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Q13409

- DC1I2_HUMAN

UniProt

Q13409 - DC1I2_HUMAN

Protein

Cytoplasmic dynein 1 intermediate chain 2

Gene

DYNC1I2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.

    GO - Molecular functioni

    1. microtubule motor activity Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. G2/M transition of mitotic cell cycle Source: Reactome
    3. metabolic process Source: GOC
    4. microtubule-based movement Source: UniProtKB
    5. mitotic cell cycle Source: Reactome
    6. transport Source: UniProtKB-KW
    7. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Host-virus interaction, Transport

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
    SignaLinkiQ13409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoplasmic dynein 1 intermediate chain 2
    Alternative name(s):
    Cytoplasmic dynein intermediate chain 2
    Dynein intermediate chain 2, cytosolic
    Short name:
    DH IC-2
    Gene namesi
    Name:DYNC1I2
    Synonyms:DNCI2, DNCIC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:2964. DYNC1I2.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytoplasmic dynein complex Source: InterPro
    4. cytosol Source: Reactome
    5. microtubule Source: UniProtKB
    6. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Dynein, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27435.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 638637Cytoplasmic dynein 1 intermediate chain 2PRO_0000114655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei90 – 901PhosphoserineBy similarity
    Modified residuei97 – 971Phosphoserine1 Publication
    Modified residuei101 – 1011Phosphoserine1 Publication
    Modified residuei104 – 1041Phosphoserine1 Publication

    Post-translational modificationi

    The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ13409.
    PaxDbiQ13409.
    PRIDEiQ13409.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00827813.

    PTM databases

    PhosphoSiteiQ13409.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13409.
    BgeeiQ13409.
    GenevestigatoriQ13409.

    Organism-specific databases

    HPAiCAB033836.

    Interactioni

    Subunit structurei

    Homodimer By similarity. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1 By similarity. Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi108119. 35 interactions.
    IntActiQ13409. 6 interactions.
    MINTiMINT-5004520.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13409.
    SMRiQ13409. Positions 136-164, 333-583.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati277 – 32650WD 1Add
    BLAST
    Repeati330 – 37041WD 2Add
    BLAST
    Repeati379 – 42042WD 3Add
    BLAST
    Repeati429 – 46941WD 4Add
    BLAST
    Repeati474 – 51946WD 5Add
    BLAST
    Repeati522 – 56241WD 6Add
    BLAST
    Repeati568 – 60740WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the dynein intermediate chain family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG308180.
    HOVERGENiHBG004083.
    KOiK10415.
    OrthoDBiEOG7FR7FX.
    PhylomeDBiQ13409.
    TreeFamiTF300553.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR025956. Dynein_IC_1/2.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF11540. Dynein_IC2. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 2A (identifier: Q13409-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE    50
    SDLEKKRREA EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG 100
    SQDSGDGAVG SRTLHWDTDP SVLQLHSDSD LGRGPIKLGM AKITQVDFPP 150
    REIVTYTKET QTPVMAQPKE DEEEDDDVVA PKPPIEPEEE KTLKKDEEND 200
    SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ INIFFDYSGR 250
    DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN 300
    NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG 350
    GTYSGQIVLW DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS 400
    ISTDGKICSW SLDMLSHPQD SMELVHKQSK AVAVTSMSFP VGDVNNFVVG 450
    SEEGSVYTAC RHGSKAGISE MFEGHQGPIT GIHCHAAVGA VDFSHLFVTS 500
    SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF ACVDGMGRLD 550
    LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG 600
    EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA 638
    Length:638
    Mass (Da):71,457
    Last modified:September 19, 2002 - v3
    Checksum:i2F868EC9556C47F2
    GO
    Isoform 2B (identifier: Q13409-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-82: Missing.

    Note: Contains a phosphoserine at position 73. Contains a phosphoserine at position 81.

