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Q13368

- MPP3_HUMAN

UniProt

Q13368 - MPP3_HUMAN

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Protein

MAGUK p55 subfamily member 3

Gene

MPP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. guanylate kinase activity Source: ProtInc

GO - Biological processi

  1. nucleotide phosphorylation Source: GOC
  2. signal transduction Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 3
Alternative name(s):
Discs large homolog 3
Protein MPP3
Gene namesi
Name:MPP3
Synonyms:DLG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7221. MPP3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585MAGUK p55 subfamily member 3PRO_0000094575Add
BLAST

Proteomic databases

PaxDbiQ13368.
PRIDEiQ13368.

PTM databases

PhosphoSiteiQ13368.

Expressioni

Gene expression databases

BgeeiQ13368.
CleanExiHS_DLG3.
HS_MPP3.
ExpressionAtlasiQ13368. baseline and differential.
GenevestigatoriQ13368.

Organism-specific databases

HPAiHPA021818.
HPA024742.

Interactioni

Subunit structurei

May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi110496. 23 interactions.
IntActiQ13368. 28 interactions.
MINTiMINT-1377781.
STRINGi9606.ENSP00000381425.

Structurei

3D structure databases

ProteinModelPortaliQ13368.
SMRiQ13368. Positions 7-116, 134-217, 229-580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6055L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini61 – 11858L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 21276PDZPROSITE-ProRule annotationAdd
BLAST
Domaini226 – 29671SH3PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 570186Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0194.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ13368.
PhylomeDBiQ13368.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13368-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH
60 70 80 90 100
EKLRYYERQS PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL
110 120 130 140 150
RAVLMVHDTV AQKNFDPVLP PLPDNIDEDF DEESVKIVRL VKNKEPLGAT
160 170 180 190 200
IRRDEHSGAV VVARIMRGGA ADRSGLVHVG DELREVNGIA VLHKRPDEIS
210 220 230 240 250
QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR EDRAIPCQEA
260 270 280 290 300
GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR
310 320 330 340 350
AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER
360 370 380 390 400
LGGSQEGKMS SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE
410 420 430 440 450
LKQKVVAENP QHFGVAVPHT TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK
460 470 480 490 500
FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL VDVEPEALKQ LRTSEFKPYI
510 520 530 540 550
IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF IDRHYGHLVD
560 570 580
AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR
Length:585
Mass (Da):66,152
Last modified:June 26, 2007 - v2
Checksum:i782DAE54096A4993
GO

Sequence cautioni

The sequence AAH47017.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → D in AAB36964. (PubMed:8824795)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti585 – 5851R → G.
Corresponds to variant rs17742683 [ dbSNP | Ensembl ].
VAR_050014

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37707 mRNA. Translation: AAB36964.1.
AM050144 mRNA. Translation: CAJ18313.1.
AM050145 mRNA. Translation: CAJ18315.1.
AK313045 mRNA. Translation: BAG35877.1.
CH471178 Genomic DNA. Translation: EAW51664.1.
CH471178 Genomic DNA. Translation: EAW51665.1.
BC047017 mRNA. Translation: AAH47017.1. Different initiation.
BC056865 mRNA. Translation: AAH56865.1.
CCDSiCCDS42344.1.
PIRiG02165.
RefSeqiNP_001923.2. NM_001932.4.
XP_006721978.1. XM_006721915.1.
UniGeneiHs.396566.

Genome annotation databases

EnsembliENST00000398389; ENSP00000381425; ENSG00000161647.
ENST00000496503; ENSP00000465486; ENSG00000161647.
GeneIDi4356.
KEGGihsa:4356.
UCSCiuc002iei.4. human.

Polymorphism databases

DMDMi150421601.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37707 mRNA. Translation: AAB36964.1 .
AM050144 mRNA. Translation: CAJ18313.1 .
AM050145 mRNA. Translation: CAJ18315.1 .
AK313045 mRNA. Translation: BAG35877.1 .
CH471178 Genomic DNA. Translation: EAW51664.1 .
CH471178 Genomic DNA. Translation: EAW51665.1 .
BC047017 mRNA. Translation: AAH47017.1 . Different initiation.
BC056865 mRNA. Translation: AAH56865.1 .
CCDSi CCDS42344.1.
PIRi G02165.
RefSeqi NP_001923.2. NM_001932.4.
XP_006721978.1. XM_006721915.1.
UniGenei Hs.396566.

3D structure databases

ProteinModelPortali Q13368.
SMRi Q13368. Positions 7-116, 134-217, 229-580.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110496. 23 interactions.
IntActi Q13368. 28 interactions.
MINTi MINT-1377781.
STRINGi 9606.ENSP00000381425.

PTM databases

PhosphoSitei Q13368.

Polymorphism databases

DMDMi 150421601.

Proteomic databases

PaxDbi Q13368.
PRIDEi Q13368.

Protocols and materials databases

DNASUi 4356.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398389 ; ENSP00000381425 ; ENSG00000161647 .
ENST00000496503 ; ENSP00000465486 ; ENSG00000161647 .
GeneIDi 4356.
KEGGi hsa:4356.
UCSCi uc002iei.4. human.

Organism-specific databases

CTDi 4356.
GeneCardsi GC17M041888.
HGNCi HGNC:7221. MPP3.
HPAi HPA021818.
HPA024742.
MIMi 601114. gene.
neXtProti NX_Q13368.
PharmGKBi PA30926.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0194.
GeneTreei ENSGT00760000118866.
HOGENOMi HOG000233034.
HOVERGENi HBG001858.
InParanoidi Q13368.
PhylomeDBi Q13368.
TreeFami TF314263.

Miscellaneous databases

GenomeRNAii 4356.
NextBioi 17138.
PROi Q13368.
SOURCEi Search...

Gene expression databases

Bgeei Q13368.
CleanExi HS_DLG3.
HS_MPP3.
ExpressionAtlasi Q13368. baseline and differential.
Genevestigatori Q13368.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21."
    Smith S.A., Holik P., Stevens J., Mazoyer S., Melis R., Williams B., White R., Albertsen H.
    Genomics 31:145-150(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human retinal membrane palmitoylated protein 3 (mpp3): molecular cloning and characterization."
    Kantardzhieva A., Alexeeva S., Versteeg I., de Jong P.T.V.M., Wijnholds J.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Pancreas.
  6. "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
    Fukuhara H., Masuda M., Yageta M., Fukami T., Kuramochi M., Maruyama T., Kitamura T., Murakami Y.
    Oncogene 22:6160-6165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CADM1.

Entry informationi

Entry nameiMPP3_HUMAN
AccessioniPrimary (citable) accession number: Q13368
Secondary accession number(s): B2R7N0
, D3DX47, Q4GX05, Q6PGR3, Q86SV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3