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Q13439

- GOGA4_HUMAN

UniProt

Q13439 - GOGA4_HUMAN

Protein

Golgin subfamily A member 4

Gene

GOLGA4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.1 Publication

    GO - Molecular functioni

    1. GTPase binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. Golgi to plasma membrane protein transport Source: UniProtKB
    2. protein targeting to Golgi Source: InterPro
    3. vesicle-mediated transport Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgin subfamily A member 4
    Alternative name(s):
    256 kDa golgin
    Golgin-245
    Protein 72.1
    Trans-Golgi p230
    Gene namesi
    Name:GOLGA4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:4427. GOLGA4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. Golgi apparatus Source: UniProtKB
    3. Golgi membrane Source: UniProtKB-SubCell
    4. intracellular membrane-bounded organelle Source: HPA
    5. nucleus Source: HPA
    6. trans-Golgi network Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi2177 – 21771Y → A: Loss of Golgi membrane localization. Loss of ARL1-binding. 2 Publications
    Mutagenesisi2177 – 21771Y → F: No effect. 2 Publications
    Mutagenesisi2181 – 21811V → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2183 – 21831F → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2186 – 21861M → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2193 – 21931T → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2194 – 21941M → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2197 – 21971V → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2198 – 21981I → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2202 – 22021L → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2204 – 22041F → A: Abolishes Golgi localization. 1 Publication
    Mutagenesisi2212 – 22121I → A: Abolishes Golgi localization. 1 Publication

    Organism-specific databases

    PharmGKBiPA28808.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22302230Golgin subfamily A member 4PRO_0000190059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei71 – 711Phosphoserine3 Publications
    Modified residuei78 – 781Phosphoserine1 Publication
    Modified residuei89 – 891Phosphoserine1 Publication
    Modified residuei266 – 2661Phosphoserine4 Publications
    Modified residuei2223 – 22231Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ13439.
    PaxDbiQ13439.
    PRIDEiQ13439.

    PTM databases

    PhosphoSiteiQ13439.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13439.
    BgeeiQ13439.
    CleanExiHS_GOLGA4.
    GenevestigatoriQ13439.

    Organism-specific databases

    HPAiHPA035102.
    HPA040675.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANKRD27Q96NW42EBI-1037845,EBI-6125599

    Protein-protein interaction databases

    BioGridi109065. 9 interactions.
    IntActiQ13439. 8 interactions.
    MINTiMINT-3027757.
    STRINGi9606.ENSP00000354486.

    Structurei

    Secondary structure

    1
    2230
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2173 – 218614
    Helixi2191 – 220111
    Helixi2206 – 222520

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1R4AX-ray2.30E/F/G/H2172-2222[»]
    1UPTX-ray1.70B/D/F/H2170-2228[»]
    ProteinModelPortaliQ13439.
    SMRiQ13439. Positions 2172-2222.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13439.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2168 – 221548GRIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 20371Interaction with MACF1Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili133 – 21852053Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi252 – 20961845Glu-richAdd
    BLAST

    Domaini

    Extended rod-like protein with coiled-coil domains.

    Sequence similaritiesi

    Contains 1 GRIP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000112753.
    HOVERGENiHBG051754.
    InParanoidiQ13439.
    OMAiNEEYVES.
    OrthoDBiEOG72C4ZF.
    PhylomeDBiQ13439.
    TreeFamiTF325082.

