Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein OS-9

Gene

OS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130Carbohydrate1
Binding sitei182Carbohydrate1
Binding sitei188Carbohydrate1
Binding sitei212Carbohydrate1
Binding sitei218Carbohydrate1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • glycoprotein binding Source: UniProtKB

GO - Biological processi

  • endoplasmic reticulum mannose trimming Source: Reactome
  • ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • negative regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
  • protein retention in ER lumen Source: UniProtKB
  • protein targeting Source: Ensembl
  • protein ubiquitination Source: UniProtKB
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  • response to endoplasmic reticulum stress Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135506-MONOMER.
ReactomeiR-HSA-382556. ABC-family proteins mediated transport.
R-HSA-5358346. Hedgehog ligand biogenesis.
R-HSA-5362768. Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.
R-HSA-5678895. Defective CFTR causes cystic fibrosis.
R-HSA-901032. ER Quality Control Compartment (ERQC).

Protein family/group databases

TCDBi8.A.67.1.1. the os-9 quality control (erad) protein (os-9) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9
Alternative name(s):
Amplified in osteosarcoma 9
Gene namesi
Name:OS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16994. OS9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi188R → A: Loss of glycan-binding activity and partial inhibition of ERAD of the misfolded glycoprotein NHK (PubMed:19346256). Reduced interaction with SEL1L (PubMed:18264092) not confirmed in (PubMed:19346256). 3 Publications1

Organism-specific databases

DisGeNETi10956.
OpenTargetsiENSG00000135506.
PharmGKBiPA164724245.

Polymorphism and mutation databases

BioMutaiOS9.
DMDMi3024310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000002195126 – 667Protein OS-9Add BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 123
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi181 ↔ 216
Disulfide bondi196 ↔ 228

Post-translational modificationi

Intramolecular disulfide bonds.
Isoform 1 and isoform 2 are N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13438.
MaxQBiQ13438.
PaxDbiQ13438.
PeptideAtlasiQ13438.
PRIDEiQ13438.

PTM databases

iPTMnetiQ13438.
PhosphoSitePlusiQ13438.

Expressioni

Tissue specificityi

Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.

Inductioni

Up-regulated in response to endoplasmic reticulum stress (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000135506.
ExpressionAtlasiQ13438. baseline and differential.
GenevisibleiQ13438. HS.

Organism-specific databases

HPAiCAB011518.
HPA013694.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro (By similarity). Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly (PubMed:18502753, PubMed:18264092, PubMed:19084021). Through this complex it may interact with ERLEC1 and HSPA5 (PubMed:18502753). Interacts with DERL2 (PubMed:19084021). Interacts with HSP90B1 (PubMed:18264092). Interacts with CREB3 (PubMed:20546900). Interacts with SYVN1 (PubMed:18264092).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EGLN1Q9GZT94EBI-725454,EBI-1174818
EGLN3Q9H6Z92EBI-725454,EBI-1175354
HIF1AQ166659EBI-725454,EBI-447269

Protein-protein interaction databases

BioGridi116156. 110 interactors.
DIPiDIP-37493N.
IntActiQ13438. 30 interactors.
MINTiMINT-1187753.
STRINGi9606.ENSP00000318165.

Structurei

Secondary structure

1667
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi111 – 115Combined sources5
Beta strandi118 – 123Combined sources6
Turni124 – 126Combined sources3
Beta strandi127 – 131Combined sources5
Beta strandi143 – 155Combined sources13
Beta strandi169 – 176Combined sources8
Turni182 – 184Combined sources3
Beta strandi189 – 196Combined sources8
Beta strandi206 – 214Combined sources9
Beta strandi217 – 224Combined sources8
Helixi225 – 227Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AIHX-ray2.10A/B108-229[»]
ProteinModelPortaliQ13438.
SMRiQ13438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13438.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 178PRKCSHAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi414 – 429Asp/Glu-rich (acidic)Add BLAST16

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3394. Eukaryota.
ENOG410XR8A. LUCA.
GeneTreeiENSGT00530000063603.
HOGENOMiHOG000293348.
HOVERGENiHBG000974.
InParanoidiQ13438.
KOiK10088.
OMAiSKESDFW.
OrthoDBiEOG091G02WQ.
PhylomeDBiQ13438.
TreeFamiTF314309.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.

