Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q13418

- ILK_HUMAN

UniProt

Q13418 - ILK_HUMAN

Protein

Integrin-linked protein kinase

Gene

ILK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 2 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei220 – 2201ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi199 – 2079ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein kinase binding Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB
    5. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: Ensembl
    2. cell aging Source: Ensembl
    3. cell cycle arrest Source: Ensembl
    4. cell junction assembly Source: Reactome
    5. cell-matrix adhesion Source: ProtInc
    6. cell proliferation Source: UniProtKB
    7. establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
    8. extracellular fibril organization Source: Ensembl
    9. integrin-mediated signaling pathway Source: MGI
    10. myelin assembly Source: Ensembl
    11. myelination in peripheral nervous system Source: Ensembl
    12. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. negative regulation of protein kinase activity Source: Ensembl
    15. negative regulation of smooth muscle cell migration Source: Ensembl
    16. negative regulation of smooth muscle cell proliferation Source: Ensembl
    17. nerve development Source: Ensembl
    18. neuron projection morphogenesis Source: Ensembl
    19. peptidyl-serine phosphorylation Source: Ensembl
    20. positive regulation of axon extension Source: Ensembl
    21. positive regulation of BMP signaling pathway Source: Ensembl
    22. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
    23. positive regulation of cell-matrix adhesion Source: Ensembl
    24. positive regulation of cell migration Source: Ensembl
    25. positive regulation of cell proliferation Source: Ensembl
    26. positive regulation of dendrite morphogenesis Source: Ensembl
    27. positive regulation of MAP kinase activity Source: Ensembl
    28. positive regulation of myoblast differentiation Source: Ensembl
    29. positive regulation of osteoblast differentiation Source: Ensembl
    30. positive regulation of phosphorylation Source: UniProtKB
    31. positive regulation of protein kinase B signaling Source: Ensembl
    32. positive regulation of transcription, DNA-templated Source: UniProtKB
    33. protein heterooligomerization Source: Ensembl
    34. protein kinase B signaling Source: Ensembl
    35. protein phosphorylation Source: UniProtKB
    36. regulation of actin cytoskeleton organization Source: Ensembl
    37. substrate adhesion-dependent cell spreading Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    ReactomeiREACT_20617. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
    REACT_20649. Cell-extracellular matrix interactions.
    SignaLinkiQ13418.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin-linked protein kinase (EC:2.7.11.1)
    Alternative name(s):
    59 kDa serine/threonine-protein kinase
    ILK-1
    ILK-2
    p59ILK
    Gene namesi
    Name:ILK
    Synonyms:ILK1, ILK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6040. ILK.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: Ensembl
    2. cell junction Source: HPA
    3. costamere Source: Ensembl
    4. cytoplasm Source: HPA
    5. cytosol Source: Reactome
    6. dendritic shaft Source: Ensembl
    7. focal adhesion Source: HPA
    8. lamellipodium Source: UniProtKB-SubCell
    9. membrane Source: UniProtKB
    10. neuronal cell body Source: Ensembl
    11. nucleus Source: HPA
    12. plasma membrane Source: UniProtKB-SubCell
    13. protein complex Source: Ensembl
    14. sarcomere Source: UniProtKB-SubCell
    15. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi99 – 991H → D: Alters interaction with LIMS1. 1 Publication
    Mutagenesisi359 – 3591E → K: Inactivation of ILK. 1 Publication

    Organism-specific databases

    PharmGKBiPA29855.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Integrin-linked protein kinasePRO_0000086020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications
    Modified residuei186 – 1861Phosphoserine1 Publication
    Modified residuei426 – 4261N6-acetyllysineBy similarity

    Post-translational modificationi

    Autophosphorylated on serine residues.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13418.
    PaxDbiQ13418.
    PeptideAtlasiQ13418.
    PRIDEiQ13418.

    2D gel databases

    OGPiQ13418.

    PTM databases

    PhosphoSiteiQ13418.

    Expressioni

    Tissue specificityi

    Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

    Gene expression databases

    ArrayExpressiQ13418.
    BgeeiQ13418.
    CleanExiHS_ILK.
    GenevestigatoriQ13418.

    Organism-specific databases

    HPAiCAB004041.
    HPA048437.

    Interactioni

    Subunit structurei

    Interacts with FERMT2 By similarity. Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1.By similarity8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CASP8Q147902EBI-747644,EBI-78060
    CASP9P552112EBI-747644,EBI-516799
    ILKAPQ9H0C83EBI-747644,EBI-2620298
    LIMS1P480595EBI-747644,EBI-306928
    PARVAQ9NVD77EBI-747644,EBI-747655
    RICTORQ6R3278EBI-747644,EBI-1387196
    SLC4A1APQ9BWU08EBI-747644,EBI-1999704
    SYNPO2Q9UMS66EBI-747644,EBI-3453434

    Protein-protein interaction databases

    BioGridi109824. 115 interactions.
    DIPiDIP-38657N.
    IntActiQ13418. 85 interactions.
    MINTiMINT-1465247.
    STRINGi9606.ENSP00000299421.

