Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q13421

- MSLN_HUMAN

UniProt

Q13421 - MSLN_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mesothelin

Gene

MSLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Membrane-anchored forms may play a role in cellular adhesion.
Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. pancreas development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Mesothelin
Alternative name(s):
CAK1 antigen
Pre-pro-megakaryocyte-potentiating factor
Cleaved into the following 2 chains:
Gene namesi
Name:MSLN
Synonyms:MPF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:7371. MSLN.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: Ensembl
  3. extracellular space Source: Ensembl
  4. Golgi apparatus Source: UniProtKB-KW
  5. membrane Source: UniProtKB
  6. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.1 Publication

Organism-specific databases

PharmGKBiPA31176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 36361 PublicationAdd
BLAST
Chaini37 – 606570MesothelinPRO_0000253559Add
BLAST
Chaini37 – 286250Megakaryocyte-potentiating factorPRO_0000253560Add
BLAST
Chaini296 – 606311Mesothelin, cleaved formPRO_0000253561Add
BLAST
Propeptidei607 – 63024Removed in mature formSequence AnalysisPRO_0000021769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Curated
Disulfide bondi302 ↔ 3261 Publication
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
Lipidationi606 – 6061GPI-anchor amidated serineSequence Analysis

Post-translational modificationi

Both MPF and the cleaved form of mesothelin are N-glycosylated.3 Publications
Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ13421.
PaxDbiQ13421.
PRIDEiQ13421.

PTM databases

PhosphoSiteiQ13421.

Expressioni

Tissue specificityi

Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).2 Publications

Gene expression databases

BgeeiQ13421.
ExpressionAtlasiQ13421. baseline and differential.
GenevestigatoriQ13421.

Organism-specific databases

HPAiCAB002216.
HPA017172.

Interactioni

Subunit structurei

Interacts with MUC16.2 Publications

Protein-protein interaction databases

BioGridi115526. 12 interactions.
IntActiQ13421. 1 interaction.

Structurei

Secondary structure

1
630
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi313 – 3175
Helixi320 – 3267
Helixi329 – 3346
Helixi336 – 3416
Helixi346 – 35813

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F3FX-ray2.65C302-359[»]
ProteinModelPortaliQ13421.
SMRiQ13421. Positions 302-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni262 – 28625Required for megakaryocyte-potentiating factor activityAdd
BLAST

Sequence similaritiesi

Belongs to the mesothelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40535.
GeneTreeiENSGT00530000064019.
HOVERGENiHBG081988.
InParanoidiQ13421.
OMAiCDLPGRF.
OrthoDBiEOG7M3HZW.
PhylomeDBiQ13421.
TreeFamiTF331713.

Family and domain databases

InterProiIPR010335. Mesothelin.
IPR026664. Stereocilin_related.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 1 hit.
PfamiPF06060. Mesothelin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13421-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQEAAPLDG
60 70 80 90 100
VLANPPNISS LSPRQLLGFP CAEVSGLSTE RVRELAVALA QKNVKLSTEQ
110 120 130 140 150
LRCLAHRLSE PPEDLDALPL DLLLFLNPDA FSGPQACTRF FSRITKANVD
160 170 180 190 200
LLPRGAPERQ RLLPAALACW GVRGSLLSEA DVRALGGLAC DLPGRFVAES
210 220 230 240 250
AEVLLPRLVS CPGPLDQDQQ EAARAALQGG GPPYGPPSTW SVSTMDALRG
260 270 280 290 300
LLPVLGQPII RSIPQGIVAA WRQRSSRDPS WRQPERTILR PRFRREVEKT
310 320 330 340 350
ACPSGKKARE IDESLIFYKK WELEACVDAA LLATQMDRVN AIPFTYEQLD
360 370 380 390 400
VLKHKLDELY PQGYPESVIQ HLGYLFLKMS PEDIRKWNVT SLETLKALLE
410 420 430 440 450
VNKGHEMSPQ APRRPLPQVA TLIDRFVKGR GQLDKDTLDT LTAFYPGYLC
460 470 480 490 500
SLSPEELSSV PPSSIWAVRP QDLDTCDPRQ LDVLYPKARL AFQNMNGSEY
510 520 530 540 550
FVKIQSFLGG APTEDLKALS QQNVSMDLAT FMKLRTDAVL PLTVAEVQKL
560 570 580 590 600
LGPHVEGLKA EERHRPVRDW ILRQRQDDLD TLGLGLQGGI PNGYLVLDLS
610 620 630
MQEALSGTPC LLGPGPVLTV LALLLASTLA

