Q13439 (GOGA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Golgin subfamily A member 4

Alternative name(s):
256 kDa golgin
Golgin-245
Protein 72.1
Trans-Golgi p230

Gene names

Name:

GOLGA4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2230 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Ref.5
Subunit structure	Homodimer. Interacts with ARL1 with bound GTP. Interacts with MACF1. Ref.5 Ref.13
Subcellular location	Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus Ref.5 Ref.13.
Domain	Extended rod-like protein with coiled-coil domains.
Miscellaneous	Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.
Sequence similarities	Contains 1 GRIP domain.
Sequence caution	The sequence CAA58041.1 differs from that shown. Reason: Frameshift at position 2153.

Ontologies

Keywords
Cellular component	Cytoplasm Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Golgi to plasma membrane protein transport Inferred from direct assay Ref.5. Source: UniProtKB protein targeting to Golgi Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network Traceable author statement. Source: ProtInc
Molecular function	GTPase binding Inferred from physical interaction Ref.12. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q13439-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3 (identifier: Q13439-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2103-2109: Missing.

Isoform 4 (identifier: Q13439-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2222-2230: FTSPRSGIF → SWLRSSS

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2230

2230

Golgin subfamily A member 4

PRO_0000190059

Regions

Domain

2168 – 2215

48

GRIP

Region

133 – 203

71

Interaction with MACF1

Coiled coil

133 – 2185

2053

Potential

Compositional bias

252 – 2096

1845

Glu-rich

Amino acid modifications

Modified residue

40

1

Phosphoserine Ref.9

Modified residue

41

1

Phosphoserine Ref.9

Modified residue

71

1

Phosphoserine Ref.6 Ref.8 Ref.9 Ref.10

Modified residue

89

1

Phosphoserine Ref.8

Modified residue

266

1

Phosphoserine Ref.8 Ref.9 Ref.10

Modified residue

342

1

Phosphothreonine Ref.7

Modified residue

346

1

Phosphothreonine Ref.7

Modified residue

2223

1

Phosphothreonine Ref.8

Natural variations

Alternative sequence

2103 – 2109

7

Missing in isoform 3.

VSP_004274

Alternative sequence

2222 – 2230

9

FTSPRSGIF → SWLRSSS in isoform 4.

VSP_004275

Natural variant

1028

1

Q → K.
Corresponds to variant rs11718848 [ dbSNP | Ensembl ].

VAR_033975

Natural variant

1552

1

N → S.
Corresponds to variant rs9840779 [ dbSNP | Ensembl ].

VAR_033976

Natural variant

2058

1

R → S.
Corresponds to variant rs11924014 [ dbSNP | Ensembl ].

VAR_049258

Experimental info

Mutagenesis

2177

1

Y → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2177

1

Y → F: No effect. Ref.13

Mutagenesis

2181

1

V → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2183

1

F → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2186

1

M → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2193

1

T → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2194

1

M → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2197

1

V → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2198

1

I → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2202

1

L → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2204

1

F → A: Abolishes Golgi localization. Ref.13

Mutagenesis

2212

1

I → A: Abolishes Golgi localization. Ref.13

Sequence conflict

188

1

R → K in AAC51791. Ref.3

Sequence conflict

220

1

Y → H in AAC51791. Ref.3

Sequence conflict

276

1

T → A in AAC51791. Ref.3

Sequence conflict

584

1

K → E in AAC51791. Ref.3

Sequence conflict

628

1

T → A in AAC51791. Ref.3

Sequence conflict

630

1

K → E in AAC51791. Ref.3

Sequence conflict

682

1

K → N in AAC51791. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

2230

Helix Strand Turn

Details...