    Structurei

    Secondary structure

    1
    452
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 107
    Helixi13 – 219
    Helixi37 – 437
    Helixi47 – 559
    Helixi70 – 767
    Helixi80 – 889
    Helixi92 – 943
    Helixi103 – 1097
    Helixi113 – 1219
    Beta strandi126 – 1283
    Beta strandi131 – 1333
    Helixi136 – 1394
    Helixi142 – 15413
    Turni167 – 1693
    Helixi190 – 1923
    Beta strandi194 – 2029
    Beta strandi205 – 2128
    Beta strandi215 – 2228
    Helixi229 – 23810
    Helixi239 – 2424
    Beta strandi255 – 2573
    Turni259 – 2613
    Beta strandi262 – 2643
    Beta strandi266 – 2705
    Helixi277 – 2826
    Helixi291 – 30818
    Beta strandi311 – 3133
    Beta strandi324 – 3274
    Beta strandi333 – 3364
    Helixi337 – 3393
    Helixi353 – 3553
    Helixi358 – 3625
    Helixi365 – 3673
    Helixi370 – 38718
    Turni391 – 3944
    Helixi397 – 40610
    Helixi419 – 42810
    Helixi433 – 4353
    Helixi439 – 44911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2KBXNMR-A1-171[»]
    3F6QX-ray1.60A1-170[»]
    3IXEX-ray1.90A1-174[»]
    3KMUX-ray1.80A183-452[»]
    3KMWX-ray2.00A183-452[»]
    3REPX-ray1.80A183-452[»]
    4HI8X-ray1.20A1-174[»]
    4HI9X-ray1.20A1-174[»]
    ProteinModelPortaliQ13418.
    SMRiQ13418. Positions 2-171, 185-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13418.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 3029ANK 1Add
    BLAST
    Repeati31 – 6333ANK 2Add
    BLAST
    Repeati64 – 9633ANK 3Add
    BLAST
    Repeati97 – 12933ANK 4Add
    BLAST
    Repeati130 – 17445ANK 5Add
    BLAST
    Domaini193 – 446254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 139107Interaction with LIMS1Add
    BLAST
    Regioni180 – 21233PH-like; mediates interaction with TGFB1I1Add
    BLAST

    Domaini

    A PH-like domain is involved in phosphatidylinositol phosphate binding.2 Publications

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000047828.
    HOVERGENiHBG002437.
    InParanoidiQ13418.
    KOiK06272.
    OMAiMLKVRDW.
    OrthoDBiEOG7T1RB0.
    PhylomeDBiQ13418.
    TreeFamiTF315194.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR016253. Integrin-linked_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000654. Integrin-linked_kinase. 1 hit.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13418-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV    50
    EMLIMRGARI NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG 100
    NVPLHYACFW GQDQVAEDLV ANGALVSICN KYGEMPVDKA KAPLRELLRE 150
    RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG TLNKHSGIDF KQLNFLTKLN 200
    ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP RLRIFSHPNV 250
    LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300
    MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM 350
    YAPAWVAPEA LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI 400
    GMKVALEGLR PTIPPGISPH VCKLMKICMN EDPAKRPKFD MIVPILEKMQ 450
    DK 452
    Length:452
    Mass (Da):51,419
    Last modified:August 1, 1998 - v2
    Checksum:iE37DC2AD5311A1C2
    GO
    Isoform 2 (identifier: Q13418-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-206: DLVANGALVS...TKLNENHSGE → SGQRRWARISTVFHTRTHSGRGPPALGP

    Note: No experimental confirmation available.

    Show »
    Length:391
    Mass (Da):44,349
    Checksum:i3290120580572F3C
    GO
    Isoform 3 (identifier: Q13418-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-134: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:318
    Mass (Da):36,467
    Checksum:i7516E37CB8353644
    GO

    Sequence cautioni

    The sequence CAB94832.1 differs from that shown. Reason: Probable cloning artifact. Was originally thought to be distinct gene (ILK2) (PubMed:10871859).

