ORC2

Functionⁱ

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.2 Publications

GO - Molecular functionⁱ

DNA replication origin binding Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

DNA replication Source: Reactome
DNA replication initiation
Source: ProtInc
Traceable author statementⁱ
- 8808289
G1/S transition of mitotic cell cycle Source: Reactome
negative regulation of transcription from RNA polymerase II promoter
Source: ProtInc
Traceable author statementⁱ
- 8808289

Complete GO annotation...

Keywordsⁱ

Biological process	DNA replication

Biological process

DNA replication

Enzyme and pathway databases

Reactomeⁱ	R-HSA-113507. E2F-enabled inhibition of pre-replication complex formation. R-HSA-176187. Activation of ATR in response to replication stress. R-HSA-68616. Assembly of the ORC complex at the origin of replication. R-HSA-68689. CDC6 association with the ORC:origin complex. R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex. R-HSA-68867. Assembly of the pre-replicative complex. R-HSA-68949. Orc1 removal from chromatin. R-HSA-68962. Activation of the pre-replicative complex. R-HSA-69298. Association of licensing factors with the pre-replicative complex. R-HSA-69300. Removal of licensing factors from origins.
SIGNORⁱ	Q13416.

Reactomeⁱ

R-HSA-113507. E2F-enabled inhibition of pre-replication complex formation.
R-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-68616. Assembly of the ORC complex at the origin of replication.
R-HSA-68689. CDC6 association with the ORC:origin complex.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68867. Assembly of the pre-replicative complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-68962. Activation of the pre-replicative complex.
R-HSA-69298. Association of licensing factors with the pre-replicative complex.
R-HSA-69300. Removal of licensing factors from origins.

SIGNORⁱ

Q13416.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Origin recognition complex subunit 2
Gene namesⁱ	Name:ORC2 Synonyms:ORC2L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8488. ORC2.

HGNCⁱ

HGNC:8488. ORC2.

Subcellular locationⁱ

Nucleus

GO - Cellular componentⁱ

centrosome
Source: CACAO
Inferred from direct assayⁱ
- 15215892
condensed chromosome inner kinetochore Source: Ensembl
heterochromatin
Source: CACAO
Inferred from direct assayⁱ
- 15215892
membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 19946888
nuclear chromosome, telomeric region
Source: BHF-UCL
Inferred from direct assayⁱ
- 19135898
nuclear origin of replication recognition complex
Source: UniProtKB
Inferred from direct assayⁱ
- 20932478
- 21029866
nucleoplasm Source: HPA
nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 21383955
origin recognition complex
Source: UniProtKB
Inferred from direct assayⁱ
- 17716973

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4999.
Open Targets More...OpenTargetsⁱ	ENSG00000115942.
PharmGKBⁱ	PA32809.

Polymorphism and mutation databases

BioMutaⁱ	ORC2.
DMDMⁱ	8488999.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127075	1 – 577	Origin recognition complex subunit 2Add BLAST		577

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	116	PhosphothreonineCombined sources	1
Modified residueⁱ	122	PhosphoserineCombined sources	1
Modified residueⁱ	138	PhosphoserineCombined sources	1
Modified residueⁱ	226	PhosphothreonineCombined sources	1
Modified residueⁱ	248	PhosphoserineCombined sources	1
Modified residueⁱ	280	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q13416.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13416.
PaxDbⁱ	Q13416.
PeptideAtlas More...PeptideAtlasⁱ	Q13416.
PRIDEⁱ	Q13416.

PTM databases

iPTMnetⁱ	Q13416.
PhosphoSitePlusⁱ	Q13416.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000115942.
CleanExⁱ	HS_ORC2L.
ExpressionAtlasⁱ	Q13416. baseline and differential.
Genevisibleⁱ	Q13416. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003693. HPA073881.

HPAⁱ

CAB003693.
HPA073881.