    Family and domain databases

    Gene3Di1.10.220.60. 1 hit.
    InterProiIPR000237. GRIP.
    [Graphical view]
    PfamiPF01465. GRIP. 1 hit.
    [Graphical view]
    SMARTiSM00755. Grip. 1 hit.
    [Graphical view]
    SUPFAMiSSF101283. SSF101283. 1 hit.
    PROSITEiPS50913. GRIP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q13439-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT     50
    PNRESGDTQS FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE 100
    SLNRLDLDSS TASFDPPSDM DSEAEDLVGN SDSLNKEQLI QRLRRMERSL 150
    SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ SQDKSLRRIA ELREELQMDQ 200
    QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM NVDVLKPLPQ 250
    LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE 300
    TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD 350
    AKNLIEQLEQ DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE 400
    LREQKEKSER AAFEELEKAL STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE 450
    ERISLQQELS RVKQEVVDVM KKSSEEQIAK LQKLHEKELA RKEQELTKKL 500
    QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL ELQKKAILTE 550
    SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK 600
    HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE 650
    QEKETLLKDK EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR 700
    HKLEEELSVL KDQTDKMKQE LEAKMDEQKN HHQQQVDSII KEHEVSIQRT 750
    EKALKDQINQ LELLLKERDK HLKEHQAHVE NLEADIKRSE GELQQASAKL 800
    DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK QVAEVEAQKK 850
    DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE 900
    QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK 950
    NQEKKMEKVK QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN 1000
    AKMLEMAQAN SAGISDAVSR LETNQKEQIE SLTEVHRREL NDVISIWEKK 1050
    LNQQAEELQE IHEIQLQEKE QEVAELKQKI LLFGCEKEEM NKEITWLKEE 1100
    GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE VDLNKSLKEN 1150
    TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE 1200
    DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI 1250
    SHCQHRTTKV KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE 1300
    EKENQIKSMK ADIESLVTEK EALQKEGGNQ QQAASEKESC ITQLKKELSE 1350
    NINAVTLMKE ELKEKKVEIS SLSKQLTDLN VQLQNSISLS EKEAAISSLR 1400
    KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN KFSEWKKKAQ 1450
    SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG 1500
    EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN 1550
    YNQQKDIEHK ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE 1600
    LETKKKELEH VNLSVKSKEE ELKALEDRLE SESAAKLAEL KRKAEQKIAA 1650
    IKKQLLSQME EKEEQYKKGT ESHLSELNTK LQEREREVHI LEEKLKSVES 1700
    SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV LQRNLTEKEK 1750
    LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE 1800
    LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ 1850
    ILEQKIKELD SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL 1900
    EENTEEKSKS HLVQPKLLSN MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ 1950
    KDLRMLRKEH QQELEILKKE YDQEREEKIK QEQEDLELKH NSTLKQLMRE 2000
    FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ LLKKIAEKDD 2050
    DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN 2100
    DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT 2150
    TVGTPYKGGN LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT 2200
    VLKFPDDQTQ KILEREDARL MFTSPRSGIF 2230
    Length:2,230
    Mass (Da):261,140
    Last modified:November 1, 1996 - v1
    Checksum:i3BB733DB1EA86134
    GO
    Isoform 3 (identifier: Q13439-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2103-2109: Missing.

    Show »
    Length:2,223
    Mass (Da):260,325
    Checksum:iB401B4C93E612E70
    GO
    Isoform 4 (identifier: Q13439-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2222-2230: FTSPRSGIF → SWLRSSS

    Show »
    Length:2,228
    Mass (Da):260,951
    Checksum:i9E1B1F1B13A6A218
    GO
    Isoform 5 (identifier: Q13439-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         54-54: E → ENASTHASKSPDSVNGSEPSIPQ
         2103-2109: Missing.
         2222-2230: FTSPRSGIF → SWLRSSS

    Note: No experimental confirmation available.

    Show »
    Length:2,243
    Mass (Da):262,328
    Checksum:iEDD8BCB88E02B9A4
    GO

    Sequence cautioni

    The sequence CAA58041.1 differs from that shown. Reason: Frameshift at position 2153.
    The sequence BAD92930.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti188 – 1881R → K in AAC51791. (PubMed:8537393)Curated
    Sequence conflicti220 – 2201Y → H in AAC51791. (PubMed:8537393)Curated
    Sequence conflicti276 – 2761T → A in AAC51791. (PubMed:8537393)Curated
    Sequence conflicti584 – 5841K → E in AAC51791. (PubMed:8537393)Curated
    Sequence conflicti628 – 6281T → A in AAC51791. (PubMed:8537393)Curated
    Sequence conflicti630 – 6301K → E in AAC51791. (PubMed:8537393)Curated
    Sequence conflicti682 – 6821K → N in AAC51791. (PubMed:8537393)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1028 – 10281Q → K.
    Corresponds to variant rs11718848 [ dbSNP | Ensembl ].
    VAR_033975
    Natural varianti1552 – 15521N → S.
    Corresponds to variant rs9840779 [ dbSNP | Ensembl ].
    VAR_033976
    Natural varianti2058 – 20581R → S.
    Corresponds to variant rs11924014 [ dbSNP | Ensembl ].
    VAR_049258

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei54 – 541E → ENASTHASKSPDSVNGSEPS IPQ in isoform 5. 1 PublicationVSP_044819
    Alternative sequencei2103 – 21097Missing in isoform 3 and isoform 5. 1 PublicationVSP_004274
    Alternative sequencei2222 – 22309FTSPRSGIF → SWLRSSS in isoform 4 and isoform 5. 1 PublicationVSP_004275

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41740 mRNA. Translation: AAC50434.1.
    X82834 mRNA. Translation: CAA58041.1. Frameshift.
    AC097359 Genomic DNA. No translation available.
    AB209693 mRNA. Translation: BAD92930.1. Different initiation.
    U31906 mRNA. Translation: AAC51791.1.
    X76942 mRNA. Translation: CAA54261.1.
    CCDSiCCDS2666.1. [Q13439-1]
    CCDS54564.1. [Q13439-5]
    RefSeqiNP_001166184.1. NM_001172713.1. [Q13439-5]
    NP_002069.2. NM_002078.4. [Q13439-1]
    UniGeneiHs.344151.

