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Q13409

- DC1I2_HUMAN

UniProt

Q13409 - DC1I2_HUMAN

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Protein

Cytoplasmic dynein 1 intermediate chain 2

Gene

DYNC1I2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

GO - Molecular functioni

  1. microtubule motor activity Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. G2/M transition of mitotic cell cycle Source: Reactome
  3. metabolic process Source: GOC
  4. microtubule-based movement Source: UniProtKB
  5. mitotic cell cycle Source: Reactome
  6. transport Source: UniProtKB-KW
  7. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Host-virus interaction, Transport

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
SignaLinkiQ13409.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 intermediate chain 2
Alternative name(s):
Cytoplasmic dynein intermediate chain 2
Dynein intermediate chain 2, cytosolic
Short name:
DH IC-2
Gene namesi
Name:DYNC1I2
Synonyms:DNCI2, DNCIC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2964. DYNC1I2.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic dynein complex Source: InterPro
  4. cytosol Source: Reactome
  5. microtubule Source: UniProtKB
  6. vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 638637Cytoplasmic dynein 1 intermediate chain 2PRO_0000114655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei97 – 971Phosphoserine1 Publication
Modified residuei101 – 1011Phosphoserine1 Publication
Modified residuei104 – 1041Phosphoserine1 Publication

Post-translational modificationi

The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ13409.
PaxDbiQ13409.
PRIDEiQ13409.

2D gel databases

REPRODUCTION-2DPAGEIPI00827813.

PTM databases

PhosphoSiteiQ13409.

Expressioni

Gene expression databases

BgeeiQ13409.
ExpressionAtlasiQ13409. baseline.
GenevestigatoriQ13409.

Organism-specific databases

HPAiCAB033836.

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.By similarity1 Publication

Protein-protein interaction databases

BioGridi108119. 37 interactions.
IntActiQ13409. 6 interactions.
MINTiMINT-5004520.

Structurei

3D structure databases

ProteinModelPortaliQ13409.
SMRiQ13409. Positions 136-164, 333-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati277 – 32650WD 1Add
BLAST
Repeati330 – 37041WD 2Add
BLAST
Repeati379 – 42042WD 3Add
BLAST
Repeati429 – 46941WD 4Add
BLAST
Repeati474 – 51946WD 5Add
BLAST
Repeati522 – 56241WD 6Add
BLAST
Repeati568 – 60740WD 7Add
BLAST

Sequence similaritiesi

Belongs to the dynein intermediate chain family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG308180.
GeneTreeiENSGT00730000110228.
HOVERGENiHBG004083.
InParanoidiQ13409.
KOiK10415.
OrthoDBiEOG7FR7FX.
PhylomeDBiQ13409.
TreeFamiTF300553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR025956. Dynein_IC_1/2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF11540. Dynein_IC2. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 2A (identifier: Q13409-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE
60 70 80 90 100
SDLEKKRREA EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG
110 120 130 140 150
SQDSGDGAVG SRTLHWDTDP SVLQLHSDSD LGRGPIKLGM AKITQVDFPP
160 170 180 190 200
REIVTYTKET QTPVMAQPKE DEEEDDDVVA PKPPIEPEEE KTLKKDEEND
210 220 230 240 250
SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ INIFFDYSGR
260 270 280 290 300
DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN
310 320 330 340 350
NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG
360 370 380 390 400
GTYSGQIVLW DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS
410 420 430 440 450
ISTDGKICSW SLDMLSHPQD SMELVHKQSK AVAVTSMSFP VGDVNNFVVG
460 470 480 490 500
SEEGSVYTAC RHGSKAGISE MFEGHQGPIT GIHCHAAVGA VDFSHLFVTS
510 520 530 540 550
SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF ACVDGMGRLD
560 570 580 590 600
LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG
610 620 630
EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA
Length:638
Mass (Da):71,457
Last modified:September 19, 2002 - v3
Checksum:i2F868EC9556C47F2
GO
Isoform 2B (identifier: Q13409-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.

