Q13421 (MSLN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mesothelin

Alternative name(s):
CAK1 antigen
Pre-pro-megakaryocyte-potentiating factor

Cleaved into the following 2 chains:

1. Megakaryocyte-potentiating factor
   Short name=MPF
2. Mesothelin, cleaved form

Gene names

Name:	MSLN
Synonyms:	MPF

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	630 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Membrane-anchored forms may play a role in cellular adhesion. Ref.9 Ref.11 Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. Ref.9 Ref.11
Subunit structure	Interacts with MUC16. Ref.11
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor. Golgi apparatus Ref.2 Ref.13. Megakaryocyte-potentiating factor: Secreted Ref.2. Isoform 3: Secreted Ref.2.
Tissue specificity	Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). Ref.1 Ref.12
Post-translational modification	Both MPF and the cleaved form of mesothelin are N-glycosylated. Ref.2 Ref.9 Ref.12 Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. Ref.2
Involvement in disease	Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Ref.4
Sequence similarities	Belongs to the mesothelin family.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Golgi apparatus Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Cleavage on pair of basic residues GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	cell adhesion Non-traceable author statement Ref.2. Source: UniProtKB
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q13421-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Minor form.

Isoform 2 (identifier: Q13421-3)

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.

Note: Major form.

Isoform 3 (identifier: Q13421-2)

Also known as: SMRP;

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.
     601-630: MQEALSGTPCLLGPGPVLTVLALLLASTLA → VQGGRGGQAR...HPGLRAPLPC

Note: Soluble form found in the sera from patients with ovarian carcinoma.

Isoform 4 (identifier: Q13421-4)

