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Protein

Butyrophilin subfamily 1 member A1

Gene

BTN1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).By similarity

GO - Molecular functioni

  • receptor activity Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 1 member A1
Short name:
BT
Gene namesi
Name:BTN1A1
Synonyms:BTN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124557.12
HGNCiHGNC:1135 BTN1A1
MIMi601610 gene
neXtProtiNX_Q13410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 242ExtracellularSequence analysisAdd BLAST216
Transmembranei243 – 269HelicalSequence analysisAdd BLAST27
Topological domaini270 – 526CytoplasmicSequence analysisAdd BLAST257

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi696
OpenTargetsiENSG00000124557
PharmGKBiPA25455

Polymorphism and mutation databases

BioMutaiBTN1A1
DMDMi317373471

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001452727 – 526Butyrophilin subfamily 1 member A1Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 124PROSITE-ProRule annotation
Glycosylationi55N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi164 ↔ 218PROSITE-ProRule annotation
Glycosylationi215N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13410
MaxQBiQ13410
PaxDbiQ13410
PeptideAtlasiQ13410
PRIDEiQ13410

PTM databases

iPTMnetiQ13410
PhosphoSitePlusiQ13410

Expressioni

Gene expression databases

BgeeiENSG00000124557
CleanExiHS_BTN1A1
ExpressionAtlasiQ13410 baseline and differential
GenevisibleiQ13410 HS

Organism-specific databases

HPAiHPA011126

Interactioni

Subunit structurei

Seems to associate with xanthine dehydrogenase/oxidase.By similarity

Protein-protein interaction databases

BioGridi107161, 3 interactors
IntActiQ13410, 3 interactors
STRINGi9606.ENSP00000244513

Structurei

3D structure databases

ProteinModelPortaliQ13410
SMRiQ13410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 138Ig-like V-type 1Add BLAST112
Domaini148 – 234Ig-like V-type 2Add BLAST87
Domaini285 – 479B30.2/SPRYPROSITE-ProRule annotationAdd BLAST195

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJI4 Eukaryota
ENOG410YA6W LUCA
GeneTreeiENSGT00760000118933
HOGENOMiHOG000230860
HOVERGENiHBG050747
InParanoidiQ13410
KOiK06712
OMAiPQVQWRT
OrthoDBiEOG091G05L2
PhylomeDBiQ13410
TreeFamiTF331083

Family and domain databases

CDDicd15819 SPRY_PRY_BTN1_2, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013162 CD80_C2-set
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR037958 SPRY/PRY_BTN1/2
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAELPC
60 70 80 90 100
RLSPNASAEH LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD
110 120 130 140 150
GIAKGRVALR IRGVRVSDDG EYTCFFREDG SYEEALVHLK VAALGSDPHI
160 170 180 190 200
SMQVQENGEI CLECTSVGWY PEPQVQWRTS KGEKFPSTSE SRNPDEEGLF
210 220 230 240 250
TVAASVIIRD TSAKNVSCYI QNLLLGQEKK VEISIPASSL PRLTPWIVAV
260 270 280 290 300
AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL
310 320 330 340 350
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR
360 370 380 390 400
ETFTSGRHYW EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG
410 420 430 440 450
NGYWALTPLR TPLPLAGPPR RVGIFLDYES GDISFYNMND GSDIYTFSNV
460 470 480 490 500
TFSGPLRPFF CLWSSGKKPL TICPIADGPE RVTVIANAQD LSKEIPLSPM
510 520
GEDSAPRDAD TLHSKLIPTQ PSQGAP
Length:526
Mass (Da):58,960
Last modified:January 11, 2011 - v3
Checksum:i4585D5CE88A2ECA4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021169213A → T3 PublicationsCorresponds to variant dbSNP:rs3736781Ensembl.1
Natural variantiVAR_030770303V → A. Corresponds to variant dbSNP:rs1980600Ensembl.1
Natural variantiVAR_026546503D → E3 PublicationsCorresponds to variant dbSNP:rs9393728Ensembl.1
Natural variantiVAR_061302521P → S. Corresponds to variant dbSNP:rs35555795Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39576 mRNA Translation: AAC50489.1
AL121936 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55585.1
BC096312 mRNA Translation: AAH96312.1
BC096313 mRNA Translation: AAH96313.1
CCDSiCCDS4614.1
PIRiS70587
RefSeqiNP_001723.2, NM_001732.2
UniGeneiHs.153058

Genome annotation databases

EnsembliENST00000244513; ENSP00000244513; ENSG00000124557
GeneIDi696
KEGGihsa:696
UCSCiuc003nif.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBT1A1_HUMAN
AccessioniPrimary (citable) accession number: Q13410
Secondary accession number(s): Q4VAN3, Q4VAN4, Q9H458
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health