Q13387 (JIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-Jun-amino-terminal kinase-interacting protein 2
Short name=JIP-2
Short name=JNK-interacting protein 2

Alternative name(s):
Islet-brain-2
Short name=IB-2
JNK MAP kinase scaffold protein 2
Mitogen-activated protein kinase 8-interacting protein 2

Gene names

Name:	MAPK8IP2
Synonyms:	IB2, JIP2, PRKM8IPL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	824 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interations with the JNK-signaling components and motor proteins By similarity.
Subunit structure	Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK, MAPKK7 and MLK2, MLK3 and DLK. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location By similarity. Interacts with the cytoplasmic domain of APP By similarity. Interacts with DCLK2 By similarity.
Subcellular location	Cytoplasm. Note: Accumulates in cell surface projections.
Tissue specificity	Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.
Sequence similarities	Belongs to the JIP scaffold family. Contains 1 PID domain. Contains 1 SH3 domain.
Sequence caution	The sequence CAA16714.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH3 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	MAPKKK cascade Inferred from direct assay. Source: MGI behavioral fear response Inferred from sequence or structural similarity. Source: BHF-UCL dendrite morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL nonassociative learning Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of anti-apoptosis Non-traceable author statement Ref.2. Source: UniProtKB regulation of JNK cascade Inferred from direct assay Ref.1. Source: UniProtKB regulation of N-methyl-D-aspartate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from sequence or structural similarity. Source: BHF-UCL regulation of excitatory postsynaptic membrane potential Inferred from sequence or structural similarity. Source: BHF-UCL regulation of synaptic transmission, glutamatergic Inferred from sequence or structural similarity. Source: BHF-UCL signal complex assembly Traceable author statement. Source: ProtInc social behavior Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB postsynaptic density Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular function	MAP-kinase scaffold activity Non-traceable author statement Ref.1. Source: UniProtKB beta-amyloid binding Non-traceable author statement. Source: UniProtKB kinesin binding Inferred from sequence or structural similarity. Source: UniProtKB protein kinase activator activity Inferred from direct assay. Source: MGI protein kinase binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q13387-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q13387-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MADRAEMFSL...LSYDSDHCEK → MLPDFPSPSTWAPGLLLPSGPALLSPSVLQ

Isoform 3 (identifier: Q13387-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MADRAEMFSL...LSYDSDHCEK → MLPDFPSPSTWAPGLLLPSGPALLSPSVLQ
     152-394: Missing.
     415-439: Missing.
     768-768: C → CEAPQGAAFQWERGVDRKRVLQTRGNVQPHLGAGQGAALNRATEGSSTGSEKGEWTPLVIMELTQSVNSC

Note: Might be artifactual as it is only predicted from a genomic sequence.

Isoform 4 (identifier: Q13387-4)

The sequence of this isoform differs from the canonical sequence as follows:
     88-468: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 824	824	C-Jun-amino-terminal kinase-interacting protein 2		PRO_0000220631
Regions
	Domain	604 – 665	62	SH3
	Domain	677 – 813	137	PID
	Region	110 – 275	166	JNK-binding domain (JBD)
	Compositional bias	30 – 36	7	Asp/Glu-rich (acidic)
	Compositional bias	85 – 103	19	Asp/Glu-rich (acidic)
	Compositional bias	279 – 291	13	Ser-rich
	Compositional bias	417 – 434	18	Pro-rich
	Compositional bias	469 – 481	13	Asp/Glu-rich (acidic)
Natural variations
	Alternative sequence	1 – 57	57	MADRA…DHCEK → MLPDFPSPSTWAPGLLLPSG PALLSPSVLQ in isoform 2 and isoform 3.		VSP_002770
	Alternative sequence	88 – 468	381	Missing in isoform 4.		VSP_002771
	Alternative sequence	152 – 394	243	Missing in isoform 3.		VSP_002772
	Alternative sequence	415 – 439	25	Missing in isoform 3.		VSP_002773
	Alternative sequence	768	1	C → CEAPQGAAFQWERGVDRKRV LQTRGNVQPHLGAGQGAALN RATEGSSTGSEKGEWTPLVI MELTQSVNSC in isoform 3.		VSP_002774
	Natural variant	743	1	P → L. Corresponds to variant rs1140555 [ dbSNP | Ensembl ].		VAR_049666