Interactionⁱ

Subunit structureⁱ

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with MCM10 (PubMed:11095689). Interacts with LRWD1 throughout the cell cycle; this interaction, wich occurs only with non-ubiquitinated form of LRWD1, prevents LRWD1 ubiquitination and hence stabilizes the protein (PubMed:22645314). Interacts with POLQ (PubMed:24989122).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CDC5L	Q99459	2	EBI-374957,EBI-374880
EBNA1	P03211	6	EBI-374957,EBI-996522	From Epstein-Barr virus (strain B95-8).
FOXM1	Q08050	2	EBI-374957,EBI-866480
MCM10	Q7L590	5	EBI-374957,EBI-374912
MCM3	P25205	2	EBI-374957,EBI-355153
ORC1	Q13415	8	EBI-374957,EBI-374847
ORC4	O43929	6	EBI-374957,EBI-374889
ORC5	O43913	8	EBI-374957,EBI-374928
TERF2	Q15554	3	EBI-374957,EBI-706637

Show more details

Protein-protein interaction databases

BioGridⁱ	111041. 60 interactors.
Database of interacting proteins More...DIPⁱ	DIP-29689N.
IntActⁱ	Q13416. 40 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1201828.
STRINGⁱ	9606.ENSP00000234296.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	474 – 481	Combined sources	8
Helixⁱ	486 – 501	Combined sources	16
Turnⁱ	502 – 504	Combined sources	3
Helixⁱ	513 – 522	Combined sources	10
Helixⁱ	529 – 541	Combined sources	13
Beta strandⁱ	546 – 549	Combined sources	4
Beta strandⁱ	555 – 558	Combined sources	4
Helixⁱ	563 – 572	Combined sources	10

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5C8H	X-ray	2.01	A	458-577	[»]
	5UJ8	X-ray	6.00	E/F/G/H	231-577	[»]
	5UJM	electron microscopy	18.00	B	231-577	[»]
ProteinModelPortalⁱ	Q13416.
SMRⁱ	Q13416.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	1 – 100	Involved in LRWD1-bindingAdd BLAST		100

Sequence similaritiesⁱ

Belongs to the ORC2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2928. Eukaryota. COG5575. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015228.
HOGENOMⁱ	HOG000045588.
HOVERGENⁱ	HBG007874.
InParanoidⁱ	Q13416.
KEGG Orthology (KO) More...KOⁱ	K02604.
OMAⁱ	ETAFENS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H5Q.
PhylomeDBⁱ	Q13416.
TreeFamⁱ	TF101092.

Family and domain databases

InterProⁱ	View protein in InterPro IPR007220. ORC2.
PANTHERⁱ	PTHR14052. PTHR14052. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04084. ORC2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q13416-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII 
        60         70         80         90        100
KKPEYDLEED DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR 
       110        120        130        140        150
KHSEKMAKLA SELAKTPQKS VSFSLKNDPE ITINVPQSSK GHSASDKVQP 
       160        170        180        190        200
KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE SEYSASNSED DEGVAQEHEE 
       210        220        230        240        250
DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV EEYFEAHSSS 
       260        270        280        290        300
KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK 
       310        320        330        340        350
WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS 
       360        370        380        390        400
VLNSITEEVL DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML 
       410        420        430        440        450
RGEKSQQIIG QLSSLHNIYL IASIDHLNAP LMWDHAKQSL FNWLWYETTT 
       460        470        480        490        500
YSPYTEETSY ENSLLVKQSG SLPLSSLTHV LRSLTPNARG IFRLLIKYQL 
       510        520        530        540        550
DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR DHKLIRTKKG 
       560        570 
TDGVEYLLIP VDNGTLTDFL EKEEEEA

Length:577

Mass (Da):65,972

Last modified:May 30, 2000 - v2

Checksum:ⁱDF3F9C2CF147DA5F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	131	I → V in AAB33970 (PubMed:8808289).Curated	1
Sequence conflictⁱ	236	T → L in AAB33970 (PubMed:8808289).Curated	1
Sequence conflictⁱ	392	I → M in AAB33970 (PubMed:8808289).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014515	106	M → K1 PublicationCorresponds to variant dbSNP:rs2307361Ensembl.		1
Natural variantⁱVAR_021276	521	R → Q1 PublicationCorresponds to variant dbSNP:rs16835624Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40268 mRNA. Translation: AAC50326.2. U27459 mRNA. Translation: AAB33970.1. AY652588 Genomic DNA. Translation: AAT46690.1. AC005037 Genomic DNA. Translation: AAY14725.1. CH471063 Genomic DNA. Translation: EAW70228.1. BC014834 mRNA. Translation: AAH14834.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2334.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_006181.1. NM_006190.4. XP_006712618.1. XM_006712555.3.
UniGeneⁱ	Hs.444870.

Genome annotation databases

Ensemblⁱ	ENST00000234296; ENSP00000234296; ENSG00000115942.
GeneIDⁱ	4999.
KEGGⁱ	hsa:4999.
UCSC genome browser More...UCSCⁱ	uc002uwr.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40268 mRNA. Translation: AAC50326.2. U27459 mRNA. Translation: AAB33970.1. AY652588 Genomic DNA. Translation: AAT46690.1. AC005037 Genomic DNA. Translation: AAY14725.1. CH471063 Genomic DNA. Translation: EAW70228.1. BC014834 mRNA. Translation: AAH14834.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2334.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_006181.1. NM_006190.4. XP_006712618.1. XM_006712555.3.
UniGeneⁱ	Hs.444870.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5C8H	X-ray	2.01	A	458-577	[»]
	5UJ8	X-ray	6.00	E/F/G/H	231-577	[»]
	5UJM	electron microscopy	18.00	B	231-577	[»]
ProteinModelPortalⁱ	Q13416.
SMRⁱ	Q13416.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111041. 60 interactors.
Database of interacting proteins More...DIPⁱ	DIP-29689N.
IntActⁱ	Q13416. 40 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1201828.
STRINGⁱ	9606.ENSP00000234296.

PTM databases

iPTMnetⁱ	Q13416.
PhosphoSitePlusⁱ	Q13416.

Polymorphism and mutation databases

BioMutaⁱ	ORC2.
DMDMⁱ	8488999.

Proteomic databases

EPDⁱ	Q13416.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q13416.
PaxDbⁱ	Q13416.
PeptideAtlas More...PeptideAtlasⁱ	Q13416.
PRIDEⁱ	Q13416.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4999.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000234296; ENSP00000234296; ENSG00000115942.
GeneIDⁱ	4999.
KEGGⁱ	hsa:4999.
UCSC genome browser More...UCSCⁱ	uc002uwr.4. human.

Organism-specific databases

CTDⁱ	4999.
DisGeNET More...DisGeNETⁱ	4999.
GeneCardsⁱ	ORC2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8488. ORC2.
Human Protein Atlas More...HPAⁱ	CAB003693. HPA073881.
MIMⁱ	601182. gene.
neXtProtⁱ	NX_Q13416.
Open Targets More...OpenTargetsⁱ	ENSG00000115942.
PharmGKBⁱ	PA32809.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2928. Eukaryota. COG5575. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015228.
HOGENOMⁱ	HOG000045588.
HOVERGENⁱ	HBG007874.
InParanoidⁱ	Q13416.
KEGG Orthology (KO) More...KOⁱ	K02604.
OMAⁱ	ETAFENS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H5Q.
PhylomeDBⁱ	Q13416.
TreeFamⁱ	TF101092.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-113507. E2F-enabled inhibition of pre-replication complex formation. R-HSA-176187. Activation of ATR in response to replication stress. R-HSA-68616. Assembly of the ORC complex at the origin of replication. R-HSA-68689. CDC6 association with the ORC:origin complex. R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex. R-HSA-68867. Assembly of the pre-replicative complex. R-HSA-68949. Orc1 removal from chromatin. R-HSA-68962. Activation of the pre-replicative complex. R-HSA-69298. Association of licensing factors with the pre-replicative complex. R-HSA-69300. Removal of licensing factors from origins.
SIGNORⁱ	Q13416.

Reactomeⁱ

R-HSA-113507. E2F-enabled inhibition of pre-replication complex formation.
R-HSA-176187. Activation of ATR in response to replication stress.
R-HSA-68616. Assembly of the ORC complex at the origin of replication.
R-HSA-68689. CDC6 association with the ORC:origin complex.
R-HSA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-HSA-68867. Assembly of the pre-replicative complex.
R-HSA-68949. Orc1 removal from chromatin.
R-HSA-68962. Activation of the pre-replicative complex.
R-HSA-69298. Association of licensing factors with the pre-replicative complex.
R-HSA-69300. Removal of licensing factors from origins.

SIGNORⁱ

Q13416.

Miscellaneous databases

ChiTaRSⁱ	ORC2. human.
GeneWikiⁱ	ORC2. ORC2L.
GenomeRNAiⁱ	4999.
Protein Ontology More...PROⁱ	PR:Q13416.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000115942.
CleanExⁱ	HS_ORC2L.
ExpressionAtlasⁱ	Q13416. baseline and differential.
Genevisibleⁱ	Q13416. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR007220. ORC2.
PANTHERⁱ	PTHR14052. PTHR14052. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04084. ORC2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ORC2_HUMAN
Accessionⁱ	Q13416Primary (citable) accession number: Q13416 Secondary accession number(s): Q13204, Q53TX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 30, 2000
	Last modified:	July 5, 2017
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q13416 (ORC2_HUMAN)

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Origin recognition complex subunit 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