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Q13433

- S39A6_HUMAN

UniProt

Q13433 - S39A6_HUMAN

Protein

Zinc transporter ZIP6

Gene

SLC39A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    May act as a zinc-influx transporter.1 Publication

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: BHF-UCL

    GO - Biological processi

    1. cellular zinc ion homeostasis Source: BHF-UCL
    2. transmembrane transport Source: Reactome
    3. zinc ion transmembrane import Source: BHF-UCL
    4. zinc ion transmembrane transport Source: UniProtKB

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

    Protein family/group databases

    TCDBi2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP6
    Alternative name(s):
    Estrogen-regulated protein LIV-1
    Solute carrier family 39 member 6
    Zrt- and Irt-like protein 6
    Short name:
    ZIP-6
    Gene namesi
    Name:SLC39A6
    Synonyms:LIV1, ZIP6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:18607. SLC39A6.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of plasma membrane Source: BHF-UCL
    3. lamellipodium membrane Source: UniProtKB
    4. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134905551.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 755727Zinc transporter ZIP6PRO_0000041650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)2 Publications
    Glycosylationi68 – 681N-linked (GlcNAc...); atypical2 Publications
    Glycosylationi241 – 2411N-linked (GlcNAc...)2 Publications
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ13433.
    PaxDbiQ13433.
    PRIDEiQ13433.

    PTM databases

    PhosphoSiteiQ13433.

    Expressioni

    Tissue specificityi

    Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.1 Publication

    Inductioni

    Up-regulated by estrogen in breast cancer cells lines.1 Publication

    Gene expression databases

    ArrayExpressiQ13433.
    BgeeiQ13433.
    CleanExiHS_SLC39A6.
    GenevestigatoriQ13433.

    Organism-specific databases

    HPAiHPA042377.

    Interactioni

    Protein-protein interaction databases

    BioGridi117332. 6 interactions.
    STRINGi9606.ENSP00000269187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13433.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 325297ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini347 – 3559CytoplasmicSequence Analysis
    Topological domaini377 – 42347ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini445 – 657213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini679 – 6868ExtracellularSequence Analysis
    Topological domaini708 – 72417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini746 – 75510ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei326 – 34621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei658 – 67821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei687 – 70721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei725 – 74521Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili464 – 48017Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi91 – 13444His-richAdd
    BLAST
    Compositional biasi376 – 39116His-richAdd
    BLAST
    Compositional biasi448 – 4536Poly-Lys
    Compositional biasi513 – 5164Poly-Glu
    Compositional biasi541 – 57838His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    HOGENOMiHOG000013093.
    HOVERGENiHBG055748.
    InParanoidiQ13433.
    KOiK14712.
    OMAiFNYLCPA.
    OrthoDBiEOG7H791W.
    PhylomeDBiQ13433.
    TreeFamiTF318470.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13433-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI    50
    STRQYHLQQL FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS 100
    DHEHHSDHER HSDHEHHSEH EHHSDHDHHS HHNHAASGKN KRKALCPDHD 150
    SDSSGKDPRN SQGKGAHRPE HASGRRNVKD SVSASEVTST VYNTVSEGTH 200
    FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT NESVSEPRKG 250
    FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA 300
    RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN 350
    RVFFKFLLSF LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR 400
    GPLFSHLSSQ NIEESAYFDS TWKGLTALGG LYFMFLVEHV LTLIKQFKDK 450
    KKKNQKKPEN DDDVEIKKQL SKYESQLSTN EEKVDTDDRT EGYLRADSQE 500
    PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC HSHFHDTLGQ 550
    SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI 600
    MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA 650
    GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV 700
    ALVDMVPEML HNDASDHGCS RWGYFFLQNA GMLLGFGIML LISIFEHKIV 750
    FRINF 755
    Length:755
    Mass (Da):85,047
    Last modified:March 23, 2010 - v3
    Checksum:i8BC1D02CA116DD25
    GO
    Isoform 2 (identifier: Q13433-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-275: Missing.
         707-708: PE → SF
         709-755: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:433
    Mass (Da):48,605
    Checksum:i72B8B90BD0A1867B
    GO

    Sequence cautioni

    The sequence BAG61161.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1326Missing in AAA96258. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191E → D.3 Publications
    Corresponds to variant rs1789528 [ dbSNP | Ensembl ].
    VAR_059964