Note: Contains a phosphoserine at position 73. Contains a phosphoserine at position 81.

Show »
Length:632
Mass (Da):70,645
Checksum:i5E643B54A2979294
GO
Isoform 2C (identifier: Q13409-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.
     113-132: Missing.

Note: Contains a phosphoserine at position 73. Contains a phosphoserine at position 81.

Show »
Length:612
Mass (Da):68,426
Checksum:i518E1D765A2CBB15
GO
Isoform 2E (identifier: Q13409-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     602-602: Missing.

Show »
Length:637
Mass (Da):71,328
Checksum:i0526BC20523DF804
GO
Isoform 2F (identifier: Q13409-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-82: Missing.
     113-132: Missing.
     602-602: Missing.

Note: Contains a phosphoserine at position 73. Contains a phosphoserine at position 81.

Show »
Length:611
Mass (Da):68,298
Checksum:i9DB5032F12C11F5B
GO
Isoform 3 (identifier: Q13409-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-81: VFSEYW → AEQPLRVVTADTCLFHYL
     113-132: Missing.

Note: No experimental confirmation available.

Show »
Length:630
Mass (Da):70,485
Checksum:i5C3022F6F62D9C67
GO

Sequence cautioni

The sequence AAA89166.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti510 – 5101T → S in AAP97254. 1 PublicationCurated
Sequence conflicti525 – 5251D → G in AAP97254. 1 PublicationCurated
Sequence conflicti572 – 5721A → G in AAI09376. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei76 – 816VFSEYW → AEQPLRVVTADTCLFHYL in isoform 3. 1 PublicationVSP_054377
Alternative sequencei77 – 826Missing in isoform 2B, isoform 2C and isoform 2F. 5 PublicationsVSP_001336
Alternative sequencei113 – 13220Missing in isoform 2C, isoform 2F and isoform 3. 6 PublicationsVSP_001337Add
BLAST
Alternative sequencei602 – 6021Missing in isoform 2E and isoform 2F. 1 PublicationVSP_023011

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134477 mRNA. Translation: AAP97254.1.
AF250307 mRNA. Translation: AAK37426.1.
AY037160 mRNA. Translation: AAK67638.1.
BT007130 mRNA. Translation: AAP35794.1.
AK055491 mRNA. Translation: BAB70932.1.
AK316119 mRNA. Translation: BAH14490.1.
AL137519 mRNA. Translation: CAB70785.1.
BX537412 mRNA. Translation: CAD97654.1.
AC064826 Genomic DNA. No translation available.
AC068039 Genomic DNA. Translation: AAY24133.1.
CH471058 Genomic DNA. Translation: EAX11202.1.
CH471058 Genomic DNA. Translation: EAX11204.1.
CH471058 Genomic DNA. Translation: EAX11206.1.
CH471058 Genomic DNA. Translation: EAX11207.1.
CH471058 Genomic DNA. Translation: EAX11208.1.
CH471058 Genomic DNA. Translation: EAX11209.1.
BC091498 mRNA. Translation: AAH91498.1.
BC109375 mRNA. Translation: AAI09376.1.
BC015038 mRNA. Translation: AAH15038.1.
U39575 mRNA. Translation: AAA89166.1. Sequence problems.
CCDSiCCDS46450.1. [Q13409-1]
CCDS63054.1. [Q13409-7]
CCDS63056.1. [Q13409-3]
CCDS63057.1. [Q13409-6]
PIRiT46365.
RefSeqiNP_001258714.1. NM_001271785.1. [Q13409-1]
NP_001258715.1. NM_001271786.1. [Q13409-7]
NP_001258716.1. NM_001271787.1. [Q13409-7]
NP_001258717.1. NM_001271788.1. [Q13409-3]
NP_001258718.1. NM_001271789.1. [Q13409-3]
NP_001258719.1. NM_001271790.1. [Q13409-6]
NP_001369.1. NM_001378.2. [Q13409-1]
XP_005246423.1. XM_005246366.1. [Q13409-2]
XP_005246424.1. XM_005246367.1. [Q13409-2]
XP_005246426.1. XM_005246369.2. [Q13409-6]
UniGeneiHs.546250.

