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Protein

Beta-2-syntrophin

Gene

SNTB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural molecule activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168807-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 2
Syntrophin-3
Short name:
SNT3
Syntrophin-like
Short name:
SNTL
Gene namesi
Name:SNTB2
Synonyms:D16S2531E, SNT2B2, SNTL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11169. SNTB2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • dystrophin-associated glycoprotein complex Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • membrane Source: ProtInc
  • microtubule Source: UniProtKB-KW
  • protein complex Source: MGI
  • transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi6645.
OpenTargetsiENSG00000168807.
PharmGKBiPA36009.

Polymorphism and mutation databases

BioMutaiSNTB2.
DMDMi23822158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840111 – 540Beta-2-syntrophinAdd BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Partially dephosphorylated upon insulin stimulation.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ13425.
MaxQBiQ13425.
PaxDbiQ13425.
PeptideAtlasiQ13425.
PRIDEiQ13425.

PTM databases

iPTMnetiQ13425.
PhosphoSitePlusiQ13425.
SwissPalmiQ13425.

Expressioni

Tissue specificityi

Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.

Gene expression databases

BgeeiENSG00000168807.
CleanExiHS_SNTB2.
ExpressionAtlasiQ13425. baseline and differential.
GenevisibleiQ13425. HS.

Organism-specific databases

HPAiHPA001394.

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN.By similarityCurated4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CASKO149362EBI-80411,EBI-1215506

Protein-protein interaction databases

BioGridi112528. 39 interactors.
IntActiQ13425. 20 interactors.
MINTiMINT-239533.
STRINGi9606.ENSP00000338191.

Structurei

Secondary structure

1540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi113 – 119Combined sources7
Beta strandi127 – 133Combined sources7
Helixi134 – 136Combined sources3
Beta strandi138 – 145Combined sources8
Helixi150 – 154Combined sources5
Beta strandi161 – 166Combined sources6
Helixi176 – 184Combined sources9
Beta strandi188 – 196Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VRFX-ray2.00A/B/C/D112-200[»]
ProteinModelPortaliQ13425.
SMRiQ13425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13425.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini115 – 198PDZPROSITE-ProRule annotationAdd BLAST84
Domaini163 – 300PH 1PROSITE-ProRule annotationAdd BLAST138
Domaini325 – 437PH 2PROSITE-ProRule annotationAdd BLAST113
Domaini484 – 540SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni518 – 540Calmodulin-bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 57Poly-Ala4
Compositional biasi66 – 69Poly-Ala4

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRK. Eukaryota.
ENOG4111J6R. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ13425.
OMAiGFTITRE.
OrthoDBiEOG091G0O31.
PhylomeDBiQ13425.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028550. SNTB2.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 2 hits.
PTHR10554:SF8. PTHR10554:SF8. 2 hits.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13425-1) [UniParc]FASTAAdd to basket
Also known as: Beta2-syntrophin58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVAAATAAA GAGPAMAVWT RATKAGLVEL LLRERWVRVV AELSGESLSL
60 70 80 90 100
TGDAAAAELE PALGPAAAAF NGLPNGGGAG DSLPGSPSRG LGPPSPPAPP
110 120 130 140 150
RGPAGEAGAS PPVRRVRVVK QEAGGLGISI KGGRENRMPI LISKIFPGLA
160 170 180 190 200
ADQSRALRLG DAILSVNGTD LRQATHDQAV QALKRAGKEV LLEVKFIREV
210 220 230 240 250
TPYIKKPSLV SDLPWEGAAP QSPSFSGSED SGSPKHQNST KDRKIIPLKM
260 270 280 290 300
CFAARNLSMP DLENRLIELH SPDSRNTLIL RCKDTATAHS WFVAIHTNIM
310 320 330 340 350
ALLPQVLAEL NAMLGATSTA GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM
360 370 380 390 400
AVTEKDLLLY DCMPWTRDAW ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL
410 420 430 440 450
TFATRTGSRQ GIEMHLFRVE THRDLSSWTR ILVQGCHAAA ELIKEVSLGC
460 470 480 490 500
MLNGQEVRLT IHYENGFTIS RENGGSSSIL YRYPFERLKM SADDGIRNLY
510 520 530 540
LDFGGPEGEL TMDLHSCPKP IVFVLHTFLS AKVTRMGLLV
Length:540
Mass (Da):57,950
Last modified:November 1, 1996 - v1
Checksum:i53A9F3340DC024ED
GO
Isoform 2 (identifier: Q13425-2) [UniParc]FASTAAdd to basket
Also known as: Beta2-syntrophin28

The sequence of this isoform differs from the canonical sequence as follows:
     266-267: LI → QN
     268-540: Missing.

