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Q13422

- IKZF1_HUMAN

UniProt

Q13422 - IKZF1_HUMAN

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Protein
DNA-binding protein Ikaros
Gene
IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei159 – 1591Required for both pericentromeric heterochromatin localization and complete DNA binding By similarity
Sitei162 – 1621Required for both pericentromeric heterochromatin localization and complete DNA binding By similarity
Sitei188 – 1881Required for both pericentromeric heterochromatin localization and DNA binding By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri117 – 13923C2H2-type 1
Add
BLAST
Zinc fingeri145 – 16723C2H2-type 2
Add
BLAST
Zinc fingeri173 – 19523C2H2-type 3
Add
BLAST
Zinc fingeri201 – 22424C2H2-type 4
Add
BLAST
Zinc fingeri462 – 48423C2H2-type 5
Add
BLAST
Zinc fingeri490 – 51425C2H2-type 6
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. B cell differentiation Source: Ensembl
  2. Peyer's patch development Source: Ensembl
  3. T cell differentiation Source: Ensembl
  4. cell cycle Source: UniProtKB-KW
  5. chromatin modification Source: UniProtKB-KW
  6. forebrain development Source: Ensembl
  7. gland development Source: Ensembl
  8. lymph node development Source: Ensembl
  9. mesoderm development Source: ProtInc
  10. natural killer cell differentiation Source: Ensembl
  11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. positive regulation of NK T cell differentiation Source: Ensembl
  13. positive regulation of multicellular organism growth Source: Ensembl
  14. positive regulation of neutrophil differentiation Source: Ensembl
  15. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  16. retina development in camera-type eye Source: Ensembl
  17. thymus development Source: Ensembl
  18. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein, Repressor

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ13422.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein Ikaros
Alternative name(s):
Ikaros family zinc finger protein 1
Lymphoid transcription factor LyF-1
Gene namesi
Name:IKZF1
Synonyms:IK1, IKAROS, LYF1, ZNFN1A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13176. IKZF1.

Subcellular locationi

Nucleus
Note: In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events By similarity.1 Publication
Isoform Ik2 : Nucleus
Note: In resting lymphocytes, distributed diffusely throughout the nucleus. Localizes to pericentromeric heterochromatin in proliferating cells. This localization requires DNA binding which is regulated by phosphorylation / dephosphorylation events By similarity.1 Publication
Isoform Ik6 : Cytoplasm By similarity 1 Publication

GO - Cellular componenti

  1. centromeric heterochromatin Source: Ensembl
  2. cytoplasm Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in IKZF1 are frequent occurrences (28.6%) in acute lymphoblasic leukemia (ALL). Such alterations or deletions lead to poor prognosis for ALL.
Chromosomal aberrations involving IKZF1 are a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;7)(q27;p12), with BCL6.

Organism-specific databases

Orphaneti317473. Pancytopenia due to IKZF1 mutations.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBiPA37748.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519DNA-binding protein Ikaros
PRO_0000047094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131Phosphoserine By similarity
Modified residuei23 – 231Phosphothreonine By similarity
Cross-linki58 – 58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei63 – 631Phosphoserine1 Publication
Modified residuei101 – 1011Phosphoserine By similarity
Modified residuei140 – 1401Phosphothreonine By similarity
Modified residuei168 – 1681Phosphoserine By similarity
Modified residuei196 – 1961Phosphoserine By similarity
Cross-linki241 – 241Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei258 – 2581Phosphoserine1 Publication
Modified residuei261 – 2611Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine By similarity
Modified residuei361 – 3611Phosphoserine2 Publications
Modified residuei364 – 3641Phosphoserine2 Publications
Modified residuei389 – 3891Phosphoserine By similarity
Modified residuei391 – 3911Phosphoserine By similarity
Modified residuei393 – 3931Phosphoserine By similarity
Modified residuei397 – 3971Phosphoserine By similarity
Modified residuei398 – 3981Phosphothreonine By similarity

