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Protein
Submitted name:

Insulin-like growth factor I

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of oocyte development Source: AgBase
  • positive regulation of glycoprotein biosynthetic process Source: AgBase
  • positive regulation of protein secretion Source: AgBase
  • protein stabilization Source: AgBase
  • proteoglycan biosynthetic process Source: AgBase
  • regulation of gene expression Source: AgBase

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor IImported
Gene namesi
Name:IGF1Imported
Synonyms:IGF-IImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000017427.15
HGNCiHGNC:5464 IGF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000017427
PharmGKBiPA29697

Protein family/group databases

Allergomei11751 Hom s IGF-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_501410247330 – 139Sequence analysisAdd BLAST110

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiQ13429
PRIDEiQ13429

Expressioni

Gene expression databases

BgeeiENSG00000017427
ExpressionAtlasiQ13429 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ13429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 90IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T Eukaryota
ENOG4111MIV LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137

Family and domain databases

InterProiView protein in InterPro
IPR022341 IGF-I
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02005 INSLNLIKEGF1
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Fragment.

Q13429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LKVKMHTMSS SHLFYLALCL LTFTSSATAG PETLCGAELV DALQFVCGDR
60 70 80 90 100
GFYFNKPTGY GSSSRRAPQT GIVDECCFRS CDLRRLEMYC APLKPAKSAR
110 120 130
SVRAQRHTDM PKTQKYQPPS TNKNTKSQRR KGSTFEERK
Length:139
Mass (Da):15,611
Last modified:November 1, 1996 - v1
Checksum:iA62271872CA29DE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010202 Genomic DNA No translation available.
U40870 mRNA Translation: AAA96152.1
RefSeqiNP_001104753.1, NM_001111283.2
UniGeneiHs.160562

Genome annotation databases

EnsembliENST00000392905; ENSP00000376638; ENSG00000017427
GeneIDi3479
UCSCiuc058ske.1 human

Similar proteinsi

Entry informationi

Entry nameiQ13429_HUMAN
AccessioniPrimary (citable) accession number: Q13429
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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