Sequences (8)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13438-1) [UniParc]FASTAAdd to basket
Also known as: OS-9-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAETLLSSL LGLLLLGLLL PASLTGGVGS LNLEELSEMR YGIEILPLPV
60 70 80 90 100
MGGQSQSSDV VIVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE
110 120 130 140 150
LLSPMRDAPC LLKTKDWWTY EFCYGRHIQQ YHMEDSEIKG EVLYLGYYQS
160 170 180 190 200
AFDWDDETAK ASKQHRLKRY HSQTYGNGSK CDLNGRPREA EVRFLCDEGA
210 220 230 240 250
GISGDYIDRV DEPLSCSYVL TIRTPRLCPH PLLRPPPSAA PQAILCHPSL
260 270 280 290 300
QPEEYMAYVQ RQADSKQYGD KIIEELQDLG PQVWSETKSG VAPQKMAGAS
310 320 330 340 350
PTKDDSKDSD FWKMLNEPED QAPGGEEVPA EEQDPSPEAA DSASGAPNDF
360 370 380 390 400
QNNVQVKVIR SPADLIRFIE ELKGGTKKGK PNIGQEQPVD DAAEVPQREP
410 420 430 440 450
EKERGDPERQ REMEEEEDED EDEDEDEDER QLLGEFEKEL EGILLPSDRD
460 470 480 490 500
RLRSEVKAGM ERELENIIQE TEKELDPDGL KKESERDRAM LALTSTLNKL
510 520 530 540 550
IKRLEEKQSP ELVKKHKKKR VVPKKPPPSP QPTEEDPEHR VRVRVTKLRL
560 570 580 590 600
GGPNQDLTVL EMKRENPQLK QIEGLVKELL EREGLTAAGK IEIKIVRPWA
610 620 630 640 650
EGTEEGARWL TDEDTRNLKE IFFNILVPGA EEAQKERQRQ KELESNYRRV
660
WGSPGGEGTG DLDEFDF
Note: Major isoform.
Length:667
Mass (Da):75,562
Last modified:November 1, 1996 - v1
Checksum:i65BA3F66CEC58756
GO
Isoform 2 (identifier: Q13438-2) [UniParc]FASTAAdd to basket
Also known as: OS-9-2

The sequence of this isoform differs from the canonical sequence as follows:
     534-588: Missing.

Note: Major isoform.
Show »
Length:612
Mass (Da):69,246
Checksum:i1FD06F7B23101015
GO
Isoform 3 (identifier: Q13438-3) [UniParc]FASTAAdd to basket
Also known as: OS-9-3

The sequence of this isoform differs from the canonical sequence as follows:
     456-470: Missing.
     534-588: Missing.

Show »
Length:597
Mass (Da):67,505
Checksum:i7D00C1EA449B3DA1
GO
Isoform 4 (identifier: Q13438-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-470: Missing.

Note: No experimental confirmation available.
Show »
Length:652
Mass (Da):73,821
Checksum:i7D44F2347B609055
GO
Isoform 5 (identifier: Q13438-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-193: Missing.
     263-263: A → AV
     534-588: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):65,520
Checksum:iBE4EEA80CF8EA076
GO
Isoform 6 (identifier: Q13438-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-193: Missing.
     534-588: Missing.

Note: No experimental confirmation available.
Show »
Length:560
Mass (Da):63,155
Checksum:iEBF3F8A812BDAF60
GO
Isoform 7 (identifier: Q13438-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-263: A → AV
     534-588: Missing.

Note: Gene prediction based on EST data.
Show »
Length:613
Mass (Da):69,346
Checksum:i353DE17278AB9546
GO
Isoform 8 (identifier: Q13438-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-113: Missing.
     456-470: Missing.
     534-588: Missing.