    Show »
    Length:632
    Mass (Da):70,645
    Checksum:i5E643B54A2979294
    GO
    Isoform 2C (identifier: Q13409-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-82: Missing.
         113-132: Missing.

    Note: Contains a phosphoserine at position 73. Contains a phosphoserine at position 81.

    Show »
    Length:612
    Mass (Da):68,426
    Checksum:i518E1D765A2CBB15
    GO
    Isoform 2E (identifier: Q13409-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         602-602: Missing.

    Show »
    Length:637
    Mass (Da):71,328
    Checksum:i0526BC20523DF804
    GO
    Isoform 2F (identifier: Q13409-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-82: Missing.
         113-132: Missing.
         602-602: Missing.

    Note: Contains a phosphoserine at position 73. Contains a phosphoserine at position 81.

    Show »
    Length:611
    Mass (Da):68,298
    Checksum:i9DB5032F12C11F5B
    GO
    Isoform 3 (identifier: Q13409-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         76-81: VFSEYW → AEQPLRVVTADTCLFHYL
         113-132: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:630
    Mass (Da):70,485
    Checksum:i5C3022F6F62D9C67
    GO

    Sequence cautioni

    The sequence AAA89166.1 differs from that shown. Reason: Unlikely isoform. Several sequence problems.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti510 – 5101T → S in AAP97254. 1 PublicationCurated
    Sequence conflicti525 – 5251D → G in AAP97254. 1 PublicationCurated
    Sequence conflicti572 – 5721A → G in AAI09376. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei76 – 816VFSEYW → AEQPLRVVTADTCLFHYL in isoform 3. 1 PublicationVSP_054377
    Alternative sequencei77 – 826Missing in isoform 2B, isoform 2C and isoform 2F. 5 PublicationsVSP_001336
    Alternative sequencei113 – 13220Missing in isoform 2C, isoform 2F and isoform 3. 6 PublicationsVSP_001337Add
    BLAST
    Alternative sequencei602 – 6021Missing in isoform 2E and isoform 2F. 1 PublicationVSP_023011

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134477 mRNA. Translation: AAP97254.1.
    AF250307 mRNA. Translation: AAK37426.1.
    AY037160 mRNA. Translation: AAK67638.1.
    BT007130 mRNA. Translation: AAP35794.1.
    AK055491 mRNA. Translation: BAB70932.1.
    AK316119 mRNA. Translation: BAH14490.1.
    AL137519 mRNA. Translation: CAB70785.1.
    BX537412 mRNA. Translation: CAD97654.1.
    AC064826 Genomic DNA. No translation available.
    AC068039 Genomic DNA. Translation: AAY24133.1.
    CH471058 Genomic DNA. Translation: EAX11202.1.
    CH471058 Genomic DNA. Translation: EAX11204.1.
    CH471058 Genomic DNA. Translation: EAX11206.1.
    CH471058 Genomic DNA. Translation: EAX11207.1.
    CH471058 Genomic DNA. Translation: EAX11208.1.
    CH471058 Genomic DNA. Translation: EAX11209.1.
    BC091498 mRNA. Translation: AAH91498.1.
    BC109375 mRNA. Translation: AAI09376.1.
    BC015038 mRNA. Translation: AAH15038.1.
    U39575 mRNA. Translation: AAA89166.1. Sequence problems.
    CCDSiCCDS46450.1. [Q13409-1]
    CCDS63054.1. [Q13409-7]
    CCDS63056.1. [Q13409-3]
    CCDS63057.1. [Q13409-6]
    PIRiT46365.
    RefSeqiNP_001258714.1. NM_001271785.1. [Q13409-1]
    NP_001258715.1. NM_001271786.1. [Q13409-7]
    NP_001258716.1. NM_001271787.1. [Q13409-7]
    NP_001258717.1. NM_001271788.1. [Q13409-3]
    NP_001258718.1. NM_001271789.1. [Q13409-3]
    NP_001258719.1. NM_001271790.1. [Q13409-6]
    NP_001369.1. NM_001378.2. [Q13409-1]
    XP_005246423.1. XM_005246366.1. [Q13409-2]
    XP_005246424.1. XM_005246367.1. [Q13409-2]
    XP_005246426.1. XM_005246369.2. [Q13409-6]
    UniGeneiHs.546250.

