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Q13370

- PDE3B_HUMAN

UniProt

Q13370 - PDE3B_HUMAN

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Protein
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Gene
PDE3B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.2 Publications

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

Enzyme regulationi

Inhibited by cGMP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei737 – 7371Proton donor By similarity
Metal bindingi741 – 7411Divalent metal cation 1
Metal bindingi821 – 8211Divalent metal cation 1
Metal bindingi822 – 8221Divalent metal cation 1
Metal bindingi822 – 8221Divalent metal cation 2
Metal bindingi937 – 9371Divalent metal cation 1

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
  2. cGMP-inhibited cyclic-nucleotide phosphodiesterase activity Source: ProtInc
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct
  5. protein kinase B binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. blood coagulation Source: Reactome
  3. cAMP catabolic process Source: BHF-UCL
  4. cellular response to insulin stimulus Source: BHF-UCL
  5. endocrine pancreas development Source: Ensembl
  6. glucose homeostasis Source: Ensembl
  7. insulin receptor signaling pathway Source: Reactome
  8. negative regulation of angiogenesis Source: UniProtKB
  9. negative regulation of cAMP-mediated signaling Source: BHF-UCL
  10. negative regulation of cell adhesion Source: BHF-UCL
  11. negative regulation of cell adhesion mediated by integrin Source: BHF-UCL
  12. negative regulation of lipid catabolic process Source: BHF-UCL
  13. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Angiogenesis

Keywords - Ligandi

cAMP, cGMP, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_1451. PDE3B signalling.
REACT_19327. G alpha (s) signalling events.
REACT_23767. cGMP effects.
SignaLinkiQ13370.

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC:3.1.4.17)
Alternative name(s):
CGIPDE1
Short name:
CGIP1
Cyclic GMP-inhibited phosphodiesterase B
Short name:
CGI-PDE B
Gene namesi
Name:PDE3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8779. PDE3B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Transmembranei192 – 21221Helical; Reviewed prediction
Add
BLAST
Transmembranei220 – 24021Helical; Reviewed prediction
Add
BLAST
Transmembranei247 – 26721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: BHF-UCL
  2. cytosol Source: Reactome
  3. endoplasmic reticulum Source: BHF-UCL
  4. guanyl-nucleotide exchange factor complex Source: BHF-UCL
  5. integral component of membrane Source: UniProtKB-KW
  6. membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21R → A: Abolishes interaction with RAPGEF3. 1 Publication
Mutagenesisi3 – 31R → A: Abolishes interaction with RAPGEF3. 1 Publication
Mutagenesisi6 – 61R → A: Abolishes interaction with RAPGEF3. 1 Publication
Mutagenesisi8 – 81A → D: Impairs interaction with RAPGEF3. 1 Publication
Mutagenesisi9 – 91K → A: Abolishes interaction with RAPGEF3. 1 Publication
Mutagenesisi10 – 101A → D: Impairss interaction with RAPGEF3. 1 Publication
Mutagenesisi12 – 121R → A: Abolishes interaction with RAPGEF3. 1 Publication
Mutagenesisi439 – 4391R → A: Impairss interaction with PIK3R6. 1 Publication
Mutagenesisi440 – 4401R → A: Impairss interaction with PIK3R6. 1 Publication
Mutagenesisi445 – 4451S → A: Impairss interaction with PIK3R6. 1 Publication
Mutagenesisi449 – 4491P → A: Impairss interaction with PIK3R6. 1 Publication

Organism-specific databases

PharmGKBiPA33127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11121112cGMP-inhibited 3',5'-cyclic phosphodiesterase B
PRO_0000198802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei295 – 2951Phosphoserine; by PKB/AKT1 or PKB/AKT2 By similarity
Modified residuei442 – 4421Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13370.
PaxDbiQ13370.
PRIDEiQ13370.

PTM databases

PhosphoSiteiQ13370.