Genome annotation databases

EnsembliENST00000340296; ENSP00000339430; ENSG00000077380. [Q13409-3]
ENST00000397119; ENSP00000380308; ENSG00000077380. [Q13409-1]
ENST00000409197; ENSP00000386397; ENSG00000077380. [Q13409-3]
ENST00000409317; ENSP00000386591; ENSG00000077380. [Q13409-2]
ENST00000409453; ENSP00000386886; ENSG00000077380. [Q13409-5]
ENST00000409773; ENSP00000386415; ENSG00000077380. [Q13409-1]
ENST00000410079; ENSP00000386522; ENSG00000077380. [Q13409-7]
ENST00000508530; ENSP00000423339; ENSG00000077380. [Q13409-6]
GeneIDi1781.
KEGGihsa:1781.
UCSCiuc002uha.2. human. [Q13409-1]
uc002uhb.2. human. [Q13409-3]
uc002uhc.4. human. [Q13409-6]
uc002uhd.2. human. [Q13409-2]

Polymorphism databases

DMDMi23503058.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134477 mRNA. Translation: AAP97254.1 .
AF250307 mRNA. Translation: AAK37426.1 .
AY037160 mRNA. Translation: AAK67638.1 .
BT007130 mRNA. Translation: AAP35794.1 .
AK055491 mRNA. Translation: BAB70932.1 .
AK316119 mRNA. Translation: BAH14490.1 .
AL137519 mRNA. Translation: CAB70785.1 .
BX537412 mRNA. Translation: CAD97654.1 .
AC064826 Genomic DNA. No translation available.
AC068039 Genomic DNA. Translation: AAY24133.1 .
CH471058 Genomic DNA. Translation: EAX11202.1 .
CH471058 Genomic DNA. Translation: EAX11204.1 .
CH471058 Genomic DNA. Translation: EAX11206.1 .
CH471058 Genomic DNA. Translation: EAX11207.1 .
CH471058 Genomic DNA. Translation: EAX11208.1 .
CH471058 Genomic DNA. Translation: EAX11209.1 .
BC091498 mRNA. Translation: AAH91498.1 .
BC109375 mRNA. Translation: AAI09376.1 .
BC015038 mRNA. Translation: AAH15038.1 .
U39575 mRNA. Translation: AAA89166.1 . Sequence problems.
CCDSi CCDS46450.1. [Q13409-1 ]
CCDS63054.1. [Q13409-7 ]
CCDS63056.1. [Q13409-3 ]
CCDS63057.1. [Q13409-6 ]
PIRi T46365.
RefSeqi NP_001258714.1. NM_001271785.1. [Q13409-1 ]
NP_001258715.1. NM_001271786.1. [Q13409-7 ]
NP_001258716.1. NM_001271787.1. [Q13409-7 ]
NP_001258717.1. NM_001271788.1. [Q13409-3 ]
NP_001258718.1. NM_001271789.1. [Q13409-3 ]
NP_001258719.1. NM_001271790.1. [Q13409-6 ]
NP_001369.1. NM_001378.2. [Q13409-1 ]
XP_005246423.1. XM_005246366.1. [Q13409-2 ]
XP_005246424.1. XM_005246367.1. [Q13409-2 ]
XP_005246426.1. XM_005246369.2. [Q13409-6 ]
UniGenei Hs.546250.

3D structure databases

ProteinModelPortali Q13409.
SMRi Q13409. Positions 136-164, 333-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108119. 37 interactions.
IntActi Q13409. 6 interactions.
MINTi MINT-5004520.

