Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Golgin subfamily A member 4

Gene

GOLGA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).2 Publications

Miscellaneous

Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

GO - Molecular functioni

  • GTPase binding Source: UniProtKB

GO - Biological processi

  • Golgi to plasma membrane protein transport Source: UniProtKB
  • positive regulation of axon extension Source: UniProtKB
  • vesicle-mediated transport Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 4
Alternative name(s):
256 kDa golgin
Golgin-245
Protein 72.1
Trans-Golgi p230
Gene namesi
Name:GOLGA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144674.16
HGNCiHGNC:4427 GOLGA4
MIMi602509 gene
neXtProtiNX_Q13439

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2F → A: Loss of TBC1D23-binding. 1 Publication1
Mutagenesisi2177Y → A: Loss of localization at the Golgi apparatus. Loss of ARL1-binding. 4 Publications1
Mutagenesisi2177Y → F: No effect on localization at the Golgi apparatus. 2 Publications1
Mutagenesisi2181V → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2183F → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2185Y → A: Loss of localization at the Golgi apparatus. 1 Publication1
Mutagenesisi2186M → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2193T → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2194M → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2197V → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2198I → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2202L → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2204F → A: Abolishes Golgi localization. 1 Publication1
Mutagenesisi2212I → A: Abolishes Golgi localization. 1 Publication1

Organism-specific databases

DisGeNETi2803
OpenTargetsiENSG00000144674
PharmGKBiPA28808

Polymorphism and mutation databases

BioMutaiGOLGA4
DMDMi12643718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900591 – 2230Golgin subfamily A member 4Add BLAST2230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei41PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Glycosylationi585N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1612N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Modified residuei2223PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ13439
MaxQBiQ13439
PaxDbiQ13439
PeptideAtlasiQ13439
PRIDEiQ13439
ProteomicsDBi59436
59437 [Q13439-3]
59438 [Q13439-4]

PTM databases

GlyConnecti690
iPTMnetiQ13439
PhosphoSitePlusiQ13439
UniCarbKBiQ13439

Expressioni

Gene expression databases

BgeeiENSG00000144674
CleanExiHS_GOLGA4
ExpressionAtlasiQ13439 baseline and differential
GenevisibleiQ13439 HS

Organism-specific databases

HPAiHPA035102

Interactioni

Subunit structurei

Homodimer (PubMed:14718928). Interacts with RAB6A (PubMed:10209123). Interacts with Interacts with GTP-bound ARL1 and ARL3 (PubMed:11303027, PubMed:14580338, PubMed:14718928). Interacts with MACF1 (PubMed:15265687). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may mediated by TBC1D23 (PubMed:29084197).6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD27Q96NW42EBI-1037845,EBI-6125599

GO - Molecular functioni

  • GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109065, 36 interactors
IntActiQ13439, 23 interactors
MINTiQ13439
STRINGi9606.ENSP00000349305

Structurei

Secondary structure

12230
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2173 – 2186Combined sources14
Helixi2191 – 2201Combined sources11
Helixi2206 – 2221Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R4AX-ray2.30E/F/G/H2172-2222[»]
1UPTX-ray1.70B/D/F/H2170-2228[»]
ProteinModelPortaliQ13439
SMRiQ13439
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13439

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2168 – 2215GRIPPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 203Interaction with MACF11 PublicationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili133 – 2185Sequence analysisAdd BLAST2053

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi252 – 2096Glu-richAdd BLAST1845

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEA5 Eukaryota
ENOG410XQQG LUCA
GeneTreeiENSGT00730000111139
HOGENOMiHOG000112753
HOVERGENiHBG051754
InParanoidiQ13439
KOiK20283
OMAiKQRLRNG
OrthoDBiEOG091G009M
PhylomeDBiQ13439
TreeFamiTF325082

