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Reviewed, UniProtKB/Swiss-Prot Q13416 (ORC2_HUMAN)

Last modified January 19, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Origin recognition complex subunit 2
Gene names
Name: ORC2L
Synonyms: ORC2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.

Subunit structure

ORC is composed of six subunits. Interacts with DBF4 By similarity. Interacts with MCM10. Ref.6

Subcellular location

Nucleus.

Sequence similarities

Belongs to the ORC2 family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA replication initiation Ref.3

Traceable author statement. Source: ProtInc

negative regulation of transcription from RNA polymerase II promoter Ref.3

Traceable author statement. Source: ProtInc

   Cellular componentnucleoplasm Ref.6

Inferred from Experiment. Source: Reactome

   Molecular functionDNA replication origin binding Ref.3

Traceable author statement. Source: ProtInc

protein binding Ref.6

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 577577Origin recognition complex subunit 2
PRO_0000127075

Amino acid modifications

Modified residue1161Phosphothreonine Ref.7
Modified residue2261Phosphothreonine Ref.9
Modified residue2801Phosphoserine Ref.7

Natural variations

Natural variant1061M → K: dbSNP rs2307361. Ref.4
VAR_014515
Natural variant5211R → Q: dbSNP rs16835624. Ref.4
VAR_021276

Experimental info

Sequence conflict1311I → V in AAB33970. Ref.3
Sequence conflict2361T → L in AAB33970. Ref.3
Sequence conflict3921I → M in AAB33970. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q13416-1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: DF3F9C2CF147DA5F

FASTA57765,972
        10         20         30         40         50         60 
MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED 

        70         80         90        100        110        120 
DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS 

       130        140        150        160        170        180 
VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE 

       190        200        210        220        230        240 
SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV 

       250        260        270        280        290        300 
EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK 

       310        320        330        340        350        360 
WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL 

       370        380        390        400        410        420 
DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL 

       430        440        450        460        470        480 
IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV 

       490        500        510        520        530        540 
LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR 

       550        560        570 
DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA 

« Hide

References

« Hide 'large scale' references
[1]"Conserved initiator proteins in eukaryotes."
Gavin K.A., Hidaka M., Stillman B.D.
Science 270:1667-1671(1995) [PubMed: 7502077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Hidaka M., Stillman B.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 41-42.
[3]"Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L."
Takahara K., Bong M., Brevard R., Eddy R.L., Haley L.L., Sait S.J., Shows T.B., Hoffman G.G., Greenspan D.S.
Genomics 31:119-122(1996) [PubMed: 8808289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]NIEHS SNPs program
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-106 AND GLN-521.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase."
Izumi M., Yanagi K., Mizuno T., Yokoi M., Kawasaki Y., Moon K.Y., Hurwitz J., Yatagai F., Hanaoka F.
Nucleic Acids Res. 28:4769-4777(2000) [PubMed: 11095689] [Abstract]
Cited for: INTERACTION WITH MCM10.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-116 AND SER-280, MASS SPECTROMETRY.
[8]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-226, MASS SPECTROMETRY.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40268 mRNA. Translation: AAC50326.2.
U27459 mRNA. Translation: AAB33970.1.
AY652588 Genomic DNA. Translation: AAT46690.1.
BC014834 mRNA. Translation: AAH14834.1.
IPIIPI00013216.
RefSeqNP_006181.1.
UniGeneHs.444870

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29689N.
IntActQ13416. 14 interactions.
STRINGQ13416.

PTM databases

PhosphoSiteQ13416.

Proteomic databases

PeptideAtlasQ13416.
PRIDEQ13416.

Genome annotation databases

EnsemblENST00000234296; ENSP00000234296; ENSG00000115942; Homo sapiens. [Genome view]
GeneID4999.
KEGGhsa:4999.
UCSCuc002uwr.1. human.

Organism-specific databases

CTD4999.
GeneCardsGC02M201483.
H-InvDBHIX0017677.
HGNCHGNC:8488. ORC2L.
HPACAB003693.
MIM601182. gene.
PharmGKBPA32809.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG05587.
HOGENOMHBG713936.
HOVERGENQ13416.
InParanoidQ13416.
OMANWLWYET.
OrthoDBEOG9W3W6C.
PhylomeDBQ13416.

Enzyme and pathway databases

ReactomeREACT_152. Cell Cycle, Mitotic.
REACT_1538. Cell Cycle Checkpoints.
REACT_383. DNA Replication.

Gene expression databases

ArrayExpressQ13416.
BgeeQ13416.
CleanExHS_ORC2L.
GenevestigatorQ13416.
GermOnlineENSG00000115942. Homo sapiens.

Family and domain databases

InterProIPR007220. ORC2.
[Graphical view]
PANTHERPTHR14052. ORC2. 1 hit.
PfamPF04084. ORC2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio19244.
SOURCESearch...

Entry information

Entry nameORC2_HUMAN
AccessionPrimary (citable) accession number: Q13416
Secondary accession number(s): Q13204
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: January 19, 2010
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents