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Q13421

- MSLN_HUMAN

UniProt

Q13421 - MSLN_HUMAN

Protein

Mesothelin

Gene

MSLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Membrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. pancreas development Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mesothelin
    Alternative name(s):
    CAK1 antigen
    Pre-pro-megakaryocyte-potentiating factor
    Cleaved into the following 2 chains:
    Gene namesi
    Name:MSLN
    Synonyms:MPF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:7371. MSLN.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: Ensembl
    3. extracellular space Source: Ensembl
    4. Golgi apparatus Source: UniProtKB-SubCell
    5. membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.1 Publication

    Organism-specific databases

    PharmGKBiPA31176.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 36361 PublicationAdd
    BLAST
    Chaini37 – 606570MesothelinPRO_0000253559Add
    BLAST
    Chaini37 – 286250Megakaryocyte-potentiating factorPRO_0000253560Add
    BLAST
    Chaini296 – 606311Mesothelin, cleaved formPRO_0000253561Add
    BLAST
    Propeptidei607 – 63024Removed in mature formSequence AnalysisPRO_0000021769Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Curated
    Disulfide bondi302 ↔ 3261 Publication
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
    Lipidationi606 – 6061GPI-anchor amidated serineSequence Analysis

    Post-translational modificationi

    Both MPF and the cleaved form of mesothelin are N-glycosylated.3 Publications
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    MaxQBiQ13421.
    PaxDbiQ13421.
    PRIDEiQ13421.

    PTM databases

    PhosphoSiteiQ13421.

    Expressioni

    Tissue specificityi

    Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ13421.
    BgeeiQ13421.
    GenevestigatoriQ13421.

    Organism-specific databases

    HPAiCAB002216.
    HPA017172.

    Interactioni

    Subunit structurei

    Interacts with MUC16.2 Publications

    Protein-protein interaction databases

    BioGridi115526. 12 interactions.
    IntActiQ13421. 1 interaction.

    Structurei

    Secondary structure

    1
    630
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi313 – 3175
    Helixi320 – 3267
    Helixi329 – 3346
    Helixi336 – 3416
    Helixi346 – 35813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4F3FX-ray2.65C302-359[»]
    ProteinModelPortaliQ13421.
    SMRiQ13421. Positions 302-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni262 – 28625Required for megakaryocyte-potentiating factor activityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the mesothelin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40535.
    HOVERGENiHBG081988.
    InParanoidiQ13421.
    OMAiCDLPGRF.
    OrthoDBiEOG7M3HZW.
    PhylomeDBiQ13421.
    TreeFamiTF331713.

    Family and domain databases

    InterProiIPR010335. Mesothelin.
    IPR026664. Stereocilin_related.
    [Graphical view]
    PANTHERiPTHR23412. PTHR23412. 1 hit.
    PfamiPF06060. Mesothelin. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13421-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG    50
    VLANPPNISS LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ 100
    LRCLAHRLSE PPEDLDALPL DLLLFLNPDA FSGPQACTRF FSRITKANVD 150
    LLPRGAPERQ RLLPAALACW GVRGSLLSEA DVRALGGLAC DLPGRFVAES 200
    AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW SVSTMDALRG 250
    LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT 300
    ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD 350
    VLKHKLDELY PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE 400
    VNKGHEMSPQ APRRPLPQVA TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC 450
    SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ LDVLYPKARL AFQNMNGSEY 500
    FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL PLTVAEVQKL 550
    LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS 600
    MQEALSGTPC LLGPGPVLTV LALLLASTLA 630

    Note: Minor form.

    Length:630
    Mass (Da):68,986
    Last modified:October 17, 2006 - v2
    Checksum:iFA17E3609B6CC9CA
    GO
    Isoform 2 (identifier: Q13421-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         409-416: Missing.

    Note: Major form.

    Show »
    Length:622
    Mass (Da):68,070
    Checksum:i1F0FE52883D0DDB8
    GO
    Isoform 3 (identifier: Q13421-2) [UniParc]FASTAAdd to Basket

    Also known as: SMRP

    The sequence of this isoform differs from the canonical sequence as follows:
         409-416: Missing.
         601-630: MQEALSGTPCLLGPGPVLTVLALLLASTLA → VQGGRGGQAR...HPGLRAPLPC

    Note: Soluble form found in the sera from patients with ovarian carcinoma.

    Show »
    Length:656
    Mass (Da):71,492
    Checksum:iC1B783689D5DC266
    GO
    Isoform 4 (identifier: Q13421-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         44-44: Missing.
         409-416: Missing.

