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Q13433 (S39A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP6
Alternative name(s):
Estrogen-regulated protein LIV-1
Solute carrier family 39 member 6
Zrt- and Irt-like protein 6
Short name=ZIP-6
Gene names
Name:SLC39A6
Synonyms:LIV1, ZIP6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length755 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a zinc-influx transporter. Ref.8

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.8.

Tissue specificity

Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. Ref.8

Induction

Up-regulated by estrogen in breast cancer cells lines. Ref.7

Post-translational modification

N-glycosylated. Ref.8

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Sequence caution

The sequence BAG61161.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q13433-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q13433-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-275: Missing.
     707-708: PE → SF
     709-755: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.6
Chain29 – 755727Zinc transporter ZIP6
PRO_0000041650

Regions

Topological domain29 – 325297Extracellular Potential
Transmembrane326 – 34621Helical; Name=1; Potential
Topological domain347 – 3559Cytoplasmic Potential
Transmembrane356 – 37621Helical; Name=2; Potential
Topological domain377 – 42347Extracellular Potential
Transmembrane424 – 44421Helical; Name=3; Potential
Topological domain445 – 657213Cytoplasmic Potential
Transmembrane658 – 67821Helical; Name=4; Potential
Topological domain679 – 6868Extracellular Potential
Transmembrane687 – 70721Helical; Name=5; Potential
Topological domain708 – 72417Cytoplasmic Potential
Transmembrane725 – 74521Helical; Name=6; Potential
Topological domain746 – 75510Extracellular Potential
Coiled coil464 – 48017 Potential
Compositional bias91 – 13444His-rich
Compositional bias376 – 39116His-rich
Compositional bias448 – 4536Poly-Lys
Compositional bias513 – 5164Poly-Glu
Compositional bias541 – 57838His-rich

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Ref.11
Glycosylation681N-linked (GlcNAc...); atypical Ref.11
Glycosylation2411N-linked (GlcNAc...) Ref.11
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation6841N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 275275Missing in isoform 2.
VSP_014309
Alternative sequence707 – 7082PE → SF in isoform 2.
VSP_014310
Alternative sequence709 – 75547Missing in isoform 2.
VSP_014311
Natural variant1191E → D. Ref.1 Ref.2 Ref.4
Corresponds to variant rs1789528 [ dbSNP | Ensembl ].
VAR_059964

Experimental info

Sequence conflict127 – 1326Missing in AAA96258. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 23, 2010. Version 3.
Checksum: 8BC1D02CA116DD25

FASTA75585,047
        10         20         30         40         50         60 
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI STRQYHLQQL 

        70         80         90        100        110        120 
FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHDHHS DHEHHSDHER HSDHEHHSEH 

       130        140        150        160        170        180 
EHHSDHDHHS HHNHAASGKN KRKALCPDHD SDSSGKDPRN SQGKGAHRPE HASGRRNVKD 

       190        200        210        220        230        240 
SVSASEVTST VYNTVSEGTH FLETIETPRP GKLFPKDVSS STPPSVTSKS RVSRLAGRKT 

       250        260        270        280        290        300 
NESVSEPRKG FMYSRNTNEN PQECFNASKL LTSHGMGIQV PLNATEFNYL CPAIINQIDA 

       310        320        330        340        350        360 
RSCLIHTSEK KAEIPPKTYS LQIAWVGGFI AISIISFLSL LGVILVPLMN RVFFKFLLSF 

       370        380        390        400        410        420 
LVALAVGTLS GDAFLHLLPH SHASHHHSHS HEEPAMEMKR GPLFSHLSSQ NIEESAYFDS 

       430        440        450        460        470        480 
TWKGLTALGG LYFMFLVEHV LTLIKQFKDK KKKNQKKPEN DDDVEIKKQL SKYESQLSTN 

       490        500        510        520        530        540 
EEKVDTDDRT EGYLRADSQE PSHFDSQQPA VLEEEEVMIA HAHPQEVYNE YVPRGCKNKC 

       550        560        570        580        590        600 
HSHFHDTLGQ SDDLIHHHHD YHHILHHHHH QNHHPHSHSQ RYSREELKDA GVATLAWMVI 

       610        620        630        640        650        660 
MGDGLHNFSD GLAIGAAFTE GLSSGLSTSV AVFCHELPHE LGDFAVLLKA GMTVKQAVLY 

       670        680        690        700        710        720 
NALSAMLAYL GMATGIFIGH YAENVSMWIF ALTAGLFMYV ALVDMVPEML HNDASDHGCS 

       730        740        750 
RWGYFFLQNA GMLLGFGIML LISIFEHKIV FRINF 

« Hide

Isoform 2 [UniParc].

Checksum: 72B8B90BD0A1867B
Show »

FASTA43348,605

References

« Hide 'large scale' references
[1]Green C., Morgan H.E.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-119.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-119.
Tissue: Teratocarcinoma and Trachea.
[3]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-119.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-755 (ISOFORM 1).
Tissue: Eye and Lymph.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-43.
[7]"Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line."
Manning D.L., Daly R.J., Lord P.G., Kelly K.F., Green C.D.
Mol. Cell. Endocrinol. 59:205-212(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters."
Taylor K.M., Morgan H.E., Johnson A., Hadley L.J., Nicholson R.I.
Biochem. J. 375:51-59(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-67; ASN-68 AND ASN-241.
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41060 mRNA. Translation: AAA96258.2.
AK299102 mRNA. Translation: BAG61161.1. Different initiation.
AK304079 mRNA. Translation: BAG64986.1.
AC091060 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01372.1.
BC008317 mRNA. Translation: AAH08317.2.
BC039498 mRNA. Translation: AAH39498.1.
PIRG02273.
RefSeqNP_001092876.1. NM_001099406.1.
NP_036451.3. NM_012319.3.
UniGeneHs.79136.

3D structure databases

ProteinModelPortalQ13433.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117332. 4 interactions.
STRING9606.ENSP00000269187.

Protein family/group databases

TCDB2.A.5.4.13. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSiteQ13433.

Polymorphism databases

DMDM292495066.

Proteomic databases

PaxDbQ13433.
PRIDEQ13433.

Protocols and materials databases

DNASU25800.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269187; ENSP00000269187; ENSG00000141424. [Q13433-1]
ENST00000440549; ENSP00000401139; ENSG00000141424. [Q13433-2]
ENST00000590986; ENSP00000465915; ENSG00000141424. [Q13433-1]
GeneID25800.
KEGGhsa:25800.
UCSCuc002kzj.2. human. [Q13433-2]
uc010dmy.3. human. [Q13433-1]

Organism-specific databases

CTD25800.
GeneCardsGC18M033688.
HGNCHGNC:18607. SLC39A6.
HPAHPA042377.
MIM608731. gene.
neXtProtNX_Q13433.
PharmGKBPA134905551.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0428.
HOGENOMHOG000013093.
HOVERGENHBG055748.
InParanoidQ13433.
KOK14712.
OMAFNYLCPA.
OrthoDBEOG7H791W.
PhylomeDBQ13433.
TreeFamTF318470.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ13433.
BgeeQ13433.
CleanExHS_SLC39A6.
GenevestigatorQ13433.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC39A6. human.
GeneWikiSLC39A6.
GenomeRNAi25800.
NextBio46997.
PROQ13433.
SOURCESearch...

Entry information

Entry nameS39A6_HUMAN
AccessionPrimary (citable) accession number: Q13433
Secondary accession number(s): B4DR49 expand/collapse secondary AC list , B4E224, Q8IXR3, Q96HP5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 23, 2010
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM