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Q13433

- S39A6_HUMAN

UniProt

Q13433 - S39A6_HUMAN

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Protein

Zinc transporter ZIP6

Gene

SLC39A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.1 Publication

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  1. cellular zinc ion homeostasis Source: BHF-UCL
  2. transmembrane transport Source: Reactome
  3. zinc ion transmembrane import Source: BHF-UCL
  4. zinc ion transmembrane transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP6
Alternative name(s):
Estrogen-regulated protein LIV-1
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name:
ZIP-6
Gene namesi
Name:SLC39A6
Synonyms:LIV1, ZIP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:18607. SLC39A6.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 325297ExtracellularSequence AnalysisAdd
BLAST
Transmembranei326 – 34621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini347 – 3559CytoplasmicSequence Analysis
Transmembranei356 – 37621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini377 – 42347ExtracellularSequence AnalysisAdd
BLAST
Transmembranei424 – 44421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini445 – 657213CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei658 – 67821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini679 – 6868ExtracellularSequence Analysis
Transmembranei687 – 70721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini708 – 72417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei725 – 74521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini746 – 75510ExtracellularSequence Analysis

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. endoplasmic reticulum Source: Ensembl
  3. integral component of plasma membrane Source: BHF-UCL
  4. lamellipodium membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134905551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 755727Zinc transporter ZIP6PRO_0000041650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)1 Publication
Glycosylationi68 – 681N-linked (GlcNAc...); atypical1 Publication
Glycosylationi241 – 2411N-linked (GlcNAc...)1 Publication
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ13433.
PaxDbiQ13433.
PRIDEiQ13433.

PTM databases

PhosphoSiteiQ13433.

Expressioni

Tissue specificityi

Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.1 Publication

Inductioni

Up-regulated by estrogen in breast cancer cells lines.1 Publication

Gene expression databases

BgeeiQ13433.
CleanExiHS_SLC39A6.
ExpressionAtlasiQ13433. baseline and differential.
GenevestigatoriQ13433.

Organism-specific databases

HPAiHPA042377.

Interactioni

Protein-protein interaction databases

BioGridi117332. 15 interactions.
STRINGi9606.ENSP00000269187.

Structurei

3D structure databases

ProteinModelPortaliQ13433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili464 – 48017Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi91 – 13444His-richAdd
BLAST
Compositional biasi376 – 39116His-richAdd
BLAST
Compositional biasi448 – 4536Poly-Lys
Compositional biasi513 – 5164Poly-Glu
Compositional biasi541 – 57838His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ13433.
KOiK14712.
OMAiFNYLCPA.
OrthoDBiEOG7H791W.
PhylomeDBiQ13433.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13433-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI
60 70 80 90 100
STRQYHLQQL FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS
110 120 130 140 150
DHEHHSDHER HSDHEHHSEH EHHSDHDHHS HHNHAASGKN KRKALCPDHD
160 170 180 190 200
SDSSGKDPRN SQGKGAHRPE HASGRRNVKD SVSASEVTST VYNTVSEGTH
210 220 230 240 250
FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT NESVSEPRKG
260 270 280 290 300
FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA
310 320 330 340 350
RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN
360 370 380 390 400
RVFFKFLLSF LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR
410 420 430 440 450
GPLFSHLSSQ NIEESAYFDS TWKGLTALGG LYFMFLVEHV LTLIKQFKDK
460 470 480 490 500
KKKNQKKPEN DDDVEIKKQL SKYESQLSTN EEKVDTDDRT EGYLRADSQE
510 520 530 540 550
PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC HSHFHDTLGQ
560 570 580 590 600
SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI
610 620 630 640 650
MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA
660 670 680 690 700
GMTVKQAVLY NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV
710 720 730 740 750
ALVDMVPEML HNDASDHGCS RWGYFFLQNA GMLLGFGIML LISIFEHKIV

FRINF
Length:755
Mass (Da):85,047
Last modified:March 23, 2010 - v3
Checksum:i8BC1D02CA116DD25
GO
Isoform 2 (identifier: Q13433-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     707-708: PE → SF
     709-755: Missing.

Note: No experimental confirmation available.