    Show »
    Length:621
    Mass (Da):67,940
    Checksum:i1A736774094C28D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 118PTARPLLG → QRLDPCW in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti15 – 184TPAL → DRP in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti32 – 343QPS → HPA in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti43 – 453QEA → TES in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti49 – 491D → G in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti53 – 564ANPP → TTPH in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti139 – 1391R → H in AAV87530. (PubMed:15897581)Curated
    Sequence conflicti402 – 4021N → D in AAC50348. (PubMed:8552591)Curated
    Sequence conflicti604 – 6041A → T in AAC50348. (PubMed:8552591)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721A → V.
    Corresponds to variant rs9927389 [ dbSNP | Ensembl ].
    VAR_028381
    Natural varianti309 – 3091R → P.1 Publication
    Corresponds to variant rs17850474 [ dbSNP | Ensembl ].
    VAR_028382
    Natural varianti497 – 4971G → E.
    Corresponds to variant rs35935235 [ dbSNP | Ensembl ].
    VAR_054012
    Natural varianti601 – 6011M → V.6 Publications
    Corresponds to variant rs1135210 [ dbSNP | Ensembl ].
    VAR_028383

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei44 – 441Missing in isoform 4. 1 PublicationVSP_021058
    Alternative sequencei409 – 4168Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_021059
    Alternative sequencei601 – 63030MQEAL…ASTLA → VQGGRGGQARAGGRAGGVEV GALSHPSLCRGPLGDALPPR TWTCSHRPGTAPSLHPGLRA PLPC in isoform 3. 1 PublicationVSP_021060Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49441 mRNA. Translation: BAA08419.1.
    U40434 mRNA. Translation: AAC50348.1.
    AY743922 mRNA. Translation: AAV87530.1.
    AE006464 Genomic DNA. Translation: AAK61253.1.
    AL031258 Genomic DNA. Translation: CAC37289.1.
    CH471112 Genomic DNA. Translation: EAW85719.1.
    CH471112 Genomic DNA. Translation: EAW85720.1.
    BC003512 mRNA. Translation: AAH03512.1.
    BC009272 mRNA. Translation: AAH09272.1.
    AF180951 mRNA. Translation: AAF01409.1.
    CCDSiCCDS32356.1. [Q13421-1]
    CCDS45370.1. [Q13421-3]
    RefSeqiNP_001170826.1. NM_001177355.1. [Q13421-3]
    NP_005814.2. NM_005823.5. [Q13421-3]
    NP_037536.2. NM_013404.4. [Q13421-1]
    XP_005255091.1. XM_005255034.2. [Q13421-4]
    XP_006720899.1. XM_006720836.1. [Q13421-3]
    XP_006720900.1. XM_006720837.1. [Q13421-3]
    UniGeneiHs.408488.

    Genome annotation databases

    EnsembliENST00000382862; ENSP00000372313; ENSG00000102854. [Q13421-1]
    ENST00000545450; ENSP00000442965; ENSG00000102854. [Q13421-3]
    ENST00000563941; ENSP00000456008; ENSG00000102854. [Q13421-3]
    ENST00000566549; ENSP00000456702; ENSG00000102854. [Q13421-3]
    GeneIDi10232.
    KEGGihsa:10232.
    UCSCiuc002cjt.1. human. [Q13421-3]
    uc002cjw.2. human. [Q13421-1]
    uc010brd.1. human. [Q13421-4]

    Polymorphism databases

    DMDMi116242654.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49441 mRNA. Translation: BAA08419.1 .
    U40434 mRNA. Translation: AAC50348.1 .
    AY743922 mRNA. Translation: AAV87530.1 .
    AE006464 Genomic DNA. Translation: AAK61253.1 .
    AL031258 Genomic DNA. Translation: CAC37289.1 .
    CH471112 Genomic DNA. Translation: EAW85719.1 .
    CH471112 Genomic DNA. Translation: EAW85720.1 .
    BC003512 mRNA. Translation: AAH03512.1 .
    BC009272 mRNA. Translation: AAH09272.1 .
    AF180951 mRNA. Translation: AAF01409.1 .
    CCDSi CCDS32356.1. [Q13421-1 ]
    CCDS45370.1. [Q13421-3 ]
    RefSeqi NP_001170826.1. NM_001177355.1. [Q13421-3 ]
    NP_005814.2. NM_005823.5. [Q13421-3 ]
    NP_037536.2. NM_013404.4. [Q13421-1 ]
    XP_005255091.1. XM_005255034.2. [Q13421-4 ]
    XP_006720899.1. XM_006720836.1. [Q13421-3 ]
    XP_006720900.1. XM_006720837.1. [Q13421-3 ]
    UniGenei Hs.408488.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4F3F X-ray 2.65 C 302-359 [» ]
    ProteinModelPortali Q13421.
    SMRi Q13421. Positions 302-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115526. 12 interactions.
    IntActi Q13421. 1 interaction.

