Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD(P) transhydrogenase, mitochondrial

Gene

NNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.1 Publication

Catalytic activityi

NADPH + NAD+ = NADP+ + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei933NADP; via amide nitrogen1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 259NADBy similarityAdd BLAST31
Nucleotide bindingi965 – 970NADP1 Publication6
Nucleotide bindingi1007 – 1011NADP1 Publication5
Nucleotide bindingi1042 – 1049NADP1 Publication8
Nucleotide bindingi1068 – 1069NADP1 Publication2

GO - Molecular functioni

  • NAD(P)+ transhydrogenase (AB-specific) activity Source: GO_Central
  • NAD(P)+ transhydrogenase (B-specific) activity Source: UniProtKB
  • NAD(P)+ transhydrogenase activity Source: Reactome
  • NAD binding Source: UniProtKB
  • NADP binding Source: UniProtKB

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • NADPH regeneration Source: GO_Central
  • oxidation-reduction process Source: UniProtKB
  • proton transport Source: UniProtKB
  • reactive oxygen species metabolic process Source: UniProtKB
  • tricarboxylic acid cycle Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS03639-MONOMER.
ZFISH:HS03639-MONOMER.
BRENDAi1.6.1.2. 2681.
ReactomeiR-HSA-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P) transhydrogenase, mitochondrial (EC:1.6.1.2)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase
Pyridine nucleotide transhydrogenase
Gene namesi
Name:NNT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:7863. NNT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 474Mitochondrial matrixAdd BLAST431
Transmembranei475 – 493HelicalSequence analysisAdd BLAST19
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Transmembranei527 – 546HelicalSequence analysisAdd BLAST20
Transmembranei558 – 578HelicalSequence analysisAdd BLAST21
Topological domaini579 – 595Mitochondrial matrixAdd BLAST17
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei672 – 691HelicalSequence analysisAdd BLAST20
Transmembranei702 – 722HelicalSequence analysisAdd BLAST21
Topological domaini723 – 739CytoplasmicAdd BLAST17
Transmembranei740 – 760HelicalSequence analysisAdd BLAST21
Transmembranei778 – 797HelicalSequence analysisAdd BLAST20
Transmembranei801 – 819HelicalSequence analysisAdd BLAST19
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Transmembranei857 – 879HelicalSequence analysisAdd BLAST23
Topological domaini880 – 1086Mitochondrial matrixAdd BLAST207

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrial respiratory chain Source: UniProtKB
  • mitochondrion Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Glucocorticoid deficiency 4 (GCCD4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare, potentially lethal, autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.
See also OMIM:614736
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068781193S → N in GCCD4. 1 Publication1
Natural variantiVAR_068782357T → A in GCCD4. 1 Publication1
Natural variantiVAR_068783365H → P in GCCD4. 1 Publication1
Natural variantiVAR_068784437P → L in GCCD4. 1 PublicationCorresponds to variant rs781183677dbSNPEnsembl.1
Natural variantiVAR_068785533A → V in GCCD4. 1 PublicationCorresponds to variant rs387907232dbSNPEnsembl.1
Natural variantiVAR_068786664G → R in GCCD4. 1 PublicationCorresponds to variant rs371979800dbSNPEnsembl.1
Natural variantiVAR_068787678G → R in GCCD4. 1 Publication1
Natural variantiVAR_068788862G → D in GCCD4. 1 Publication1
Natural variantiVAR_068789977L → P in GCCD4. 1 PublicationCorresponds to variant rs387907233dbSNPEnsembl.1
Natural variantiVAR_0687901008A → P in GCCD4. 1 PublicationCorresponds to variant rs387907234dbSNPEnsembl.1
Natural variantiVAR_0687911009N → K in GCCD4. 1 PublicationCorresponds to variant rs370273690dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi23530.
MalaCardsiNNT.
MIMi614736. phenotype.
OpenTargetsiENSG00000112992.
Orphaneti361. Familial glucocorticoid deficiency.
PharmGKBiPA31667.

