Golgin subfamily A member 4 - Homo sapiens (Human)

Names and origin

Protein names

Recommended name:
    Golgin subfamily A member 4
Alternative name(s):
    Trans-Golgi p230
    256 kDa golgin
    Golgin-245
    Protein 72.1

Gene names

Name:

GOLGA4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	2230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May play a role in vesicular transport from the trans-Golgi.
Subunit structure	Homodimer. Interacts with ARL1 with bound GTP. Ref.10
Subcellular location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Ref.10
Domain	Extended rod-like protein with coiled-coil domains.
Involvement in disease	Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex. Antibodies against GOLGA4 are found in sera from hepatitis B patients.
Sequence similarities	Contains 1 GRIP domain.
Sequence caution	The sequence CAA58041.1 differs from that shown. Reason: Frameshift at position 2153.

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Ontologies

Keywords
Cellular component	Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	vesicle-mediated transport Ref.1 Traceable author statement. Source: ProtInc
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network Traceable author statement. Source: ProtInc
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q13439-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q13439-3) The sequence of this isoform differs from the canonical sequence as follows: 2103-2109: Missing.

Isoform 4 (identifier: Q13439-4) The sequence of this isoform differs from the canonical sequence as follows: 2222-2230: FTSPRSGIF → SWLRSSS

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2230

2230

Golgin subfamily A member 4

PRO_0000190059

Regions

Domain

2168 – 2215

48

GRIP

Coiled coil

133 – 2185

2053

Potential

Compositional bias

252 – 2096

1845

Glu-rich

Amino acid modifications

Modified residue

41

1

Phosphoserine By similarity

Modified residue

71

1

Phosphoserine Ref.5 Ref.7

Modified residue

89

1

Phosphoserine Ref.7

Modified residue

266

1

Phosphoserine Ref.7

Modified residue

342

1

Phosphothreonine Ref.6

Modified residue

346

1

Phosphothreonine Ref.6

Modified residue

2223

1

Phosphothreonine Ref.7

Natural variations

Alternative sequence

2103 – 2109

7

Missing in isoform 3.

VSP_004274

Alternative sequence

2222 – 2230

9

FTSPRSGIF → SWLRSSS in isoform 4.

VSP_004275

Natural variant

1028

1

Q → K: dbSNP rs11718848.

VAR_033975

Natural variant

1552

1

N → S: dbSNP rs9840779.

VAR_033976

Natural variant

2058

1

R → S: dbSNP rs11924014.

VAR_049258

Experimental info

Mutagenesis

2177

1

Y → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2177

1

Y → F: No effect. Ref.10

Mutagenesis

2181

1

V → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2183

1

F → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2186

1

M → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2193

1

T → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2194

1

M → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2197

1

V → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2198

1

I → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2202

1

L → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2204

1

F → A: Abolishes Golgi localization. Ref.10

Mutagenesis

2212

1

I → A: Abolishes Golgi localization. Ref.10

Sequence conflict

188

1

R → K in AAC51791. Ref.3

Sequence conflict

220

1

Y → H in AAC51791. Ref.3

Sequence conflict

276

1

T → A in AAC51791. Ref.3

Sequence conflict

584

1

K → E in AAC51791. Ref.3

Sequence conflict

628

1

T → A Ref.3

Sequence conflict

630

1

K → E Ref.3

Sequence conflict

682

1

K → N in AAC51791. Ref.3

Secondary structure

1

.