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q13439-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFKKLKQKIS EEQQQLQQAL APAQASSNSS TPTRMRSRTS SFTEQLDEGT
60 70 80 90 100
PNRESGDTQS FAQKLQLRVP SVESLFRSPI KESLFRSSSK ESLVRTSSRE
110 120 130 140 150
SLNRLDLDSS TASFDPPSDM DSEAEDLVGN SDSLNKEQLI QRLRRMERSL
160 170 180 190 200
SSYRGKYSEL VTAYQMLQRE KKKLQGILSQ SQDKSLRRIA ELREELQMDQ
210 220 230 240 250
QAKKHLQEEF DASLEEKDQY ISVLQTQVSL LKQRLRNGPM NVDVLKPLPQ
260 270 280 290 300
LEPQAEVFTK EENPESDGEP VVEDGTSVKT LETLQQRVKR QENLLKRCKE
310 320 330 340 350
TIQSHKEQCT LLTSEKEALQ EQLDERLQEL EKIKDLHMAE KTKLITQLRD
360 370 380 390 400
AKNLIEQLEQ DKGMVIAETK RQMHETLEMK EEEIAQLRSR IKQMTTQGEE
410 420 430 440 450
LREQKEKSER AAFEELEKAL STAQKTEEAR RKLKAEMDEQ IKTIEKTSEE
460 470 480 490 500
ERISLQQELS RVKQEVVDVM KKSSEEQIAK LQKLHEKELA RKEQELTKKL
510 520 530 540 550
QTREREFQEQ MKVALEKSQS EYLKISQEKE QQESLALEEL ELQKKAILTE
560 570 580 590 600
SENKLRDLQQ EAETYRTRIL ELESSLEKSL QENKNQSKDL AVHLEAEKNK
610 620 630 640 650
HNKEITVMVE KHKTELESLK HQQDALWTEK LQVLKQQYQT EMEKLREKCE
660 670 680 690 700
QEKETLLKDK EIIFQAHIEE MNEKTLEKLD VKQTELESLS SELSEVLKAR
710 720 730 740 750
HKLEEELSVL KDQTDKMKQE LEAKMDEQKN HHQQQVDSII KEHEVSIQRT
760 770 780 790 800
EKALKDQINQ LELLLKERDK HLKEHQAHVE NLEADIKRSE GELQQASAKL
810 820 830 840 850
DVFQSYQSAT HEQTKAYEEQ LAQLQQKLLD LETERILLTK QVAEVEAQKK
860 870 880 890 900
DVCTELDAHK IQVQDLMQQL EKQNSEMEQK VKSLTQVYES KLEDGNKEQE
910 920 930 940 950
QTKQILVEKE NMILQMREGQ KKEIEILTQK LSAKEDSIHI LNEEYETKFK
960 970 980 990 1000
NQEKKMEKVK QKAKEMQETL KKKLLDQEAK LKKELENTAL ELSQKEKQFN
1010 1020 1030 1040 1050
AKMLEMAQAN SAGISDAVSR LETNQKEQIE SLTEVHRREL NDVISIWEKK
1060 1070 1080 1090 1100
LNQQAEELQE IHEIQLQEKE QEVAELKQKI LLFGCEKEEM NKEITWLKEE
1110 1120 1130 1140 1150
GVKQDTTLNE LQEQLKQKSA HVNSLAQDET KLKAHLEKLE VDLNKSLKEN
1160 1170 1180 1190 1200
TFLQEQLVEL KMLAEEDKRK VSELTSKLKT TDEEFQSLKS SHEKSNKSLE
1210 1220 1230 1240 1250
DKSLEFKKLS EELAIQLDIC CKKTEALLEA KTNELINISS SKTNAILSRI
1260 1270 1280 1290 1300
SHCQHRTTKV KEALLIKTCT VSELEAQLRQ LTEEQNTLNI SFQQATHQLE
1310 1320 1330 1340 1350
EKENQIKSMK ADIESLVTEK EALQKEGGNQ QQAASEKESC ITQLKKELSE
1360 1370 1380 1390 1400
NINAVTLMKE ELKEKKVEIS SLSKQLTDLN VQLQNSISLS EKEAAISSLR
1410 1420 1430 1440 1450
KQYDEEKCEL LDQVQDLSFK VDTLSKEKIS ALEQVDDWSN KFSEWKKKAQ
1460 1470 1480 1490 1500
SRFTQHQNTV KELQIQLELK SKEAYEKDEQ INLLKEELDQ QNKRFDCLKG
1510 1520 1530 1540 1550
EMEDDKSKME KKESNLETEL KSQTARIMEL EDHITQKTIE IESLNEVLKN
1560 1570 1580 1590 1600
YNQQKDIEHK ELVQKLQHFQ ELGEEKDNRV KEAEEKILTL ENQVYSMKAE
1610 1620 1630 1640 1650
LETKKKELEH VNLSVKSKEE ELKALEDRLE SESAAKLAEL KRKAEQKIAA
1660 1670 1680 1690 1700
IKKQLLSQME EKEEQYKKGT ESHLSELNTK LQEREREVHI LEEKLKSVES
1710 1720 1730 1740 1750
SQSETLIVPR SAKNVAAYTE QEEADSQGCV QKTYEEKISV LQRNLTEKEK
1760 1770 1780 1790 1800
LLQRVGQEKE ETVSSHFEMR CQYQERLIKL EHAEAKQHED QSMIGHLQEE
1810 1820 1830 1840 1850
LEEKNKKYSL IVAQHVEKEG GKNNIQAKQN LENVFDDVQK TLQEKELTCQ
1860 1870 1880 1890 1900
ILEQKIKELD SCLVRQKEVH RVEMEELTSK YEKLQALQQM DGRNKPTELL
1910 1920 1930 1940 1950
EENTEEKSKS HLVQPKLLSN MEAQHNDLEF KLAGAEREKQ KLGKEIVRLQ
1960 1970 1980 1990 2000
KDLRMLRKEH QQELEILKKE YDQEREEKIK QEQEDLELKH NSTLKQLMRE
2010 2020 2030 2040 2050
FNTQLAQKEQ ELEMTIKETI NKAQEVEAEL LESHQEETNQ LLKKIAEKDD
2060 2070 2080 2090 2100
DLKRTAKRYE EILDAREEEM TAKVRDLQTQ LEELQKKYQQ KLEQEENPGN
2110 2120 2130 2140 2150
DNVTIMELQT QLAQKTTLIS DSKLKEQEFR EQIHNLEDRL KKYEKNVYAT
2160 2170 2180 2190 2200
TVGTPYKGGN LYHTDVSLFG EPTEFEYLRK VLFEYMMGRE TKTMAKVITT
2210 2220 2230
VLKFPDDQTQ KILEREDARL MFTSPRSGIF
Length:2,230
Mass (Da):261,140
Last modified:November 1, 1996 - v1
Checksum:i3BB733DB1EA86134
GO
Isoform 3 (identifier: Q13439-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2103-2109: Missing.

