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Q13405

- RM49_HUMAN

UniProt

Q13405 - RM49_HUMAN

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Protein
39S ribosomal protein L49, mitochondrial
Gene
MRPL49, C11orf4, NOF1, OK/SW-cl.67
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L49, mitochondrial
Short name:
L49mt
Short name:
MRP-L49
Alternative name(s):
Neighbor of FAU
Short name:
NOF
Protein NOF1
Gene namesi
Name:MRPL49
Synonyms:C11orf4, NOF1
ORF Names:OK/SW-cl.67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1176. MRPL49.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16616639S ribosomal protein L49, mitochondrial
PRO_0000207664Add
BLAST

Proteomic databases

MaxQBiQ13405.
PaxDbiQ13405.
PRIDEiQ13405.

PTM databases

PhosphoSiteiQ13405.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ13405.
BgeeiQ13405.
CleanExiHS_MRPL49.
GenevestigatoriQ13405.

Organism-specific databases

HPAiHPA046778.

Interactioni

Subunit structurei

Interacts with OXA1L By similarity.

Protein-protein interaction databases

BioGridi107199. 25 interactions.
IntActiQ13405. 2 interactions.
MINTiMINT-8052066.
STRINGi9606.ENSP00000279242.

Structurei

3D structure databases

ProteinModelPortaliQ13405.
SMRiQ13405. Positions 91-166.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG315103.
HOGENOMiHOG000044600.
HOVERGENiHBG023124.
InParanoidiQ13405.
KOiK17430.
OMAiYPSFVES.
PhylomeDBiQ13405.
TreeFamiTF317750.

Family and domain databases

InterProiIPR007740. Ribosomal_L49/IMG2.
[Graphical view]
PANTHERiPTHR13477. PTHR13477. 1 hit.
PfamiPF05046. Img2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13405-1 [UniParc]FASTAAdd to Basket

« Hide

MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER    50
LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI 100
THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK 150
GYFDQELKAW LLEKGF 166
Length:166
Mass (Da):19,198
Last modified:November 1, 1996 - v1
Checksum:i66AB18FDE25D92B4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91T → A.
Corresponds to variant rs17146691 [ dbSNP | Ensembl ].
VAR_021991

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39400 mRNA. Translation: AAB18826.1.
AB062395 mRNA. Translation: BAB93482.1.
AK311821 mRNA. Translation: BAG34763.1.
CH471076 Genomic DNA. Translation: EAW74355.1.
BC004378 mRNA. Translation: AAH04378.1.
CCDSiCCDS8096.1.
PIRiG02237.
RefSeqiNP_004918.1. NM_004927.3.
UniGeneiHs.744882.

Genome annotation databases

EnsembliENST00000279242; ENSP00000279242; ENSG00000149792.
ENST00000526319; ENSP00000434190; ENSG00000149792.
GeneIDi740.
KEGGihsa:740.
UCSCiuc001oda.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39400 mRNA. Translation: AAB18826.1 .
AB062395 mRNA. Translation: BAB93482.1 .
AK311821 mRNA. Translation: BAG34763.1 .
CH471076 Genomic DNA. Translation: EAW74355.1 .
BC004378 mRNA. Translation: AAH04378.1 .
CCDSi CCDS8096.1.
PIRi G02237.
RefSeqi NP_004918.1. NM_004927.3.
UniGenei Hs.744882.

3D structure databases

ProteinModelPortali Q13405.
SMRi Q13405. Positions 91-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107199. 25 interactions.
IntActi Q13405. 2 interactions.
MINTi MINT-8052066.
STRINGi 9606.ENSP00000279242.

PTM databases

PhosphoSitei Q13405.

Proteomic databases

MaxQBi Q13405.
PaxDbi Q13405.
PRIDEi Q13405.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279242 ; ENSP00000279242 ; ENSG00000149792 .
ENST00000526319 ; ENSP00000434190 ; ENSG00000149792 .
GeneIDi 740.
KEGGi hsa:740.
UCSCi uc001oda.2. human.

Organism-specific databases

CTDi 740.
GeneCardsi GC11P064889.
HGNCi HGNC:1176. MRPL49.
HPAi HPA046778.
MIMi 606866. gene.
neXtProti NX_Q13405.
PharmGKBi PA30981.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315103.
HOGENOMi HOG000044600.
HOVERGENi HBG023124.
InParanoidi Q13405.
KOi K17430.
OMAi YPSFVES.
PhylomeDBi Q13405.
TreeFami TF317750.

Miscellaneous databases

ChiTaRSi MRPL49. human.
GenomeRNAii 740.
NextBioi 3002.
PROi Q13405.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13405.
Bgeei Q13405.
CleanExi HS_MRPL49.
Genevestigatori Q13405.

Family and domain databases

InterProi IPR007740. Ribosomal_L49/IMG2.
[Graphical view ]
PANTHERi PTHR13477. PTHR13477. 1 hit.
Pfami PF05046. Img2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation."
    Kas K., Lemahieu V., Meyen E., van de Ven W.J.M., Merregaert J.
    Genomics 34:433-436(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon adenocarcinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM49_HUMAN
AccessioniPrimary (citable) accession number: Q13405
Secondary accession number(s): B2R4G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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