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Reviewed, UniProtKB/Swiss-Prot Q13433 (S39A6_HUMAN)

Last modified June 16, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc transporter ZIP6
Alternative name(s):
    Zrt- and Irt-like protein 6
      Short name=ZIP-6
    Solute carrier family 39 member 6
    Estrogen-regulated protein LIV-1
Gene names
Name: SLC39A6
Synonyms: LIV1, ZIP6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length749 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May act as a zinc-influx transporter. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein. Ref.5

Tissue specificity

Highly expressed in the breast, protate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. Ref.5

Induction

Up-regulated by estrogen in breast cancer cells lines. Ref.4

Post-translational modification

N-glycosylated. Ref.5

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

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Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Signal
Transmembrane
   LigandZinc
   PTMGlycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processzinc ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13433-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13433-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.
     701-702: PE → SF
     703-749: Missing.
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.3
Chain29 – 749721Zinc transporter ZIP6
PRO_0000041650

Regions

Topological domain29 – 319291Extracellular Potential
Transmembrane320 – 340211 Potential
Topological domain341 – 3499Cytoplasmic Potential
Transmembrane350 – 370212 Potential
Topological domain371 – 41747Extracellular Potential
Transmembrane418 – 438213 Potential
Topological domain439 – 651213Cytoplasmic Potential
Transmembrane652 – 672214 Potential
Topological domain673 – 6808Extracellular Potential
Transmembrane681 – 701215 Potential
Topological domain702 – 71817Cytoplasmic Potential
Transmembrane719 – 739216 Potential
Topological domain740 – 74910Extracellular Potential
Coiled coil458 – 48023 Potential
Compositional bias91 – 12838His-rich
Compositional bias370 – 38516His-rich
Compositional bias442 – 4476Poly-Lys
Compositional bias507 – 5104Poly-Glu
Compositional bias535 – 57238His-rich

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation2771N-linked (GlcNAc...) Potential
Glycosylation6781N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 269269Missing in isoform 2.
VSP_014309
Alternative sequence701 – 7022PE → SF in isoform 2.
VSP_014310
Alternative sequence703 – 74947Missing in isoform 2.
VSP_014311

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 6B48D4E620733F95

FASTA74984,282
        10         20         30         40         50         60 
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL 

        70         80         90        100        110        120 
FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSDH 

       130        140        150        160        170        180 
EHHSDHNHAA SGKNKRKALC PDHDSDSSGK DPRNSQGKGA HRPEHASGRR NVKDSVSASE 

       190        200        210        220        230        240 
VTSTVYNTVS EGTHFLETIE TPRPGKLFPK DVSSSTPPSV TSKSRVSRLA GRKTNESVSE 

       250        260        270        280        290        300 
PRKGFMYSRN TNENPQECFN ASKLLTSHGM GIQVPLNATE FNYLCPAIIN QIDARSCLIH 

       310        320        330        340        350        360 
TSEKKAEIPP KTYSLQIAWV GGFIAISIIS FLSLLGVILV PLMNRVFFKF LLSFLVALAV 

       370        380        390        400        410        420 
GTLSGDAFLH LLPHSHASHH HSHSHEEPAM EMKRGPLFSH LSSQNIEESA YFDSTWKGLT 

       430        440        450        460        470        480 
ALGGLYFMFL VEHVLTLIKQ FKDKKKKNQK KPENDDDVEI KKQLSKYESQ LSTNEEKVDT 

       490        500        510        520        530        540 
DDRTEGYLRA DSQEPSHFDS QQPAVLEEEE VMIAHAHPQE VYNEYVPRGC KNKCHSHFHD 

       550        560        570        580        590        600 
TLGQSDDLIH HHHDYHHILH HHHHQNHHPH SHSQRYSREE LKDAGVATLA WMVIMGDGLH 

       610        620        630        640        650        660 
NFSDGLAIGA AFTEGLSSGL STSVAVFCHE LPHELGDFAV LLKAGMTVKQ AVLYNALSAM 

       670        680        690        700        710        720 
LAYLGMATGI FIGHYAENVS MWIFALTAGL FMYVALVDMV PEMLHNDASD HGCSRWGYFF 

       730        740 
LQNAGMLLGF GIMLLISIFE HKIVFRINF

« Hide

Isoform 2.

Checksum: 72B8B90BD0A1867B
Show »

FASTA43348,605

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References

« Hide 'large scale' references
[1]Green C., Morgan H.E.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-749 (ISOFORM 1).
Tissue: Eye and Lymph.
[3]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-43.
[4]"Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line."
Manning D.L., Daly R.J., Lord P.G., Kelly K.F., Green C.D.
Mol. Cell. Endocrinol. 59:205-212(1988) [PubMed: 2903103] [Abstract]
Cited for: INDUCTION.
[5]"Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters."
Taylor K.M., Morgan H.E., Johnson A., Hadley L.J., Nicholson R.I.
Biochem. J. 375:51-59(2003) [PubMed: 12839489] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U41060 mRNA. Translation: AAA96258.2.
BC008317 mRNA. Translation: AAH08317.2.
BC039498 mRNA. Translation: AAH39498.1.
IPIIPI00298702.
IPI00607564.
PIRG02273.
RefSeqNP_001092876.1.
UniGeneHs.79136

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ13433.

Genome annotation databases

EnsemblENSG00000141424. Homo sapiens. [Contig view]
GeneID25800.
KEGGhsa:25800.

Organism-specific databases

GeneCardsGC18M031943.
H-InvDBHIX0014405.
HGNCHGNC:18607. SLC39A6.
MIM608731. gene.
PharmGKBPA134905551.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ13433.
HOVERGENQ13433.

Gene expression databases

ArrayExpressQ13433.
BgeeQ13433.
CleanExHS_SLC39A6.
GermOnlineENSG00000141424. Homo sapiens.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio46997.
SOURCESearch...

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Entry information

Entry nameS39A6_HUMAN
AccessionPrimary (citable) accession number: Q13433
Secondary accession number(s): Q8IXR3, Q96HP5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: June 16, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents