Q13393 (PLD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase D1
Short name=PLD 1
Short name=hPLD1
EC=3.1.4.4

Alternative name(s):
Choline phosphatase 1
Phosphatidylcholine-hydrolyzing phospholipase D1

Gene names

Name:

PLD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1074 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic By similarity.
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Enzyme regulation	Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.
Subunit structure	Interacts with PIP5K1B. Ref.7
Subcellular location	Cytoplasm › perinuclear region By similarity. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side By similarity. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side By similarity. Late endosome membrane; Lipid-anchor; Cytoplasmic side By similarity.
Tissue specificity	Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. Ref.6
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PH domain. Contains 2 PLD phosphodiesterase domains. Contains 1 PX (phox homology) domain.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Cytoplasm Endoplasmic reticulum Endosome Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Hydrolase
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Ras protein signal transduction Traceable author statement PubMed 10848592. Source: ProtInc chemotaxis Traceable author statement PubMed 10848592. Source: ProtInc defense response to Gram-positive bacterium Inferred from electronic annotation. Source: Compara lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phosphatidic acid biosynthetic process Traceable author statement. Source: Reactome phosphatidylglycerol biosynthetic process Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 14718562. Source: MGI Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Traceable author statement. Source: Reactome endosome Inferred from direct assay PubMed 14718562. Source: MGI late endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro phospholipase D activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform PLD1A (identifier: Q13393-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform PLD1B (identifier: Q13393-2)

The sequence of this isoform differs from the canonical sequence as follows:
     585-623: SYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHAD → N

Isoform PLD1C (identifier: Q13393-3)

The sequence of this isoform differs from the canonical sequence as follows:
     514-597: PAAMESMESL...NHYRSHHNLI → IPGPSVVYRQ...SSSAGTSQKL
     598-1074: Missing.

Isoform PLD1D (identifier: Q13393-4)

