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Q13439

- GOGA4_HUMAN

UniProt

Q13439 - GOGA4_HUMAN

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Protein
Golgin subfamily A member 4
Gene
GOLGA4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.1 Publication

GO - Molecular functioni

  1. GTPase binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. Golgi to plasma membrane protein transport Source: UniProtKB
  2. protein targeting to Golgi Source: InterPro
  3. vesicle-mediated transport Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 4
Alternative name(s):
256 kDa golgin
Golgin-245
Protein 72.1
Trans-Golgi p230
Gene namesi
Name:GOLGA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:4427. GOLGA4.

Subcellular locationi

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus 3 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB-SubCell
  3. cytoplasm Source: UniProtKB
  4. intracellular membrane-bounded organelle Source: HPA
  5. nucleus Source: HPA
  6. trans-Golgi network Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2177 – 21771Y → A: Loss of Golgi membrane localization. Loss of ARL1-binding. 2 Publications
Mutagenesisi2177 – 21771Y → F: No effect. 2 Publications
Mutagenesisi2181 – 21811V → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2183 – 21831F → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2186 – 21861M → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2193 – 21931T → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2194 – 21941M → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2197 – 21971V → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2198 – 21981I → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2202 – 22021L → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2204 – 22041F → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2212 – 22121I → A: Abolishes Golgi localization. 1 Publication

Organism-specific databases

PharmGKBiPA28808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22302230Golgin subfamily A member 4
PRO_0000190059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Phosphoserine3 Publications
Modified residuei78 – 781Phosphoserine1 Publication
Modified residuei89 – 891Phosphoserine1 Publication
Modified residuei266 – 2661Phosphoserine4 Publications
Modified residuei2223 – 22231Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13439.
PaxDbiQ13439.
PRIDEiQ13439.

PTM databases

PhosphoSiteiQ13439.

Expressioni

Gene expression databases

ArrayExpressiQ13439.
BgeeiQ13439.
CleanExiHS_GOLGA4.
GenevestigatoriQ13439.

Organism-specific databases

HPAiHPA035102.
HPA040675.

Interactioni

Subunit structurei

Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD27Q96NW42EBI-1037845,EBI-6125599

Protein-protein interaction databases

BioGridi109065. 9 interactions.
IntActiQ13439. 8 interactions.
MINTiMINT-3027757.
STRINGi9606.ENSP00000354486.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2173 – 218614
Helixi2191 – 220111
Helixi2206 – 222520

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R4AX-ray2.30E/F/G/H2172-2222[»]
1UPTX-ray1.70B/D/F/H2170-2228[»]
ProteinModelPortaliQ13439.
SMRiQ13439. Positions 2172-2222.

Miscellaneous databases

EvolutionaryTraceiQ13439.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2168 – 221548GRIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 20371Interaction with MACF1
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili133 – 21852053 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi252 – 20961845Glu-rich
Add
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000112753.
HOVERGENiHBG051754.
InParanoidiQ13439.
OMAiNEEYVES.
OrthoDBiEOG72C4ZF.
PhylomeDBiQ13439.
TreeFamiTF325082.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
SUPFAMiSSF101283. SSF101283. 1 hit.
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q13439-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT     50
PNRESGDTQS FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE 100
SLNRLDLDSS TASFDPPSDM DSEAEDLVGN SDSLNKEQLI QRLRRMERSL 150
SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ SQDKSLRRIA ELREELQMDQ 200
QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM NVDVLKPLPQ 250
LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 300
TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD 350
AKNLIEQLEQ DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE 400
LREQKEKSER AAFEELEKAL STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE 450
ERISLQQELS RVKQEVVDVM KKSSEEQIAK LQKLHEKELA RKEQELTKKL 500
QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL ELQKKAILTE 550
SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 600
HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE 650
QEKETLLKDK EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR 700
HKLEEELSVL KDQTDKMKQE LEAKMDEQKN HHQQQVDSII KEHEVSIQRT 750
EKALKDQINQ LELLLKERDK HLKEHQAHVE NLEADIKRSE GELQQASAKL 800
DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK QVAEVEAQKK 850
DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 900
QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK 950
NQEKKMEKVK QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN 1000
AKMLEMAQAN SAGISDAVSR LETNQKEQIE SLTEVHRREL NDVISIWEKK 1050
LNQQAEELQE IHEIQLQEKE QEVAELKQKI LLFGCEKEEM NKEITWLKEE 1100
GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE VDLNKSLKEN 1150
TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1200
DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI 1250
SHCQHRTTKV KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE 1300
EKENQIKSMK ADIESLVTEK EALQKEGGNQ QQAASEKESC ITQLKKELSE 1350
NINAVTLMKE ELKEKKVEIS SLSKQLTDLN VQLQNSISLS EKEAAISSLR 1400
KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN KFSEWKKKAQ 1450
SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1500
EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN 1550
YNQQKDIEHK ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE 1600
LETKKKELEH VNLSVKSKEE ELKALEDRLE SESAAKLAEL KRKAEQKIAA 1650
IKKQLLSQME EKEEQYKKGT ESHLSELNTK LQEREREVHI LEEKLKSVES 1700
SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV LQRNLTEKEK 1750
LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1800
LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ 1850
ILEQKIKELD SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL 1900
EENTEEKSKS HLVQPKLLSN MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ 1950
KDLRMLRKEH QQELEILKKE YDQEREEKIK QEQEDLELKH NSTLKQLMRE 2000
FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ LLKKIAEKDD 2050
DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2100
DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT 2150
TVGTPYKGGN LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT 2200
VLKFPDDQTQ KILEREDARL MFTSPRSGIF 2230
Length:2,230
Mass (Da):261,140
Last modified:November 1, 1996 - v1
Checksum:i3BB733DB1EA86134
GO
Isoform 3 (identifier: Q13439-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2103-2109: Missing.