Show »
Length:2,223
Mass (Da):260,325
Checksum:iB401B4C93E612E70
GO
Isoform 4 (identifier: Q13439-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2222-2230: FTSPRSGIF → SWLRSSS

Show »
Length:2,228
Mass (Da):260,951
Checksum:i9E1B1F1B13A6A218
GO
Isoform 5 (identifier: Q13439-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: E → ENASTHASKSPDSVNGSEPSIPQ
     2103-2109: Missing.
     2222-2230: FTSPRSGIF → SWLRSSS

Note: No experimental confirmation available.
Show »
Length:2,243
Mass (Da):262,328
Checksum:iEDD8BCB88E02B9A4
GO

Sequence cautioni

The sequence BAD92930 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA58041 differs from that shown. Reason: Frameshift at position 2153.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188R → K in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti220Y → H in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti276T → A in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti584K → E in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti628T → A in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti630K → E in AAC51791 (PubMed:8537393).Curated1
Sequence conflicti682K → N in AAC51791 (PubMed:8537393).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0339751028Q → K. Corresponds to variant dbSNP:rs11718848Ensembl.1
Natural variantiVAR_0339761552N → S. Corresponds to variant dbSNP:rs9840779Ensembl.1
Natural variantiVAR_0492582058R → S. Corresponds to variant dbSNP:rs11924014Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04481954E → ENASTHASKSPDSVNGSEPS IPQ in isoform 5. 1 Publication1
Alternative sequenceiVSP_0042742103 – 2109Missing in isoform 3 and isoform 5. 1 Publication7
Alternative sequenceiVSP_0042752222 – 2230FTSPRSGIF → SWLRSSS in isoform 4 and isoform 5. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41740 mRNA Translation: AAC50434.1
X82834 mRNA Translation: CAA58041.1 Frameshift.
AC097359 Genomic DNA No translation available.
AB209693 mRNA Translation: BAD92930.1 Different initiation.
U31906 mRNA Translation: AAC51791.1
X76942 mRNA Translation: CAA54261.1
CCDSiCCDS2666.1 [Q13439-1]
CCDS54564.1 [Q13439-5]
RefSeqiNP_001166184.1, NM_001172713.1 [Q13439-5]
NP_002069.2, NM_002078.4 [Q13439-1]
UniGeneiHs.344151

Genome annotation databases

EnsembliENST00000356847; ENSP00000349305; ENSG00000144674 [Q13439-5]
ENST00000361924; ENSP00000354486; ENSG00000144674 [Q13439-1]
GeneIDi2803
KEGGihsa:2803
UCSCiuc003cgv.4 human [Q13439-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGOGA4_HUMAN
AccessioniPrimary (citable) accession number: Q13439
Secondary accession number(s): F8W8Q7
, Q13270, Q13654, Q14436, Q59EW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health