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Q13405

- RM49_HUMAN

UniProt

Q13405 - RM49_HUMAN

Protein

39S ribosomal protein L49, mitochondrial

Gene

MRPL49

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L49, mitochondrial
    Short name:
    L49mt
    Short name:
    MRP-L49
    Alternative name(s):
    Neighbor of FAU
    Short name:
    NOF
    Protein NOF1
    Gene namesi
    Name:MRPL49
    Synonyms:C11orf4, NOF1
    ORF Names:OK/SW-cl.67
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1176. MRPL49.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30981.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16616639S ribosomal protein L49, mitochondrialPRO_0000207664Add
    BLAST

    Proteomic databases

    MaxQBiQ13405.
    PaxDbiQ13405.
    PRIDEiQ13405.

    PTM databases

    PhosphoSiteiQ13405.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ13405.
    BgeeiQ13405.
    CleanExiHS_MRPL49.
    GenevestigatoriQ13405.

    Organism-specific databases

    HPAiHPA046778.

    Interactioni

    Subunit structurei

    Interacts with OXA1L.By similarity

    Protein-protein interaction databases

    BioGridi107199. 25 interactions.
    IntActiQ13405. 2 interactions.
    MINTiMINT-8052066.
    STRINGi9606.ENSP00000279242.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13405.
    SMRiQ13405. Positions 91-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L49em family.Curated

    Phylogenomic databases

    eggNOGiNOG315103.
    HOGENOMiHOG000044600.
    HOVERGENiHBG023124.
    InParanoidiQ13405.
    KOiK17430.
    OMAiYPSFVES.
    PhylomeDBiQ13405.
    TreeFamiTF317750.

    Family and domain databases

    InterProiIPR007740. Ribosomal_L49/IMG2.
    [Graphical view]
    PANTHERiPTHR13477. PTHR13477. 1 hit.
    PfamiPF05046. Img2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13405-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER    50
    LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI 100
    THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK 150
    GYFDQELKAW LLEKGF 166
    Length:166
    Mass (Da):19,198
    Last modified:November 1, 1996 - v1
    Checksum:i66AB18FDE25D92B4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91T → A.
    Corresponds to variant rs17146691 [ dbSNP | Ensembl ].
    VAR_021991

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39400 mRNA. Translation: AAB18826.1.
    AB062395 mRNA. Translation: BAB93482.1.
    AK311821 mRNA. Translation: BAG34763.1.
    CH471076 Genomic DNA. Translation: EAW74355.1.
    BC004378 mRNA. Translation: AAH04378.1.
    CCDSiCCDS8096.1.
    PIRiG02237.
    RefSeqiNP_004918.1. NM_004927.3.
    UniGeneiHs.744882.

    Genome annotation databases

    EnsembliENST00000279242; ENSP00000279242; ENSG00000149792.
    ENST00000526319; ENSP00000434190; ENSG00000149792.
    GeneIDi740.
    KEGGihsa:740.
    UCSCiuc001oda.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39400 mRNA. Translation: AAB18826.1 .
    AB062395 mRNA. Translation: BAB93482.1 .
    AK311821 mRNA. Translation: BAG34763.1 .
    CH471076 Genomic DNA. Translation: EAW74355.1 .
    BC004378 mRNA. Translation: AAH04378.1 .
    CCDSi CCDS8096.1.
    PIRi G02237.
    RefSeqi NP_004918.1. NM_004927.3.
    UniGenei Hs.744882.

    3D structure databases

    ProteinModelPortali Q13405.
    SMRi Q13405. Positions 91-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107199. 25 interactions.
    IntActi Q13405. 2 interactions.
    MINTi MINT-8052066.
    STRINGi 9606.ENSP00000279242.

    PTM databases

    PhosphoSitei Q13405.

    Proteomic databases

    MaxQBi Q13405.
    PaxDbi Q13405.
    PRIDEi Q13405.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279242 ; ENSP00000279242 ; ENSG00000149792 .
    ENST00000526319 ; ENSP00000434190 ; ENSG00000149792 .
    GeneIDi 740.
    KEGGi hsa:740.
    UCSCi uc001oda.2. human.

    Organism-specific databases

    CTDi 740.
    GeneCardsi GC11P064889.
    HGNCi HGNC:1176. MRPL49.
    HPAi HPA046778.
    MIMi 606866. gene.
    neXtProti NX_Q13405.
    PharmGKBi PA30981.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315103.
    HOGENOMi HOG000044600.
    HOVERGENi HBG023124.
    InParanoidi Q13405.
    KOi K17430.
    OMAi YPSFVES.
    PhylomeDBi Q13405.
    TreeFami TF317750.

    Miscellaneous databases

    ChiTaRSi MRPL49. human.
    GenomeRNAii 740.
    NextBioi 3002.
    PROi Q13405.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13405.
    Bgeei Q13405.
    CleanExi HS_MRPL49.
    Genevestigatori Q13405.

    Family and domain databases

    InterProi IPR007740. Ribosomal_L49/IMG2.
    [Graphical view ]
    PANTHERi PTHR13477. PTHR13477. 1 hit.
    Pfami PF05046. Img2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation."
      Kas K., Lemahieu V., Meyen E., van de Ven W.J.M., Merregaert J.
      Genomics 34:433-436(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon adenocarcinoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM49_HUMAN
    AccessioniPrimary (citable) accession number: Q13405
    Secondary accession number(s): B2R4G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3