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Protein

Zinc transporter ZIP6

Gene

SLC39A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  • cellular zinc ion homeostasis Source: BHF-UCL
  • zinc II ion transmembrane import Source: BHF-UCL
  • zinc II ion transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141424-MONOMER.
ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP6
Alternative name(s):
Estrogen-regulated protein LIV-1
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name:
ZIP-6
Gene namesi
Name:SLC39A6
Synonyms:LIV1, ZIP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:18607. SLC39A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 325ExtracellularSequence analysisAdd BLAST297
Transmembranei326 – 346Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini347 – 355CytoplasmicSequence analysis9
Transmembranei356 – 376Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini377 – 423ExtracellularSequence analysisAdd BLAST47
Transmembranei424 – 444Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini445 – 657CytoplasmicSequence analysisAdd BLAST213
Transmembranei658 – 678Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini679 – 686ExtracellularSequence analysis8
Transmembranei687 – 707Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini708 – 724CytoplasmicSequence analysisAdd BLAST17
Transmembranei725 – 745Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini746 – 755ExtracellularSequence analysis10

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • endoplasmic reticulum Source: Ensembl
  • integral component of plasma membrane Source: BHF-UCL
  • lamellipodium membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25800.
OpenTargetsiENSG00000141424.
PharmGKBiPA134905551.

Polymorphism and mutation databases

BioMutaiSLC39A6.
DMDMi292495066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000004165029 – 755Zinc transporter ZIP6Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...)1 Publication1
Glycosylationi68N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi241N-linked (GlcNAc...)1 Publication1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Modified residuei471PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ13433.
MaxQBiQ13433.
PaxDbiQ13433.
PeptideAtlasiQ13433.
PRIDEiQ13433.

PTM databases

iPTMnetiQ13433.
PhosphoSitePlusiQ13433.
SwissPalmiQ13433.

Expressioni

Tissue specificityi

Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.1 Publication

Inductioni

Up-regulated by estrogen in breast cancer cells lines.1 Publication

Gene expression databases

BgeeiENSG00000141424.
CleanExiHS_SLC39A6.
ExpressionAtlasiQ13433. baseline and differential.
GenevisibleiQ13433. HS.

Organism-specific databases

HPAiHPA042377.

Interactioni

Protein-protein interaction databases

BioGridi117332. 14 interactors.
IntActiQ13433. 4 interactors.
STRINGi9606.ENSP00000269187.

Structurei

3D structure databases

ProteinModelPortaliQ13433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili464 – 480Sequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi91 – 134His-richAdd BLAST44
Compositional biasi376 – 391His-richAdd BLAST16
Compositional biasi448 – 453Poly-Lys6
Compositional biasi513 – 516Poly-Glu4
Compositional biasi541 – 578His-richAdd BLAST38

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ13433.
KOiK14712.
OMAiHRPEHAS.
OrthoDBiEOG091G02WM.
PhylomeDBiQ13433.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13433-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI
60 70 80 90 100
STRQYHLQQL FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS
110 120 130 140 150
DHEHHSDHER HSDHEHHSEH EHHSDHDHHS HHNHAASGKN KRKALCPDHD
160 170 180 190 200
SDSSGKDPRN SQGKGAHRPE HASGRRNVKD SVSASEVTST VYNTVSEGTH
210 220 230 240 250
FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT NESVSEPRKG
260 270 280 290 300
FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA
310 320 330 340 350
RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN
360 370 380 390 400
RVFFKFLLSF LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR
410 420 430 440 450
GPLFSHLSSQ NIEESAYFDS TWKGLTALGG LYFMFLVEHV LTLIKQFKDK
460 470 480 490 500
KKKNQKKPEN DDDVEIKKQL SKYESQLSTN EEKVDTDDRT EGYLRADSQE
510 520 530 540 550
PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC HSHFHDTLGQ
560 570 580 590 600
SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI
610 620 630 640 650
MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA
660 670 680 690 700
GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV
710 720 730 740 750
ALVDMVPEML HNDASDHGCS RWGYFFLQNA GMLLGFGIML LISIFEHKIV

FRINF
Length:755
Mass (Da):85,047
Last modified:March 23, 2010 - v3
Checksum:i8BC1D02CA116DD25
GO
Isoform 2 (identifier: Q13433-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     707-708: PE → SF
     709-755: Missing.

