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Protein

Golgin subfamily A member 4

Gene

GOLGA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.1 Publication

GO - Molecular functioni

  • GTPase binding Source: UniProtKB

GO - Biological processi

  • Golgi to plasma membrane protein transport Source: UniProtKB
  • positive regulation of axon extension Source: UniProtKB
  • protein targeting to Golgi Source: InterPro
  • vesicle-mediated transport Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 4
Alternative name(s):
256 kDa golgin
Golgin-245
Protein 72.1
Trans-Golgi p230
Gene namesi
Name:GOLGA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4427. GOLGA4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: HPA
  • nucleoplasm Source: HPA
  • trans-Golgi network Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2177 – 21771Y → A: Loss of Golgi membrane localization. Loss of ARL1-binding. 2 Publications
Mutagenesisi2177 – 21771Y → F: No effect. 2 Publications
Mutagenesisi2181 – 21811V → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2183 – 21831F → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2186 – 21861M → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2193 – 21931T → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2194 – 21941M → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2197 – 21971V → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2198 – 21981I → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2202 – 22021L → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2204 – 22041F → A: Abolishes Golgi localization. 1 Publication
Mutagenesisi2212 – 22121I → A: Abolishes Golgi localization. 1 Publication

Organism-specific databases

PharmGKBiPA28808.

Polymorphism and mutation databases

BioMutaiGOLGA4.
DMDMi12643718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22302230Golgin subfamily A member 4PRO_0000190059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei71 – 711Phosphoserine3 Publications
Modified residuei78 – 781Phosphoserine1 Publication
Modified residuei89 – 891Phosphoserine1 Publication
Modified residuei266 – 2661Phosphoserine5 Publications
Glycosylationi585 – 5851N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi1612 – 16121N-linked (GlcNAc...)PROSITE-ProRule annotation
Modified residuei2223 – 22231Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ13439.
PaxDbiQ13439.
PRIDEiQ13439.

PTM databases

PhosphoSiteiQ13439.

Expressioni

Gene expression databases

BgeeiQ13439.
CleanExiHS_GOLGA4.
ExpressionAtlasiQ13439. baseline and differential.
GenevestigatoriQ13439.

Organism-specific databases

HPAiHPA035102.
HPA040675.

Interactioni

Subunit structurei

Homodimer. Interacts with GTP bound ARL1. Interacts with MACF1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD27Q96NW42EBI-1037845,EBI-6125599

Protein-protein interaction databases

BioGridi109065. 14 interactions.
IntActiQ13439. 8 interactions.
MINTiMINT-3027757.
STRINGi9606.ENSP00000354486.

Structurei

Secondary structure

1
2230
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2173 – 218614Combined sources
Helixi2191 – 220111Combined sources
Helixi2206 – 222520Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R4AX-ray2.30E/F/G/H2172-2222[»]
1UPTX-ray1.70B/D/F/H2170-2228[»]
ProteinModelPortaliQ13439.
SMRiQ13439. Positions 2172-2222.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13439.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2168 – 221548GRIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 20371Interaction with MACF1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili133 – 21852053Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi252 – 20961845Glu-richAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111139.
HOGENOMiHOG000112753.
HOVERGENiHBG051754.
InParanoidiQ13439.
OMAiSTKFSEW.
OrthoDBiEOG72C4ZF.
PhylomeDBiQ13439.
TreeFamiTF325082.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
SUPFAMiSSF101283. SSF101283. 1 hit.
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q13439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT
60 70 80 90 100
PNRESGDTQS FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE
110 120 130 140 150
SLNRLDLDSS TASFDPPSDM DSEAEDLVGN SDSLNKEQLI QRLRRMERSL
160 170 180 190 200
SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ SQDKSLRRIA ELREELQMDQ
210 220 230 240 250
QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM NVDVLKPLPQ
260 270 280 290 300
LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE
310 320 330 340 350
TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD
360 370 380 390 400
AKNLIEQLEQ DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE
410 420 430 440 450
LREQKEKSER AAFEELEKAL STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE
460 470 480 490 500
ERISLQQELS RVKQEVVDVM KKSSEEQIAK LQKLHEKELA RKEQELTKKL
510 520 530 540 550
QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL ELQKKAILTE
560 570 580 590 600
SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK
610 620 630 640 650
HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE
660 670 680 690 700
QEKETLLKDK EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR
710 720 730 740 750
HKLEEELSVL KDQTDKMKQE LEAKMDEQKN HHQQQVDSII KEHEVSIQRT
760 770 780 790 800
EKALKDQINQ LELLLKERDK HLKEHQAHVE NLEADIKRSE GELQQASAKL
810 820 830 840 850
DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK QVAEVEAQKK
860 870 880 890 900
DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE
910 920 930 940 950
QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK
960 970 980 990 1000
NQEKKMEKVK QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN
1010 1020 1030 1040 1050
AKMLEMAQAN SAGISDAVSR LETNQKEQIE SLTEVHRREL NDVISIWEKK
1060 1070 1080 1090 1100
LNQQAEELQE IHEIQLQEKE QEVAELKQKI LLFGCEKEEM NKEITWLKEE
1110 1120 1130 1140 1150
GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE VDLNKSLKEN
1160 1170 1180 1190 1200
TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE
1210 1220 1230 1240 1250
DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI
1260 1270 1280 1290 1300
SHCQHRTTKV KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE
1310 1320 1330 1340 1350
EKENQIKSMK ADIESLVTEK EALQKEGGNQ QQAASEKESC ITQLKKELSE
1360 1370 1380 1390 1400
NINAVTLMKE ELKEKKVEIS SLSKQLTDLN VQLQNSISLS EKEAAISSLR
1410 1420 1430 1440 1450
KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN KFSEWKKKAQ
1460 1470 1480 1490 1500
SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG
1510 1520 1530 1540 1550
EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN
1560 1570 1580 1590 1600
YNQQKDIEHK ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE
1610 1620 1630 1640 1650
LETKKKELEH VNLSVKSKEE ELKALEDRLE SESAAKLAEL KRKAEQKIAA
1660 1670 1680 1690 1700
IKKQLLSQME EKEEQYKKGT ESHLSELNTK LQEREREVHI LEEKLKSVES
1710 1720 1730 1740 1750
SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV LQRNLTEKEK
1760 1770 1780 1790 1800
LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE
1810 1820 1830 1840 1850
LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ
1860 1870 1880 1890 1900
ILEQKIKELD SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL
1910 1920 1930 1940 1950
EENTEEKSKS HLVQPKLLSN MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ
1960 1970 1980 1990 2000
KDLRMLRKEH QQELEILKKE YDQEREEKIK QEQEDLELKH NSTLKQLMRE
2010 2020 2030 2040 2050
FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ LLKKIAEKDD
2060 2070 2080 2090 2100
DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN
2110 2120 2130 2140 2150
DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT
2160 2170 2180 2190 2200
TVGTPYKGGN LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT
2210 2220 2230
VLKFPDDQTQ KILEREDARL MFTSPRSGIF
Length:2,230
Mass (Da):261,140
Last modified:November 1, 1996 - v1
Checksum:i3BB733DB1EA86134
GO
Isoform 3 (identifier: Q13439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2103-2109: Missing.

