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Protein

39S ribosomal protein L49, mitochondrial

Gene

MRPL49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L49, mitochondrial
Short name:
L49mt
Short name:
MRP-L49
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL491 Publication
Neighbor of FAU
Short name:
NOF
Protein NOF1
Gene namesi
Name:MRPL49
Synonyms:C11orf4, NOF1
ORF Names:OK/SW-cl.67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149792.8.
HGNCiHGNC:1176. MRPL49.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi740.
OpenTargetsiENSG00000149792.
PharmGKBiPA30981.

Polymorphism and mutation databases

BioMutaiMRPL49.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076641 – 16639S ribosomal protein L49, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ13405.
MaxQBiQ13405.
PaxDbiQ13405.
PeptideAtlasiQ13405.
PRIDEiQ13405.
TopDownProteomicsiQ13405.

PTM databases

iPTMnetiQ13405.
PhosphoSitePlusiQ13405.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000149792.
CleanExiHS_MRPL49.
ExpressionAtlasiQ13405. baseline and differential.
GenevisibleiQ13405. HS.

Organism-specific databases

HPAiHPA046778.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi107199. 54 interactors.
CORUMiQ13405.
IntActiQ13405. 15 interactors.
MINTiMINT-8052066.
STRINGi9606.ENSP00000279242.

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 51Combined sources7
Beta strandi64 – 68Combined sources5
Turni69 – 71Combined sources3
Beta strandi83 – 86Combined sources4
Beta strandi96 – 104Combined sources9
Beta strandi106 – 110Combined sources5
Beta strandi113 – 115Combined sources3
Helixi117 – 132Combined sources16
Beta strandi138 – 141Combined sources4
Turni142 – 145Combined sources4
Beta strandi146 – 151Combined sources6
Helixi154 – 164Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40g1-166[»]
3J9Melectron microscopy3.50g1-166[»]
ProteinModelPortaliQ13405.
SMRiQ13405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4034. Eukaryota.
ENOG4111N34. LUCA.
GeneTreeiENSGT00390000017253.
HOGENOMiHOG000044600.
HOVERGENiHBG023124.
InParanoidiQ13405.
KOiK17430.
OMAiKPPKHEH.
OrthoDBiEOG091G1549.
PhylomeDBiQ13405.
TreeFamiTF317750.

Family and domain databases

InterProiView protein in InterPro
IPR007740. Ribosomal_L49/IMG2.
PANTHERiPTHR13477. PTHR13477. 1 hit.
PfamiView protein in Pfam
PF05046. Img2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER
60 70 80 90 100
LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI
110 120 130 140 150
THGNRQMTVI RKVEGDIWAL QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK
160
GYFDQELKAW LLEKGF
Length:166
Mass (Da):19,198
Last modified:November 1, 1996 - v1
Checksum:i66AB18FDE25D92B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0219919T → A. Corresponds to variant dbSNP:rs17146691Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39400 mRNA. Translation: AAB18826.1.
AB062395 mRNA. Translation: BAB93482.1.
AK311821 mRNA. Translation: BAG34763.1.
CH471076 Genomic DNA. Translation: EAW74355.1.
BC004378 mRNA. Translation: AAH04378.1.
CCDSiCCDS8096.1.
PIRiG02237.
RefSeqiNP_004918.1. NM_004927.3.
UniGeneiHs.744882.

Genome annotation databases

EnsembliENST00000279242; ENSP00000279242; ENSG00000149792.
ENST00000526319; ENSP00000434190; ENSG00000149792.
GeneIDi740.
KEGGihsa:740.
UCSCiuc001oda.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM49_HUMAN
AccessioniPrimary (citable) accession number: Q13405
Secondary accession number(s): B2R4G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families