The sequence of this isoform differs from the canonical sequence as follows:
     962-971: VVLGYLDDPS → SKMTPGVEDP
     972-1074: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1074	1074	Phospholipase D1		PRO_0000218802
Regions
	Domain	81 – 212	132	PX
	Domain	219 – 328	110	PH
	Domain	459 – 486	28	PLD phosphodiesterase 1
	Domain	891 – 918	28	PLD phosphodiesterase 2
	Region	463 – 928	466	Catalytic
Amino acid modifications
	Modified residue	629	1	Phosphoserine Ref.8
	Lipidation	240	1	S-palmitoyl cysteine By similarity
	Lipidation	241	1	S-palmitoyl cysteine By similarity
Natural variations
	Alternative sequence	514 – 597	84	PAAME…HHNLI → IPGPSVVYRQVWESCMGKPD SGMERTTAISSSKTGFNLIN LLLISLTGTPRPGCPGMTLP LQSTGRRLVMWHVTSSSAGT SQKL in isoform PLD1C.		VSP_005018
	Alternative sequence	585 – 623	39	SYFNH…RPHAD → N in isoform PLD1B.		VSP_005020
	Alternative sequence	598 – 1074	477	Missing in isoform PLD1C.		VSP_005019
	Alternative sequence	962 – 971	10	VVLGYLDDPS → SKMTPGVEDP in isoform PLD1D.		VSP_005021
	Alternative sequence	972 – 1074	103	Missing in isoform PLD1D.		VSP_005022
	Natural variant	49	1	P → A. Corresponds to variant rs9819927 [ dbSNP | Ensembl ].		VAR_034387
	Natural variant	622	1	A → S. Corresponds to variant rs2290480 [ dbSNP | Ensembl ].		VAR_022056
	Natural variant	820	1	V → M. Corresponds to variant rs2287579 [ dbSNP | Ensembl ].		VAR_022057
	Natural variant	1024	1	V → I. Corresponds to variant rs9827333 [ dbSNP | Ensembl ].		VAR_051703
Experimental info
	Sequence conflict	832	1	S → P in CAB76564. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform PLD1A [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 734F285790A0BF7A	FASTA	1,074	124,184
	10 20 30 40 50 60 MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA 70 80 90 100 110 120 IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFKWQVKRKF 130 140 150 160 170 180 KHFQEFHREL LKYKAFIRIP IPTRRHTFRR QNVREEPREM PSLPRSSENM IREEQFLGRR 190 200 210 220 230 240 KQLEDYLTKI LKMPMYRNYH ATTEFLDISQ LSFIHDLGPK GIEGMIMKRS GGHRIPGLNC 250 260 270 280 290 300 CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE TETKYGIRID 310 320 330 340 350 360 NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHRF GSYAAIQENA LAKWYVNAKG 370 380 390 400 410 420 YFEDVANAME EANEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 430 440 450 460 470 480 KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSTVYL WAHHEKLVII DQSVAFVGGI 490 500 510 520 530 540 DLAYGRWDDN EHRLTDVGSV KRVTSGPSLG SLPPAAMESM ESLRLKDKNE PVQNLPIQKS 550 560 570 580 590 600 IDDVDSKLKG IGKPRKFSKF SLYKQLHRHH LHDADSISSI DSTSSYFNHY RSHHNLIHGL 610 620 630 640 650 660 KPHFKLFHPS SESEQGLTRP HADTGSIRSL QTGVGELHGE TRFWHGKDYC NFVFKDWVQL 670 680 690 700 710 720 DKPFADFIDR YSTPRMPWHD IASAVHGKAA RDVARHFIQR WNFTKIMKSK YRSLSYPFLL 730 740 750 760 770 780 PKSQTTAHEL RYQVPGSVHA NVQLLRSAAD WSAGIKYHEE SIHAAYVHVI ENSRHYIYIE 790 800 810 820 830 840 NQFFISCADD KVVFNKIGDA IAQRILKAHR ENQKYRVYVV IPLLPGFEGD ISTGGGNALQ 850 860 870 880 890 900 AIMHFNYRTM CRGENSILGQ LKAELGNQWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL 910 920 930 940 950 960 IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FARGLRLQCF 970 980 990 1000 1010 1020 RVVLGYLDDP SEDIQDPVSD KFFKEVWVST AARNATIYDK VFRCLPNDEV HNLIQLRDFI 1030 1040 1050 1060 1070 NKPVLAKEDP IRAEEELKKI RGFLVQFPFY FLSEESLLPS VGTKEAIVPM EVWT
	Isoform PLD1B [UniParc]. Checksum: 7AFA088570479777	FASTA	1,036	119,693
	10 20 30 40 50 60 MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA 70 80 90 100 110 120 IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFKWQVKRKF 130 140 150 160 170 180 KHFQEFHREL LKYKAFIRIP IPTRRHTFRR QNVREEPREM PSLPRSSENM IREEQFLGRR 190 200 210 220 230 240 KQLEDYLTKI LKMPMYRNYH ATTEFLDISQ LSFIHDLGPK GIEGMIMKRS GGHRIPGLNC 250 260 270 280 290 300 CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE TETKYGIRID 310 320 330 340 350 360 NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHRF GSYAAIQENA LAKWYVNAKG 370 380 390 400 410 420 YFEDVANAME EANEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 430 440 450 460 470 480 KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSTVYL WAHHEKLVII DQSVAFVGGI 490 500 510 520 530 540 DLAYGRWDDN EHRLTDVGSV KRVTSGPSLG SLPPAAMESM ESLRLKDKNE PVQNLPIQKS 550 560 570 580 590 600 IDDVDSKLKG IGKPRKFSKF SLYKQLHRHH LHDADSISSI DSTSNTGSIR SLQTGVGELH 610 620 630 640 650 660 GETRFWHGKD YCNFVFKDWV QLDKPFADFI DRYSTPRMPW HDIASAVHGK AARDVARHFI 670 680 690 700 710 720 QRWNFTKIMK SKYRSLSYPF LLPKSQTTAH ELRYQVPGSV HANVQLLRSA ADWSAGIKYH 730 740 750 760 770 780 EESIHAAYVH VIENSRHYIY IENQFFISCA DDKVVFNKIG DAIAQRILKA HRENQKYRVY 790 800 810 820 830 840 VVIPLLPGFE GDISTGGGNA LQAIMHFNYR TMCRGENSIL GQLKAELGNQ WINYISFCGL 850 860 870 880 890 900 RTHAELEGNL VTELIYVHSK LLIADDNTVI IGSANINDRS MLGKRDSEMA VIVQDTETVP 910 920 930 940 950 960 SVMDGKEYQA GRFARGLRLQ CFRVVLGYLD DPSEDIQDPV SDKFFKEVWV STAARNATIY 970 980 990 1000 1010 1020 DKVFRCLPND EVHNLIQLRD FINKPVLAKE DPIRAEEELK KIRGFLVQFP FYFLSEESLL 1030 PSVGTKEAIV PMEVWT