Polymorphism and mutation databases

BioMutaiNNT.
DMDMi51338801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43MitochondrionBy similarityAdd BLAST43
ChainiPRO_000000105544 – 1086NAD(P) transhydrogenase, mitochondrialAdd BLAST1043

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei117N6-succinyllysineBy similarity1
Modified residuei224N6-succinyllysineBy similarity1
Modified residuei294N6-succinyllysineBy similarity1
Modified residuei331N6-succinyllysineBy similarity1
Modified residuei397N6-acetyllysineCombined sources1
Modified residuei1079N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ13423.
MaxQBiQ13423.
PaxDbiQ13423.
PeptideAtlasiQ13423.
PRIDEiQ13423.

PTM databases

iPTMnetiQ13423.
PhosphoSitePlusiQ13423.
SwissPalmiQ13423.

Expressioni

Tissue specificityi

Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.1 Publication

Gene expression databases

BgeeiENSG00000112992.
CleanExiHS_NNT.
ExpressionAtlasiQ13423. baseline and differential.
GenevisibleiQ13423. HS.

Organism-specific databases

HPAiCAB004975.
HPA004829.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi117076. 53 interactors.
IntActiQ13423. 19 interactors.
MINTiMINT-3027647.
STRINGi9606.ENSP00000264663.

Structurei

Secondary structure

11086
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi914 – 923Combined sources10
Beta strandi925 – 931Combined sources7
Helixi933 – 938Combined sources6
Helixi941 – 953Combined sources13
Beta strandi957 – 962Combined sources6
Beta strandi967 – 969Combined sources3
Helixi972 – 979Combined sources8
Helixi984 – 986Combined sources3
Beta strandi987 – 989Combined sources3
Helixi990 – 993Combined sources4
Helixi994 – 999Combined sources6
Beta strandi1001 – 1007Combined sources7
Helixi1010 – 1012Combined sources3
Helixi1015 – 1018Combined sources4
Turni1023 – 1026Combined sources4
Helixi1032 – 1034Combined sources3
Beta strandi1035 – 1045Combined sources11
Helixi1055 – 1058Combined sources4
Beta strandi1062 – 1067Combined sources6
Helixi1069 – 1081Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DJLX-ray2.00A/B880-1086[»]
1PT9X-ray2.42A/B880-1086[»]
1U31X-ray2.20A/B880-1086[»]
ProteinModelPortaliQ13423.
SMRiQ13423.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13423.