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 5, 2001. Version 2. Checksum: 7EFC8F3BC58E37BB	FASTA	824	87,975
	10 20 30 40 50 60 MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL 70 80 90 100 110 120 SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE EEEGDGEGQE GGDPGSEAPA 130 140 150 160 170 180 PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD SLNNNGGFDL VRPASWQETA LCSPAPEALR 190 200 210 220 230 240 ELPGPLPATD TGPGGAQSPV RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR 250 260 270 280 290 300 GGRRSSQELS SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA 310 320 330 340 350 360 SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL LSNLVSRMIS 370 380 390 400 410 420 EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA AGPGGVELVD METLCAPPPP 430 440 450 460 470 480 APAAPRPGPA QPGPCLFLSN PTRDTITPLW AAPGRAARPG RACSAACSEE EDEEDDEEEE 490 500 510 520 530 540 DAEDSAGSPG GRGTGPSAPR DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS 550 560 570 580 590 600 GGEASEEEAG AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV 610 620 630 640 650 660 NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG ERGVFPAFYA 670 680 690 700 710 720 HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG ILCAAMQKIA TARKLTVHLR 730 740 750 760 770 780 PPASCDLEIS LRGVKLSLSG GGPEFQRCSH FFQMKNISFC GCHPRNSCYF GFITKHPLLS 790 800 810 820 RFACHVFVSQ ESMRPVAQSV GRAFLEYYQE HLAYACPTED IYLE
	Isoform 2 [UniParc]. Checksum: 715D63743DF04E7B	FASTA	797	84,711
	10 20 30 40 50 60 MLPDFPSPST WAPGLLLPSG PALLSPSVLQ DSLSLGRSEQ PHPICSFQDD FQEFEMIDDN 70 80 90 100 110 120 EEEDDEDEEE EEEEEEGDGE GQEGGDPGSE APAPGPLIPS PSVEEPHKHR PTTLRLTTLG 130 140 150 160 170 180 AQDSLNNNGG FDLVRPASWQ ETALCSPAPE ALRELPGPLP ATDTGPGGAQ SPVRPGCDCE 190 200 210 220 230 240 GNRPAEPPAP GGTSPSSDPG IEADLRSRSS GGRGGRRSSQ ELSSPGSDSE DAGGARLGRM 250 260 270 280 290 300 ISSISETELE LSSDGGSSSS GRSSHLTNSI EEASSPASEP EPPREPPRRP AFLPVGPDDT 310 320 330 340 350 360 NSEYESGSES EPDLSEDADS PWLLSNLVSR MISEGSSPIR CPGQCLSPAP RPPGEPVSPA 370 380 390 400 410 420 GGAAQDSQDP EAAAGPGGVE LVDMETLCAP PPPAPAAPRP GPAQPGPCLF LSNPTRDTIT 430 440 450 460 470 480 PLWAAPGRAA RPGRACSAAC SEEEDEEDDE EEEDAEDSAG SPGGRGTGPS APRDASLVYD 490 500 510 520 530 540 AVKYTLVVDE HTQLELVSLR RCAGLGHDSE EDSGGEASEE EAGAALLGGG QVSGDTSPDS 550 560 570 580 590 600 PDLTFSKKFL NVFVNSTSRS SSTESFGLFS CLVNGEEREQ THRAVFRFIP RHPDELELDV 610 620 630 640 650 660 DDPVLVEAEE DDFWFRGFNM RTGERGVFPA FYAHAVPGPA KDLLGSKRSP CWVERFDVQF 670 680 690 700 710 720 LGSVEVPCHQ GNGILCAAMQ KIATARKLTV HLRPPASCDL EISLRGVKLS LSGGGPEFQR 730 740 750 760 770 780 CSHFFQMKNI SFCGCHPRNS CYFGFITKHP LLSRFACHVF VSQESMRPVA QSVGRAFLEY 790 YQEHLAYACP TEDIYLE
	Isoform 3 [UniParc]. Checksum: 863EA918E833DCAE	FASTA	598	64,934
	10 20 30 40 50 60 MLPDFPSPST WAPGLLLPSG PALLSPSVLQ DSLSLGRSEQ PHPICSFQDD FQEFEMIDDN 70 80 90 100 110 120 EEEDDEDEEE EEEEEEGDGE GQEGGDPGSE APAPGPLIPS PSVEEPHKHR PTTLRLTTLG 130 140 150 160 170 180 AQDSQDPEAA AGPGGVELVD METLNPTRDT ITPLWAAPGR AARPGRACSA ACSEEEDEED 190 200 210 220 230 240 DEEEEDAEDS AGSPGGRGTG PSAPRDASLV YDAVKYTLVV DEHTQLELVS LRRCAGLGHD 250 260 270 280 290 300 SEEDSGGEAS EEEAGAALLG GGQVSGDTSP DSPDLTFSKK FLNVFVNSTS RSSSTESFGL 310 320 330 340 350 360 FSCLVNGEER EQTHRAVFRF IPRHPDELEL DVDDPVLVEA EEDDFWFRGF NMRTGERGVF 370 380 390 400 410 420 PAFYAHAVPG PAKDLLGSKR SPCWVERFDV QFLGSVEVPC HQGNGILCAA MQKIATARKL 430 440 450 460 470 480 TVHLRPPASC DLEISLRGVK LSLSGGGPEF QRCSHFFQMK NISFCGCHPR NSCEAPQGAA 490 500 510 520 530 540 FQWERGVDRK RVLQTRGNVQ PHLGAGQGAA LNRATEGSST GSEKGEWTPL VIMELTQSVN 550 560 570 580 590 SCYFGFITKH PLLSRFACHV FVSQESMRPV AQSVGRAFLE YYQEHLAYAC PTEDIYLE
	Isoform 4 [UniParc]. Checksum: 6340E55966B6EFC3	FASTA	443	49,070