Note: No experimental confirmation available.
Show »
Length:538
Mass (Da):60,847
Checksum:i30188F4A2A67AD8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7L → V in CAG33072 (Ref. 5) Curated1
Sequence conflicti194F → V in BAG64798 (PubMed:14702039).Curated1
Sequence conflicti371E → G in BAG56939 (PubMed:14702039).Curated1
Sequence conflicti497L → F in BAG64798 (PubMed:14702039).Curated1
Sequence conflicti522V → I in BAG60733 (PubMed:14702039).Curated1
Sequence conflicti653S → P in BAG56939 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069062305D → N.1 PublicationCorresponds to variant rs141986192dbSNPEnsembl.1
Natural variantiVAR_011897398R → W.Corresponds to variant rs1804598dbSNPEnsembl.1
Natural variantiVAR_034364454S → L.Corresponds to variant rs34764811dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04677055 – 113Missing in isoform 8. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_046001142 – 193Missing in isoform 6. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_044701161 – 193Missing in isoform 5. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_044702263A → AV in isoform 5 and isoform 7. 1 Publication1
Alternative sequenceiVSP_004352456 – 470Missing in isoform 3, isoform 4 and isoform 8. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_004353534 – 588Missing in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8. 3 PublicationsAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41635 mRNA. Translation: AAB06495.1.
AB002805 Genomic DNA. Translation: BAA24362.1.
AB002806 mRNA. Translation: BAA24363.1.
AK291374 mRNA. Translation: BAF84063.1.
AK293435 mRNA. Translation: BAG56939.1.
AK296770 mRNA. Translation: BAG59349.1.
AK298532 mRNA. Translation: BAG60733.1.
AK303858 mRNA. Translation: BAG64798.1.
CR456791 mRNA. Translation: CAG33072.1.
AC025165 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97045.1.
CH471054 Genomic DNA. Translation: EAW97046.1.
CH471054 Genomic DNA. Translation: EAW97047.1.
BC000532 mRNA. Translation: AAH00532.1.
BC007254 mRNA. Translation: AAH07254.1.
BC023513 mRNA. Translation: AAH23513.2.
U81031 Genomic DNA. Translation: AAC39523.2.
CCDSiCCDS31843.1. [Q13438-1]
CCDS31844.1. [Q13438-2]
CCDS31845.1. [Q13438-4]
CCDS31846.1. [Q13438-3]
CCDS58246.1. [Q13438-6]
CCDS58247.1. [Q13438-7]
CCDS58248.1. [Q13438-5]
CCDS58249.1. [Q13438-8]
PIRiJC5889.
RefSeqiNP_001017956.1. NM_001017956.2. [Q13438-2]
NP_001017957.1. NM_001017957.2. [Q13438-3]
NP_001017958.1. NM_001017958.2. [Q13438-4]
NP_001248349.1. NM_001261420.1. [Q13438-7]
NP_001248350.1. NM_001261421.1. [Q13438-5]
NP_001248351.1. NM_001261422.1. [Q13438-6]
NP_001248352.1. NM_001261423.1. [Q13438-8]
NP_006803.1. NM_006812.3. [Q13438-1]
UniGeneiHs.527861.

Genome annotation databases

EnsembliENST00000257966; ENSP00000257966; ENSG00000135506. [Q13438-7]
ENST00000315970; ENSP00000318165; ENSG00000135506. [Q13438-1]
ENST00000389142; ENSP00000373794; ENSG00000135506. [Q13438-3]
ENST00000389146; ENSP00000373798; ENSG00000135506. [Q13438-4]
ENST00000435406; ENSP00000389632; ENSG00000135506. [Q13438-6]
ENST00000439210; ENSP00000407360; ENSG00000135506. [Q13438-8]
ENST00000551035; ENSP00000447866; ENSG00000135506. [Q13438-5]
ENST00000552285; ENSP00000450010; ENSG00000135506. [Q13438-2]
GeneIDi10956.
KEGGihsa:10956.
UCSCiuc001spj.4. human. [Q13438-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41635 mRNA. Translation: AAB06495.1.
AB002805 Genomic DNA. Translation: BAA24362.1.
AB002806 mRNA. Translation: BAA24363.1.
AK291374 mRNA. Translation: BAF84063.1.
AK293435 mRNA. Translation: BAG56939.1.
AK296770 mRNA. Translation: BAG59349.1.
AK298532 mRNA. Translation: BAG60733.1.
AK303858 mRNA. Translation: BAG64798.1.
CR456791 mRNA. Translation: CAG33072.1.
AC025165 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97045.1.
CH471054 Genomic DNA. Translation: EAW97046.1.
CH471054 Genomic DNA. Translation: EAW97047.1.
BC000532 mRNA. Translation: AAH00532.1.
BC007254 mRNA. Translation: AAH07254.1.
BC023513 mRNA. Translation: AAH23513.2.
U81031 Genomic DNA. Translation: AAC39523.2.
CCDSiCCDS31843.1. [Q13438-1]
CCDS31844.1. [Q13438-2]
CCDS31845.1. [Q13438-4]
CCDS31846.1. [Q13438-3]
CCDS58246.1. [Q13438-6]
CCDS58247.1. [Q13438-7]
CCDS58248.1. [Q13438-5]
CCDS58249.1. [Q13438-8]
PIRiJC5889.
RefSeqiNP_001017956.1. NM_001017956.2. [Q13438-2]
NP_001017957.1. NM_001017957.2. [Q13438-3]
NP_001017958.1. NM_001017958.2. [Q13438-4]
NP_001248349.1. NM_001261420.1. [Q13438-7]
NP_001248350.1. NM_001261421.1. [Q13438-5]
NP_001248351.1. NM_001261422.1. [Q13438-6]
NP_001248352.1. NM_001261423.1. [Q13438-8]
NP_006803.1. NM_006812.3. [Q13438-1]
UniGeneiHs.527861.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AIHX-ray2.10A/B108-229[»]
ProteinModelPortaliQ13438.
SMRiQ13438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116156. 110 interactors.
DIPiDIP-37493N.
IntActiQ13438. 30 interactors.
MINTiMINT-1187753.
STRINGi9606.ENSP00000318165.