2230

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3BB733DB1EA86134 Show »	FASTA	2,230	261,140
10 20 30 40 50 60 MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS 70 80 90 100 110 120 FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM 130 140 150 160 170 180 DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ 190 200 210 220 230 240 SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM 250 260 270 280 290 300 NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 310 320 330 340 350 360 TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ 370 380 390 400 410 420 DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL 430 440 450 460 470 480 STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK 490 500 510 520 530 540 LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL 550 560 570 580 590 600 ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 610 620 630 640 650 660 HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK 670 680 690 700 710 720 EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE 730 740 750 760 770 780 LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE 790 800 810 820 830 840 NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK 850 860 870 880 890 900 QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 910 920 930 940 950 960 QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK 970 980 990 1000 1010 1020 QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR 1030 1040 1050 1060 1070 1080 LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI 1090 1100 1110 1120 1130 1140 LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE 1150 1160 1170 1180 1190 1200 VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1210 1220 1230 1240 1250 1260 DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV 1270 1280 1290 1300 1310 1320 KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK 1330 1340 1350 1360 1370 1380 EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN 1390 1400 1410 1420 1430 1440 VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN 1450 1460 1470 1480 1490 1500 KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1510 1520 1530 1540 1550 1560 EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK 1570 1580 1590 1600 1610 1620 ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE 1630 1640 1650 1660 1670 1680 ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK 1690 1700 1710 1720 1730 1740 LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV 1750 1760 1770 1780 1790 1800 LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1810 1820 1830 1840 1850 1860 LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD 1870 1880 1890 1900 1910 1920 SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN 1930 1940 1950 1960 1970 1980 MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK 1990 2000 2010 2020 2030 2040 QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ 2050 2060 2070 2080 2090 2100 LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2110 2120 2130 2140 2150 2160 DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT TVGTPYKGGN 2170 2180 2190 2200 2210 2220 LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT VLKFPDDQTQ KILEREDARL 2230 MFTSPRSGIF « Hide
Isoform 3. Checksum: B401B4C93E612E70 Show »	FASTA	2,223	260,325
10 20 30 40 50 60 MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS 70 80 90 100 110 120 FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM 130 140 150 160 170 180 DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ 190 200 210 220 230 240 SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM 250 260 270 280 290 300 NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 310 320 330 340 350 360 TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ 370 380 390 400 410 420 DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL 430 440 450 460 470 480 STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK 490 500 510 520 530 540 LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL 550 560 570 580 590 600 ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 610 620 630 640 650 660 HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK 670 680 690 700 710 720 EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE 730 740 750 760 770 780 LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE 790 800 810 820 830 840 NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK 850 860 870 880 890 900 QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 910 920 930 940 950 960 QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK 970 980 990 1000 1010 1020 QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR 1030 1040 1050 1060 1070 1080 LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI 1090 1100 1110 1120 1130 1140 LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE 1150 1160 1170 1180 1190 1200 VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1210 1220 1230 1240 1250 1260 DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV 1270 1280 1290 1300 1310 1320 KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK 1330 1340 1350 1360 1370 1380 EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN 1390 1400 1410 1420 1430 1440 VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN 1450 1460 1470 1480 1490 1500 KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1510 1520 1530 1540 1550 1560 EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK 1570 1580 1590 1600 1610 1620 ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE 1630 1640 1650 1660 1670 1680 ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK 1690 1700 1710 1720 1730 1740 LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV 1750 1760 1770 1780 1790 1800 LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1810 1820 1830 1840 1850 1860 LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD 1870 1880 1890 1900 1910 1920 SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN 1930 1940 1950 1960 1970 1980 MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK 1990 2000 2010 2020 2030 2040 QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ 2050 2060 2070 2080 2090 2100 LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2110 2120 2130 2140 2150 2160 DNTQLAQKTT LISDSKLKEQ EFREQIHNLE DRLKKYEKNV YATTVGTPYK GGNLYHTDVS 2170 2180 2190 2200 2210 2220 LFGEPTEFEY LRKVLFEYMM GRETKTMAKV ITTVLKFPDD QTQKILERED ARLMFTSPRS GIF « Hide
Isoform 4. Checksum: 9E1B1F1B13A6A218 Show »	FASTA	2,228	260,951
10 20 30 40 50 60 MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS 70 80 90 100 110 120 FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM 130 140 150 160 170 180 DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ 190 200 210 220 230 240 SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM 250 260 270 280 290 300 NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 310 320 330 340 350 360 TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ 370 380 390 400 410 420 DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL 430 440 450 460 470 480 STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK 490 500 510 520 530 540 LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL 550 560 570 580 590 600 ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 610 620 630 640 650 660 HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK 670 680 690 700 710 720 EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE 730 740 750 760 770 780 LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE 790 800 810 820 830 840 NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK 850 860 870 880 890 900 QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 910 920 930 940 950 960 QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK 970 980 990 1000 1010 1020 QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR 1030 1040 1050 1060 1070 1080 LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI 1090 1100 1110 1120 1130 1140 LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE 1150 1160 1170 1180 1190 1200 VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1210 1220 1230 1240 1250 1260 DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV 1270 1280 1290 1300 1310 1320 KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK 1330 1340 1350 1360 1370 1380 EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN 1390 1400 1410 1420 1430 1440 VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN 1450 1460 1470 1480 1490 1500 KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1510 1520 1530 1540 1550 1560 EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK 1570 1580 1590 1600 1610 1620 ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE 1630 1640 1650 1660 1670 1680 ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK 1690 1700 1710 1720 1730 1740 LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV 1750 1760 1770 1780 1790 1800 LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1810 1820 1830 1840 1850 1860 LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD 1870 1880 1890 1900 1910 1920 SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN 1930 1940 1950 1960 1970 1980 MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK 1990 2000 2010 2020 2030 2040 QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ 2050 2060 2070 2080 2090 2100 LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2110 2120 2130 2140 2150 2160 DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT TVGTPYKGGN 2170 2180 2190 2200 2210 2220 LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT VLKFPDDQTQ KILEREDARL MSWLRSSS « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif." Erlich R., Gleeson P.A., Campbell P., Dietzsch E., Toh B.-H. J. Biol. Chem. 271:8328-8337(1996) [PubMed: 8626529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]	Seelig H.P. Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular characterization of golgin-245, a novel Golgi complex protein containing a granin signature." Fritzler M.J., Lung C.-C., Hamel J.C., Griffith K.J., Chan E.K.L. J. Biol. Chem. 270:31262-31268(1995) [PubMed: 8537393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-2230. Tissue: Placenta.
[4]	Balague C. Thesis (1994), Instituto municipal de investigacion medica, Spain Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 524-672. Tissue: Gastric fundus.
[5]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-342 AND THR-346, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89; SER-266 AND THR-2223, MASS SPECTROMETRY.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]	"Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus." Panic B., Perisic O., Veprintsev D.B., Williams R.L., Munro S. Mol. Cell 12:863-874(2003) [PubMed: 14580338] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2170-2221 IN COMPLEX WITH ARL1.
[10]	"Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1." Wu M., Lu L., Hong W., Song H. Nat. Struct. Mol. Biol. 11:86-94(2004) [PubMed: 14718928] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2172-2222 IN COMPLEX WITH ARL1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177; VAL-2181; PHE-2183; MET-2186; THR-2193; MET-2194; VAL-2197; ILE-2198; LEU-2202; PHE-2204 AND ILE-2212, SUBUNIT.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U41740 mRNA. Translation: AAC50434.1.
X82834 mRNA. Translation: CAA58041.1. Frameshift.
U31906 mRNA. Translation: AAC51791.1.
X76942 mRNA. Translation: CAA54261.1.