    Genome annotation databases

    EnsembliENST00000340296; ENSP00000339430; ENSG00000077380. [Q13409-3]
    ENST00000397119; ENSP00000380308; ENSG00000077380. [Q13409-1]
    ENST00000409197; ENSP00000386397; ENSG00000077380. [Q13409-3]
    ENST00000409317; ENSP00000386591; ENSG00000077380. [Q13409-2]
    ENST00000409453; ENSP00000386886; ENSG00000077380. [Q13409-5]
    ENST00000409773; ENSP00000386415; ENSG00000077380. [Q13409-1]
    ENST00000410079; ENSP00000386522; ENSG00000077380. [Q13409-7]
    ENST00000508530; ENSP00000423339; ENSG00000077380. [Q13409-6]
    GeneIDi1781.
    KEGGihsa:1781.
    UCSCiuc002uha.2. human. [Q13409-1]
    uc002uhb.2. human. [Q13409-3]
    uc002uhc.4. human. [Q13409-6]
    uc002uhd.2. human. [Q13409-2]

    Polymorphism databases

    DMDMi23503058.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134477 mRNA. Translation: AAP97254.1 .
    AF250307 mRNA. Translation: AAK37426.1 .
    AY037160 mRNA. Translation: AAK67638.1 .
    BT007130 mRNA. Translation: AAP35794.1 .
    AK055491 mRNA. Translation: BAB70932.1 .
    AK316119 mRNA. Translation: BAH14490.1 .
    AL137519 mRNA. Translation: CAB70785.1 .
    BX537412 mRNA. Translation: CAD97654.1 .
    AC064826 Genomic DNA. No translation available.
    AC068039 Genomic DNA. Translation: AAY24133.1 .
    CH471058 Genomic DNA. Translation: EAX11202.1 .
    CH471058 Genomic DNA. Translation: EAX11204.1 .
    CH471058 Genomic DNA. Translation: EAX11206.1 .
    CH471058 Genomic DNA. Translation: EAX11207.1 .
    CH471058 Genomic DNA. Translation: EAX11208.1 .
    CH471058 Genomic DNA. Translation: EAX11209.1 .
    BC091498 mRNA. Translation: AAH91498.1 .
    BC109375 mRNA. Translation: AAI09376.1 .
    BC015038 mRNA. Translation: AAH15038.1 .
    U39575 mRNA. Translation: AAA89166.1 . Sequence problems.
    CCDSi CCDS46450.1. [Q13409-1 ]
    CCDS63054.1. [Q13409-7 ]
    CCDS63056.1. [Q13409-3 ]
    CCDS63057.1. [Q13409-6 ]
    PIRi T46365.
    RefSeqi NP_001258714.1. NM_001271785.1. [Q13409-1 ]
    NP_001258715.1. NM_001271786.1. [Q13409-7 ]
    NP_001258716.1. NM_001271787.1. [Q13409-7 ]
    NP_001258717.1. NM_001271788.1. [Q13409-3 ]
    NP_001258718.1. NM_001271789.1. [Q13409-3 ]
    NP_001258719.1. NM_001271790.1. [Q13409-6 ]
    NP_001369.1. NM_001378.2. [Q13409-1 ]
    XP_005246423.1. XM_005246366.1. [Q13409-2 ]
    XP_005246424.1. XM_005246367.1. [Q13409-2 ]
    XP_005246426.1. XM_005246369.2. [Q13409-6 ]
    UniGenei Hs.546250.

    3D structure databases

    ProteinModelPortali Q13409.
    SMRi Q13409. Positions 136-164, 333-583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108119. 35 interactions.
    IntActi Q13409. 6 interactions.
    MINTi MINT-5004520.