Protein family/group databases

TCDBi8.A.67.1.1. the os-9 quality control (erad) protein (os-9) family.

PTM databases

iPTMnetiQ13438.
PhosphoSitePlusiQ13438.

Polymorphism and mutation databases

BioMutaiOS9.
DMDMi3024310.

Proteomic databases

EPDiQ13438.
MaxQBiQ13438.
PaxDbiQ13438.
PeptideAtlasiQ13438.
PRIDEiQ13438.

Protocols and materials databases

DNASUi10956.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257966; ENSP00000257966; ENSG00000135506. [Q13438-7]
ENST00000315970; ENSP00000318165; ENSG00000135506. [Q13438-1]
ENST00000389142; ENSP00000373794; ENSG00000135506. [Q13438-3]
ENST00000389146; ENSP00000373798; ENSG00000135506. [Q13438-4]
ENST00000435406; ENSP00000389632; ENSG00000135506. [Q13438-6]
ENST00000439210; ENSP00000407360; ENSG00000135506. [Q13438-8]
ENST00000551035; ENSP00000447866; ENSG00000135506. [Q13438-5]
ENST00000552285; ENSP00000450010; ENSG00000135506. [Q13438-2]
GeneIDi10956.
KEGGihsa:10956.
UCSCiuc001spj.4. human. [Q13438-1]

Organism-specific databases

CTDi10956.
DisGeNETi10956.
GeneCardsiOS9.
HGNCiHGNC:16994. OS9.
HPAiCAB011518.
HPA013694.
MIMi609677. gene.
neXtProtiNX_Q13438.
OpenTargetsiENSG00000135506.
PharmGKBiPA164724245.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3394. Eukaryota.
ENOG410XR8A. LUCA.
GeneTreeiENSGT00530000063603.
HOGENOMiHOG000293348.
HOVERGENiHBG000974.
InParanoidiQ13438.
KOiK10088.
OMAiSKESDFW.
OrthoDBiEOG091G02WQ.
PhylomeDBiQ13438.
TreeFamiTF314309.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135506-MONOMER.
ReactomeiR-HSA-382556. ABC-family proteins mediated transport.
R-HSA-5358346. Hedgehog ligand biogenesis.
R-HSA-5362768. Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.
R-HSA-5678895. Defective CFTR causes cystic fibrosis.
R-HSA-901032. ER Quality Control Compartment (ERQC).

Miscellaneous databases

ChiTaRSiOS9. human.
EvolutionaryTraceiQ13438.
GeneWikiiOS9_(gene).
GenomeRNAii10956.
PROiQ13438.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135506.
ExpressionAtlasiQ13438. baseline and differential.
GenevisibleiQ13438. HS.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOS9_HUMAN
AccessioniPrimary (citable) accession number: Q13438
Secondary accession number(s): A6NDD1
, A6NFR7, A6NLB2, A8K5Q9, B4DE28, B4DPX1, B4E1I6, E7ENT8, E7EW91, F8VUH2, G3XA88, O00579, Q6IBL2, Q8IZ58, Q9BW99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.