Note: Lacks domains required for interaction with dystrophin related proteins. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:267
Mass (Da):27,677
Checksum:i45DF36C82C013228
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073697376S → R.1 Publication1
Natural variantiVAR_014076424D → E.Corresponds to variant rs1058482dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006358266 – 267LI → QN in isoform 2. 1 Publication2
Alternative sequenceiVSP_006359268 – 540Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40572 mRNA. Translation: AAC50449.1.
AF243385 mRNA. Translation: AAK15149.1.
BC048215 mRNA. Translation: AAH48215.1.
CCDSiCCDS10873.1. [Q13425-1]
RefSeqiNP_006741.1. NM_006750.3. [Q13425-1]
UniGeneiHs.461117.

Genome annotation databases

EnsembliENST00000336278; ENSP00000338191; ENSG00000168807. [Q13425-1]
ENST00000467311; ENSP00000436443; ENSG00000168807. [Q13425-2]
ENST00000562438; ENSP00000458999; ENSG00000260873.
GeneIDi6645.
KEGGihsa:6645.
UCSCiuc002ewu.4. human. [Q13425-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40572 mRNA. Translation: AAC50449.1.
AF243385 mRNA. Translation: AAK15149.1.
BC048215 mRNA. Translation: AAH48215.1.
CCDSiCCDS10873.1. [Q13425-1]
RefSeqiNP_006741.1. NM_006750.3. [Q13425-1]
UniGeneiHs.461117.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VRFX-ray2.00A/B/C/D112-200[»]
ProteinModelPortaliQ13425.
SMRiQ13425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112528. 39 interactors.
IntActiQ13425. 20 interactors.
MINTiMINT-239533.
STRINGi9606.ENSP00000338191.

PTM databases

iPTMnetiQ13425.
PhosphoSitePlusiQ13425.
SwissPalmiQ13425.

Polymorphism and mutation databases

BioMutaiSNTB2.
DMDMi23822158.

Proteomic databases

EPDiQ13425.
MaxQBiQ13425.
PaxDbiQ13425.
PeptideAtlasiQ13425.
PRIDEiQ13425.

Protocols and materials databases

DNASUi6645.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336278; ENSP00000338191; ENSG00000168807. [Q13425-1]
ENST00000467311; ENSP00000436443; ENSG00000168807. [Q13425-2]
ENST00000562438; ENSP00000458999; ENSG00000260873.
GeneIDi6645.
KEGGihsa:6645.
UCSCiuc002ewu.4. human. [Q13425-1]

Organism-specific databases

CTDi6645.
DisGeNETi6645.
GeneCardsiSNTB2.
HGNCiHGNC:11169. SNTB2.
HPAiHPA001394.
MIMi600027. gene.
neXtProtiNX_Q13425.
OpenTargetsiENSG00000168807.
PharmGKBiPA36009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMRK. Eukaryota.
ENOG4111J6R. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ13425.
OMAiGFTITRE.
OrthoDBiEOG091G0O31.
PhylomeDBiQ13425.
TreeFamiTF317932.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168807-MONOMER.

Miscellaneous databases

ChiTaRSiSNTB2. human.
EvolutionaryTraceiQ13425.
GeneWikiiSNTB2.
GenomeRNAii6645.
PROiQ13425.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168807.
CleanExiHS_SNTB2.
ExpressionAtlasiQ13425. baseline and differential.
GenevisibleiQ13425. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028550. SNTB2.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 2 hits.
PTHR10554:SF8. PTHR10554:SF8. 2 hits.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNTB2_HUMAN
AccessioniPrimary (citable) accession number: Q13425
Secondary accession number(s): Q9BY09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.