	Isoform PLD1C [UniParc]. Checksum: BA03FFD5DD72AED7	FASTA	597	68,898
	10 20 30 40 50 60 MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA 70 80 90 100 110 120 IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFKWQVKRKF 130 140 150 160 170 180 KHFQEFHREL LKYKAFIRIP IPTRRHTFRR QNVREEPREM PSLPRSSENM IREEQFLGRR 190 200 210 220 230 240 KQLEDYLTKI LKMPMYRNYH ATTEFLDISQ LSFIHDLGPK GIEGMIMKRS GGHRIPGLNC 250 260 270 280 290 300 CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE TETKYGIRID 310 320 330 340 350 360 NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHRF GSYAAIQENA LAKWYVNAKG 370 380 390 400 410 420 YFEDVANAME EANEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 430 440 450 460 470 480 KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSTVYL WAHHEKLVII DQSVAFVGGI 490 500 510 520 530 540 DLAYGRWDDN EHRLTDVGSV KRVTSGPSLG SLPIPGPSVV YRQVWESCMG KPDSGMERTT 550 560 570 580 590 AISSSKTGFN LINLLLISLT GTPRPGCPGM TLPLQSTGRR LVMWHVTSSS AGTSQKL
	Isoform PLD1D [UniParc]. Checksum: 0B7F963953A48ECC	FASTA	971	112,184
	10 20 30 40 50 60 MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA 70 80 90 100 110 120 IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFKWQVKRKF 130 140 150 160 170 180 KHFQEFHREL LKYKAFIRIP IPTRRHTFRR QNVREEPREM PSLPRSSENM IREEQFLGRR 190 200 210 220 230 240 KQLEDYLTKI LKMPMYRNYH ATTEFLDISQ LSFIHDLGPK GIEGMIMKRS GGHRIPGLNC 250 260 270 280 290 300 CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE TETKYGIRID 310 320 330 340 350 360 NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHRF GSYAAIQENA LAKWYVNAKG 370 380 390 400 410 420 YFEDVANAME EANEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 430 440 450 460 470 480 KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSTVYL WAHHEKLVII DQSVAFVGGI 490 500 510 520 530 540 DLAYGRWDDN EHRLTDVGSV KRVTSGPSLG SLPPAAMESM ESLRLKDKNE PVQNLPIQKS 550 560 570 580 590 600 IDDVDSKLKG IGKPRKFSKF SLYKQLHRHH LHDADSISSI DSTSSYFNHY RSHHNLIHGL 610 620 630 640 650 660 KPHFKLFHPS SESEQGLTRP HADTGSIRSL QTGVGELHGE TRFWHGKDYC NFVFKDWVQL 670 680 690 700 710 720 DKPFADFIDR YSTPRMPWHD IASAVHGKAA RDVARHFIQR WNFTKIMKSK YRSLSYPFLL 730 740 750 760 770 780 PKSQTTAHEL RYQVPGSVHA NVQLLRSAAD WSAGIKYHEE SIHAAYVHVI ENSRHYIYIE 790 800 810 820 830 840 NQFFISCADD KVVFNKIGDA IAQRILKAHR ENQKYRVYVV IPLLPGFEGD ISTGGGNALQ 850 860 870 880 890 900 AIMHFNYRTM CRGENSILGQ LKAELGNQWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL 910 920 930 940 950 960 IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FARGLRLQCF 970 RSKMTPGVED P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family." Hammond S.M., Altshuller Y.M., Sung T.-C., Rudge S.A., Rose K., Engebrecht J., Morris A.J., Frohman M.A. J. Biol. Chem. 270:29640-29643(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLD1A).
[2]	"Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha." Hammond S.M., Jenco J.M., Nakashima S., Cadwallader K., Gu Q.-M., Cook S., Nozawa Y., Prestwich G.D., Frohman M.A., Morris A.J. J. Biol. Chem. 272:3860-3868(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PLD1A AND PLD1B).
[3]	"Characterization of human PLD2 and the analysis of PLD isoform splice variants." Steed P.M., Clark K.L., Boyar W.C., Lasala D.J. FASEB J. 12:1309-1317(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PLD1A; PLD1B AND PLD1C). Tissue: Brain, Cervix carcinoma, Chondrocyte and Skeletal muscle.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PLD1A). Tissue: Testis.
[5]	"A novel human phospholipase D1 splice variant displays conserved regulation in vitro but altered localisation in vivo." Hughes W.E., Parker P.J. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 739-1074 (ISOFORM PLD1D).
[6]	"Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2." Lopez I., Arnold R.S., Lambeth J.D. J. Biol. Chem. 273:12846-12852(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity." Divecha N., Roefs M., Halstead J.R., D'Andrea S., Fernandez-Borga M., Oomen L., Saqib K.M., Wakelam M.J.O., D'Santos C. EMBO J. 19:5440-5449(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PIP5K1B.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Web resources

