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Protein

Limbic system-associated membrane protein

Gene

LSAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • locomotory exploration behavior Source: Ensembl
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:G66-33684-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Limbic system-associated membrane protein
Short name:
LSAMP
Alternative name(s):
IgLON family member 3
Gene namesi
Name:LSAMP
Synonyms:IGLON3, LAMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6705. LSAMP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4045.
OpenTargetsiENSG00000185565.
PharmGKBiPA30470.

Polymorphism and mutation databases

BioMutaiLSAMP.
DMDMi116242621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001510229 – 315Limbic system-associated membrane proteinAdd BLAST287
PropeptideiPRO_0000015103316 – 338Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 111PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Modified residuei94PhosphotyrosineBy similarity1
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Disulfide bondi239 ↔ 290PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)1 Publication1
Lipidationi315GPI-anchor amidated asparagine; alternateSequence analysis1
Glycosylationi315N-linked (GlcNAc...); alternateSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ13449.
MaxQBiQ13449.
PaxDbiQ13449.
PeptideAtlasiQ13449.
PRIDEiQ13449.

PTM databases

iPTMnetiQ13449.
PhosphoSitePlusiQ13449.

Expressioni

Tissue specificityi

Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.

Gene expression databases

BgeeiENSG00000185565.
CleanExiHS_LSAMP.
ExpressionAtlasiQ13449. baseline and differential.
GenevisibleiQ13449. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NEGR1Q7Z3B12EBI-4314821,EBI-4314838
NTMQ9P1212EBI-4314821,EBI-4315078

Protein-protein interaction databases

BioGridi110223. 5 interactors.
IntActiQ13449. 3 interactors.
STRINGi9606.ENSP00000419000.

Structurei

3D structure databases

ProteinModelPortaliQ13449.
SMRiQ13449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 122Ig-like C2-type 1Add BLAST94
Domaini132 – 214Ig-like C2-type 2Add BLAST83
Domaini219 – 304Ig-like C2-type 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJB. Eukaryota.
ENOG41100IG. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ13449.
KOiK06772.
PhylomeDBiQ13449.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI
60 70 80 90 100
LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK
110 120 130 140 150
VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT
160 170 180 190 200
LVCMANGRPE PVITWRHLTP TGREFEGEEE YLEILGITRE QSGKYECKAA
210 220 230 240 250
NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE
260 270 280 290 300
WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
310 320 330
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC
Length:338
Mass (Da):37,393
Last modified:October 17, 2006 - v2
Checksum:i88CF00E07302817B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → G in AAC50569 (PubMed:8666243).Curated1
Sequence conflicti55V → L in AAC50569 (PubMed:8666243).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41901 mRNA. Translation: AAC50569.1.
BC033803 mRNA. Translation: AAH33803.1.
CCDSiCCDS2982.1.
PIRiJC4776.
RefSeqiNP_001305844.1. NM_001318915.1.
NP_002329.2. NM_002338.4.
UniGeneiHs.26409.
Hs.667390.
Hs.723683.

Genome annotation databases

EnsembliENST00000490035; ENSP00000419000; ENSG00000185565.
GeneIDi4045.
KEGGihsa:4045.
UCSCiuc003ebs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41901 mRNA. Translation: AAC50569.1.
BC033803 mRNA. Translation: AAH33803.1.
CCDSiCCDS2982.1.
PIRiJC4776.
RefSeqiNP_001305844.1. NM_001318915.1.
NP_002329.2. NM_002338.4.
UniGeneiHs.26409.
Hs.667390.
Hs.723683.

3D structure databases

ProteinModelPortaliQ13449.
SMRiQ13449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110223. 5 interactors.
IntActiQ13449. 3 interactors.
STRINGi9606.ENSP00000419000.

PTM databases

iPTMnetiQ13449.
PhosphoSitePlusiQ13449.

Polymorphism and mutation databases

BioMutaiLSAMP.
DMDMi116242621.

Proteomic databases

EPDiQ13449.
MaxQBiQ13449.
PaxDbiQ13449.
PeptideAtlasiQ13449.
PRIDEiQ13449.

Protocols and materials databases

DNASUi4045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000490035; ENSP00000419000; ENSG00000185565.
GeneIDi4045.
KEGGihsa:4045.
UCSCiuc003ebs.4. human.

Organism-specific databases

CTDi4045.
DisGeNETi4045.
GeneCardsiLSAMP.
HGNCiHGNC:6705. LSAMP.
MIMi603241. gene.
neXtProtiNX_Q13449.
OpenTargetsiENSG00000185565.
PharmGKBiPA30470.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJB. Eukaryota.
ENOG41100IG. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ13449.
KOiK06772.
PhylomeDBiQ13449.
TreeFamiTF325565.

Enzyme and pathway databases

BioCyciZFISH:G66-33684-MONOMER.

Miscellaneous databases

ChiTaRSiLSAMP. human.
GenomeRNAii4045.
PROiQ13449.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185565.
CleanExiHS_LSAMP.
ExpressionAtlasiQ13449. baseline and differential.
GenevisibleiQ13449. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSAMP_HUMAN
AccessioniPrimary (citable) accession number: Q13449
Secondary accession number(s): Q8IV49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.