.1. [Q13451-2]
    NP_004108.1. NM_004117.3. [Q13451-1]
    UniGeneiHs.407190.

    Genome annotation databases

    EnsembliENST00000357266; ENSP00000349811; ENSG00000096060. [Q13451-1]
    ENST00000536438; ENSP00000444810; ENSG00000096060. [Q13451-1]
    ENST00000539068; ENSP00000441205; ENSG00000096060. [Q13451-1]
    ENST00000542713; ENSP00000442340; ENSG00000096060. [Q13451-2]
    GeneIDi2289.
    KEGGihsa:2289.
    UCSCiuc003okx.2. human. [Q13451-1]

    Polymorphism databases

    DMDMi2851536.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71321 mRNA. Translation: AAC51189.1 .
    AF194172 mRNA. Translation: AAL54872.1 .
    AK312422 mRNA. Translation: BAG35332.1 .
    AB209893 mRNA. Translation: BAD93130.1 . Frameshift.
    AL033519 Genomic DNA. Translation: CAI20256.1 .
    AL157823 Genomic DNA. No translation available.
    AL590400 Genomic DNA. No translation available.
    CH471081 Genomic DNA. Translation: EAX03842.1 .
    BC042605 mRNA. Translation: AAH42605.1 .
    U42031 mRNA. Translation: AAA86245.1 .
    CCDSi CCDS4808.1. [Q13451-1 ]
    CCDS54996.1. [Q13451-2 ]
    PIRi JC5422.
    RefSeqi NP_001139247.1. NM_001145775.2. [Q13451-1 ]
    NP_001139248.1. NM_001145776.1. [Q13451-1 ]
    NP_001139249.1. NM_001145777.1. [Q13451-2 ]
    NP_004108.1. NM_004117.3. [Q13451-1 ]
    UniGenei Hs.407190.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KT0 X-ray 2.70 A 1-457 [» ]
    3O5D X-ray 4.00 A/B 1-260 [» ]
    3O5E X-ray 1.60 A 1-140 [» ]
    3O5F X-ray 1.65 A 1-140 [» ]
    3O5G X-ray 2.00 A 16-140 [» ]
    3O5I X-ray 1.80 A/B 16-140 [» ]
    3O5J X-ray 1.70 A 16-140 [» ]
    3O5K X-ray 2.70 A/B/C/D 16-140 [» ]
    3O5L X-ray 1.30 A 16-140 [» ]
    3O5M X-ray 1.60 A/B 16-140 [» ]
    3O5O X-ray 1.15 A 16-140 [» ]
    3O5P X-ray 1.00 A 16-140 [» ]
    3O5Q X-ray 0.96 A 16-140 [» ]
    3O5R X-ray 1.10 A 16-140 [» ]
    4DRH X-ray 2.30 A/D 1-140 [» ]
    4DRI X-ray 1.45 A 1-140 [» ]
    4DRK X-ray 1.50 A/B 16-140 [» ]
    4DRM X-ray 1.48 A 16-140 [» ]
    4DRN X-ray 1.07 A 16-140 [» ]
    4DRO X-ray 1.10 A 16-140 [» ]
    4DRP X-ray 1.80 A 16-140 [» ]
    4DRQ X-ray 1.00 A 16-140 [» ]
    4JFI X-ray 1.05 A 16-139 [» ]
    4JFJ X-ray 1.08 A 16-140 [» ]
    4JFK X-ray 1.15 A 16-140 [» ]
    4JFL X-ray 1.20 A 16-140 [» ]
    4JFM X-ray 1.02 A 16-140 [» ]
    ProteinModelPortali Q13451.
    SMRi Q13451. Positions 13-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108579. 36 interactions.
    DIPi DIP-27597N.
    IntActi Q13451. 109 interactions.
    MINTi MINT-1142816.
    STRINGi 9606.ENSP00000338160.

    Chemistry

    ChEMBLi CHEMBL2052031.

    PTM databases

    PhosphoSitei Q13451.

    Polymorphism databases

    DMDMi 2851536.

    Proteomic databases

    MaxQBi Q13451.
    PaxDbi Q13451.
    PRIDEi Q13451.

    Protocols and materials databases

    DNASUi 2289.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357266 ; ENSP00000349811 ; ENSG00000096060 . [Q13451-1 ]
    ENST00000536438 ; ENSP00000444810 ; ENSG00000096060 . [Q13451-1 ]
    ENST00000539068 ; ENSP00000441205 ; ENSG00000096060 . [Q13451-1 ]
    ENST00000542713 ; ENSP00000442340 ; ENSG00000096060 . [Q13451-2 ]
    GeneIDi 2289.
    KEGGi hsa:2289.
    UCSCi uc003okx.2. human. [Q13451-1 ]

    Organism-specific databases

    CTDi 2289.
    GeneCardsi GC06M035541.
    HGNCi HGNC:3721. FKBP5.
    HPAi CAB009315.
    HPA031092.
    HPA031093.
    HPA031095.
    MIMi 602623. gene.
    neXtProti NX_Q13451.
    PharmGKBi PA28162.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000256916.
    HOVERGENi HBG051624.
    InParanoidi Q13451.
    KOi K09571.
    OMAi HLEGCCG.
    OrthoDBi EOG725DHH.
    PhylomeDBi Q13451.
    TreeFami TF105292.

    Miscellaneous databases

    ChiTaRSi FKBP5. human.
    EvolutionaryTracei Q13451.
    GeneWikii FKBP5.
    GenomeRNAii 2289.
    NextBioi 9303.
    PROi Q13451.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13451.
    Bgeei Q13451.
    CleanExi HS_FKBP5.
    Genevestigatori Q13451.

    Family and domain databases

    Gene3Di 1.10.150.160. 1 hit.
    1.25.40.10. 1 hit.
    InterProi IPR023114. Elongated_TPR_rpt_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 2 hits.
    PF00515. TPR_1. 2 hits.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 2 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition."
      Baughman G., Wiederrecht G.J., Chang F., Martin M.M., Bourgeois S.
      Biochem. Biophys. Res. Commun. 232:437-443(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Thymus.
    2. "Identification of AIG6 as an androgen response gene in human prostate cancer cell line LNCaP."
      Zhang J.S., Smith D.I.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Aortic endothelium.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    8. "Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor."
      Nair S.C., Rimerman R.A., Toran E.J., Chen S., Prapapanich V., Butts R.N., Smith D.F.
      Mol. Cell. Biol. 17:594-603(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-457 (ISOFORM 1).
    9. "FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts."
      Smith D.F., Albers M.W., Schreiber S.L., Leach K.L., Deibel M.R. Jr.
      J. Biol. Chem. 268:24270-24273(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes."
      Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J.
      Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).

    Entry informationi

    Entry nameiFKBP5_HUMAN
    AccessioniPrimary (citable) accession number: Q13451
    Secondary accession number(s): F5H7R1, Q59EB8, Q5TGM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3