Note: Minor form.

Length:630
Mass (Da):68,986
Last modified:October 17, 2006 - v2
Checksum:iFA17E3609B6CC9CA
GO
Isoform 2 (identifier: Q13421-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.

Note: Major form.

Show »
Length:622
Mass (Da):68,070
Checksum:i1F0FE52883D0DDB8
GO
Isoform 3 (identifier: Q13421-2) [UniParc]FASTAAdd to Basket

Also known as: SMRP

The sequence of this isoform differs from the canonical sequence as follows:
     409-416: Missing.
     601-630: MQEALSGTPCLLGPGPVLTVLALLLASTLA → VQGGRGGQAR...HPGLRAPLPC

Note: Soluble form found in the sera from patients with ovarian carcinoma.

Show »
Length:656
Mass (Da):71,492
Checksum:iC1B783689D5DC266
GO
Isoform 4 (identifier: Q13421-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Missing.
     409-416: Missing.

Show »
Length:621
Mass (Da):67,940
Checksum:i1A736774094C28D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 118PTARPLLG → QRLDPCW in AAC50348. (PubMed:8552591)Curated
Sequence conflicti15 – 184TPAL → DRP in AAC50348. (PubMed:8552591)Curated
Sequence conflicti32 – 343QPS → HPA in AAC50348. (PubMed:8552591)Curated
Sequence conflicti43 – 453QEA → TES in AAC50348. (PubMed:8552591)Curated
Sequence conflicti49 – 491D → G in AAC50348. (PubMed:8552591)Curated
Sequence conflicti53 – 564ANPP → TTPH in AAC50348. (PubMed:8552591)Curated
Sequence conflicti139 – 1391R → H in AAV87530. (PubMed:15897581)Curated
Sequence conflicti402 – 4021N → D in AAC50348. (PubMed:8552591)Curated
Sequence conflicti604 – 6041A → T in AAC50348. (PubMed:8552591)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721A → V.
Corresponds to variant rs9927389 [ dbSNP | Ensembl ].
VAR_028381
Natural varianti309 – 3091R → P.1 Publication
Corresponds to variant rs17850474 [ dbSNP | Ensembl ].
VAR_028382
Natural varianti497 – 4971G → E.
Corresponds to variant rs35935235 [ dbSNP | Ensembl ].
VAR_054012
Natural varianti601 – 6011M → V.6 Publications
Corresponds to variant rs1135210 [ dbSNP | Ensembl ].
VAR_028383

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 441Missing in isoform 4. 1 PublicationVSP_021058
Alternative sequencei409 – 4168Missing in isoform 2, isoform 3 and isoform 4. 5 PublicationsVSP_021059
Alternative sequencei601 – 63030MQEAL…ASTLA → VQGGRGGQARAGGRAGGVEV GALSHPSLCRGPLGDALPPR TWTCSHRPGTAPSLHPGLRA PLPC in isoform 3. 1 PublicationVSP_021060Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49441 mRNA. Translation: BAA08419.1.
U40434 mRNA. Translation: AAC50348.1.
AY743922 mRNA. Translation: AAV87530.1.
AE006464 Genomic DNA. Translation: AAK61253.1.
AL031258 Genomic DNA. Translation: CAC37289.1.
CH471112 Genomic DNA. Translation: EAW85719.1.
CH471112 Genomic DNA. Translation: EAW85720.1.
BC003512 mRNA. Translation: AAH03512.1.
BC009272 mRNA. Translation: AAH09272.1.
AF180951 mRNA. Translation: AAF01409.1.
CCDSiCCDS32356.1. [Q13421-1]
CCDS45370.1. [Q13421-3]
RefSeqiNP_001170826.1. NM_001177355.1. [Q13421-3]
NP_005814.2. NM_005823.5. [Q13421-3]
NP_037536.2. NM_013404.4. [Q13421-1]
XP_005255091.1. XM_005255034.2. [Q13421-4]
XP_006720899.1. XM_006720836.1. [Q13421-3]
XP_006720900.1. XM_006720837.1. [Q13421-3]
UniGeneiHs.408488.