Post-translational modificationi

Phosphorylation controls cell-cycle progression from late G1 stage to S stage. Hyperphosphorylated during G2/M phase. Dephosphorylated state during late G1 phase. Phosphorylation on Thr-140 is required for DNA and pericentromeric location during mitosis. CK2 is the main kinase, in vitro. GSK3 and CDK may also contribute to phosphorylation of the C-terminal serine and threonine residues. Phosphorylation on these C-terminal residues reduces the DNA-binding ability. Phosphorylation/dephosphorylation events on Ser-13 and Ser-295 regulate TDT expression during thymocyte differentiation. Dephosphorylation by protein phosphatase 1 regulates stability and pericentromeric heterochromatin location. Phosphorylated in both lymphoid and non-lymphoid tissues By similarity. Phosphorylation at Ser-361 and Ser-364 downstream of SYK induces nuclear translocation.1 Publication
Sumoylated. Simulataneous sumoylation on the 2 sites results in a loss of both HDAC-dependent and HDAC-independent repression. Has no effect on pericentromeric heterochromatin location. Desumoylated by SENP1 By similarity.
Polyubiquitinated By similarity.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ13422.
PaxDbiQ13422.
PRIDEiQ13422.

PTM databases

PhosphoSiteiQ13422.

Expressioni

Tissue specificityi

Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine.

Gene expression databases

ArrayExpressiQ13422.
BgeeiQ13422.
CleanExiHS_IKZF1.
GenevestigatoriQ13422.

Organism-specific databases

HPAiCAB009247.

Interactioni

Subunit structurei

Heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5 By similarity. Component of the chromatin-remodeling NuRD repressor complex which includes at least HDAC1, HDAC2, RBBP4, RBBP7, IKZF1, MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4. Interacts directly with the CHD4 component of the NuRD complex. Component of the BAF (SWI/SNF) gene activator complex which includes ACTB, ARID1A, ARID1B, IKZF1, ARID1A, ARID1B, SMARCA2, SMARCA4 and at least one BAF subunit. Interacts directly with the SMARCA4 component of the BAF complex By similarity. Interacts with SUMO1; the interaction sumoylates IKAROS, promoted by PIAS2 and PIAS3. Interacts with PIAS2 (isoform alpha); the interaction promotes sumoylation and reduces transcription repression. Interacts, to a lesser extent, with PIAS3. Interacts with PPP1CC; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with IKZF3 By similarity.2 Publications

Protein-protein interaction databases

BioGridi115604. 38 interactions.
IntActiQ13422. 18 interactions.
MINTiMINT-129252.
STRINGi9606.ENSP00000331614.

Structurei

3D structure databases

ProteinModelPortaliQ13422.
SMRiQ13422. Positions 112-259, 460-519.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 16310Required for both high-affinity DNA binding and pericentromeric heterochromatin localization By similarity
Regioni180 – 19516Required for both high-affinity DNA binding and pericentromeric heterochromatin localization By similarity
Add
BLAST
Regioni468 – 4714Required for binding PP1CC By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi373 – 3764Poly-Leu

Domaini

The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin By similarity.
The C-terminal zinc-finger domain is required for dimerization By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG244744.
HOVERGENiHBG004752.
InParanoidiQ13422.
KOiK09220.
OMAiGDKCLSD.
PhylomeDBiQ13422.
TreeFamiTF331189.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform Ik1 (identifier: Q13422-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDADEGQDMS QVSGKESPPV SDTPDEGDEP MPIPEDLSTT SGGQQSSKSD    50
RVVASNVKVE TQSDEENGRA CEMNGEECAE DLRMLDASGE KMNGSHRDQG 100
SSALSGVGGI RLPNGKLKCD ICGIICIGPN VLMVHKRSHT GERPFQCNQC 150
GASFTQKGNL LRHIKLHSGE KPFKCHLCNY ACRRRDALTG HLRTHSVGKP 200
HKCGYCGRSY KQRSSLEEHK ERCHNYLESM GLPGTLYPVI KEETNHSEMA 250
EDLCKIGSER SLVLDRLASN VAKRKSSMPQ KFLGDKGLSD TPYDSSASYE 300
KENEMMKSHV MDQAINNAIN YLGAESLRPL VQTPPGGSEV VPVISPMYQL 350
HKPLAEGTPR SNHSAQDSAV ENLLLLSKAK LVPSEREASP SNSCQDSTDT 400
ESNNEEQRSG LIYLTNHIAP HARNGLSLKE EHRAYDLLRA ASENSQDALR 450
VVSTSGEQMK VYKCEHCRVL FLDHVMYTIH MGCHGFRDPF ECNMCGYHSQ 500
DRYEFSSHIT RGEHRFHMS 519
Length:519
Mass (Da):57,528
Last modified:November 1, 1996 - v1
Checksum:i7B0129C4E3FE41A8
GO
Isoform Ik2 (identifier: Q13422-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-140: Missing.