Show »
Length:2,223
Mass (Da):260,325
Checksum:iB401B4C93E612E70
GO
Isoform 4 (identifier: Q13439-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2222-2230: FTSPRSGIF → SWLRSSS

Show »
Length:2,228
Mass (Da):260,951
Checksum:i9E1B1F1B13A6A218
GO
Isoform 5 (identifier: Q13439-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: E → ENASTHASKSPDSVNGSEPSIPQ
     2103-2109: Missing.
     2222-2230: FTSPRSGIF → SWLRSSS

Note: No experimental confirmation available.

Show »
Length:2,243
Mass (Da):262,328
Checksum:iEDD8BCB88E02B9A4
GO

Sequence cautioni

The sequence BAD92930.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA58041.1 differs from that shown. Reason: Frameshift at position 2153. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881R → K in AAC51791 (PubMed:8537393).Curated
Sequence conflicti220 – 2201Y → H in AAC51791 (PubMed:8537393).Curated
Sequence conflicti276 – 2761T → A in AAC51791 (PubMed:8537393).Curated
Sequence conflicti584 – 5841K → E in AAC51791 (PubMed:8537393).Curated
Sequence conflicti628 – 6281T → A in AAC51791 (PubMed:8537393).Curated
Sequence conflicti630 – 6301K → E in AAC51791 (PubMed:8537393).Curated
Sequence conflicti682 – 6821K → N in AAC51791 (PubMed:8537393).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1028 – 10281Q → K.
Corresponds to variant rs11718848 [ dbSNP | Ensembl ].
VAR_033975
Natural varianti1552 – 15521N → S.
Corresponds to variant rs9840779 [ dbSNP | Ensembl ].
VAR_033976
Natural varianti2058 – 20581R → S.
Corresponds to variant rs11924014 [ dbSNP | Ensembl ].
VAR_049258

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 541E → ENASTHASKSPDSVNGSEPS IPQ in isoform 5. 1 PublicationVSP_044819
Alternative sequencei2103 – 21097Missing in isoform 3 and isoform 5. 1 PublicationVSP_004274
Alternative sequencei2222 – 22309FTSPRSGIF → SWLRSSS in isoform 4 and isoform 5. 1 PublicationVSP_004275

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41740 mRNA. Translation: AAC50434.1.
X82834 mRNA. Translation: CAA58041.1. Frameshift.
AC097359 Genomic DNA. No translation available.
AB209693 mRNA. Translation: BAD92930.1. Different initiation.
U31906 mRNA. Translation: AAC51791.1.
X76942 mRNA. Translation: CAA54261.1.
CCDSiCCDS2666.1. [Q13439-1]
CCDS54564.1. [Q13439-5]
RefSeqiNP_001166184.1. NM_001172713.1. [Q13439-5]
NP_002069.2. NM_002078.4. [Q13439-1]
UniGeneiHs.344151.