Genome annotation databases

EnsembliENST00000382862; ENSP00000372313; ENSG00000102854. [Q13421-1]
ENST00000545450; ENSP00000442965; ENSG00000102854. [Q13421-3]
ENST00000563941; ENSP00000456008; ENSG00000102854. [Q13421-3]
ENST00000566549; ENSP00000456702; ENSG00000102854. [Q13421-3]
ENST00000620831; ENSP00000482893; ENSG00000102854. [Q13421-1]
GeneIDi10232.
KEGGihsa:10232.
UCSCiuc002cjt.1. human. [Q13421-3]
uc002cjw.2. human. [Q13421-1]
uc010brd.1. human. [Q13421-4]

Polymorphism databases

DMDMi116242654.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49441 mRNA. Translation: BAA08419.1 .
U40434 mRNA. Translation: AAC50348.1 .
AY743922 mRNA. Translation: AAV87530.1 .
AE006464 Genomic DNA. Translation: AAK61253.1 .
AL031258 Genomic DNA. Translation: CAC37289.1 .
CH471112 Genomic DNA. Translation: EAW85719.1 .
CH471112 Genomic DNA. Translation: EAW85720.1 .
BC003512 mRNA. Translation: AAH03512.1 .
BC009272 mRNA. Translation: AAH09272.1 .
AF180951 mRNA. Translation: AAF01409.1 .
CCDSi CCDS32356.1. [Q13421-1 ]
CCDS45370.1. [Q13421-3 ]
RefSeqi NP_001170826.1. NM_001177355.1. [Q13421-3 ]
NP_005814.2. NM_005823.5. [Q13421-3 ]
NP_037536.2. NM_013404.4. [Q13421-1 ]
XP_005255091.1. XM_005255034.2. [Q13421-4 ]
XP_006720899.1. XM_006720836.1. [Q13421-3 ]
XP_006720900.1. XM_006720837.1. [Q13421-3 ]
UniGenei Hs.408488.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4F3F X-ray 2.65 C 302-359 [» ]
ProteinModelPortali Q13421.
SMRi Q13421. Positions 302-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115526. 12 interactions.
IntActi Q13421. 1 interaction.

PTM databases

PhosphoSitei Q13421.

Polymorphism databases

DMDMi 116242654.

Proteomic databases

MaxQBi Q13421.
PaxDbi Q13421.
PRIDEi Q13421.

Protocols and materials databases

DNASUi 10232.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382862 ; ENSP00000372313 ; ENSG00000102854 . [Q13421-1 ]
ENST00000545450 ; ENSP00000442965 ; ENSG00000102854 . [Q13421-3 ]
ENST00000563941 ; ENSP00000456008 ; ENSG00000102854 . [Q13421-3 ]
ENST00000566549 ; ENSP00000456702 ; ENSG00000102854 . [Q13421-3 ]
ENST00000620831 ; ENSP00000482893 ; ENSG00000102854 . [Q13421-1 ]
GeneIDi 10232.
KEGGi hsa:10232.
UCSCi uc002cjt.1. human. [Q13421-3 ]
uc002cjw.2. human. [Q13421-1 ]
uc010brd.1. human. [Q13421-4 ]

Organism-specific databases

CTDi 10232.
GeneCardsi GC16P000810.
HGNCi HGNC:7371. MSLN.
HPAi CAB002216.
HPA017172.
MIMi 601051. gene.
neXtProti NX_Q13421.
PharmGKBi PA31176.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40535.
GeneTreei ENSGT00530000064019.
HOVERGENi HBG081988.
InParanoidi Q13421.
OMAi CDLPGRF.
OrthoDBi EOG7M3HZW.
PhylomeDBi Q13421.
TreeFami TF331713.