    Genome annotation databases

    EnsembliENST00000356847; ENSP00000349305; ENSG00000144674. [Q13439-5]
    ENST00000361924; ENSP00000354486; ENSG00000144674. [Q13439-1]
    GeneIDi2803.
    KEGGihsa:2803.
    UCSCiuc003cgv.3. human. [Q13439-1]
    uc003cgx.3. human. [Q13439-4]

    Polymorphism databases

    DMDMi12643718.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41740 mRNA. Translation: AAC50434.1 .
    X82834 mRNA. Translation: CAA58041.1 . Frameshift.
    AC097359 Genomic DNA. No translation available.
    AB209693 mRNA. Translation: BAD92930.1 . Different initiation.
    U31906 mRNA. Translation: AAC51791.1 .
    X76942 mRNA. Translation: CAA54261.1 .
    CCDSi CCDS2666.1. [Q13439-1 ]
    CCDS54564.1. [Q13439-5 ]
    RefSeqi NP_001166184.1. NM_001172713.1. [Q13439-5 ]
    NP_002069.2. NM_002078.4. [Q13439-1 ]
    UniGenei Hs.344151.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1R4A X-ray 2.30 E/F/G/H 2172-2222 [» ]
    1UPT X-ray 1.70 B/D/F/H 2170-2228 [» ]
    ProteinModelPortali Q13439.
    SMRi Q13439. Positions 2172-2222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109065. 9 interactions.
    IntActi Q13439. 8 interactions.
    MINTi MINT-3027757.
    STRINGi 9606.ENSP00000354486.

    PTM databases

    PhosphoSitei Q13439.

    Polymorphism databases

    DMDMi 12643718.

    Proteomic databases

    MaxQBi Q13439.
    PaxDbi Q13439.
    PRIDEi Q13439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356847 ; ENSP00000349305 ; ENSG00000144674 . [Q13439-5 ]
    ENST00000361924 ; ENSP00000354486 ; ENSG00000144674 . [Q13439-1 ]
    GeneIDi 2803.
    KEGGi hsa:2803.
    UCSCi uc003cgv.3. human. [Q13439-1 ]
    uc003cgx.3. human. [Q13439-4 ]

    Organism-specific databases

    CTDi 2803.
    GeneCardsi GC03P037284.
    HGNCi HGNC:4427. GOLGA4.
    HPAi HPA035102.
    HPA040675.
    MIMi 602509. gene.
    neXtProti NX_Q13439.
    PharmGKBi PA28808.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000112753.
    HOVERGENi HBG051754.
    InParanoidi Q13439.
    OMAi NEEYVES.
    OrthoDBi EOG72C4ZF.
    PhylomeDBi Q13439.
    TreeFami TF325082.

    Miscellaneous databases

    ChiTaRSi GOLGA4. human.
    EvolutionaryTracei Q13439.
    GeneWikii GOLGA4.
    GenomeRNAii 2803.
    NextBioi 11049.
    PROi Q13439.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13439.
    Bgeei Q13439.
    CleanExi HS_GOLGA4.
    Genevestigatori Q13439.

    Family and domain databases

    Gene3Di 1.10.220.60. 1 hit.
    InterProi IPR000237. GRIP.
    [Graphical view ]
    Pfami PF01465. GRIP. 1 hit.
    [Graphical view ]
    SMARTi SM00755. Grip. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101283. SSF101283. 1 hit.
    PROSITEi PS50913. GRIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif."
      Erlich R., Gleeson P.A., Campbell P., Dietzsch E., Toh B.-H.
      J. Biol. Chem. 271:8328-8337(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
    2. Seelig H.P.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1279 (ISOFORM 5).
      Tissue: Brain.
    5. "Molecular characterization of golgin-245, a novel Golgi complex protein containing a granin signature."
      Fritzler M.J., Lung C.-C., Hamel J.C., Griffith K.J., Chan E.K.L.
      J. Biol. Chem. 270:31262-31268(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-2230.
      Tissue: Placenta.
    6. Balague C.
      Thesis (1994), Instituto municipal de investigacion medica, Spain
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 524-672.
      Tissue: Gastric fundus.
    7. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."
      Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., Kahn R.A.
      J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARL1 AND ARL3, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177.
    8. "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery."
      Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H.
      Exp. Cell Res. 298:388-398(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MACF1.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89; SER-266 AND THR-2223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-78 AND SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus."
      Panic B., Perisic O., Veprintsev D.B., Williams R.L., Munro S.
      Mol. Cell 12:863-874(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2170-2221 IN COMPLEX WITH ARL1.
    16. "Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1."
      Wu M., Lu L., Hong W., Song H.
      Nat. Struct. Mol. Biol. 11:86-94(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2172-2222 IN COMPLEX WITH ARL1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177; VAL-2181; PHE-2183; MET-2186; THR-2193; MET-2194; VAL-2197; ILE-2198; LEU-2202; PHE-2204 AND ILE-2212, SUBUNIT.

    Entry informationi

    Entry nameiGOGA4_HUMAN
    AccessioniPrimary (citable) accession number: Q13439
    Secondary accession number(s): F8W8Q7
    , Q13270, Q13654, Q14436, Q59EW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3