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Q133H2 (GLPK_RHOPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:RPD_3544
OrganismRhodopseudomonas palustris (strain BisB5) [Complete proteome] [HAMAP]
Taxonomic identifier316057 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Glycerol kinase HAMAP MF_00186
PRO_1000020768

Regions

Nucleotide binding411 – 4155ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q133H2 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 697F1B308B00C5C2

FASTA50054,239
        10         20         30         40         50         60 
MPFVMAIDQG TTSSRAILFR GDISIAASAQ QEFPQHFPAS GWVEHEPEDI WNSTLSTCRA 

        70         80         90        100        110        120 
AMEKAGARAS DIAGIGITNQ RETVVVWDRV SGQAIHRAIV WQDRRTADVC TRLKADGYEP 

       130        140        150        160        170        180 
MITDKTGLIV DPYFSGTKVA WLLDNVPGAR GRAERGELMF GTIDCYLLWR LSGGTVHATD 

       190        200        210        220        230        240 
ATNASRTLLF NIHTGEWDDE LLKLLRVPRS MLPEVKDSSA HFGDSAYELF GGSIAIRGIA 

       250        260        270        280        290        300 
GDQQAATIGQ ACFTPGMIKS TYGTGCFALL NTGAKPVRSN NKLLTTIAYQ LDGKRSYALE 

       310        320        330        340        350        360 
GSIFVAGSAV QWLRDGLGII KHASETGPLA DKSDSMQSVY LVPAFVGLGA PYWNPRVRGA 

       370        380        390        400        410        420 
LFGMTRNTGP AELAHATLES VCYQTYDLWA AMRADWPDAD AAPPVLRVDG GMTASDWTMQ 

       430        440        450        460        470        480 
RLADLLDAPV DRPVIQETTA LGAAYLAGLS AGVYPEPQKF ADNWRLDRRF KPAMSAATRE 

       490        500 
RKLAGWGRAV KGLLASDEGE

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisB5."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Lykidis A., Oda Y., Harwood C.S., Richardson P.
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisB5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000283 Genomic DNA. Translation: ABE40767.1.
RefSeqYP_570668.1. NC_007958.1.

3D structure databases

ProteinModelPortalQ133H2.
SMRQ133H2. Positions 3-493.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ133H2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4024058.
GenomeReviewsGene locus RPD_3544 in contig CP000283_GR.
KEGGrpd:RPD_3544.
PATRIC23282229. VBIRhoPal120395_3670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMACYQTRDL.
ProtClustDBCLSK818559.

Enzyme and pathway databases

BioCycRPAL316057:RPD_3544-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_RHOPS
AccessionPrimary (citable) accession number: Q133H2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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