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Protein

39S ribosomal protein L49, mitochondrial

Gene

MRPL49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L49, mitochondrial
Short name:
L49mt
Short name:
MRP-L49
Alternative name(s):
Neighbor of FAU
Short name:
NOF
Protein NOF1
Gene namesi
Name:MRPL49
Synonyms:C11orf4, NOF1
ORF Names:OK/SW-cl.67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1176. MRPL49.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16616639S ribosomal protein L49, mitochondrialPRO_0000207664Add
BLAST

Proteomic databases

MaxQBiQ13405.
PaxDbiQ13405.
PRIDEiQ13405.

PTM databases

PhosphoSiteiQ13405.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ13405.
CleanExiHS_MRPL49.
ExpressionAtlasiQ13405. baseline and differential.
GenevestigatoriQ13405.

Organism-specific databases

HPAiHPA046778.

Interactioni

Subunit structurei

Interacts with OXA1L.By similarity

Protein-protein interaction databases

BioGridi107199. 31 interactions.
IntActiQ13405. 2 interactions.
MINTiMINT-8052066.
STRINGi9606.ENSP00000279242.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40g1-166[»]
ProteinModelPortaliQ13405.
SMRiQ13405. Positions 91-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L49em family.Curated

Phylogenomic databases

eggNOGiNOG315103.
GeneTreeiENSGT00390000017253.
HOGENOMiHOG000044600.
HOVERGENiHBG023124.
InParanoidiQ13405.
KOiK17430.
OMAiYPSFVES.
PhylomeDBiQ13405.
TreeFamiTF317750.

Family and domain databases

InterProiIPR007740. Ribosomal_L49/IMG2.
[Graphical view]
PANTHERiPTHR13477. PTHR13477. 1 hit.
PfamiPF05046. Img2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13405-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER
60 70 80 90 100
LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI
110 120 130 140 150
THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK
160
GYFDQELKAW LLEKGF
Length:166
Mass (Da):19,198
Last modified:November 1, 1996 - v1
Checksum:i66AB18FDE25D92B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91T → A.
Corresponds to variant rs17146691 [ dbSNP | Ensembl ].
VAR_021991

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39400 mRNA. Translation: AAB18826.1.
AB062395 mRNA. Translation: BAB93482.1.
AK311821 mRNA. Translation: BAG34763.1.
CH471076 Genomic DNA. Translation: EAW74355.1.
BC004378 mRNA. Translation: AAH04378.1.
CCDSiCCDS8096.1.
PIRiG02237.
RefSeqiNP_004918.1. NM_004927.3.
UniGeneiHs.744882.

Genome annotation databases

EnsembliENST00000279242; ENSP00000279242; ENSG00000149792.
ENST00000526319; ENSP00000434190; ENSG00000149792.
GeneIDi740.
KEGGihsa:740.
UCSCiuc001oda.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39400 mRNA. Translation: AAB18826.1.
AB062395 mRNA. Translation: BAB93482.1.
AK311821 mRNA. Translation: BAG34763.1.
CH471076 Genomic DNA. Translation: EAW74355.1.
BC004378 mRNA. Translation: AAH04378.1.
CCDSiCCDS8096.1.
PIRiG02237.
RefSeqiNP_004918.1. NM_004927.3.
UniGeneiHs.744882.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40g1-166[»]
ProteinModelPortaliQ13405.
SMRiQ13405. Positions 91-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107199. 31 interactions.
IntActiQ13405. 2 interactions.
MINTiMINT-8052066.
STRINGi9606.ENSP00000279242.

PTM databases

PhosphoSiteiQ13405.

Proteomic databases

MaxQBiQ13405.
PaxDbiQ13405.
PRIDEiQ13405.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279242; ENSP00000279242; ENSG00000149792.
ENST00000526319; ENSP00000434190; ENSG00000149792.
GeneIDi740.
KEGGihsa:740.
UCSCiuc001oda.2. human.

Organism-specific databases

CTDi740.
GeneCardsiGC11P064889.
HGNCiHGNC:1176. MRPL49.
HPAiHPA046778.
MIMi606866. gene.
neXtProtiNX_Q13405.
PharmGKBiPA30981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315103.
GeneTreeiENSGT00390000017253.
HOGENOMiHOG000044600.
HOVERGENiHBG023124.
InParanoidiQ13405.
KOiK17430.
OMAiYPSFVES.
PhylomeDBiQ13405.
TreeFamiTF317750.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPL49. human.
GenomeRNAii740.
NextBioi3002.
PROiQ13405.
SOURCEiSearch...

Gene expression databases

BgeeiQ13405.
CleanExiHS_MRPL49.
ExpressionAtlasiQ13405. baseline and differential.
GenevestigatoriQ13405.

Family and domain databases

InterProiIPR007740. Ribosomal_L49/IMG2.
[Graphical view]
PANTHERiPTHR13477. PTHR13477. 1 hit.
PfamiPF05046. Img2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation."
    Kas K., Lemahieu V., Meyen E., van de Ven W.J.M., Merregaert J.
    Genomics 34:433-436(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon adenocarcinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM49_HUMAN
AccessioniPrimary (citable) accession number: Q13405
Secondary accession number(s): B2R4G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.