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Protein

Butyrophilin subfamily 1 member A1

Gene

BTN1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).By similarity

GO - Molecular functioni

  • receptor activity Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 1 member A1
Short name:
BT
Gene namesi
Name:BTN1A1
Synonyms:BTN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1135. BTN1A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 242216ExtracellularSequence analysisAdd
BLAST
Transmembranei243 – 26927HelicalSequence analysisAdd
BLAST
Topological domaini270 – 526257CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25455.

Polymorphism and mutation databases

BioMutaiBTN1A1.
DMDMi317373471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 526500Butyrophilin subfamily 1 member A1PRO_0000014527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 124PROSITE-ProRule annotation
Glycosylationi55 – 551N-linked (GlcNAc...)1 Publication
Disulfide bondi164 ↔ 218PROSITE-ProRule annotation
Glycosylationi215 – 2151N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13410.
MaxQBiQ13410.
PaxDbiQ13410.
PeptideAtlasiQ13410.
PRIDEiQ13410.

PTM databases

iPTMnetiQ13410.
PhosphoSiteiQ13410.

Expressioni

Gene expression databases

BgeeiENSG00000124557.
CleanExiHS_BTN1A1.
ExpressionAtlasiQ13410. baseline and differential.
GenevisibleiQ13410. HS.

Interactioni

Subunit structurei

Seems to associate with xanthine dehydrogenase/oxidase.By similarity

Protein-protein interaction databases

BioGridi107161. 3 interactions.
IntActiQ13410. 1 interaction.
STRINGi9606.ENSP00000244513.

Structurei

3D structure databases

ProteinModelPortaliQ13410.
SMRiQ13410. Positions 27-237, 294-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 138112Ig-like V-type 1Add
BLAST
Domaini148 – 23487Ig-like V-type 2Add
BLAST
Domaini285 – 479195B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJI4. Eukaryota.
ENOG410YA6W. LUCA.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ13410.
KOiK06712.
OMAiQVQENGE.
OrthoDBiEOG091G05L2.
PhylomeDBiQ13410.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAELPC
60 70 80 90 100
RLSPNASAEH LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD
110 120 130 140 150
GIAKGRVALR IRGVRVSDDG EYTCFFREDG SYEEALVHLK VAALGSDPHI
160 170 180 190 200
SMQVQENGEI CLECTSVGWY PEPQVQWRTS KGEKFPSTSE SRNPDEEGLF
210 220 230 240 250
TVAASVIIRD TSAKNVSCYI QNLLLGQEKK VEISIPASSL PRLTPWIVAV
260 270 280 290 300
AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL
310 320 330 340 350
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR
360 370 380 390 400
ETFTSGRHYW EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG
410 420 430 440 450
NGYWALTPLR TPLPLAGPPR RVGIFLDYES GDISFYNMND GSDIYTFSNV
460 470 480 490 500
TFSGPLRPFF CLWSSGKKPL TICPIADGPE RVTVIANAQD LSKEIPLSPM
510 520
GEDSAPRDAD TLHSKLIPTQ PSQGAP
Length:526
Mass (Da):58,960
Last modified:January 11, 2011 - v3
Checksum:i4585D5CE88A2ECA4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131A → T.3 Publications
Corresponds to variant rs3736781 [ dbSNP | Ensembl ].
VAR_021169
Natural varianti303 – 3031V → A.
Corresponds to variant rs1980600 [ dbSNP | Ensembl ].
VAR_030770
Natural varianti503 – 5031D → E.3 Publications
Corresponds to variant rs9393728 [ dbSNP | Ensembl ].
VAR_026546
Natural varianti521 – 5211P → S.
Corresponds to variant rs35555795 [ dbSNP | Ensembl ].
VAR_061302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39576 mRNA. Translation: AAC50489.1.
AL121936 Genomic DNA. Translation: CAC16802.1.
CH471087 Genomic DNA. Translation: EAW55585.1.
BC096312 mRNA. Translation: AAH96312.1.
BC096313 mRNA. Translation: AAH96313.1.
CCDSiCCDS4614.1.
PIRiS70587.
RefSeqiNP_001723.2. NM_001732.2.
UniGeneiHs.153058.

Genome annotation databases

EnsembliENST00000244513; ENSP00000244513; ENSG00000124557.
GeneIDi696.
KEGGihsa:696.
UCSCiuc003nif.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39576 mRNA. Translation: AAC50489.1.
AL121936 Genomic DNA. Translation: CAC16802.1.
CH471087 Genomic DNA. Translation: EAW55585.1.
BC096312 mRNA. Translation: AAH96312.1.
BC096313 mRNA. Translation: AAH96313.1.
CCDSiCCDS4614.1.
PIRiS70587.
RefSeqiNP_001723.2. NM_001732.2.
UniGeneiHs.153058.

3D structure databases

ProteinModelPortaliQ13410.
SMRiQ13410. Positions 27-237, 294-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107161. 3 interactions.
IntActiQ13410. 1 interaction.
STRINGi9606.ENSP00000244513.

PTM databases

iPTMnetiQ13410.
PhosphoSiteiQ13410.

Polymorphism and mutation databases

BioMutaiBTN1A1.
DMDMi317373471.

Proteomic databases

EPDiQ13410.
MaxQBiQ13410.
PaxDbiQ13410.
PeptideAtlasiQ13410.
PRIDEiQ13410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244513; ENSP00000244513; ENSG00000124557.
GeneIDi696.
KEGGihsa:696.
UCSCiuc003nif.5. human.

Organism-specific databases

CTDi696.
GeneCardsiBTN1A1.
H-InvDBHIX0200920.
HGNCiHGNC:1135. BTN1A1.
MIMi601610. gene.
neXtProtiNX_Q13410.
PharmGKBiPA25455.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJI4. Eukaryota.
ENOG410YA6W. LUCA.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ13410.
KOiK06712.
OMAiQVQENGE.
OrthoDBiEOG091G05L2.
PhylomeDBiQ13410.
TreeFamiTF331083.

Miscellaneous databases

GeneWikiiButyrophilin,_subfamily_1,_member_A1.
GenomeRNAii696.
PROiQ13410.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124557.
CleanExiHS_BTN1A1.
ExpressionAtlasiQ13410. baseline and differential.
GenevisibleiQ13410. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBT1A1_HUMAN
AccessioniPrimary (citable) accession number: Q13410
Secondary accession number(s): Q4VAN3, Q4VAN4, Q9H458
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.