Expressioni

Tissue specificityi

Abundant in adipose tissues.

Gene expression databases

ArrayExpressiQ13370.
BgeeiQ13370.
CleanExiHS_PDE3B.
GenevestigatoriQ13370.

Organism-specific databases

HPAiCAB009497.
HPA024342.

Interactioni

Subunit structurei

Interacts with PIK3CG By similarity. Interacts with RAPGEF3 and PIK3R6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PIK3CGP487363EBI-6172856,EBI-1030384
PIK3R6Q5UE933EBI-6172856,EBI-6172907
RAPGEF3O953988EBI-6172856,EBI-6172806

Protein-protein interaction databases

BioGridi111166. 3 interactions.
IntActiQ13370. 3 interactions.
STRINGi9606.ENSP00000282096.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi662 – 67413
Helixi681 – 6888
Helixi689 – 6946
Helixi695 – 70612
Helixi709 – 7124
Helixi717 – 72812
Beta strandi735 – 7384
Helixi739 – 75214
Helixi802 – 8043
Helixi808 – 82013
Turni821 – 8244
Helixi830 – 8356
Helixi839 – 8435
Turni844 – 8463
Helixi849 – 86315
Helixi866 – 8683
Turni870 – 8734
Helixi876 – 89116
Helixi895 – 8973
Helixi898 – 90912
Beta strandi911 – 9133
Helixi922 – 93716
Helixi940 – 9423
Helixi945 – 96824
Helixi984 – 99411
Helixi996 – 100510
Beta strandi1012 – 10154
Beta strandi1055 – 10584
Helixi1060 – 107213

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SO2X-ray2.40A/B/C/D654-1073[»]
1SOJX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L654-1073[»]
ProteinModelPortaliQ13370.
SMRiQ13370. Positions 656-1073.

Miscellaneous databases

EvolutionaryTraceiQ13370.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2525Interaction with RAPGEF3
Add
BLAST
Regioni436 – 46025Interaction with PIK3R6
Add
BLAST
Regioni713 – 1072360Catalytic By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1077 – 10804Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145074.
HOGENOMiHOG000060144.
HOVERGENiHBG053541.
InParanoidiQ13370.
KOiK13296.
OMAiSIHESEY.
PhylomeDBiQ13370.
TreeFamiTF329631.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13370-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRDERDAKA MRSLQPPDGA GSPPESLRNG YVKSCVSPLR QDPPRGFFFH     50
LCRFCNVELR PPPASPQQPR RCSPFCRARL SLGALAAFVL ALLLGAEPES 100
WAAGAAWLRT LLSVCSHSLS PLFSIACAFF FLTCFLTRTK RGPGPGRSCG 150
SWWLLALPAC CYLGDFLVWQ WWSWPWGDGD AGSAAPHTPP EAAAGRLLLV 200
LSCVGLLLTL AHPLRLRHCV LVLLLASFVW WVSFTSLGSL PSALRPLLSG 250
LVGGAGCLLA LGLDHFFQIR EAPLHPRLSS AAEEKVPVIR PRRRSSCVSL 300
GETAASYYGS CKIFRRPSLP CISREQMILW DWDLKQWYKP HYQNSGGGNG 350
VDLSVLNEAR NMVSDLLTDP SLPPQVISSL RSISSLMGAF SGSCRPKINP 400
LTPFPGFYPC SEIEDPAEKG DRKLNKGLNR NSLPTPQLRR SSGTSGLLPV 450
EQSSRWDRNN GKRPHQEFGI SSQGCYLNGP FNSNLLTIPK QRSSSVSLTH 500
HVGLRRAGVL SSLSPVNSSN HGPVSTGSLT NRSPIEFPDT ADFLNKPSVI 550
LQRSLGNAPN TPDFYQQLRN SDSNLCNSCG HQMLKYVSTS ESDGTDCCSG 600
KSGEEENIFS KESFKLMETQ QEEETEKKDS RKLFQEGDKW LTEEAQSEQQ 650
TNIEQEVSLD LILVEEYDSL IEKMSNWNFP IFELVEKMGE KSGRILSQVM 700
YTLFQDTGLL EIFKIPTQQF MNYFRALENG YRDIPYHNRI HATDVLHAVW 750
YLTTRPVPGL QQIHNGCGTG NETDSDGRIN HGRIAYISSK SCSNPDESYG 800
CLSSNIPALE LMALYVAAAM HDYDHPGRTN AFLVATNAPQ AVLYNDRSVL 850
ENHHAASAWN LYLSRPEYNF LLHLDHVEFK RFRFLVIEAI LATDLKKHFD 900
FLAEFNAKAN DVNSNGIEWS NENDRLLVCQ VCIKLADING PAKVRDLHLK 950
WTEGIVNEFY EQGDEEANLG LPISPFMDRS SPQLAKLQES FITHIVGPLC 1000
NSYDAAGLLP GQWLEAEEDN DTESGDDEDG EELDTEDEEM ENNLNPKPPR 1050
RKSRRRIFCQ LMHHLTENHK IWKEIVEEEE KCKADGNKLQ VENSSLPQAD 1100
EIQVIEEADE EE 1112
Length:1,112
Mass (Da):124,333
Last modified:April 3, 2007 - v2
Checksum:i55451C3DA142EF6A
GO
Isoform 2 (identifier: Q13370-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-426: Missing.

