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Protein

28 kDa heat- and acid-stable phosphoprotein

Gene

PDAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106244-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
28 kDa heat- and acid-stable phosphoprotein
Alternative name(s):
PDGF-associated protein
Short name:
PAP
PDGFA-associated protein 1
Short name:
PAP1
Gene namesi
Name:PDAP1
Synonyms:HASPP28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14634. PDAP1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi11333.
OpenTargetsiENSG00000106244.
PharmGKBiPA33102.

Polymorphism and mutation databases

BioMutaiPDAP1.
DMDMi2498464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838971 – 18128 kDa heat- and acid-stable phosphoproteinAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei70PhosphotyrosineBy similarity1
Modified residuei126N6-methyllysineCombined sources1
Modified residuei132N6-acetyllysineCombined sources1
Modified residuei164N6-acetyllysineBy similarity1
Modified residuei176PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ13442.
MaxQBiQ13442.
PaxDbiQ13442.
PeptideAtlasiQ13442.
PRIDEiQ13442.
TopDownProteomicsiQ13442.

PTM databases

iPTMnetiQ13442.
PhosphoSitePlusiQ13442.

Miscellaneous databases

PMAP-CutDBQ13442.

Expressioni

Gene expression databases

BgeeiENSG00000106244.
CleanExiHS_PDAP1.
ExpressionAtlasiQ13442. baseline and differential.
GenevisibleiQ13442. HS.

Organism-specific databases

HPAiCAB021103.
HPA050294.
HPA060836.

Interactioni

Protein-protein interaction databases

BioGridi116461. 17 interactors.
IntActiQ13442. 8 interactors.
MINTiMINT-5002803.
STRINGi9606.ENSP00000222968.

Structurei

3D structure databases

ProteinModelPortaliQ13442.
SMRiQ13442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDAP1 family.Curated

Phylogenomic databases

eggNOGiKOG3375. Eukaryota.
ENOG4111T3A. LUCA.
GeneTreeiENSGT00390000018509.
HOGENOMiHOG000241539.
HOVERGENiHBG000319.
InParanoidiQ13442.
OMAiCTGRKGG.
OrthoDBiEOG091G16GX.
PhylomeDBiQ13442.
TreeFamiTF324338.

Family and domain databases

InterProiIPR019380. Casein_kinase_sb_PP28.
[Graphical view]
PfamiPF10252. PP28. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGGRKGGH KGRARQYTSP EEIDAQLQAE KQKAREEEEQ KEGGDGAAGD
60 70 80 90 100
PKKEKKSLDS DESEDEEDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD
110 120 130 140 150
LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR
160 170 180
EEAARKKEEE RKAKDDATLS GKRMQSLSLN K
Length:181
Mass (Da):20,630
Last modified:November 1, 1996 - v1
Checksum:iF97914C7920ABAB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → MI in AAB07135 (Ref. 5) Curated1
Sequence conflicti13R → W in AAB07135 (Ref. 5) Curated1
Sequence conflicti25A → T in AAB07135 (Ref. 5) Curated1
Sequence conflicti29A → S in AAB07135 (Ref. 5) Curated1
Sequence conflicti67E → D in AAB07135 (Ref. 5) Curated1
Sequence conflicti80L → F in AAB07135 (Ref. 5) Curated1
Sequence conflicti126K → R in AAB07135 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41745 mRNA. Translation: AAC50462.1.
AC004922 Genomic DNA. Translation: AAF03506.1.
CH471091 Genomic DNA. Translation: EAW76675.1.
CH471091 Genomic DNA. Translation: EAW76676.1.
BC000684 mRNA. Translation: AAH00684.1.
BC007873 mRNA. Translation: AAH07873.1.
U65960 Genomic DNA. Translation: AAB07135.1.
CCDSiCCDS5662.1.
RefSeqiNP_055706.1. NM_014891.6.
UniGeneiHs.632296.

Genome annotation databases

EnsembliENST00000350498; ENSP00000222968; ENSG00000106244.
GeneIDi11333.
KEGGihsa:11333.
UCSCiuc003uqe.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41745 mRNA. Translation: AAC50462.1.
AC004922 Genomic DNA. Translation: AAF03506.1.
CH471091 Genomic DNA. Translation: EAW76675.1.
CH471091 Genomic DNA. Translation: EAW76676.1.
BC000684 mRNA. Translation: AAH00684.1.
BC007873 mRNA. Translation: AAH07873.1.
U65960 Genomic DNA. Translation: AAB07135.1.
CCDSiCCDS5662.1.
RefSeqiNP_055706.1. NM_014891.6.
UniGeneiHs.632296.

3D structure databases

ProteinModelPortaliQ13442.
SMRiQ13442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116461. 17 interactors.
IntActiQ13442. 8 interactors.
MINTiMINT-5002803.
STRINGi9606.ENSP00000222968.

PTM databases

iPTMnetiQ13442.
PhosphoSitePlusiQ13442.

Polymorphism and mutation databases

BioMutaiPDAP1.
DMDMi2498464.

Proteomic databases

EPDiQ13442.
MaxQBiQ13442.
PaxDbiQ13442.
PeptideAtlasiQ13442.
PRIDEiQ13442.
TopDownProteomicsiQ13442.

Protocols and materials databases

DNASUi11333.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350498; ENSP00000222968; ENSG00000106244.
GeneIDi11333.
KEGGihsa:11333.
UCSCiuc003uqe.5. human.

Organism-specific databases

CTDi11333.
DisGeNETi11333.
GeneCardsiPDAP1.
HGNCiHGNC:14634. PDAP1.
HPAiCAB021103.
HPA050294.
HPA060836.
MIMi607075. gene.
neXtProtiNX_Q13442.
OpenTargetsiENSG00000106244.
PharmGKBiPA33102.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3375. Eukaryota.
ENOG4111T3A. LUCA.
GeneTreeiENSGT00390000018509.
HOGENOMiHOG000241539.
HOVERGENiHBG000319.
InParanoidiQ13442.
OMAiCTGRKGG.
OrthoDBiEOG091G16GX.
PhylomeDBiQ13442.
TreeFamiTF324338.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106244-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiPDAP1. human.
GeneWikiiPDAP1.
GenomeRNAii11333.
PMAP-CutDBQ13442.
PROiQ13442.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106244.
CleanExiHS_PDAP1.
ExpressionAtlasiQ13442. baseline and differential.
GenevisibleiQ13442. HS.

Family and domain databases

InterProiIPR019380. Casein_kinase_sb_PP28.
[Graphical view]
PfamiPF10252. PP28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAP28_HUMAN
AccessioniPrimary (citable) accession number: Q13442
Secondary accession number(s): D6W5S5, Q92906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.