	10 20 30 40 50 60 MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL 70 80 90 100 110 120 SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DEEDDEEEED AEDSAGSPGG RGTGPSAPRD 130 140 150 160 170 180 ASLVYDAVKY TLVVDEHTQL ELVSLRRCAG LGHDSEEDSG GEASEEEAGA ALLGGGQVSG 190 200 210 220 230 240 DTSPDSPDLT FSKKFLNVFV NSTSRSSSTE SFGLFSCLVN GEEREQTHRA VFRFIPRHPD 250 260 270 280 290 300 ELELDVDDPV LVEAEEDDFW FRGFNMRTGE RGVFPAFYAH AVPGPAKDLL GSKRSPCWVE 310 320 330 340 350 360 RFDVQFLGSV EVPCHQGNGI LCAAMQKIAT ARKLTVHLRP PASCDLEISL RGVKLSLSGG 370 380 390 400 410 420 GPEFQRCSHF FQMKNISFCG CHPRNSCYFG FITKHPLLSR FACHVFVSQE SMRPVAQSVG 430 440 RAFLEYYQEH LAYACPTEDI YLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The JIP group of mitogen-activated protein kinase scaffold proteins." Yasuda J., Whitmarsh A.J., Cavanagh J., Sharma M., Davis R.J. Mol. Cell. Biol. 19:7245-7254(1999) [PubMed: 10490659] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"cDNA cloning and mapping of a novel islet-brain/JNK interacting protein." Negri S., Oberson A., Steinmann M., Sauser C., Nicod P., Waeber G., Schorderet D.F., Bonny C. Genomics 64:324-330(2000) [PubMed: 10756100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain and Insulinoma.
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Adams M.D. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Brain.
[6]	"Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed: 12529303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-824.
[7]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed: 9110174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 599-824 (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF136382 mRNA. Translation: AAF00980.1. AF218778 mRNA. Translation: AAF32323.1. U62317 Genomic DNA. Translation: AAB03340.1. BC009940 mRNA. Translation: AAH09940.2. AL021708 mRNA. Translation: CAA16714.1. Different initiation. U79261 mRNA. Translation: AAB50207.1.
IPI	IPI00031777. IPI00221227. IPI00221228. IPI00221229.
RefSeq	NP_036456.1. NM_012324.3. NP_057515.1. NM_016431.3.
UniGene	Hs.558180.
3D structure databases
ProteinModelPortal	Q13387.
SMR	Q13387. Positions 606-814.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q13387. 1 interaction.
MINT	MINT-111751.
STRING	Q13387.
PTM databases
PhosphoSite	Q13387.
Polymorphism databases
DMDM	17433017.
Proteomic databases
PRIDE	Q13387.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329492; ENSP00000330572; ENSG00000008735.
GeneID	23542.
KEGG	hsa:23542.
Organism-specific databases
CTD	23542.
GeneCards	GC22P051039.
H-InvDB	HIX0027837.
HGNC	HGNC:6883. MAPK8IP2.
HPA	HPA034780.
MIM	607755. gene.
neXtProt	NX_Q13387.
PharmGKB	PA30627.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11185.
HOGENOM	HBG713638.
HOVERGEN	HBG018568.
InParanoid	Q13387.
Gene expression databases
ArrayExpress	Q13387.
Bgee	Q13387.
CleanEx	HS_MAPK8IP2.
Genevestigator	Q13387.
GermOnline	ENSG00000008735. Homo sapiens.
Family and domain databases
InterPro	IPR011993. PH_type. IPR006020. PTyr_interaction_dom. IPR001452. SH3_domain. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
KO	K04435.
Pfam	PF00640. PID. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
SMART	SM00462. PTB. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS01179. PID. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	46052.
SOURCE	Search...

Entry information

Entry name

JIP2_HUMAN

Accession

Primary (citable) accession number: Q13387
Secondary accession number(s): Q96G62 , Q99771, Q9NZ59, Q9UKQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	December 5, 2001
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.