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AlaDH/PNT family.Curated
In the C-terminal section; belongs to the PNT beta subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEMU. Eukaryota.
COG1282. LUCA.
COG3288. LUCA.
GeneTreeiENSGT00390000004624.
HOGENOMiHOG000160623.
HOVERGENiHBG006511.
InParanoidiQ13423.
KOiK00323.
OMAiKPGIPYK.
OrthoDBiEOG091G01NO.
PhylomeDBiQ13423.
TreeFamiTF300636.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008143. Ala_DH/PNT_CS2.
IPR008142. AlaDH/PNT_CS1.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR016040. NAD(P)-bd_dom.
IPR012136. NADH_DH_b.
IPR026255. NADP_transhyd_a.
IPR024605. NADP_transhyd_a_C.
IPR030168. NADP_transhyd_mt.
[Graphical view]
PANTHERiPTHR10160:SF22. PTHR10160:SF22. 1 hit.
PfamiPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
PF02233. PNTB. 1 hit.
PF12769. PNTB_4TM. 1 hit.
[Graphical view]
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52467. SSF52467. 1 hit.
TIGRFAMsiTIGR00561. pntA. 1 hit.
PROSITEiPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLLKTVVT GCSCPLLSNL GSCKGLRVKK DFLRTFYTHQ ELWCKAPVKP
60 70 80 90 100
GIPYKQLTVG VPKEIFQNEK RVALSPAGVQ NLVKQGFNVV VESGAGEASK
110 120 130 140 150
FSDDHYRVAG AQIQGAKEVL ASDLVVKVRA PMVNPTLGVH EADLLKTSGT
160 170 180 190 200
LISFIYPAQN PELLNKLSQR KTTVLAMDQV PRVTIAQGYD ALSSMANIAG
210 220 230 240 250
YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL ASAGAAKSMG
260 270 280 290 300
AIVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE
310 320 330 340 350
MKLFAQQCKE VDILISTALI PGKKAPVLFN KEMIESMKEG SVVVDLAAEA
360 370 380 390 400
GGNFETTKPG ELYIHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS
410 420 430 440 450
PDKDNFYFDV KDDFDFGTMG HVIRGTVVMK DGKVIFPAPT PKNIPQGAPV
460 470 480 490 500
KQKTVAELEA EKAATITPFR KTMSTASAYT AGLTGILGLG IAAPNLAFSQ
510 520 530 540 550
MVTTFGLAGI VGYHTVWGVT PALHSPLMSV TNAISGLTAV GGLALMGGHL
560 570 580 590 600
YPSTTSQGLA ALAAFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL
610 620 630 640 650
PAGTFVGGYL AALYSGYNIE QIMYLGSGLC CVGALAGLST QGTARLGNAL
660 670 680 690 700
GMIGVAGGLA ATLGVLKPGP ELLAQMSGAM ALGGTIGLTI AKRIQISDLP
710 720 730 740 750
QLVAAFHSLV GLAAVLTCIA EYIIEYPHFA TDAAANLTKI VAYLGTYIGG
760 770 780 790 800
VTFSGSLIAY GKLQGLLKSA PLLLPGRHLL NAGLLAASVG GIIPFMVDPS
810 820 830 840 850
FTTGITCLGS VSALSAVMGV TLTAAIGGAD MPVVITVLNS YSGWALCAEG
860 870 880 890 900
FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG
910 920 930 940 950
KPMEISGTHT EINLDNAIDM IREANSIIIT PGYGLCAAKA QYPIADLVKM
960 970 980 990 1000
LTEQGKKVRF GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINHDFPDT
1010 1020 1030 1040 1050
DLVLVIGAND TVNSAAQEDP NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA
1060 1070 1080
AVDNPIFYKP NTAMLLGDAK KTCDALQAKV RESYQK
Length:1,086
Mass (Da):113,896
Last modified:August 16, 2004 - v3
Checksum:i8A437658CA0EB41B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176A → T in CAA90428 (PubMed:8616157).Curated1
Sequence conflicti212G → E in CAD38536 (PubMed:17974005).Curated1
Sequence conflicti246A → E in AAC51914 (PubMed:9524818).Curated1
Sequence conflicti262A → S in AAC51914 (PubMed:9524818).Curated1
Sequence conflicti706F → S in AAC51914 (PubMed:9524818).Curated1
Sequence conflicti731T → P in AAC51914 (PubMed:9524818).Curated1
Sequence conflicti810S → A in CAA90428 (PubMed:8616157).Curated1
Sequence conflicti824A → P in CAA90428 (PubMed:8616157).Curated1
Sequence conflicti871I → P in AAC51914 (PubMed:9524818).Curated1
Sequence conflicti929I → F in AAC51914 (PubMed:9524818).Curated1
Sequence conflicti1059K → R in CAD38536 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068781193S → N in GCCD4. 1 Publication1
Natural variantiVAR_068782357T → A in GCCD4. 1 Publication1
Natural variantiVAR_068783365H → P in GCCD4. 1 Publication1
Natural variantiVAR_068784437P → L in GCCD4. 1 PublicationCorresponds to variant rs781183677dbSNPEnsembl.1
Natural variantiVAR_068785533A → V in GCCD4. 1 PublicationCorresponds to variant rs387907232dbSNPEnsembl.1
Natural variantiVAR_068786664G → R in GCCD4. 1 PublicationCorresponds to variant rs371979800dbSNPEnsembl.1
Natural variantiVAR_068787678G → R in GCCD4. 1 Publication1
Natural variantiVAR_068788862G → D in GCCD4. 1 Publication1
Natural variantiVAR_068789977L → P in GCCD4. 1 PublicationCorresponds to variant rs387907233dbSNPEnsembl.1
Natural variantiVAR_0687901008A → P in GCCD4. 1 PublicationCorresponds to variant rs387907234dbSNPEnsembl.1
Natural variantiVAR_0687911009N → K in GCCD4. 1 PublicationCorresponds to variant rs370273690dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40490 mRNA. Translation: AAC51914.1.
Z50101 mRNA. Translation: CAA90428.1.
AL831822 mRNA. Translation: CAD38536.1.
BC110543 mRNA. Translation: AAI10544.1.
CCDSiCCDS3949.1.
PIRiG02257.
RefSeqiNP_036475.3. NM_012343.3.
NP_892022.2. NM_182977.2.
XP_005248331.1. XM_005248274.4.
XP_011512303.1. XM_011514001.2.
XP_016864782.1. XM_017009293.1.
UniGeneiHs.482043.