Show »
Length:2,223
Mass (Da):260,325
Checksum:iB401B4C93E612E70
GO
Isoform 4 (identifier: Q13439-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2222-2230: FTSPRSGIF → SWLRSSS

Show »
Length:2,228
Mass (Da):260,951
Checksum:i9E1B1F1B13A6A218
GO
Isoform 5 (identifier: Q13439-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: E → ENASTHASKSPDSVNGSEPSIPQ
     2103-2109: Missing.
     2222-2230: FTSPRSGIF → SWLRSSS

Note: No experimental confirmation available.

Show »
Length:2,243
Mass (Da):262,328
Checksum:iEDD8BCB88E02B9A4
GO

Sequence cautioni

The sequence CAA58041.1 differs from that shown. Reason: Frameshift at position 2153.
The sequence BAD92930.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1028 – 10281Q → K.
Corresponds to variant rs11718848 [ dbSNP | Ensembl ].
VAR_033975
Natural varianti1552 – 15521N → S.
Corresponds to variant rs9840779 [ dbSNP | Ensembl ].
VAR_033976
Natural varianti2058 – 20581R → S.
Corresponds to variant rs11924014 [ dbSNP | Ensembl ].
VAR_049258

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 541E → ENASTHASKSPDSVNGSEPS IPQ in isoform 5.
VSP_044819
Alternative sequencei2103 – 21097Missing in isoform 3 and isoform 5.
VSP_004274
Alternative sequencei2222 – 22309FTSPRSGIF → SWLRSSS in isoform 4 and isoform 5.
VSP_004275

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881R → K in AAC51791. 1 Publication
Sequence conflicti220 – 2201Y → H in AAC51791. 1 Publication
Sequence conflicti276 – 2761T → A in AAC51791. 1 Publication
Sequence conflicti584 – 5841K → E in AAC51791. 1 Publication
Sequence conflicti628 – 6281T → A in AAC51791. 1 Publication
Sequence conflicti630 – 6301K → E in AAC51791. 1 Publication
Sequence conflicti682 – 6821K → N in AAC51791. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41740 mRNA. Translation: AAC50434.1.
X82834 mRNA. Translation: CAA58041.1. Frameshift.
AC097359 Genomic DNA. No translation available.
AB209693 mRNA. Translation: BAD92930.1. Different initiation.
U31906 mRNA. Translation: AAC51791.1.
X76942 mRNA. Translation: CAA54261.1.
CCDSiCCDS2666.1. [Q13439-1]
CCDS54564.1. [Q13439-5]
RefSeqiNP_001166184.1. NM_001172713.1. [Q13439-5]
NP_002069.2. NM_002078.4. [Q13439-1]
UniGeneiHs.344151.