Genome annotation databases

EnsembliENST00000356847; ENSP00000349305; ENSG00000144674. [Q13439-5]
ENST00000361924; ENSP00000354486; ENSG00000144674. [Q13439-1]
GeneIDi2803.
KEGGihsa:2803.
UCSCiuc003cgv.3. human. [Q13439-1]
uc003cgx.3. human. [Q13439-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41740 mRNA. Translation: AAC50434.1.
X82834 mRNA. Translation: CAA58041.1. Frameshift.
AC097359 Genomic DNA. No translation available.
AB209693 mRNA. Translation: BAD92930.1. Different initiation.
U31906 mRNA. Translation: AAC51791.1.
X76942 mRNA. Translation: CAA54261.1.
CCDSiCCDS2666.1. [Q13439-1]
CCDS54564.1. [Q13439-5]
RefSeqiNP_001166184.1. NM_001172713.1. [Q13439-5]
NP_002069.2. NM_002078.4. [Q13439-1]
UniGeneiHs.344151.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R4AX-ray2.30E/F/G/H2172-2222[»]
1UPTX-ray1.70B/D/F/H2170-2228[»]
ProteinModelPortaliQ13439.
SMRiQ13439. Positions 2172-2222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109065. 14 interactions.
IntActiQ13439. 8 interactions.
MINTiMINT-3027757.
STRINGi9606.ENSP00000354486.

PTM databases

PhosphoSiteiQ13439.

Polymorphism and mutation databases

BioMutaiGOLGA4.
DMDMi12643718.

Proteomic databases

MaxQBiQ13439.
PaxDbiQ13439.
PRIDEiQ13439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356847; ENSP00000349305; ENSG00000144674. [Q13439-5]
ENST00000361924; ENSP00000354486; ENSG00000144674. [Q13439-1]
GeneIDi2803.
KEGGihsa:2803.
UCSCiuc003cgv.3. human. [Q13439-1]
uc003cgx.3. human. [Q13439-4]

Organism-specific databases

CTDi2803.
GeneCardsiGC03P037284.
HGNCiHGNC:4427. GOLGA4.
HPAiHPA035102.
HPA040675.
MIMi602509. gene.
neXtProtiNX_Q13439.
PharmGKBiPA28808.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111139.
HOGENOMiHOG000112753.
HOVERGENiHBG051754.
InParanoidiQ13439.
OMAiSTKFSEW.
OrthoDBiEOG72C4ZF.
PhylomeDBiQ13439.
TreeFamiTF325082.

Miscellaneous databases

ChiTaRSiGOLGA4. human.
EvolutionaryTraceiQ13439.
GeneWikiiGOLGA4.
GenomeRNAii2803.
NextBioi11049.
PROiQ13439.
SOURCEiSearch...

Gene expression databases

BgeeiQ13439.
CleanExiHS_GOLGA4.
ExpressionAtlasiQ13439. baseline and differential.
GenevestigatoriQ13439.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
SUPFAMiSSF101283. SSF101283. 1 hit.
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of trans-Golgi p230: a human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif."
    Erlich R., Gleeson P.A., Campbell P., Dietzsch E., Toh B.-H.
    J. Biol. Chem. 271:8328-8337(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING.
  2. Seelig H.P.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1279 (ISOFORM 5).
    Tissue: Brain.
  5. "Molecular characterization of golgin-245, a novel Golgi complex protein containing a granin signature."
    Fritzler M.J., Lung C.-C., Hamel J.C., Griffith K.J., Chan E.K.L.
    J. Biol. Chem. 270:31262-31268(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 131-2230.
    Tissue: Placenta.
  6. Balague C.
    Thesis (1994), Instituto municipal de investigacion medica, Spain
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 524-672.
    Tissue: Gastric fundus.
  7. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."
    Van Valkenburgh H., Shern J.F., Sharer J.D., Zhu X., Kahn R.A.
    J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL1 AND ARL3, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177.
  8. "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery."
    Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H.
    Exp. Cell Res. 298:388-398(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MACF1.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-89; SER-266 AND THR-2223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-78 AND SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71 AND SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus."
    Panic B., Perisic O., Veprintsev D.B., Williams R.L., Munro S.
    Mol. Cell 12:863-874(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2170-2221 IN COMPLEX WITH ARL1.
  17. "Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1."
    Wu M., Lu L., Hong W., Song H.
    Nat. Struct. Mol. Biol. 11:86-94(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 2172-2222 IN COMPLEX WITH ARL1, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-2177; VAL-2181; PHE-2183; MET-2186; THR-2193; MET-2194; VAL-2197; ILE-2198; LEU-2202; PHE-2204 AND ILE-2212, SUBUNIT.

Entry informationi

Entry nameiGOGA4_HUMAN
AccessioniPrimary (citable) accession number: Q13439
Secondary accession number(s): F8W8Q7
, Q13270, Q13654, Q14436, Q59EW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 27, 2015
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.