Show »
Length:433
Mass (Da):48,605
Checksum:i72B8B90BD0A1867B
GO

Sequence cautioni

The sequence BAG61161.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1326Missing in AAA96258. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191E → D.3 Publications
Corresponds to variant rs1789528 [ dbSNP | Ensembl ].
VAR_059964

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 275275Missing in isoform 2. 1 PublicationVSP_014309Add
BLAST
Alternative sequencei707 – 7082PE → SF in isoform 2. 1 PublicationVSP_014310
Alternative sequencei709 – 75547Missing in isoform 2. 1 PublicationVSP_014311Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41060 mRNA. Translation: AAA96258.2.
AK299102 mRNA. Translation: BAG61161.1. Different initiation.
AK304079 mRNA. Translation: BAG64986.1.
AC091060 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01372.1.
BC008317 mRNA. Translation: AAH08317.2.
BC039498 mRNA. Translation: AAH39498.1.
CCDSiCCDS42428.1. [Q13433-1]
CCDS45854.1. [Q13433-2]
PIRiG02273.
RefSeqiNP_001092876.1. NM_001099406.1. [Q13433-2]
NP_036451.3. NM_012319.3.
UniGeneiHs.79136.

Genome annotation databases

EnsembliENST00000269187; ENSP00000269187; ENSG00000141424. [Q13433-1]
ENST00000440549; ENSP00000401139; ENSG00000141424. [Q13433-2]
ENST00000590986; ENSP00000465915; ENSG00000141424. [Q13433-1]
GeneIDi25800.
KEGGihsa:25800.
UCSCiuc002kzj.2. human. [Q13433-2]
uc010dmy.3. human. [Q13433-1]

Polymorphism databases

DMDMi292495066.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41060 mRNA. Translation: AAA96258.2 .
AK299102 mRNA. Translation: BAG61161.1 . Different initiation.
AK304079 mRNA. Translation: BAG64986.1 .
AC091060 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01372.1 .
BC008317 mRNA. Translation: AAH08317.2 .
BC039498 mRNA. Translation: AAH39498.1 .
CCDSi CCDS42428.1. [Q13433-1 ]
CCDS45854.1. [Q13433-2 ]
PIRi G02273.
RefSeqi NP_001092876.1. NM_001099406.1. [Q13433-2 ]
NP_036451.3. NM_012319.3.
UniGenei Hs.79136.

3D structure databases

ProteinModelPortali Q13433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117332. 15 interactions.
STRINGi 9606.ENSP00000269187.

Protein family/group databases

TCDBi 2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSitei Q13433.

Polymorphism databases

DMDMi 292495066.

Proteomic databases

MaxQBi Q13433.
PaxDbi Q13433.
PRIDEi Q13433.

Protocols and materials databases

DNASUi 25800.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269187 ; ENSP00000269187 ; ENSG00000141424 . [Q13433-1 ]
ENST00000440549 ; ENSP00000401139 ; ENSG00000141424 . [Q13433-2 ]
ENST00000590986 ; ENSP00000465915 ; ENSG00000141424 . [Q13433-1 ]
GeneIDi 25800.
KEGGi hsa:25800.
UCSCi uc002kzj.2. human. [Q13433-2 ]
uc010dmy.3. human. [Q13433-1 ]

Organism-specific databases

CTDi 25800.
GeneCardsi GC18M033688.
HGNCi HGNC:18607. SLC39A6.
HPAi HPA042377.
MIMi 608731. gene.
neXtProti NX_Q13433.
PharmGKBi PA134905551.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00760000119115.
HOGENOMi HOG000013093.
HOVERGENi HBG055748.
InParanoidi Q13433.
KOi K14712.
OMAi FNYLCPA.
OrthoDBi EOG7H791W.
PhylomeDBi Q13433.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi SLC39A6. human.
GeneWikii SLC39A6.
GenomeRNAii 25800.
NextBioi 46997.
PROi Q13433.
SOURCEi Search...

Gene expression databases

Bgeei Q13433.
CleanExi HS_SLC39A6.
ExpressionAtlasi Q13433. baseline and differential.
Genevestigatori Q13433.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Green C., Morgan H.E.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-119.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-119.
    Tissue: Teratocarcinoma and Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-119.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-755 (ISOFORM 1).
    Tissue: Eye and Lymph.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-43.
  7. "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line."
    Manning D.L., Daly R.J., Lord P.G., Kelly K.F., Green C.D.
    Mol. Cell. Endocrinol. 59:205-212(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters."
    Taylor K.M., Morgan H.E., Johnson A., Hadley L.J., Nicholson R.I.
    Biochem. J. 375:51-59(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-67; ASN-68 AND ASN-241.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiS39A6_HUMAN
AccessioniPrimary (citable) accession number: Q13433
Secondary accession number(s): B4DR49
, B4E224, Q8IXR3, Q96HP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 23, 2010
Last modified: October 29, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3