Show »
Length:432
Mass (Da):48,289
Checksum:iE8E57F8BF5B306E6
GO
Isoform Ik3 (identifier: Q13422-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-283: Missing.

Show »
Length:432
Mass (Da):47,634
Checksum:i1093D253341A95E8
GO
Isoform Ik4 (identifier: Q13422-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-53: Missing.
     197-283: Missing.

Show »
Length:388
Mass (Da):43,093
Checksum:i137C942A5278A9F0
GO
Isoform Ik5 (identifier: Q13422-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-283: Missing.

Show »
Length:376
Mass (Da):41,229
Checksum:i0B060551CB3E0082
GO
Isoform Ik6 (identifier: Q13422-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-283: Missing.

Show »
Length:289
Mass (Da):31,989
Checksum:iEB96A15185C62A18
GO
Isoform Ik7 (identifier: Q13422-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-238: Missing.

Show »
Length:477
Mass (Da):52,706
Checksum:iB19FE76450EA40E4
GO
Isoform Ikx (identifier: Q13422-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-238: Missing.
     260-268: RSLVLDRLA → ISRAGQTSK
     269-519: Missing.

Show »
Length:226
Mass (Da):24,470
Checksum:i2BB5B70D38F73264
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei10 – 5344Missing in isoform Ik4.
VSP_006847Add
BLAST
Alternative sequencei54 – 283230Missing in isoform Ik6.
VSP_006849Add
BLAST
Alternative sequencei54 – 14087Missing in isoform Ik2.
VSP_006848Add
BLAST
Alternative sequencei141 – 283143Missing in isoform Ik5.
VSP_006852Add
BLAST
Alternative sequencei197 – 28387Missing in isoform Ik3 and isoform Ik4.
VSP_006850Add
BLAST
Alternative sequencei197 – 23842Missing in isoform Ik7 and isoform Ikx.
VSP_006851Add
BLAST
Alternative sequencei260 – 2689RSLVLDRLA → ISRAGQTSK in isoform Ikx.
VSP_053404
Alternative sequencei269 – 519251Missing in isoform Ikx.
VSP_053405Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 122QV → FS in AAB50683. 1 Publication
Sequence conflicti214 – 2141S → T in AAB50683. 1 Publication
Sequence conflicti245 – 2451N → K in AAB50683. 1 Publication
Sequence conflicti296 – 2961Missing in AAB50683. 1 Publication
Sequence conflicti298 – 2981S → T in AAB50683. 1 Publication
Sequence conflicti352 – 3554KPLA → RRS in AAB50683. 1 Publication
Sequence conflicti372 – 3721N → Y in AAB50683. 1 Publication
Sequence conflicti420 – 4267PHARNGL → RRAQRV in AAB50683. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40462 mRNA. Translation: AAC50459.1.
S80876 mRNA. Translation: AAB50683.1.
AY377974 mRNA. Translation: AAR84585.1.
AK303586 mRNA. Translation: BAG64603.1.
BT009836 mRNA. Translation: AAP88838.1.
AC124014 Genomic DNA. No translation available.
AC233268 Genomic DNA. No translation available.
CH471128 Genomic DNA. Translation: EAW60977.1.
CH471128 Genomic DNA. Translation: EAW60978.1.
CH471128 Genomic DNA. Translation: EAW60981.1.
CH236955 Genomic DNA. Translation: EAL23900.1.
CH471128 Genomic DNA. Translation: EAW60979.1.
BC018349 mRNA. Translation: AAH18349.1.
CCDSiCCDS59055.1. [Q13422-7]
CCDS69299.1. [Q13422-5]
RefSeqiNP_001207694.1. NM_001220765.2. [Q13422-7]
NP_001207696.1. NM_001220767.2.
NP_001207697.1. NM_001220768.2. [Q13422-3]
NP_001207699.1. NM_001220770.2.
NP_001207700.1. NM_001220771.2. [Q13422-5]
NP_001278766.1. NM_001291837.1. [Q13422-7]
NP_001278767.1. NM_001291838.1. [Q13422-2]
NP_001278768.1. NM_001291839.1.
NP_001278769.1. NM_001291840.1. [Q13422-6]
NP_001278770.1. NM_001291841.1.
NP_001278771.1. NM_001291842.1.
NP_001278772.1. NM_001291843.1.
NP_001278773.1. NM_001291844.1.
NP_006051.1. NM_006060.5. [Q13422-1]
UniGeneiHs.435949.
Hs.488251.
Hs.731495.