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti262 – 2621A → V Found in a patient with severe dilated cardiomyopathy; unknown pathological significance. 1 Publication
    VAR_069753

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 134134Missing in isoform 3. 1 PublicationVSP_055925Add
    BLAST
    Alternative sequencei118 – 20689DLVAN…NHSGE → SGQRRWARISTVFHTRTHSG RGPPALGP in isoform 2. 1 PublicationVSP_054920Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40282 mRNA. Translation: AAC16892.1.
    AJ277481 mRNA. Translation: CAB94832.1. Sequence problems.
    AF244139 Genomic DNA. Translation: AAF74449.1.
    AJ404847 Genomic DNA. Translation: CAB99253.1.
    AK293474 mRNA. Translation: BAH11516.1.
    AK296628 mRNA. Translation: BAH12404.1.
    CR407673 mRNA. Translation: CAG28601.1.
    CR749220 mRNA. Translation: CAH18077.1.
    AC091564 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68688.1.
    CH471064 Genomic DNA. Translation: EAW68689.1.
    CH471064 Genomic DNA. Translation: EAW68690.1.
    BC001554 mRNA. Translation: AAH01554.1.
    CCDSiCCDS60712.1. [Q13418-2]
    CCDS7768.1. [Q13418-1]
    PIRiS68455.
    RefSeqiNP_001014794.1. NM_001014794.2. [Q13418-1]
    NP_001014795.1. NM_001014795.2. [Q13418-1]
    NP_001265370.1. NM_001278441.1. [Q13418-2]
    NP_001265371.1. NM_001278442.1.
    NP_004508.1. NM_004517.3. [Q13418-1]
    XP_005252961.1. XM_005252904.2. [Q13418-1]
    XP_005252962.1. XM_005252905.1.
    UniGeneiHs.706355.

    Genome annotation databases

    EnsembliENST00000299421; ENSP00000299421; ENSG00000166333. [Q13418-1]
    ENST00000396751; ENSP00000379975; ENSG00000166333. [Q13418-1]
    ENST00000420936; ENSP00000403487; ENSG00000166333. [Q13418-1]
    ENST00000528995; ENSP00000435323; ENSG00000166333. [Q13418-2]
    ENST00000537806; ENSP00000439606; ENSG00000166333.
    GeneIDi3611.
    KEGGihsa:3611.
    UCSCiuc001mee.3. human. [Q13418-1]

    Polymorphism databases

    DMDMi9973397.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40282 mRNA. Translation: AAC16892.1 .
    AJ277481 mRNA. Translation: CAB94832.1 . Sequence problems.
    AF244139 Genomic DNA. Translation: AAF74449.1 .
    AJ404847 Genomic DNA. Translation: CAB99253.1 .
    AK293474 mRNA. Translation: BAH11516.1 .
    AK296628 mRNA. Translation: BAH12404.1 .
    CR407673 mRNA. Translation: CAG28601.1 .
    CR749220 mRNA. Translation: CAH18077.1 .
    AC091564 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68688.1 .
    CH471064 Genomic DNA. Translation: EAW68689.1 .
    CH471064 Genomic DNA. Translation: EAW68690.1 .
    BC001554 mRNA. Translation: AAH01554.1 .
    CCDSi CCDS60712.1. [Q13418-2 ]
    CCDS7768.1. [Q13418-1 ]
    PIRi S68455.
    RefSeqi NP_001014794.1. NM_001014794.2. [Q13418-1 ]
    NP_001014795.1. NM_001014795.2. [Q13418-1 ]
    NP_001265370.1. NM_001278441.1. [Q13418-2 ]
    NP_001265371.1. NM_001278442.1.
    NP_004508.1. NM_004517.3. [Q13418-1 ]
    XP_005252961.1. XM_005252904.2. [Q13418-1 ]
    XP_005252962.1. XM_005252905.1.
    UniGenei Hs.706355.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2KBX NMR - A 1-171 [» ]
    3F6Q X-ray 1.60 A 1-170 [» ]
    3IXE X-ray 1.90 A 1-174 [» ]
    3KMU X-ray 1.80 A 183-452 [» ]
    3KMW X-ray 2.00 A 183-452 [» ]
    3REP X-ray 1.80 A 183-452 [» ]
    4HI8 X-ray 1.20 A 1-174 [» ]
    4HI9 X-ray 1.20 A 1-174 [» ]
    ProteinModelPortali Q13418.
    SMRi Q13418. Positions 2-171, 185-452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109824. 115 interactions.
    DIPi DIP-38657N.
    IntActi Q13418. 85 interactions.
    MINTi MINT-1465247.
    STRINGi 9606.ENSP00000299421.

    Chemistry

    BindingDBi Q13418.
    ChEMBLi CHEMBL5247.

    PTM databases

    PhosphoSitei Q13418.

    Polymorphism databases

    DMDMi 9973397.

    2D gel databases

    OGPi Q13418.

    Proteomic databases

    MaxQBi Q13418.
    PaxDbi Q13418.
    PeptideAtlasi Q13418.
    PRIDEi Q13418.