IPI

IPI00013272.
IPI00220522.
IPI00927614.

RefSeq

NP_002069.2.

UniGene

Hs.344151

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1R4A	X-ray	2.30	E/F/G/H	2172-2222	[»]
1UPT	X-ray	1.70	B/D/F/H	2170-2221	[»]

ModBase

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Protein-protein interaction databases

IntAct

Q13439. 6 interactions.

PTM databases

PhosphoSite

Q13439.

Proteomic databases

PRIDE

Q13439.

Genome annotation databases

Ensembl

ENSG00000144674. Homo sapiens. [Contig view]

GeneID

2803.

KEGG

hsa:2803.

Organism-specific databases

GeneCards

GC03P037259.

H-InvDB

HIX0020830.

HGNC

HGNC:4427. GOLGA4.

MIM

602509. gene.

PharmGKB

PA28808.

GenAtlas

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Phylogenomic databases

HOGENOM

Q13439.

HOVERGEN

Q13439.

OMA

Q13439. DDKTNVV.

Gene expression databases

ArrayExpress

Q13439.

Bgee

Q13439.

CleanEx

HS_GOLGA4.

GermOnline

ENSG00000144674. Homo sapiens.

Family and domain databases

InterPro

IPR000237. GRIP.
[Graphical view]

Pfam

PF01465. GRIP. 1 hit.
[Graphical view]

SMART

SM00755. Grip. 1 hit.
[Graphical view]

PROSITE

PS50913. GRIP. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

NextBio

11049.

SOURCE

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Entry information

Entry name

GOGA4_HUMAN

Accession

Primary (citable) accession number: Q13439
Secondary accession number(s): Q13270, Q13654, Q14436

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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