Genome annotation databases

EnsembliENST00000356847; ENSP00000349305; ENSG00000144674. [Q13439-5]
ENST00000361924; ENSP00000354486; ENSG00000144674. [Q13439-1]
GeneIDi2803.
KEGGihsa:2803.
UCSCiuc003cgv.3. human. [Q13439-1]
uc003cgx.3. human. [Q13439-4]

Polymorphism databases

DMDMi12643718.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41740 mRNA. Translation: AAC50434.1 .
X82834 mRNA. Translation: CAA58041.1 . Frameshift.
AC097359 Genomic DNA. No translation available.
AB209693 mRNA. Translation: BAD92930.1 . Different initiation.
U31906 mRNA. Translation: AAC51791.1 .
X76942 mRNA. Translation: CAA54261.1 .
CCDSi CCDS2666.1. [Q13439-1 ]
CCDS54564.1. [Q13439-5 ]
RefSeqi NP_001166184.1. NM_001172713.1. [Q13439-5 ]
NP_002069.2. NM_002078.4. [Q13439-1 ]
UniGenei Hs.344151.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R4A X-ray 2.30 E/F/G/H 2172-2222 [» ]
1UPT X-ray 1.70 B/D/F/H 2170-2228 [» ]
ProteinModelPortali Q13439.
SMRi Q13439. Positions 2172-2222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109065. 9 interactions.
IntActi Q13439. 8 interactions.
MINTi MINT-3027757.
STRINGi 9606.ENSP00000354486.

PTM databases

PhosphoSitei Q13439.

Polymorphism databases

DMDMi 12643718.

Proteomic databases

MaxQBi Q13439.
PaxDbi Q13439.
PRIDEi Q13439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356847 ; ENSP00000349305 ; ENSG00000144674 . [Q13439-5 ]
ENST00000361924 ; ENSP00000354486 ; ENSG00000144674 . [Q13439-1 ]
GeneIDi 2803.
KEGGi hsa:2803.
UCSCi uc003cgv.3. human. [Q13439-1 ]
uc003cgx.3. human. [Q13439-4 ]

Organism-specific databases

CTDi 2803.
GeneCardsi GC03P037284.
HGNCi HGNC:4427. GOLGA4.
HPAi HPA035102.
HPA040675.
MIMi 602509. gene.
neXtProti NX_Q13439.
PharmGKBi PA28808.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000112753.
HOVERGENi HBG051754.
InParanoidi Q13439.
OMAi NEEYVES.
OrthoDBi EOG72C4ZF.
PhylomeDBi Q13439.
TreeFami TF325082.

Miscellaneous databases

ChiTaRSi GOLGA4. human.
EvolutionaryTracei Q13439.
GeneWikii GOLGA4.
GenomeRNAii 2803.
NextBioi 11049.
PROi Q13439.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13439.
Bgeei Q13439.
CleanExi HS_GOLGA4.
Genevestigatori Q13439.

Family and domain databases

Gene3Di 1.10.220.60. 1 hit.
InterProi IPR000237. GRIP.
[Graphical view ]
Pfami PF01465. GRIP. 1 hit.
[Graphical view ]
SMARTi SM00755. Grip. 1 hit.
[Graphical view ]
SUPFAMi SSF101283. SSF101283. 1 hit.
PROSITEi PS50913. GRIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif."
    Erlich R., Gleeson P.A., Campbell P., Dietzsch E., Toh B.-H.
    J. Biol. Chem. 271:8328-8337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
  2. Seelig H.P.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1279 (ISOFORM 5).
    Tissue: Brain.
  5. "Molecular characterization of golgin-245, a novel Golgi complex protein containing a granin signature."
    Fritzler M.J., Lung C.-C., Hamel J.C., Griffith K.J., Chan E.K.L.
    J. Biol. Chem. 270:31262-31268(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-2230.
    Tissue: Placenta.
  6. Balague C.
    Thesis (1994), Instituto municipal de investigacion medica, Spain
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 524-672.
    Tissue: Gastric fundus.
  7. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."
    Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., Kahn R.A.
    J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL1 AND ARL3, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177.
  8. "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery."
    Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H.
    Exp. Cell Res. 298:388-398(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MACF1.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89; SER-266 AND THR-2223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-78 AND SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus."
    Panic B., Perisic O., Veprintsev D.B., Williams R.L., Munro S.
    Mol. Cell 12:863-874(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2170-2221 IN COMPLEX WITH ARL1.
  16. "Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1."
    Wu M., Lu L., Hong W., Song H.
    Nat. Struct. Mol. Biol. 11:86-94(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2172-2222 IN COMPLEX WITH ARL1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177; VAL-2181; PHE-2183; MET-2186; THR-2193; MET-2194; VAL-2197; ILE-2198; LEU-2202; PHE-2204 AND ILE-2212, SUBUNIT.

Entry informationi

Entry nameiGOGA4_HUMAN
AccessioniPrimary (citable) accession number: Q13439
Secondary accession number(s): F8W8Q7
, Q13270, Q13654, Q14436, Q59EW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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