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 275275Missing in isoform 2. 1 PublicationVSP_014309Add
    BLAST
    Alternative sequencei707 – 7082PE → SF in isoform 2. 1 PublicationVSP_014310
    Alternative sequencei709 – 75547Missing in isoform 2. 1 PublicationVSP_014311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41060 mRNA. Translation: AAA96258.2.
    AK299102 mRNA. Translation: BAG61161.1. Different initiation.
    AK304079 mRNA. Translation: BAG64986.1.
    AC091060 Genomic DNA. No translation available.
    CH471088 Genomic DNA. Translation: EAX01372.1.
    BC008317 mRNA. Translation: AAH08317.2.
    BC039498 mRNA. Translation: AAH39498.1.
    CCDSiCCDS42428.1. [Q13433-1]
    CCDS45854.1. [Q13433-2]
    PIRiG02273.
    RefSeqiNP_001092876.1. NM_001099406.1. [Q13433-2]
    NP_036451.3. NM_012319.3.
    UniGeneiHs.79136.

    Genome annotation databases

    EnsembliENST00000269187; ENSP00000269187; ENSG00000141424. [Q13433-1]
    ENST00000440549; ENSP00000401139; ENSG00000141424. [Q13433-2]
    ENST00000590986; ENSP00000465915; ENSG00000141424. [Q13433-1]
    GeneIDi25800.
    KEGGihsa:25800.
    UCSCiuc002kzj.2. human. [Q13433-2]
    uc010dmy.3. human. [Q13433-1]

    Polymorphism databases

    DMDMi292495066.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41060 mRNA. Translation: AAA96258.2 .
    AK299102 mRNA. Translation: BAG61161.1 . Different initiation.
    AK304079 mRNA. Translation: BAG64986.1 .
    AC091060 Genomic DNA. No translation available.
    CH471088 Genomic DNA. Translation: EAX01372.1 .
    BC008317 mRNA. Translation: AAH08317.2 .
    BC039498 mRNA. Translation: AAH39498.1 .
    CCDSi CCDS42428.1. [Q13433-1 ]
    CCDS45854.1. [Q13433-2 ]
    PIRi G02273.
    RefSeqi NP_001092876.1. NM_001099406.1. [Q13433-2 ]
    NP_036451.3. NM_012319.3.
    UniGenei Hs.79136.

    3D structure databases

    ProteinModelPortali Q13433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117332. 6 interactions.
    STRINGi 9606.ENSP00000269187.

    Protein family/group databases

    TCDBi 2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    PTM databases

    PhosphoSitei Q13433.

    Polymorphism databases

    DMDMi 292495066.

    Proteomic databases

    MaxQBi Q13433.
    PaxDbi Q13433.
    PRIDEi Q13433.

    Protocols and materials databases

    DNASUi 25800.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269187 ; ENSP00000269187 ; ENSG00000141424 . [Q13433-1 ]
    ENST00000440549 ; ENSP00000401139 ; ENSG00000141424 . [Q13433-2 ]
    ENST00000590986 ; ENSP00000465915 ; ENSG00000141424 . [Q13433-1 ]
    GeneIDi 25800.
    KEGGi hsa:25800.
    UCSCi uc002kzj.2. human. [Q13433-2 ]
    uc010dmy.3. human. [Q13433-1 ]

    Organism-specific databases

    CTDi 25800.
    GeneCardsi GC18M033688.
    HGNCi HGNC:18607. SLC39A6.
    HPAi HPA042377.
    MIMi 608731. gene.
    neXtProti NX_Q13433.
    PharmGKBi PA134905551.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0428.
    HOGENOMi HOG000013093.
    HOVERGENi HBG055748.
    InParanoidi Q13433.
    KOi K14712.
    OMAi FNYLCPA.
    OrthoDBi EOG7H791W.
    PhylomeDBi Q13433.
    TreeFami TF318470.

    Enzyme and pathway databases

    Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A6. human.
    GeneWikii SLC39A6.
    GenomeRNAii 25800.
    NextBioi 46997.
    PROi Q13433.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13433.
    Bgeei Q13433.
    CleanExi HS_SLC39A6.
    Genevestigatori Q13433.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Green C., Morgan H.E.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-119.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-119.
      Tissue: Teratocarcinoma and Trachea.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-119.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-755 (ISOFORM 1).
      Tissue: Eye and Lymph.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-43.
    7. "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line."
      Manning D.L., Daly R.J., Lord P.G., Kelly K.F., Green C.D.
      Mol. Cell. Endocrinol. 59:205-212(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    8. "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters."
      Taylor K.M., Morgan H.E., Johnson A., Hadley L.J., Nicholson R.I.
      Biochem. J. 375:51-59(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-67; ASN-68 AND ASN-241.
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiS39A6_HUMAN
    AccessioniPrimary (citable) accession number: Q13433
    Secondary accession number(s): B4DR49
    , B4E224, Q8IXR3, Q96HP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3