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Missing.
     409-416: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Ref.1 Ref.9
	Chain	37 – 606	570	Mesothelin		PRO_0000253559
	Chain	37 – 286	250	Megakaryocyte-potentiating factor		PRO_0000253560
	Chain	296 – 606	311	Mesothelin, cleaved form		PRO_0000253561
	Propeptide	607 – 630	24	Removed in mature form Potential		PRO_0000021769
Regions
	Region	262 – 286	25	Required for megakaryocyte-potentiating factor activity
Amino acid modifications
	Lipidation	606	1	GPI-anchor amidated serine Potential
	Glycosylation	57	1	N-linked (GlcNAc...) Probable
	Glycosylation	388	1	N-linked (GlcNAc...) Potential
	Glycosylation	496	1	N-linked (GlcNAc...) Potential
	Glycosylation	523	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	44	1	Missing in isoform 4.		VSP_021058
	Alternative sequence	409 – 416	8	Missing in isoform 2, isoform 3 and isoform 4.		VSP_021059
	Alternative sequence	601 – 630	30	MQEAL…ASTLA → VQGGRGGQARAGGRAGGVEV GALSHPSLCRGPLGDALPPR TWTCSHRPGTAPSLHPGLRA PLPC in isoform 3.		VSP_021060
	Natural variant	72	1	A → V. Corresponds to variant rs9927389 [ dbSNP | Ensembl ].		VAR_028381
	Natural variant	309	1	R → P. Ref.8 Corresponds to variant rs17850474 [ dbSNP | Ensembl ].		VAR_028382
	Natural variant	497	1	G → E. Corresponds to variant rs35935235 [ dbSNP | Ensembl ].		VAR_054012
	Natural variant	601	1	M → V. Ref.1 Ref.2 Ref.4 Ref.7 Ref.8 Ref.10 Corresponds to variant rs1135210 [ dbSNP | Ensembl ].		VAR_028383
Experimental info
	Sequence conflict	4 – 11	8	PTARPLLG → QRLDPCW in AAC50348. Ref.2
	Sequence conflict	15 – 18	4	TPAL → DRP in AAC50348. Ref.2
	Sequence conflict	32 – 34	3	QPS → HPA in AAC50348. Ref.2
	Sequence conflict	43 – 45	3	QEA → TES in AAC50348. Ref.2
	Sequence conflict	49	1	D → G in AAC50348. Ref.2
	Sequence conflict	53 – 56	4	ANPP → TTPH in AAC50348. Ref.2
	Sequence conflict	139	1	R → H in AAV87530. Ref.4
	Sequence conflict	402	1	N → D in AAC50348. Ref.2
	Sequence conflict	604	1	A → T in AAC50348. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: FA17E3609B6CC9CA	FASTA	630	68,986
	10 20 30 40 50 60 MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS 70 80 90 100 110 120 LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL 130 140 150 160 170 180 DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA 190 200 210 220 230 240 DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW 250 260 270 280 290 300 SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT 310 320 330 340 350 360 ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY 370 380 390 400 410 420 PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ APRRPLPQVA 430 440 450 460 470 480 TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ 490 500 510 520 530 540 LDVLYPKARL AFQNMNGSEY FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL 550 560 570 580 590 600 PLTVAEVQKL LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS 610 620 630 MQEALSGTPC LLGPGPVLTV LALLLASTLA
	Isoform 2 [UniParc]. Checksum: 1F0FE52883D0DDB8	FASTA	622	68,070
	10 20 30 40 50 60 MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS 70 80 90 100 110 120 LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL 130 140 150 160 170 180 DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA 190 200 210 220 230 240 DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW 250 260 270 280 290 300 SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT 310 320 330 340 350 360 ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY 370 380 390 400 410 420 PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ VATLIDRFVK 430 440 450 460 470 480 GRGQLDKDTL DTLTAFYPGY LCSLSPEELS SVPPSSIWAV RPQDLDTCDP RQLDVLYPKA 490 500 510 520 530 540 RLAFQNMNGS EYFVKIQSFL GGAPTEDLKA LSQQNVSMDL ATFMKLRTDA VLPLTVAEVQ 550 560 570 580 590 600 KLLGPHVEGL KAEERHRPVR DWILRQRQDD LDTLGLGLQG GIPNGYLVLD LSMQEALSGT 610 620 PCLLGPGPVL TVLALLLAST LA
	Isoform 3 (SMRP) [UniParc]. Checksum: C1B783689D5DC266	FASTA	656	71,492
	10 20 30 40 50 60 MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG VLANPPNISS 70 80 90 100 110 120 LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ LRCLAHRLSE PPEDLDALPL 130 140 150 160 170 180 DLLLFLNPDA FSGPQACTRF FSRITKANVD LLPRGAPERQ RLLPAALACW GVRGSLLSEA 190 200 210 220 230 240 DVRALGGLAC DLPGRFVAES AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW 250 260 270 280 290 300 SVSTMDALRG LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT 310 320 330 340 350 360 ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD VLKHKLDELY 370 380 390 400 410 420 PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE VNKGHEMSPQ VATLIDRFVK 430 440 450 460 470 480 GRGQLDKDTL DTLTAFYPGY LCSLSPEELS SVPPSSIWAV RPQDLDTCDP RQLDVLYPKA 490 500 510 520 530 540 RLAFQNMNGS EYFVKIQSFL GGAPTEDLKA LSQQNVSMDL ATFMKLRTDA VLPLTVAEVQ 550 560 570 580 590 600 KLLGPHVEGL KAEERHRPVR DWILRQRQDD LDTLGLGLQG GIPNGYLVLD LSVQGGRGGQ 610 620 630 640 650 ARAGGRAGGV EVGALSHPSL CRGPLGDALP PRTWTCSHRP GTAPSLHPGL RAPLPC
	Isoform 4 [UniParc]. Checksum: 1A736774094C28D0	FASTA	621	67,940