Genome annotation databases

EnsembliENST00000331340; ENSP00000331614; ENSG00000185811. [Q13422-1]
ENST00000343574; ENSP00000342750; ENSG00000185811. [Q13422-2]
ENST00000346667; ENSP00000340080; ENSG00000185811. [Q13422-6]
ENST00000349824; ENSP00000342485; ENSG00000185811. [Q13422-5]
ENST00000357364; ENSP00000349928; ENSG00000185811. [Q13422-3]
ENST00000359197; ENSP00000352123; ENSG00000185811. [Q13422-7]
ENST00000438033; ENSP00000396554; ENSG00000185811. [Q13422-2]
ENST00000439701; ENSP00000413025; ENSG00000185811. [Q13422-7]
ENST00000440768; ENSP00000401507; ENSG00000185811. [Q13422-8]
GeneIDi10320.
KEGGihsa:10320.
UCSCiuc003tow.4. human. [Q13422-1]
uc003tox.4. human. [Q13422-7]
uc003tpa.4. human. [Q13422-6]
uc011kck.2. human. [Q13422-2]
uc022acq.1. human. [Q13422-5]
uc022acs.1. human. [Q13422-4]
uc022acx.1. human. [Q13422-3]

Polymorphism databases

DMDMi3913926.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40462 mRNA. Translation: AAC50459.1 .
S80876 mRNA. Translation: AAB50683.1 .
AY377974 mRNA. Translation: AAR84585.1 .
AK303586 mRNA. Translation: BAG64603.1 .
BT009836 mRNA. Translation: AAP88838.1 .
AC124014 Genomic DNA. No translation available.
AC233268 Genomic DNA. No translation available.
CH471128 Genomic DNA. Translation: EAW60977.1 .
CH471128 Genomic DNA. Translation: EAW60978.1 .
CH471128 Genomic DNA. Translation: EAW60981.1 .
CH236955 Genomic DNA. Translation: EAL23900.1 .
CH471128 Genomic DNA. Translation: EAW60979.1 .
BC018349 mRNA. Translation: AAH18349.1 .
CCDSi CCDS59055.1. [Q13422-7 ]
CCDS69299.1. [Q13422-5 ]
RefSeqi NP_001207694.1. NM_001220765.2. [Q13422-7 ]
NP_001207696.1. NM_001220767.2.
NP_001207697.1. NM_001220768.2. [Q13422-3 ]
NP_001207699.1. NM_001220770.2.
NP_001207700.1. NM_001220771.2. [Q13422-5 ]
NP_001278766.1. NM_001291837.1. [Q13422-7 ]
NP_001278767.1. NM_001291838.1. [Q13422-2 ]
NP_001278768.1. NM_001291839.1.
NP_001278769.1. NM_001291840.1. [Q13422-6 ]
NP_001278770.1. NM_001291841.1.
NP_001278771.1. NM_001291842.1.
NP_001278772.1. NM_001291843.1.
NP_001278773.1. NM_001291844.1.
NP_006051.1. NM_006060.5. [Q13422-1 ]
UniGenei Hs.435949.
Hs.488251.
Hs.731495.

3D structure databases

ProteinModelPortali Q13422.
SMRi Q13422. Positions 112-259, 460-519.
ModBasei Search...

Protein-protein interaction databases

BioGridi 115604. 38 interactions.
IntActi Q13422. 18 interactions.
MINTi MINT-129252.
STRINGi 9606.ENSP00000331614.

PTM databases

PhosphoSitei Q13422.

Polymorphism databases

DMDMi 3913926.

Proteomic databases

MaxQBi Q13422.
PaxDbi Q13422.
PRIDEi Q13422.