Helix

2173 – 2186

14

Helix

2191 – 2201

11

Helix

2206 – 2215

10

Helix

2217 – 2220

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3BB733DB1EA86134	FASTA	2,230	261,140
	10 20 30 40 50 60 MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS 70 80 90 100 110 120 FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM 130 140 150 160 170 180 DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ 190 200 210 220 230 240 SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM 250 260 270 280 290 300 NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 310 320 330 340 350 360 TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ 370 380 390 400 410 420 DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL 430 440 450 460 470 480 STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK 490 500 510 520 530 540 LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL 550 560 570 580 590 600 ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 610 620 630 640 650 660 HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK 670 680 690 700 710 720 EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE 730 740 750 760 770 780 LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE 790 800 810 820 830 840 NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK 850 860 870 880 890 900 QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 910 920 930 940 950 960 QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK 970 980 990 1000 1010 1020 QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR 1030 1040 1050 1060 1070 1080 LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI 1090 1100 1110 1120 1130 1140 LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE 1150 1160 1170 1180 1190 1200 VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1210 1220 1230 1240 1250 1260 DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV 1270 1280 1290 1300 1310 1320 KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK 1330 1340 1350 1360 1370 1380 EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN 1390 1400 1410 1420 1430 1440 VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN 1450 1460 1470 1480 1490 1500 KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1510 1520 1530 1540 1550 1560 EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK 1570 1580 1590 1600 1610 1620 ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE 1630 1640 1650 1660 1670 1680 ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK 1690 1700 1710 1720 1730 1740 LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV 1750 1760 1770 1780 1790 1800 LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1810 1820 1830 1840 1850 1860 LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD 1870 1880 1890 1900 1910 1920 SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN 1930 1940 1950 1960 1970 1980 MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK 1990 2000 2010 2020 2030 2040 QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ 2050 2060 2070 2080 2090 2100 LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2110 2120 2130 2140 2150 2160 DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT TVGTPYKGGN 2170 2180 2190 2200 2210 2220 LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT VLKFPDDQTQ KILEREDARL 2230 MFTSPRSGIF
	Isoform 3 [UniParc]. Checksum: B401B4C93E612E70	FASTA	2,223	260,325
	10 20 30 40 50 60 MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS 70 80 90 100 110 120 FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM 130 140 150 160 170 180 DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ 190 200 210 220 230 240 SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM 250 260 270 280 290 300 NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 310 320 330 340 350 360 TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ 370 380 390 400 410 420 DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL 430 440 450 460 470 480 STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK 490 500 510 520 530 540 LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL 550 560 570 580 590 600 ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 610 620 630 640 650 660 HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK 670 680 690 700 710 720 EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE 730 740 750 760 770 780 LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE 790 800 810 820 830 840 NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK 850 860 870 880 890 900 QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 910 920 930 940 950 960 QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK 970 980 990 1000 1010 1020 QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR 1030 1040 1050 1060 1070 1080 LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI 1090 1100 1110 1120 1130 1140 LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE 1150 1160 1170 1180 1190 1200 VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1210 1220 1230 1240 1250 1260 DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV 1270 1280 1290 1300 1310 1320 KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK 1330 1340 1350 1360 1370 1380 EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN 1390 1400 1410 1420 1430 1440 VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN 1450 1460 1470 1480 1490 1500 KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1510 1520 1530 1540 1550 1560 EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK 1570 1580 1590 1600 1610 1620 ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE 1630 1640 1650 1660 1670 1680 ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK 1690 1700 1710 1720 1730 1740 LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV 1750 1760 1770 1780 1790 1800 LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1810 1820 1830 1840 1850 1860 LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD 1870 1880 1890 1900 1910 1920 SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN 1930 1940 1950 1960 1970 1980 MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK 1990 2000 2010 2020 2030 2040 QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ 2050 2060 2070 2080 2090 2100 LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2110 2120 2130 2140 2150 2160 DNTQLAQKTT LISDSKLKEQ EFREQIHNLE DRLKKYEKNV YATTVGTPYK GGNLYHTDVS 2170 2180 2190 2200 2210 2220 LFGEPTEFEY LRKVLFEYMM GRETKTMAKV ITTVLKFPDD QTQKILERED ARLMFTSPRS GIF