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):48,605
Checksum:i72B8B90BD0A1867B
GO

Sequence cautioni

The sequence BAG61161 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127 – 132Missing in AAA96258 (Ref. 1) Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059964119E → D.3 PublicationsCorresponds to variant rs1789528dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0143091 – 275Missing in isoform 2. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_014310707 – 708PE → SF in isoform 2. 1 Publication2
Alternative sequenceiVSP_014311709 – 755Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41060 mRNA. Translation: AAA96258.2.
AK299102 mRNA. Translation: BAG61161.1. Different initiation.
AK304079 mRNA. Translation: BAG64986.1.
AC091060 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01372.1.
BC008317 mRNA. Translation: AAH08317.2.
BC039498 mRNA. Translation: AAH39498.1.
CCDSiCCDS42428.1. [Q13433-1]
CCDS45854.1. [Q13433-2]
PIRiG02273.
RefSeqiNP_001092876.1. NM_001099406.1. [Q13433-2]
NP_036451.3. NM_012319.3.
XP_011524202.1. XM_011525900.1. [Q13433-1]
XP_011524203.1. XM_011525901.1. [Q13433-1]
UniGeneiHs.79136.

Genome annotation databases

EnsembliENST00000269187; ENSP00000269187; ENSG00000141424. [Q13433-1]
ENST00000440549; ENSP00000401139; ENSG00000141424. [Q13433-2]
ENST00000590986; ENSP00000465915; ENSG00000141424. [Q13433-1]
GeneIDi25800.
KEGGihsa:25800.
UCSCiuc002kzj.3. human. [Q13433-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41060 mRNA. Translation: AAA96258.2.
AK299102 mRNA. Translation: BAG61161.1. Different initiation.
AK304079 mRNA. Translation: BAG64986.1.
AC091060 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01372.1.
BC008317 mRNA. Translation: AAH08317.2.
BC039498 mRNA. Translation: AAH39498.1.
CCDSiCCDS42428.1. [Q13433-1]
CCDS45854.1. [Q13433-2]
PIRiG02273.
RefSeqiNP_001092876.1. NM_001099406.1. [Q13433-2]
NP_036451.3. NM_012319.3.
XP_011524202.1. XM_011525900.1. [Q13433-1]
XP_011524203.1. XM_011525901.1. [Q13433-1]
UniGeneiHs.79136.

3D structure databases

ProteinModelPortaliQ13433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117332. 14 interactors.
IntActiQ13433. 4 interactors.
STRINGi9606.ENSP00000269187.

Protein family/group databases

TCDBi2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiQ13433.
PhosphoSitePlusiQ13433.
SwissPalmiQ13433.

Polymorphism and mutation databases

BioMutaiSLC39A6.
DMDMi292495066.

Proteomic databases

EPDiQ13433.
MaxQBiQ13433.
PaxDbiQ13433.
PeptideAtlasiQ13433.
PRIDEiQ13433.

Protocols and materials databases

DNASUi25800.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269187; ENSP00000269187; ENSG00000141424. [Q13433-1]
ENST00000440549; ENSP00000401139; ENSG00000141424. [Q13433-2]
ENST00000590986; ENSP00000465915; ENSG00000141424. [Q13433-1]
GeneIDi25800.
KEGGihsa:25800.
UCSCiuc002kzj.3. human. [Q13433-1]

Organism-specific databases

CTDi25800.
DisGeNETi25800.
GeneCardsiSLC39A6.
HGNCiHGNC:18607. SLC39A6.
HPAiHPA042377.
MIMi608731. gene.
neXtProtiNX_Q13433.
OpenTargetsiENSG00000141424.
PharmGKBiPA134905551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ13433.
KOiK14712.
OMAiHRPEHAS.
OrthoDBiEOG091G02WM.
PhylomeDBiQ13433.
TreeFamiTF318470.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141424-MONOMER.
ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSiSLC39A6. human.
GeneWikiiSLC39A6.
GenomeRNAii25800.
PROiQ13433.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141424.
CleanExiHS_SLC39A6.
ExpressionAtlasiQ13433. baseline and differential.
GenevisibleiQ13433. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A6_HUMAN
AccessioniPrimary (citable) accession number: Q13433
Secondary accession number(s): B4DR49
, B4E224, Q8IXR3, Q96HP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.