Note: No experimental confirmation available.

Show »
Length:1,061
Mass (Da):118,809
Checksum:i755DBD55004867DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871A → V.1 Publication
Corresponds to variant rs1056584 [ dbSNP | Ensembl ].
VAR_031462

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei376 – 42651Missing in isoform 2.
VSP_054138Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841A → D in AAC50724. 1 Publication
Sequence conflicti84 – 841A → D in BAA09306. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38178 Genomic DNA. Translation: AAC50724.1.
D50640 Genomic DNA. Translation: BAA09306.1.
X95520 mRNA. Translation: CAA64774.1.
AY459346 mRNA. Translation: AAR24292.1.
AC018795 Genomic DNA. No translation available.
AC087207 Genomic DNA. No translation available.
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68474.1.
BC136565 mRNA. Translation: AAI36566.1.
BC136566 mRNA. Translation: AAI36567.1.
BC144248 mRNA. Translation: AAI44249.1.
CCDSiCCDS7817.1. [Q13370-1]
PIRiS70522.
RefSeqiNP_000913.2. NM_000922.3. [Q13370-1]
UniGeneiHs.445711.

Genome annotation databases

EnsembliENST00000282096; ENSP00000282096; ENSG00000152270.
ENST00000455098; ENSP00000388644; ENSG00000152270.
ENST00000574273; ENSP00000459710; ENSG00000261923.
GeneIDi5140.
KEGGihsa:5140.
UCSCiuc001mln.3. human. [Q13370-1]

Polymorphism databases

DMDMi143811435.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U38178 Genomic DNA. Translation: AAC50724.1 .
D50640 Genomic DNA. Translation: BAA09306.1 .
X95520 mRNA. Translation: CAA64774.1 .
AY459346 mRNA. Translation: AAR24292.1 .
AC018795 Genomic DNA. No translation available.
AC087207 Genomic DNA. No translation available.
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68474.1 .
BC136565 mRNA. Translation: AAI36566.1 .
BC136566 mRNA. Translation: AAI36567.1 .
BC144248 mRNA. Translation: AAI44249.1 .
CCDSi CCDS7817.1. [Q13370-1 ]
PIRi S70522.
RefSeqi NP_000913.2. NM_000922.3. [Q13370-1 ]
UniGenei Hs.445711.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SO2 X-ray 2.40 A/B/C/D 654-1073 [» ]
1SOJ X-ray 2.90 A/B/C/D/E/F/G/H/I/J/K/L 654-1073 [» ]
ProteinModelPortali Q13370.
SMRi Q13370. Positions 656-1073.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111166. 3 interactions.
IntActi Q13370. 3 interactions.
STRINGi 9606.ENSP00000282096.