	Isoform 4 [UniParc]. Checksum: 9E1B1F1B13A6A218	FASTA	2,228	260,951
	10 20 30 40 50 60 MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT PNRESGDTQS 70 80 90 100 110 120 FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE SLNRLDLDSS TASFDPPSDM 130 140 150 160 170 180 DSEAEDLVGN SDSLNKEQLI QRLRRMERSL SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ 190 200 210 220 230 240 SQDKSLRRIA ELREELQMDQ QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM 250 260 270 280 290 300 NVDVLKPLPQ LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 310 320 330 340 350 360 TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD AKNLIEQLEQ 370 380 390 400 410 420 DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE LREQKEKSER AAFEELEKAL 430 440 450 460 470 480 STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE ERISLQQELS RVKQEVVDVM KKSSEEQIAK 490 500 510 520 530 540 LQKLHEKELA RKEQELTKKL QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL 550 560 570 580 590 600 ELQKKAILTE SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 610 620 630 640 650 660 HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE QEKETLLKDK 670 680 690 700 710 720 EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR HKLEEELSVL KDQTDKMKQE 730 740 750 760 770 780 LEAKMDEQKN HHQQQVDSII KEHEVSIQRT EKALKDQINQ LELLLKERDK HLKEHQAHVE 790 800 810 820 830 840 NLEADIKRSE GELQQASAKL DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK 850 860 870 880 890 900 QVAEVEAQKK DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 910 920 930 940 950 960 QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK NQEKKMEKVK 970 980 990 1000 1010 1020 QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN AKMLEMAQAN SAGISDAVSR 1030 1040 1050 1060 1070 1080 LETNQKEQIE SLTEVHRREL NDVISIWEKK LNQQAEELQE IHEIQLQEKE QEVAELKQKI 1090 1100 1110 1120 1130 1140 LLFGCEKEEM NKEITWLKEE GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE 1150 1160 1170 1180 1190 1200 VDLNKSLKEN TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1210 1220 1230 1240 1250 1260 DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI SHCQHRTTKV 1270 1280 1290 1300 1310 1320 KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE EKENQIKSMK ADIESLVTEK 1330 1340 1350 1360 1370 1380 EALQKEGGNQ QQAASEKESC ITQLKKELSE NINAVTLMKE ELKEKKVEIS SLSKQLTDLN 1390 1400 1410 1420 1430 1440 VQLQNSISLS EKEAAISSLR KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN 1450 1460 1470 1480 1490 1500 KFSEWKKKAQ SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1510 1520 1530 1540 1550 1560 EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN YNQQKDIEHK 1570 1580 1590 1600 1610 1620 ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE LETKKKELEH VNLSVKSKEE 1630 1640 1650 1660 1670 1680 ELKALEDRLE SESAAKLAEL KRKAEQKIAA IKKQLLSQME EKEEQYKKGT ESHLSELNTK 1690 1700 1710 1720 1730 1740 LQEREREVHI LEEKLKSVES SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV 1750 1760 1770 1780 1790 1800 LQRNLTEKEK LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1810 1820 1830 1840 1850 1860 LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ ILEQKIKELD 1870 1880 1890 1900 1910 1920 SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL EENTEEKSKS HLVQPKLLSN 1930 1940 1950 1960 1970 1980 MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ KDLRMLRKEH QQELEILKKE YDQEREEKIK 1990 2000 2010 2020 2030 2040 QEQEDLELKH NSTLKQLMRE FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ 2050 2060 2070 2080 2090 2100 LLKKIAEKDD DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2110 2120 2130 2140 2150 2160 DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT TVGTPYKGGN 2170 2180 2190 2200 2210 2220 LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT VLKFPDDQTQ KILEREDARL MSWLRSSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif." Erlich R., Gleeson P.A., Campbell P., Dietzsch E., Toh B.-H. J. Biol. Chem. 271:8328-8337(1996) [PubMed: 8626529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]	Seelig H.P. Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular characterization of golgin-245, a novel Golgi complex protein containing a granin signature." Fritzler M.J., Lung C.-C., Hamel J.C., Griffith K.J., Chan E.K.L. J. Biol. Chem. 270:31262-31268(1995) [PubMed: 8537393] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-2230. Tissue: Placenta.
[4]	Balague C. Thesis (1994), Instituto municipal de investigacion medica, Spain Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 524-672. Tissue: Gastric fundus.
[5]	"Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery." Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H. Exp. Cell Res. 298:388-398(2004) [PubMed: 15265687] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MACF1.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-342 AND THR-346, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89; SER-266 AND THR-2223, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-41; SER-71 AND SER-266, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-266, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus." Panic B., Perisic O., Veprintsev D.B., Williams R.L., Munro S. Mol. Cell 12:863-874(2003) [PubMed: 14580338] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2170-2221 IN COMPLEX WITH ARL1.
[13]	"Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1." Wu M., Lu L., Hong W., Song H. Nat. Struct. Mol. Biol. 11:86-94(2004) [PubMed: 14718928] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2172-2222 IN COMPLEX WITH ARL1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177; VAL-2181; PHE-2183; MET-2186; THR-2193; MET-2194; VAL-2197; ILE-2198; LEU-2202; PHE-2204 AND ILE-2212, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U41740 mRNA. Translation: AAC50434.1.
X82834 mRNA. Translation: CAA58041.1. Frameshift.
U31906 mRNA. Translation: AAC51791.1.
X76942 mRNA. Translation: CAA54261.1.