PTM databases

PhosphoSitei Q13409.

Polymorphism databases

DMDMi 23503058.

2D gel databases

REPRODUCTION-2DPAGE IPI00827813.

Proteomic databases

MaxQBi Q13409.
PaxDbi Q13409.
PRIDEi Q13409.

Protocols and materials databases

DNASUi 1781.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340296 ; ENSP00000339430 ; ENSG00000077380 . [Q13409-3 ]
ENST00000397119 ; ENSP00000380308 ; ENSG00000077380 . [Q13409-1 ]
ENST00000409197 ; ENSP00000386397 ; ENSG00000077380 . [Q13409-3 ]
ENST00000409317 ; ENSP00000386591 ; ENSG00000077380 . [Q13409-2 ]
ENST00000409453 ; ENSP00000386886 ; ENSG00000077380 . [Q13409-5 ]
ENST00000409773 ; ENSP00000386415 ; ENSG00000077380 . [Q13409-1 ]
ENST00000410079 ; ENSP00000386522 ; ENSG00000077380 . [Q13409-7 ]
ENST00000508530 ; ENSP00000423339 ; ENSG00000077380 . [Q13409-6 ]
GeneIDi 1781.
KEGGi hsa:1781.
UCSCi uc002uha.2. human. [Q13409-1 ]
uc002uhb.2. human. [Q13409-3 ]
uc002uhc.4. human. [Q13409-6 ]
uc002uhd.2. human. [Q13409-2 ]

Organism-specific databases

CTDi 1781.
GeneCardsi GC02P172543.
HGNCi HGNC:2964. DYNC1I2.
HPAi CAB033836.
MIMi 603331. gene.
neXtProti NX_Q13409.
PharmGKBi PA27435.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308180.
GeneTreei ENSGT00730000110228.
HOVERGENi HBG004083.
InParanoidi Q13409.
KOi K10415.
OrthoDBi EOG7FR7FX.
PhylomeDBi Q13409.
TreeFami TF300553.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
REACT_15364. Loss of Nlp from mitotic centrosomes.
REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
SignaLinki Q13409.

Miscellaneous databases

ChiTaRSi DYNC1I2. human.
GeneWikii DYNC1I2.
GenomeRNAii 1781.
NextBioi 35480817.
PROi Q13409.
SOURCEi Search...

Gene expression databases

Bgeei Q13409.
ExpressionAtlasi Q13409. baseline.
Genevestigatori Q13409.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR025956. Dynein_IC_1/2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF11540. Dynein_IC2. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new human cDNA homologous to Rattus norvegicus cytoplasmic dynein intermediate chain 2C."
    Huang J., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2C).
  2. Li N., Wan T., Zhang M., Zhang W., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2C AND 2F).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2C).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2A AND 3).
    Tissue: Brain and Thalamus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2C).
    Tissue: Endometrium and Testis.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2C).
    Tissue: Kidney, Skin and Testis.
  9. "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued."
    Vaughan K.T., Vallee R.B.
    J. Cell Biol. 131:1507-1516(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-448 (ISOFORM 2A).
  10. Lubec G., Afjehi-Sadat L.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 236-250, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 (ISOFORMS 2B; 2C AND 2F), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit."
    Bremner K.H., Scherer J., Yi J., Vershinin M., Gross S.P., Vallee R.B.
    Cell Host Microbe 6:523-535(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HUMAN ADENOVIRUS HEXON PROTEIN.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 (ISOFORMS 2B; 2C AND 2F), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 (ISOFORMS 2B; 2C AND 2F), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDC1I2_HUMAN
AccessioniPrimary (citable) accession number: Q13409
Secondary accession number(s): B7ZA04
, D3DPD4, D3DPD5, D3DPD6, Q32LY9, Q53S84, Q5BJF8, Q7Z4X1, Q96NG7, Q96S87, Q9BXZ5, Q9NT58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: October 29, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3