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Protein

Putative postmeiotic segregation increased 2-like protein 3

Gene

PMS2P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative postmeiotic segregation increased 2-like protein 3
Alternative name(s):
PMS2-related protein 3
Postmeiotic segregation increased 2-like protein 9
Postmeiotic segregation increased protein 5
Putative postmeiotic segregation increased 2 pseudogene 3
Gene namesi
Name:PMS2P3
Synonyms:PMS2L3, PMS2L9, PMS5, PMSR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:9128. PMS2P3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi313104156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Putative postmeiotic segregation increased 2-like protein 3PRO_0000311100Add
BLAST

Proteomic databases

EPDiQ13401.
PaxDbiQ13401.
PeptideAtlasiQ13401.
PRIDEiQ13401.

Expressioni

Gene expression databases

CleanExiHS_PMS2L3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265849.

Structurei

3D structure databases

ProteinModelPortaliQ13401.
SMRiQ13401. Positions 8-57, 106-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8477KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1978. Eukaryota.
COG0323. LUCA.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ13401.
PhylomeDBiQ13401.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001909. KRAB.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13401-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTLQGPVSF KDVAVDFTQE EWRQLDPDEK IAYGDVMLEN YSHLVSVGYD
60 70 80 90 100
YHQAKHHHGV EVKEVEQGEE PWIMEGEFPC QHSPEPAKAI KPIDRKSVHQ
110 120 130 140 150
ICSGPVVLSL STAVKELVEN SLDAGATNID LKLKDYGVDL IEVSDNGCGV
160
EEENFEGLIS FSSETSHM
Length:168
Mass (Da):18,716
Last modified:November 30, 2010 - v2
Checksum:i995B2A9EC5AA3835
GO
Isoform 2 (identifier: Q13401-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-168: ISFSSETSHM → TMSPFLPATRR

Note: No experimental confirmation available.
Show »
Length:169
Mass (Da):18,867
Checksum:iE183275BF809864A
GO
Isoform 3 (identifier: Q13401-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-168: EPAKAIKPID...ISFSSETSHM → VQNLLRPSNLLIGSQSIRFALGQWY

Show »
Length:109
Mass (Da):12,600
Checksum:i9D727DAAB3B86A0D
GO

Sequence cautioni

The sequence AAA97459 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231R → W in BC029646 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 16884EPAKA…ETSHM → VQNLLRPSNLLIGSQSIRFA LGQWY in isoform 3. 1 PublicationVSP_040289Add
BLAST
Alternative sequencei159 – 16810ISFSSETSHM → TMSPFLPATRR in isoform 2. 1 PublicationVSP_040290

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38979 Genomic DNA. Translation: AAA97459.1. Sequence problems.
CR621744 mRNA. No translation available.
AC018720 Genomic DNA. No translation available.
CH471220 Genomic DNA. Translation: EAW71766.1.
BC029646 mRNA. No translation available.
BC101598 mRNA. Translation: AAI01599.1.
UniGeneiHs.659871.
Hs.661055.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38979 Genomic DNA. Translation: AAA97459.1. Sequence problems.
CR621744 mRNA. No translation available.
AC018720 Genomic DNA. No translation available.
CH471220 Genomic DNA. Translation: EAW71766.1.
BC029646 mRNA. No translation available.
BC101598 mRNA. Translation: AAI01599.1.
UniGeneiHs.659871.
Hs.661055.

3D structure databases

ProteinModelPortaliQ13401.
SMRiQ13401. Positions 8-57, 106-158.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265849.

Polymorphism and mutation databases

DMDMi313104156.

Proteomic databases

EPDiQ13401.
PaxDbiQ13401.
PeptideAtlasiQ13401.
PRIDEiQ13401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPMS2P3.
HGNCiHGNC:9128. PMS2P3.
neXtProtiNX_Q13401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1978. Eukaryota.
COG0323. LUCA.
HOGENOMiHOG000231475.
HOVERGENiHBG067759.
InParanoidiQ13401.
PhylomeDBiQ13401.

Miscellaneous databases

ChiTaRSiPMS2P3. human.
PROiQ13401.

Gene expression databases

CleanExiHS_PMS2L3.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR001909. KRAB.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPM2P3_HUMAN
AccessioniPrimary (citable) accession number: Q13401
Secondary accession number(s): A6NG70, Q3MJ29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 30, 2010
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of the numerous copies of postmeiotic segregation increased 2-like genes scattered in the q11-q22 region of the chromosome 7.

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.