Protocols and materials databases

DNASUi 10320.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331340 ; ENSP00000331614 ; ENSG00000185811 . [Q13422-1 ]
ENST00000343574 ; ENSP00000342750 ; ENSG00000185811 . [Q13422-2 ]
ENST00000346667 ; ENSP00000340080 ; ENSG00000185811 . [Q13422-6 ]
ENST00000349824 ; ENSP00000342485 ; ENSG00000185811 . [Q13422-5 ]
ENST00000357364 ; ENSP00000349928 ; ENSG00000185811 . [Q13422-3 ]
ENST00000359197 ; ENSP00000352123 ; ENSG00000185811 . [Q13422-7 ]
ENST00000438033 ; ENSP00000396554 ; ENSG00000185811 . [Q13422-2 ]
ENST00000439701 ; ENSP00000413025 ; ENSG00000185811 . [Q13422-7 ]
ENST00000440768 ; ENSP00000401507 ; ENSG00000185811 . [Q13422-8 ]
GeneIDi 10320.
KEGGi hsa:10320.
UCSCi uc003tow.4. human. [Q13422-1 ]
uc003tox.4. human. [Q13422-7 ]
uc003tpa.4. human. [Q13422-6 ]
uc011kck.2. human. [Q13422-2 ]
uc022acq.1. human. [Q13422-5 ]
uc022acs.1. human. [Q13422-4 ]
uc022acx.1. human. [Q13422-3 ]

Organism-specific databases

CTDi 10320.
GeneCardsi GC07P050343.
HGNCi HGNC:13176. IKZF1.
HPAi CAB009247.
MIMi 603023. gene.
neXtProti NX_Q13422.
Orphaneti 317473. Pancytopenia due to IKZF1 mutations.
99860. Precursor B-cell acute lymphoblastic leukemia.
PharmGKBi PA37748.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG244744.
HOVERGENi HBG004752.
InParanoidi Q13422.
KOi K09220.
OMAi GDKCLSD.
PhylomeDBi Q13422.
TreeFami TF331189.

Enzyme and pathway databases

SignaLinki Q13422.

Miscellaneous databases

ChiTaRSi IKZF1. human.
GeneWikii IKZF1.
GenomeRNAii 10320.
NextBioi 39123.
PROi Q13422.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13422.
Bgeei Q13422.
CleanExi HS_IKZF1.
Genevestigatori Q13422.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1."
    Nietfeld W., Meyerhans A.
    Immunol. Lett. 49:139-141(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
    Tissue: Bone marrow.
  2. "The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse."
    Molnar A., Wu P., Largespada D.A., Vortkamp A., Scherer S., Copeland N.G., Jenkins N.A., Bruns G., Georgopoulos K.
    J. Immunol. 156:585-592(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular misreading is involved in generation of Ikaros diversity."
    Sanchez-Tapia E.M., Rodriguez R.E., Gonzalez-Sarmiento R.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IKX).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK2).
    Tissue: Thymus.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK7).
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IK7).
    Tissue: Lymph.
  10. "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes."
    Kim J., Sif S., Jones B., Jackson A., Koipally J., Heller E., Winandy S., Viel A., Sawyer A., Ikeda T., Kingston R., Georgopoulos K.
    Immunity 10:345-355(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NURD COMPLEX, IDENTIFICATION IN THE BAF COMPLEX, INTERACTION WITH SMARCA4 AND CHD4, FUNCTION.
  11. "The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma."
    Hosokawa Y., Maeda Y., Ichinohasama R., Miura I., Taniwaki M., Seto M.
    Blood 95:2719-2721(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN B-CELL NON-HODGKIN LYMPHOMA, CHROMOSOMAL TRANSLOCATION WITH BCL6.
  12. "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities."
    Perdomo J., Holmes M., Chong B., Crossley M.
    J. Biol. Chem. 275:38347-38354(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IKZF4 AND IKZF5.
  13. "Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing."
    Kim J.-H., Ebersole T., Kouprina N., Noskov V.N., Ohzeki J.-I., Masumoto H., Mravinac B., Sullivan B.A., Pavlicek A., Dovat S., Pack S.D., Kwon Y.-W., Flanagan P.T., Loukinov D., Lobanenkov V., Larionov V.
    Genome Res. 19:533-544(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  14. Cited for: INVOLVEMENT IN ACUTE LYMPHOBLASIC LEUKEMIA.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-258; SER-261; SER-361 AND SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros."
    Uckun F.M., Ma H., Zhang J., Ozer Z., Dovat S., Mao C., Ishkhanian R., Goodman P., Qazi S.
    Proc. Natl. Acad. Sci. U.S.A. 109:18072-18077(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-361 AND SER-364 BY SYK, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiIKZF1_HUMAN
AccessioniPrimary (citable) accession number: Q13422
Secondary accession number(s): A4D260
, B4E0Z1, D3DVM5, O00598, Q53XL2, Q69BM4, Q8WVA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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