Miscellaneous databases

GeneWikii Mesothelin.
GenomeRNAii 10232.
NextBioi 38744.
PROi Q13421.
SOURCEi Search...

Gene expression databases

Bgeei Q13421.
ExpressionAtlasi Q13421. baseline and differential.
Genevestigatori Q13421.

Family and domain databases

InterProi IPR010335. Mesothelin.
IPR026664. Stereocilin_related.
[Graphical view ]
PANTHERi PTHR23412. PTHR23412. 1 hit.
Pfami PF06060. Mesothelin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of megakaryocyte potentiating factor cDNA."
    Kojima T., Oh-Eda M., Hattori K., Taniguchi Y., Tamura M., Ochi N., Yamaguchi N.
    J. Biol. Chem. 270:21984-21990(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 37-54 AND 90-117, TISSUE SPECIFICITY, VARIANT VAL-601.
    Tissue: Pancreatic cancer.
  2. "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers."
    Chang K., Pastan I.
    Proc. Natl. Acad. Sci. U.S.A. 93:136-140(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, GPI-ANCHOR, GLYCOSYLATION, CLEAVAGE, VARIANT VAL-601.
    Tissue: Carcinoma.
  3. "Characterization of human mesothelin transcripts in ovarian and pancreatic cancer."
    Muminova Z.E., Strong T.V., Shaw D.R.
    BMC Cancer 4:19-19(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING (ISOFORMS 2 AND 3).
  4. "Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients."
    Ho M., Hassan R., Zhang J., Wang Q.-C., Onda M., Bera T., Pastan I.
    Clin. Cancer Res. 11:3814-3820(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DISEASE, VARIANT VAL-601.
    Tissue: Lung and Spleen.
  5. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-601.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANTS PRO-309 AND VAL-601.
    Tissue: Pancreas and Placenta.
  9. "A novel cytokine exhibiting megakaryocyte potentiating activity from a human pancreatic tumor cell line HPC-Y5."
    Yamaguchi N., Hattori K., Oh-eda M., Kojima T., Imai N., Ochi N.
    J. Biol. Chem. 269:805-808(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 37-54 (ISOFORMS 1/2/3), GLYCOSYLATION, FUNCTION.
    Tissue: Pancreatic tumor.
  10. "Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma."
    Scholler N., Fu N., Yang Y., Ye Z., Goodman G.E., Hellstroem K.E., Hellstroem I.
    Proc. Natl. Acad. Sci. U.S.A. 96:11531-11536(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 297-630 (ISOFORM 3), PROTEIN SEQUENCE OF 296-314, VARIANT VAL-601.
  11. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
    Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
    J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUC16, FUNCTION.
  12. "Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma."
    Onda M., Nagata S., Ho M., Bera T.K., Hassan R., Alexander R.H., Pastan I.
    Clin. Cancer Res. 12:4225-4231(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, TISSUE SPECIFICITY.
  13. "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
    Elortza F., Mohammed S., Bunkenborg J., Foster L.J., Nuehse T.S., Brodbeck U., Peck S.C., Jensen O.N.
    J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights."
    Ma J., Tang W.K., Esser L., Pastan I., Xia D.
    J. Biol. Chem. 287:33123-33131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 302-359 IN COMPLEX WITH ANTOBODY, SUBCELLULAR LOCATION, DISULFIDE BOND.

Entry informationi

Entry nameiMSLN_HUMAN
AccessioniPrimary (citable) accession number: Q13421
Secondary accession number(s): D3DU65
, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UCB2, Q9UK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3