IPI

IPI00013272.
IPI00220522.
IPI01009738.

RefSeq

NP_001166184.1. NM_001172713.1.
NP_002069.2. NM_002078.4.

UniGene

Hs.344151.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1R4A	X-ray	2.30	E/F/G/H	2172-2222	[»]
1UPT	X-ray	1.70	B/D/F/H	2170-2221	[»]

ProteinModelPortal

Q13439.

SMR

Q13439. Positions 2172-2222.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13439. 6 interactions.

STRING

Q13439.

PTM databases

PhosphoSite

Q13439.

Polymorphism databases

DMDM

12643718.

Proteomic databases

PRIDE

Q13439.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000361924; ENSP00000354486; ENSG00000144674.
ENST00000431274; ENSP00000389199; ENSG00000144674.

GeneID

2803.

KEGG

hsa:2803.

UCSC

uc003cgv.1. human.
uc003cgx.1. human.

Organism-specific databases

CTD

2803.

GeneCards

GC03P037284.

H-InvDB

HIX0020830.

HGNC

HGNC:4427. GOLGA4.

HPA

HPA035102.

MIM

602509. gene.

neXtProt

NX_Q13439.

PharmGKB

PA28808.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG06902.

HOVERGEN

HBG051754.

InParanoid

Q13439.

OrthoDB

EOG4QRH34.

PhylomeDB

Q13439.

Gene expression databases

ArrayExpress

Q13439.

Bgee

Q13439.

CleanEx

HS_GOLGA4.

Genevestigator

Q13439.

GermOnline

ENSG00000144674. Homo sapiens.

Family and domain databases

InterPro

IPR000237. GRIP.
[Graphical view]

Gene3D

G3DSA:1.10.220.60. GRIP. 1 hit.

Pfam

PF01465. GRIP. 1 hit.
[Graphical view]

SMART

SM00755. Grip. 1 hit.
[Graphical view]

SUPFAM

SSF101283. GRIP. 1 hit.

PROSITE

PS50913. GRIP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

11049.

SOURCE

Search...

Entry information

Entry name

GOGA4_HUMAN

Accession

Primary (citable) accession number: Q13439
Secondary accession number(s): Q13270, Q13654, Q14436

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.