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Protein

Transmembrane emp24 domain-containing protein 1

Gene

TMED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • protein transport Source: UniProtKB-KW
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

TCDBi9.B.188.1.1. the transmembrane emp24 domain-containing protein (tmed) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane emp24 domain-containing protein 1
Alternative name(s):
Interleukin-1 receptor-like 1 ligand
Putative T1/ST2 receptor-binding protein
p24 family protein gamma-1
Short name:
Tp24
Short name:
p24gamma1
Gene namesi
Name:TMED1
Synonyms:IL1RL1L, IL1RL1LG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17291. TMED1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 194171ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 22712CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972147.

Polymorphism and mutation databases

DMDMi74739789.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Combined sources1 PublicationAdd
BLAST
Chaini24 – 227204Transmembrane emp24 domain-containing protein 1PRO_0000248019Add
BLAST

Proteomic databases

EPDiQ13445.
MaxQBiQ13445.
PaxDbiQ13445.
PeptideAtlasiQ13445.
PRIDEiQ13445.
TopDownProteomicsiQ13445.

PTM databases

SwissPalmiQ13445.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ13445.
CleanExiHS_TMED1.
ExpressionAtlasiQ13445. baseline and differential.
GenevisibleiQ13445. HS.

Organism-specific databases

HPAiHPA018507.

Interactioni

Subunit structurei

Homodimer in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. May interact with IL1RL1.1 Publication

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi116208. 16 interactions.
IntActiQ13445. 6 interactions.
MINTiMINT-1180917.
STRINGi9606.ENSP00000214869.

Structurei

3D structure databases

ProteinModelPortaliQ13445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 12583GOLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 17026Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 22710COPI vesicle coat-bindingSequence analysis
Motifi218 – 2192COPII vesicle coat-bindingSequence analysis

Sequence similaritiesi

Belongs to the EMP24/GP25L family.Curated
Contains 1 GOLD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ13445.
OMAiRSRQMQT.
OrthoDBiEOG7CG716.
PhylomeDBiQ13445.
TreeFamiTF313000.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA
60 70 80 90 100
PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA
110 120 130 140 150
GDYKLCFDNS FSTISEKLVF FELIFDSLQD DEEVEGWAEA VEPEEMLDVK
160 170 180 190 200
MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEGNL ERVNFWSAVN
210 220
VAVLLLVAVL QVCTLKRFFQ DKRPVPT
Length:227
Mass (Da):25,206
Last modified:November 1, 1996 - v1
Checksum:i058C5274E05F8575
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_036533

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41804 mRNA. Translation: AAC50419.1.
AC007229 Genomic DNA. Translation: AAD23605.1.
BC002443 mRNA. Translation: AAH02443.1.
CCDSiCCDS12249.1.
RefSeqiNP_006849.1. NM_006858.3.
UniGeneiHs.211463.
Hs.515139.
Hs.661691.

Genome annotation databases

EnsembliENST00000214869; ENSP00000214869; ENSG00000099203.
GeneIDi11018.
KEGGihsa:11018.
UCSCiuc002mpy.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41804 mRNA. Translation: AAC50419.1.
AC007229 Genomic DNA. Translation: AAD23605.1.
BC002443 mRNA. Translation: AAH02443.1.
CCDSiCCDS12249.1.
RefSeqiNP_006849.1. NM_006858.3.
UniGeneiHs.211463.
Hs.515139.
Hs.661691.

3D structure databases

ProteinModelPortaliQ13445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116208. 16 interactions.
IntActiQ13445. 6 interactions.
MINTiMINT-1180917.
STRINGi9606.ENSP00000214869.

Protein family/group databases

TCDBi9.B.188.1.1. the transmembrane emp24 domain-containing protein (tmed) family.

PTM databases

SwissPalmiQ13445.

Polymorphism and mutation databases

DMDMi74739789.

Proteomic databases

EPDiQ13445.
MaxQBiQ13445.
PaxDbiQ13445.
PeptideAtlasiQ13445.
PRIDEiQ13445.
TopDownProteomicsiQ13445.

Protocols and materials databases

DNASUi11018.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000214869; ENSP00000214869; ENSG00000099203.
GeneIDi11018.
KEGGihsa:11018.
UCSCiuc002mpy.5. human.

Organism-specific databases

CTDi11018.
GeneCardsiTMED1.
HGNCiHGNC:17291. TMED1.
HPAiHPA018507.
MIMi605395. gene.
neXtProtiNX_Q13445.
PharmGKBiPA134972147.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3287. Eukaryota.
ENOG410Z18S. LUCA.
GeneTreeiENSGT00670000097656.
HOGENOMiHOG000039809.
HOVERGENiHBG000271.
InParanoidiQ13445.
OMAiRSRQMQT.
OrthoDBiEOG7CG716.
PhylomeDBiQ13445.
TreeFamiTF313000.

Miscellaneous databases

GeneWikiiTMED1.
GenomeRNAii11018.
NextBioi41860.
PROiQ13445.
SOURCEiSearch...

Gene expression databases

BgeeiQ13445.
CleanExiHS_TMED1.
ExpressionAtlasiQ13445. baseline and differential.
GenevisibleiQ13445. HS.

Family and domain databases

InterProiIPR009038. GOLD_dom.
IPR015720. TMP21-related.
[Graphical view]
PANTHERiPTHR22811. PTHR22811. 1 hit.
PfamiPF01105. EMP24_GP25L. 1 hit.
[Graphical view]
SMARTiSM01190. EMP24_GP25L. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH IL1RL1.
    Tissue: Glioblastoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Melanoma.
  4. "Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
    Xu G., Shin S.B., Jaffrey S.R.
    Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE [LARGE SCALE ANALYSIS] OF 24-43.
    Tissue: Leukemic T-cell.
  5. "Coupled transport of p24 family members."
    Emery G., Rojo M., Gruenberg J.
    J. Cell Sci. 113:2507-2516(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway."
    Jenne N., Frey K., Brugger B., Wieland F.T.
    J. Biol. Chem. 277:46504-46511(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. Cited for: CLEAVAGE OF SIGNAL PEPTIDE [LARGE SCALE ANALYSIS] AFTER GLY-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-102.

Entry informationi

Entry nameiTMED1_HUMAN
AccessioniPrimary (citable) accession number: Q13445
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Found only in very low concentrations in the endoplasmic reticulum, Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment compared to other members of the EMP24/GP25L family.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.