    PTM databases

    PhosphoSitei Q13421.

    Polymorphism databases

    DMDMi 116242654.

    Proteomic databases

    MaxQBi Q13421.
    PaxDbi Q13421.
    PRIDEi Q13421.

    Protocols and materials databases

    DNASUi 10232.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382862 ; ENSP00000372313 ; ENSG00000102854 . [Q13421-1 ]
    ENST00000545450 ; ENSP00000442965 ; ENSG00000102854 . [Q13421-3 ]
    ENST00000563941 ; ENSP00000456008 ; ENSG00000102854 . [Q13421-3 ]
    ENST00000566549 ; ENSP00000456702 ; ENSG00000102854 . [Q13421-3 ]
    GeneIDi 10232.
    KEGGi hsa:10232.
    UCSCi uc002cjt.1. human. [Q13421-3 ]
    uc002cjw.2. human. [Q13421-1 ]
    uc010brd.1. human. [Q13421-4 ]

    Organism-specific databases

    CTDi 10232.
    GeneCardsi GC16P000810.
    HGNCi HGNC:7371. MSLN.
    HPAi CAB002216.
    HPA017172.
    MIMi 601051. gene.
    neXtProti NX_Q13421.
    PharmGKBi PA31176.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40535.
    HOVERGENi HBG081988.
    InParanoidi Q13421.
    OMAi CDLPGRF.
    OrthoDBi EOG7M3HZW.
    PhylomeDBi Q13421.
    TreeFami TF331713.

    Miscellaneous databases

    GeneWikii Mesothelin.
    GenomeRNAii 10232.
    NextBioi 38744.
    PROi Q13421.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13421.
    Bgeei Q13421.
    Genevestigatori Q13421.

    Family and domain databases

    InterProi IPR010335. Mesothelin.
    IPR026664. Stereocilin_related.
    [Graphical view ]
    PANTHERi PTHR23412. PTHR23412. 1 hit.
    Pfami PF06060. Mesothelin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of megakaryocyte potentiating factor cDNA."
      Kojima T., Oh-Eda M., Hattori K., Taniguchi Y., Tamura M., Ochi N., Yamaguchi N.
      J. Biol. Chem. 270:21984-21990(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 37-54 AND 90-117, TISSUE SPECIFICITY, VARIANT VAL-601.
      Tissue: Pancreatic cancer.
    2. "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers."
      Chang K., Pastan I.
      Proc. Natl. Acad. Sci. U.S.A. 93:136-140(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, GPI-ANCHOR, GLYCOSYLATION, CLEAVAGE, VARIANT VAL-601.
      Tissue: Carcinoma.
    3. "Characterization of human mesothelin transcripts in ovarian and pancreatic cancer."
      Muminova Z.E., Strong T.V., Shaw D.R.
      BMC Cancer 4:19-19(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORMS 2 AND 3).
    4. "Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients."
      Ho M., Hassan R., Zhang J., Wang Q.-C., Onda M., Bera T., Pastan I.
      Clin. Cancer Res. 11:3814-3820(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DISEASE, VARIANT VAL-601.
      Tissue: Lung and Spleen.
    5. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-601.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANTS PRO-309 AND VAL-601.
      Tissue: Pancreas and Placenta.
    9. "A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5."
      Yamaguchi N., Hattori K., Oh-eda M., Kojima T., Imai N., Ochi N.
      J. Biol. Chem. 269:805-808(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 37-54 (ISOFORMS 1/2/3), GLYCOSYLATION, FUNCTION.
      Tissue: Pancreatic tumor.
    10. "Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma."
      Scholler N., Fu N., Yang Y., Ye Z., Goodman G.E., Hellstroem K.E., Hellstroem I.
      Proc. Natl. Acad. Sci. U.S.A. 96:11531-11536(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 297-630 (ISOFORM 3), PROTEIN SEQUENCE OF 296-314, VARIANT VAL-601.
    11. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
      Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
      J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MUC16, FUNCTION.
    12. "Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma."
      Onda M., Nagata S., Ho M., Bera T.K., Hassan R., Alexander R.H., Pastan I.
      Clin. Cancer Res. 12:4225-4231(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, TISSUE SPECIFICITY.
    13. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
      Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N.
      J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights."
      Ma J., Tang W.K., Esser L., Pastan I., Xia D.
      J. Biol. Chem. 287:33123-33131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 302-359 IN COMPLEX WITH ANTOBODY, SUBCELLULAR LOCATION, DISULFIDE BOND.

    Entry informationi

    Entry nameiMSLN_HUMAN
    AccessioniPrimary (citable) accession number: Q13421
    Secondary accession number(s): D3DU65
    , Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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