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Protein

Limbic system-associated membrane protein

Gene

LSAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • locomotory exploration behavior Source: Ensembl
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Limbic system-associated membrane protein
Short name:
LSAMP
Alternative name(s):
IgLON family member 3
Gene namesi
Name:LSAMP
Synonyms:IGLON3, LAMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6705. LSAMP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30470.

Polymorphism and mutation databases

BioMutaiLSAMP.
DMDMi116242621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 315287Limbic system-associated membrane proteinPRO_0000015102Add
BLAST
Propeptidei316 – 33823Removed in mature formSequence analysisPRO_0000015103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi53 ↔ 111PROSITE-ProRule annotation
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Modified residuei94 – 941PhosphotyrosineBy similarity
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 197PROSITE-ProRule annotation
Disulfide bondi239 ↔ 290PROSITE-ProRule annotation
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence analysis
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)1 Publication
Lipidationi315 – 3151GPI-anchor amidated asparagine; alternateSequence analysis
Glycosylationi315 – 3151N-linked (GlcNAc...); alternateSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ13449.
MaxQBiQ13449.
PaxDbiQ13449.
PeptideAtlasiQ13449.
PRIDEiQ13449.

PTM databases

iPTMnetiQ13449.
PhosphoSiteiQ13449.

Expressioni

Tissue specificityi

Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.

Gene expression databases

BgeeiQ13449.
CleanExiHS_LSAMP.
ExpressionAtlasiQ13449. baseline and differential.
GenevisibleiQ13449. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NEGR1Q7Z3B12EBI-4314821,EBI-4314838
NTMQ9P1212EBI-4314821,EBI-4315078

Protein-protein interaction databases

BioGridi110223. 5 interactions.
IntActiQ13449. 3 interactions.
STRINGi9606.ENSP00000419000.

Structurei

3D structure databases

ProteinModelPortaliQ13449.
SMRiQ13449. Positions 30-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12294Ig-like C2-type 1Add
BLAST
Domaini132 – 21483Ig-like C2-type 2Add
BLAST
Domaini219 – 30486Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJB. Eukaryota.
ENOG41100IG. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ13449.
KOiK06772.
PhylomeDBiQ13449.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRVQPDRK QLPLVLLRLL CLLPTGLPVR SVDFNRGTDN ITVRQGDTAI
60 70 80 90 100
LRCVVEDKNS KVAWLNRSGI IFAGHDKWSL DPRVELEKRH SLEYSLRIQK
110 120 130 140 150
VDVYDEGSYT CSVQTQHEPK TSQVYLIVQV PPKISNISSD VTVNEGSNVT
160 170 180 190 200
LVCMANGRPE PVITWRHLTP TGREFEGEEE YLEILGITRE QSGKYECKAA
210 220 230 240 250
NEVSSADVKQ VKVTVNYPPT ITESKSNEAT TGRQASLKCE ASAVPAPDFE
260 270 280 290 300
WYRDDTRINS ANGLEIKSTE GQSSLTVTNV TEEHYGNYTC VAANKLGVTN
310 320 330
ASLVLFRPGS VRGINGSISL AVPLWLLAAS LLCLLSKC
Length:338
Mass (Da):37,393
Last modified:October 17, 2006 - v2
Checksum:i88CF00E07302817B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → G in AAC50569 (PubMed:8666243).Curated
Sequence conflicti55 – 551V → L in AAC50569 (PubMed:8666243).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41901 mRNA. Translation: AAC50569.1.
BC033803 mRNA. Translation: AAH33803.1.
CCDSiCCDS2982.1.
PIRiJC4776.
RefSeqiNP_001305844.1. NM_001318915.1.
NP_002329.2. NM_002338.4.
UniGeneiHs.26409.
Hs.667390.
Hs.723683.

Genome annotation databases

EnsembliENST00000490035; ENSP00000419000; ENSG00000185565.
GeneIDi4045.
KEGGihsa:4045.
UCSCiuc003ebs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41901 mRNA. Translation: AAC50569.1.
BC033803 mRNA. Translation: AAH33803.1.
CCDSiCCDS2982.1.
PIRiJC4776.
RefSeqiNP_001305844.1. NM_001318915.1.
NP_002329.2. NM_002338.4.
UniGeneiHs.26409.
Hs.667390.
Hs.723683.

3D structure databases

ProteinModelPortaliQ13449.
SMRiQ13449. Positions 30-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110223. 5 interactions.
IntActiQ13449. 3 interactions.
STRINGi9606.ENSP00000419000.

PTM databases

iPTMnetiQ13449.
PhosphoSiteiQ13449.

Polymorphism and mutation databases

BioMutaiLSAMP.
DMDMi116242621.

Proteomic databases

EPDiQ13449.
MaxQBiQ13449.
PaxDbiQ13449.
PeptideAtlasiQ13449.
PRIDEiQ13449.

Protocols and materials databases

DNASUi4045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000490035; ENSP00000419000; ENSG00000185565.
GeneIDi4045.
KEGGihsa:4045.
UCSCiuc003ebs.4. human.

Organism-specific databases

CTDi4045.
GeneCardsiLSAMP.
HGNCiHGNC:6705. LSAMP.
MIMi603241. gene.
neXtProtiNX_Q13449.
PharmGKBiPA30470.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJB. Eukaryota.
ENOG41100IG. LUCA.
GeneTreeiENSGT00840000129753.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ13449.
KOiK06772.
PhylomeDBiQ13449.
TreeFamiTF325565.

Miscellaneous databases

ChiTaRSiLSAMP. human.
GenomeRNAii4045.
PROiQ13449.
SOURCEiSearch...

Gene expression databases

BgeeiQ13449.
CleanExiHS_LSAMP.
ExpressionAtlasiQ13449. baseline and differential.
GenevisibleiQ13449. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and structural analysis of the human limbic-system-associated membrane protein (LAMP)."
    Pimenta A.F., Fischer I., Levitt P.
    Gene 170:189-195(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-300.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiLSAMP_HUMAN
AccessioniPrimary (citable) accession number: Q13449
Secondary accession number(s): Q8IV49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: June 8, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.