    Protocols and materials databases

    DNASUi 3611.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299421 ; ENSP00000299421 ; ENSG00000166333 . [Q13418-1 ]
    ENST00000396751 ; ENSP00000379975 ; ENSG00000166333 . [Q13418-1 ]
    ENST00000420936 ; ENSP00000403487 ; ENSG00000166333 . [Q13418-1 ]
    ENST00000528995 ; ENSP00000435323 ; ENSG00000166333 . [Q13418-2 ]
    ENST00000537806 ; ENSP00000439606 ; ENSG00000166333 .
    GeneIDi 3611.
    KEGGi hsa:3611.
    UCSCi uc001mee.3. human. [Q13418-1 ]

    Organism-specific databases

    CTDi 3611.
    GeneCardsi GC11P006581.
    HGNCi HGNC:6040. ILK.
    HPAi CAB004041.
    HPA048437.
    MIMi 602366. gene.
    neXtProti NX_Q13418.
    PharmGKBi PA29855.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000047828.
    HOVERGENi HBG002437.
    InParanoidi Q13418.
    KOi K06272.
    OMAi MLKVRDW.
    OrthoDBi EOG7T1RB0.
    PhylomeDBi Q13418.
    TreeFami TF315194.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    Reactomei REACT_20617. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
    REACT_20649. Cell-extracellular matrix interactions.
    SignaLinki Q13418.

    Miscellaneous databases

    ChiTaRSi ILK. human.
    EvolutionaryTracei Q13418.
    GeneWikii Integrin-linked_kinase.
    GenomeRNAii 3611.
    NextBioi 14119.
    PROi Q13418.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13418.
    Bgeei Q13418.
    CleanExi HS_ILK.
    Genevestigatori Q13418.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR016253. Integrin-linked_kinase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000654. Integrin-linked_kinase. 1 hit.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase."
      Hannigan G.E., Leung-Hagesteijn C., Fitz-Gibbon L., Coppolino M.G., Radeva G., Filmus J., Bell J.C., Dedhar S.
      Nature 379:91-96(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. "Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation."
      Janji B., Melchior C., Vallar L., Kieffer N.
      Oncogene 19:3069-3077(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Integrin-linked kinase genomic sequence."
      Tadic B., Hannigan G.E.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Structural organisation of the gene encoding integrin-linked kinase 1."
      Melchior C., Janji B., Kreis S., Kieffer N.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Cerebellum and Colon.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Endometrium.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix.
    11. "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase."
      Delcommenne M., Tan C., Gray V., Rue L., Woodgett J.R., Dedhar S.
      Proc. Natl. Acad. Sci. U.S.A. 95:11211-11216(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS OF GLU-359.
    12. "Cell-substrate interactions and signaling through ILK."
      Dedhar S.
      Curr. Opin. Cell Biol. 12:250-256(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction."
      Yamaji S., Suzuki A., Sugiyama Y., Koide Y., Yoshida M., Kanamori H., Mohri H., Ohno S., Ishigatsubo Y.
      J. Cell Biol. 153:1251-1264(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PARVB, SUBCELLULAR LOCATION.
    14. "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration."
      Zhang Y., Chen K., Guo L., Wu C.
      J. Biol. Chem. 277:38328-38338(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LIMS1 AND LIMS2.
    15. "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival."
      Zhang Y., Chen K., Tu Y., Wu C.
      J. Biol. Chem. 279:41695-41705(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PARVA AND PARVB.
    16. "EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility."
      Yamazaki T., Masuda J., Omori T., Usui R., Akiyama H., Maru Y.
      J. Cell Sci. 122:243-255(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPHA1.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 1-174 IN COMPLEX WITH LIMS1, DOMAIN ANK REPEATS, MUTAGENESIS OF HIS-99.
    22. "Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase."
      Yang Y., Wang X., Hawkins C.A., Chen K., Vaynberg J., Mao X., Tu Y., Zuo X., Wang J., Wang Y.-X., Wu C., Tjandra N., Qin J.
      J. Biol. Chem. 284:5836-5844(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-171 IN COMPLEX WITH LIMS1, DOMAIN ANK REPEATS.
    23. "The pseudoactive site of ILK is essential for its binding to alpha-parvin and localization to focal adhesions."
      Fukuda K., Gupta S., Chen K., Wu C., Qin J.
      Mol. Cell 36:819-830(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 183-452 IN COMPLEX WITH PARVA, INTERACTION WITH PARVA.
    24. "Structural basis for asymmetric association of the betaPIX coiled coil and shank PDZ."
      Im Y.J., Kang G.B., Lee J.H., Park K.R., Song H.E., Kim E., Song W.K., Park D., Eom S.H.
      J. Mol. Biol. 397:457-466(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 183-452 IN COMPLEX WITH PARVA, INTERACTION WITH PARVA.
    25. Cited for: VARIANT VAL-262.

    Entry informationi

    Entry nameiILK_HUMAN
    AccessioniPrimary (citable) accession number: Q13418
    Secondary accession number(s): B7Z1I0
    , B7Z418, D3DQU0, P57043, Q68DZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 159 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3