Genome annotation databases

EnsembliENST00000264663; ENSP00000264663; ENSG00000112992.
ENST00000344920; ENSP00000343873; ENSG00000112992.
GeneIDi23530.
KEGGihsa:23530.
UCSCiuc003joe.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40490 mRNA. Translation: AAC51914.1.
Z50101 mRNA. Translation: CAA90428.1.
AL831822 mRNA. Translation: CAD38536.1.
BC110543 mRNA. Translation: AAI10544.1.
CCDSiCCDS3949.1.
PIRiG02257.
RefSeqiNP_036475.3. NM_012343.3.
NP_892022.2. NM_182977.2.
XP_005248331.1. XM_005248274.4.
XP_011512303.1. XM_011514001.2.
XP_016864782.1. XM_017009293.1.
UniGeneiHs.482043.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DJLX-ray2.00A/B880-1086[»]
1PT9X-ray2.42A/B880-1086[»]
1U31X-ray2.20A/B880-1086[»]
ProteinModelPortaliQ13423.
SMRiQ13423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117076. 53 interactors.
IntActiQ13423. 19 interactors.
MINTiMINT-3027647.
STRINGi9606.ENSP00000264663.

PTM databases

iPTMnetiQ13423.
PhosphoSitePlusiQ13423.
SwissPalmiQ13423.

Polymorphism and mutation databases

BioMutaiNNT.
DMDMi51338801.

Proteomic databases

EPDiQ13423.
MaxQBiQ13423.
PaxDbiQ13423.
PeptideAtlasiQ13423.
PRIDEiQ13423.

Protocols and materials databases

DNASUi23530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264663; ENSP00000264663; ENSG00000112992.
ENST00000344920; ENSP00000343873; ENSG00000112992.
GeneIDi23530.
KEGGihsa:23530.
UCSCiuc003joe.4. human.

Organism-specific databases

CTDi23530.
DisGeNETi23530.
GeneCardsiNNT.
H-InvDBHIX0032203.
HGNCiHGNC:7863. NNT.
HPAiCAB004975.
HPA004829.
MalaCardsiNNT.
MIMi607878. gene.
614736. phenotype.
neXtProtiNX_Q13423.
OpenTargetsiENSG00000112992.
Orphaneti361. Familial glucocorticoid deficiency.
PharmGKBiPA31667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEMU. Eukaryota.
COG1282. LUCA.
COG3288. LUCA.
GeneTreeiENSGT00390000004624.
HOGENOMiHOG000160623.
HOVERGENiHBG006511.
InParanoidiQ13423.
KOiK00323.
OMAiKPGIPYK.
OrthoDBiEOG091G01NO.
PhylomeDBiQ13423.
TreeFamiTF300636.

Enzyme and pathway databases

BioCyciMetaCyc:HS03639-MONOMER.
ZFISH:HS03639-MONOMER.
BRENDAi1.6.1.2. 2681.
ReactomeiR-HSA-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

ChiTaRSiNNT. human.
EvolutionaryTraceiQ13423.
GeneWikiiNNT_(gene).
GenomeRNAii23530.
PROiQ13423.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112992.
CleanExiHS_NNT.
ExpressionAtlasiQ13423. baseline and differential.
GenevisibleiQ13423. HS.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008143. Ala_DH/PNT_CS2.
IPR008142. AlaDH/PNT_CS1.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR016040. NAD(P)-bd_dom.
IPR012136. NADH_DH_b.
IPR026255. NADP_transhyd_a.
IPR024605. NADP_transhyd_a_C.
IPR030168. NADP_transhyd_mt.
[Graphical view]
PANTHERiPTHR10160:SF22. PTHR10160:SF22. 1 hit.
PfamiPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
PF02233. PNTB. 1 hit.
PF12769. PNTB_4TM. 1 hit.
[Graphical view]
SMARTiSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52467. SSF52467. 1 hit.
TIGRFAMsiTIGR00561. pntA. 1 hit.
PROSITEiPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNNTM_HUMAN
AccessioniPrimary (citable) accession number: Q13423
Secondary accession number(s): Q16796, Q2TB60, Q8N3V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.