Chemistry

BindingDBi Q13370.
ChEMBLi CHEMBL2095153.
GuidetoPHARMACOLOGYi 1299.

PTM databases

PhosphoSitei Q13370.

Polymorphism databases

DMDMi 143811435.

Proteomic databases

MaxQBi Q13370.
PaxDbi Q13370.
PRIDEi Q13370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282096 ; ENSP00000282096 ; ENSG00000152270 .
ENST00000455098 ; ENSP00000388644 ; ENSG00000152270 .
ENST00000574273 ; ENSP00000459710 ; ENSG00000261923 .
GeneIDi 5140.
KEGGi hsa:5140.
UCSCi uc001mln.3. human. [Q13370-1 ]

Organism-specific databases

CTDi 5140.
GeneCardsi GC11P014621.
HGNCi HGNC:8779. PDE3B.
HPAi CAB009497.
HPA024342.
MIMi 602047. gene.
neXtProti NX_Q13370.
PharmGKBi PA33127.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145074.
HOGENOMi HOG000060144.
HOVERGENi HBG053541.
InParanoidi Q13370.
KOi K13296.
OMAi SIHESEY.
PhylomeDBi Q13370.
TreeFami TF329631.

Enzyme and pathway databases

Reactomei REACT_1451. PDE3B signalling.
REACT_19327. G alpha (s) signalling events.
REACT_23767. cGMP effects.
SignaLinki Q13370.

Miscellaneous databases

ChiTaRSi PDE3B. human.
EvolutionaryTracei Q13370.
GenomeRNAii 5140.
NextBioi 19820.
PROi Q13370.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13370.
Bgeei Q13370.
CleanExi HS_PDE3B.
Genevestigatori Q13370.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
InterProi IPR003607. HD/PDEase_dom.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF00233. PDEase_I. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family."
    Miki T., Taira M., Hockman S., Shimada F., Lieman J., Napolitano M., Ward D., Taira M., Makino H., Manganiello V.C.
    Genomics 36:476-485(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Adipose tissue.
  2. "Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines."
    Murata T., Taira M., Manganiello V.C.
    FEBS Lett. 390:29-33(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A) -- a gene involved in fat metabolism located at 11p15.1."
    Loebbert R.W., Winterpacht A., Seipel B., Zabel B.U.
    Genomics 37:211-218(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT VAL-87.
  4. "Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes."
    Liu H., Tang J.R., Choi Y.H., Napolitano M., Hockman S., Taira M., Degerman E., Manganiello V.C.
    J. Biol. Chem. 281:21096-21113(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells."
    Wilson L.S., Baillie G.S., Pritchard L.M., Umana B., Terrin A., Zaccolo M., Houslay M.D., Maurice D.H.
    J. Biol. Chem. 286:16285-16296(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAPGEF3 AND PIK3R6, MUTAGENESIS OF ARG-2; ARG-3; ARG-6; ALA-8; LYS-9; ALA-10; ARG-12; ARG-439; ARG-440; SER-445 AND PRO-449.
  11. "Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity."
    Scapin G., Patel S.B., Chung C., Varnerin J.P., Edmondson S.D., Mastracchio A., Parmee E.R., Singh S.B., Becker J.W., Van der Ploeg L.H., Tota M.R.
    Biochemistry 43:6091-6100(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 654-1073 IN COMPLEX WITH METAL IONS AND INHIBITORS, FUNCTION, COFACTOR.

Entry informationi

Entry nameiPDE3B_HUMAN
AccessioniPrimary (citable) accession number: Q13370
Secondary accession number(s): B7ZM37
, O00639, Q14408, Q6SEI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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