Wikipedia

Phospholipase D entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38545 mRNA. Translation: AAB49031.1. BC068976 mRNA. Translation: AAH68976.1. AJ276230 mRNA. Translation: CAB76564.1.
IPI	IPI00012865. IPI00218797. IPI00218798. IPI00218799.
RefSeq	NP_002653.1. NM_002662.4.
UniGene	Hs.382865.
3D structure databases
ProteinModelPortal	Q13393.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-40821N.
IntAct	Q13393. 1 interaction.
MINT	MINT-141519.
STRING	9606.ENSP00000342793.
PTM databases
PhosphoSite	Q13393.
Polymorphism databases
DMDM	2499703.
Proteomic databases
PaxDb	Q13393.
PRIDE	Q13393.
Protocols and materials databases
DNASU	5337.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340989; ENSP00000340326; ENSG00000075651. ENST00000342215; ENSP00000339936; ENSG00000075651. ENST00000351298; ENSP00000342793; ENSG00000075651. ENST00000356327; ENSP00000348681; ENSG00000075651.
GeneID	5337.
KEGG	hsa:5337.
UCSC	uc003fhs.3. human. uc003fht.3. human.
Organism-specific databases
CTD	5337.
GeneCards	GC03M171318.
HGNC	HGNC:9067. PLD1.
HPA	CAB004527.
MIM	602382. gene.
neXtProt	NX_Q13393.
PharmGKB	PA164742228.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1502.
HOGENOM	HOG000246972.
HOVERGEN	HBG006650.
InParanoid	Q13393.
KO	K01115.
OMA	YFEDVAD.
PhylomeDB	Q13393.
Enzyme and pathway databases
BRENDA	3.1.4.4. 2681.
Pathway_Interaction_DB	alphasynuclein_pathway. Alpha-synuclein signaling. arf6downstreampathway. Arf6 downstream pathway. arf6_traffickingpathway. Arf6 trafficking events.
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q13393.
Bgee	Q13393.
CleanEx	HS_PLD1.
Genevestigator	Q13393.
GermOnline	ENSG00000075651. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit. 3.30.1520.10. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR001683. Phox. IPR025202. PLD-like_dom. IPR001849. Pleckstrin_homology. IPR001736. PLipase_D/transphosphatidylase. IPR016555. PLipase_D_euk. IPR015679. PLipase_D_fam. [Graphical view]
PANTHER	PTHR18896. PTHR18896. 1 hit.
Pfam	PF00169. PH. 1 hit. PF00614. PLDc. 1 hit. PF13091. PLDc_2. 1 hit. PF00787. PX. 1 hit. [Graphical view]
PIRSF	PIRSF009376. Phospholipase_D_euk. 1 hit.
SMART	SM00233. PH. 1 hit. SM00155. PLDc. 2 hits. SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50003. PH_DOMAIN. False negative. PS50035. PLD. 2 hits. PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q13393.
ChEMBL	CHEMBL2536.
ChiTaRS	PLD1. human.
DrugBank	DB00122. Choline.
GenomeRNAi	5337.
NextBio	20672.
SOURCE	Search...

Entry information

Entry name

PLD1_HUMAN

Accession

Primary (citable) accession number: Q13393

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.