	10 20 30 40 50 60 MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQAAPLDGV LANPPNISSL 70 80 90 100 110 120 SPRQLLGFPC AEVSGLSTER VRELAVALAQ KNVKLSTEQL RCLAHRLSEP PEDLDALPLD 130 140 150 160 170 180 LLLFLNPDAF SGPQACTRFF SRITKANVDL LPRGAPERQR LLPAALACWG VRGSLLSEAD 190 200 210 220 230 240 VRALGGLACD LPGRFVAESA EVLLPRLVSC PGPLDQDQQE AARAALQGGG PPYGPPSTWS 250 260 270 280 290 300 VSTMDALRGL LPVLGQPIIR SIPQGIVAAW RQRSSRDPSW RQPERTILRP RFRREVEKTA 310 320 330 340 350 360 CPSGKKAREI DESLIFYKKW ELEACVDAAL LATQMDRVNA IPFTYEQLDV LKHKLDELYP 370 380 390 400 410 420 QGYPESVIQH LGYLFLKMSP EDIRKWNVTS LETLKALLEV NKGHEMSPQV ATLIDRFVKG 430 440 450 460 470 480 RGQLDKDTLD TLTAFYPGYL CSLSPEELSS VPPSSIWAVR PQDLDTCDPR QLDVLYPKAR 490 500 510 520 530 540 LAFQNMNGSE YFVKIQSFLG GAPTEDLKAL SQQNVSMDLA TFMKLRTDAV LPLTVAEVQK 550 560 570 580 590 600 LLGPHVEGLK AEERHRPVRD WILRQRQDDL DTLGLGLQGG IPNGYLVLDL SMQEALSGTP 610 620 CLLGPGPVLT VLALLLASTL A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression of megakaryocyte potentiating factor cDNA." Kojima T., Oh-Eda M., Hattori K., Taniguchi Y., Tamura M., Ochi N., Yamaguchi N. J. Biol. Chem. 270:21984-21990(1995) [PubMed: 7665620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 37-54 AND 90-117, TISSUE SPECIFICITY, VARIANT VAL-601. Tissue: Pancreatic cancer.
[2]	"Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers." Chang K., Pastan I. Proc. Natl. Acad. Sci. U.S.A. 93:136-140(1996) [PubMed: 8552591] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, GPI-ANCHOR, GLYCOSYLATION, CLEAVAGE, VARIANT VAL-601. Tissue: Carcinoma.
[3]	"Characterization of human mesothelin transcripts in ovarian and pancreatic cancer." Muminova Z.E., Strong T.V., Shaw D.R. BMC Cancer 4:19-19(2004) [PubMed: 15140265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORMS 2 AND 3).
[4]	"Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients." Ho M., Hassan R., Zhang J., Wang Q.-C., Onda M., Bera T., Pastan I. Clin. Cancer Res. 11:3814-3820(2005) [PubMed: 15897581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DISEASE, VARIANT VAL-601. Tissue: Lung and Spleen.
[5]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-601.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANTS PRO-309 AND VAL-601. Tissue: Pancreas and Placenta.
[9]	"A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5." Yamaguchi N., Hattori K., Oh-eda M., Kojima T., Imai N., Ochi N. J. Biol. Chem. 269:805-808(1994) [PubMed: 8288629] [Abstract] Cited for: PROTEIN SEQUENCE OF 37-54 (ISOFORMS 1/2/3), GLYCOSYLATION, FUNCTION. Tissue: Pancreatic tumor.
[10]	"Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma." Scholler N., Fu N., Yang Y., Ye Z., Goodman G.E., Hellstroem K.E., Hellstroem I. Proc. Natl. Acad. Sci. U.S.A. 96:11531-11536(1999) [PubMed: 10500211] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 297-630 (ISOFORM 3), PROTEIN SEQUENCE OF 296-314, VARIANT VAL-601.
[11]	"Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion." Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A. J. Biol. Chem. 279:9190-9198(2004) [PubMed: 14676194] [Abstract] Cited for: INTERACTION WITH MUC16, FUNCTION.
[12]	"Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma." Onda M., Nagata S., Ho M., Bera T.K., Hassan R., Alexander R.H., Pastan I. Clin. Cancer Res. 12:4225-4231(2006) [PubMed: 16857795] [Abstract] Cited for: GLYCOSYLATION, TISSUE SPECIFICITY.
[13]	"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment." Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N. J. Proteome Res. 5:935-943(2006) [PubMed: 16602701] [Abstract] Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49441 mRNA. Translation: BAA08419.1. U40434 mRNA. Translation: AAC50348.1. AY743922 mRNA. Translation: AAV87530.1. AE006464 Genomic DNA. Translation: AAK61253.1. AL031258 Genomic DNA. Translation: CAC37289.1. CH471112 Genomic DNA. Translation: EAW85719.1. CH471112 Genomic DNA. Translation: EAW85720.1. BC003512 mRNA. Translation: AAH03512.1. BC009272 mRNA. Translation: AAH09272.1. AF180951 mRNA. Translation: AAF01409.1.
IPI	IPI00025110. IPI00793522. IPI00793649. IPI00798210.
RefSeq	NP_001170826.1. NM_001177355.1. NP_005814.2. NM_005823.5. NP_037536.2. NM_013404.4.
UniGene	Hs.408488.
3D structure databases
ProteinModelPortal	Q13421.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13421. 1 interaction.
STRING	Q13421.
PTM databases
PhosphoSite	Q13421.
Polymorphism databases
DMDM	116242654.
Proteomic databases
PRIDE	Q13421.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382862; ENSP00000372313; ENSG00000102854.
GeneID	10232.
KEGG	hsa:10232.
UCSC	uc002cjt.1. human. uc002cjw.1. human. uc010brd.1. human.
Organism-specific databases
CTD	10232.
GeneCards	GC16P000697.
HGNC	HGNC:7371. MSLN.
HPA	CAB002216. HPA017172.
MIM	601051. gene.
neXtProt	NX_Q13421.
PharmGKB	PA31176.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04328.
GeneTree	ENSGT00530000064019.
HOVERGEN	HBG081988.
InParanoid	Q13421.
OrthoDB	EOG42JNS1.
Gene expression databases
ArrayExpress	Q13421.
Bgee	Q13421.
Genevestigator	Q13421.
GermOnline	ENSG00000102854. Homo sapiens.
Family and domain databases
InterPro	IPR010335. Mesothelin. [Graphical view]
Pfam	PF06060. Mesothelin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	38744.
SOURCE	Search...

Entry information

Entry name

MSLN_HUMAN

Accession

Primary (citable) accession number: Q13421
Secondary accession number(s): D3DU65 , Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.