    PTM databases

    PhosphoSitei Q13409.

    Polymorphism databases

    DMDMi 23503058.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00827813.

    Proteomic databases

    MaxQBi Q13409.
    PaxDbi Q13409.
    PRIDEi Q13409.

    Protocols and materials databases

    DNASUi 1781.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340296 ; ENSP00000339430 ; ENSG00000077380 . [Q13409-3 ]
    ENST00000397119 ; ENSP00000380308 ; ENSG00000077380 . [Q13409-1 ]
    ENST00000409197 ; ENSP00000386397 ; ENSG00000077380 . [Q13409-3 ]
    ENST00000409317 ; ENSP00000386591 ; ENSG00000077380 . [Q13409-2 ]
    ENST00000409453 ; ENSP00000386886 ; ENSG00000077380 . [Q13409-5 ]
    ENST00000409773 ; ENSP00000386415 ; ENSG00000077380 . [Q13409-1 ]
    ENST00000410079 ; ENSP00000386522 ; ENSG00000077380 . [Q13409-7 ]
    ENST00000508530 ; ENSP00000423339 ; ENSG00000077380 . [Q13409-6 ]
    GeneIDi 1781.
    KEGGi hsa:1781.
    UCSCi uc002uha.2. human. [Q13409-1 ]
    uc002uhb.2. human. [Q13409-3 ]
    uc002uhc.4. human. [Q13409-6 ]
    uc002uhd.2. human. [Q13409-2 ]

    Organism-specific databases

    CTDi 1781.
    GeneCardsi GC02P172543.
    HGNCi HGNC:2964. DYNC1I2.
    HPAi CAB033836.
    MIMi 603331. gene.
    neXtProti NX_Q13409.
    PharmGKBi PA27435.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308180.
    HOVERGENi HBG004083.
    KOi K10415.
    OrthoDBi EOG7FR7FX.
    PhylomeDBi Q13409.
    TreeFami TF300553.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
    SignaLinki Q13409.

    Miscellaneous databases

    ChiTaRSi DYNC1I2. human.
    GeneWikii DYNC1I2.
    GenomeRNAii 1781.
    NextBioi 35480817.
    PROi Q13409.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13409.
    Bgeei Q13409.
    Genevestigatori Q13409.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR025956. Dynein_IC_1/2.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF11540. Dynein_IC2. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new human cDNA homologous to Rattus norvegicus cytoplasmic dynein intermediate chain 2C."
      Huang J., Yu L., Zhao S.Y.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2C).
    2. Li N., Wan T., Zhang M., Zhang W., Cao X.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2C AND 2F).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2C).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2A AND 3).
      Tissue: Brain and Thalamus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2C).
      Tissue: Endometrium and Testis.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2C).
      Tissue: Kidney, Skin and Testis.
    9. "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued."
      Vaughan K.T., Vallee R.B.
      J. Cell Biol. 131:1507-1516(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 82-448 (ISOFORM 2A).
    10. Lubec G., Afjehi-Sadat L.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 236-250, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain and Cajal-Retzius cell.
    11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 (ISOFORMS 2B; 2C AND 2F), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit."
      Bremner K.H., Scherer J., Yi J., Vershinin M., Gross S.P., Vallee R.B.
      Cell Host Microbe 6:523-535(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HUMAN ADENOVIRUS HEXON PROTEIN.
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 (ISOFORMS 2B; 2C AND 2F), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 (ISOFORMS 2B; 2C AND 2F), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDC1I2_HUMAN
    AccessioniPrimary (citable) accession number: Q13409
    Secondary accession number(s): B7ZA04
    , D3DPD4, D3DPD5, D3DPD6, Q32LY9, Q53S84, Q5BJF8, Q7Z4X1, Q96NG7, Q96S87, Q9BXZ5, Q9NT58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3