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Q13368

- MPP3_HUMAN

UniProt

Q13368 - MPP3_HUMAN

Protein

MAGUK p55 subfamily member 3

Gene

MPP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. guanylate kinase activity Source: ProtInc

    GO - Biological processi

    1. nucleotide phosphorylation Source: GOC
    2. signal transduction Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAGUK p55 subfamily member 3
    Alternative name(s):
    Discs large homolog 3
    Protein MPP3
    Gene namesi
    Name:MPP3
    Synonyms:DLG3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7221. MPP3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30926.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585MAGUK p55 subfamily member 3PRO_0000094575Add
    BLAST

    Proteomic databases

    PaxDbiQ13368.
    PRIDEiQ13368.

    PTM databases

    PhosphoSiteiQ13368.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13368.
    BgeeiQ13368.
    CleanExiHS_DLG3.
    HS_MPP3.
    GenevestigatoriQ13368.

    Organism-specific databases

    HPAiHPA021818.
    HPA024742.

    Interactioni

    Subunit structurei

    May interact with HTR2A By similarity. Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi110496. 22 interactions.
    IntActiQ13368. 28 interactions.
    MINTiMINT-1377781.
    STRINGi9606.ENSP00000381425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13368.
    SMRiQ13368. Positions 7-116, 134-217, 229-580.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 6055L27 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini61 – 11858L27 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini137 – 21276PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 29671SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 570186Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 2 L27 domains.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0194.
    HOGENOMiHOG000233034.
    HOVERGENiHBG001858.
    InParanoidiQ13368.
    PhylomeDBiQ13368.
    TreeFamiTF314263.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 2 hits.
    PF00595. PDZ. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q13368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH    50
    EKLRYYERQS PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL 100
    RAVLMVHDTV AQKNFDPVLP PLPDNIDEDF DEESVKIVRL VKNKEPLGAT 150
    IRRDEHSGAV VVARIMRGGA ADRSGLVHVG DELREVNGIA VLHKRPDEIS 200
    QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR EDRAIPCQEA 250
    GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR 300
    AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER 350
    LGGSQEGKMS SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE 400
    LKQKVVAENP QHFGVAVPHT TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK 450
    FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL VDVEPEALKQ LRTSEFKPYI 500
    IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF IDRHYGHLVD 550
    AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR 585
    Length:585
    Mass (Da):66,152
    Last modified:June 26, 2007 - v2
    Checksum:i782DAE54096A4993
    GO

    Sequence cautioni

    The sequence AAH47017.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371V → D in AAB36964. (PubMed:8824795)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti585 – 5851R → G.
    Corresponds to variant rs17742683 [ dbSNP | Ensembl ].
    VAR_050014

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37707 mRNA. Translation: AAB36964.1.
    AM050144 mRNA. Translation: CAJ18313.1.
    AM050145 mRNA. Translation: CAJ18315.1.
    AK313045 mRNA. Translation: BAG35877.1.
    CH471178 Genomic DNA. Translation: EAW51664.1.
    CH471178 Genomic DNA. Translation: EAW51665.1.
    BC047017 mRNA. Translation: AAH47017.1. Different initiation.
    BC056865 mRNA. Translation: AAH56865.1.
    CCDSiCCDS42344.1.
    PIRiG02165.
    RefSeqiNP_001923.2. NM_001932.4.
    XP_006721978.1. XM_006721915.1.
    UniGeneiHs.396566.

    Genome annotation databases

    EnsembliENST00000398389; ENSP00000381425; ENSG00000161647.
    ENST00000496503; ENSP00000465486; ENSG00000161647.
    GeneIDi4356.
    KEGGihsa:4356.
    UCSCiuc002iei.4. human.

    Polymorphism databases

    DMDMi150421601.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37707 mRNA. Translation: AAB36964.1 .
    AM050144 mRNA. Translation: CAJ18313.1 .
    AM050145 mRNA. Translation: CAJ18315.1 .
    AK313045 mRNA. Translation: BAG35877.1 .
    CH471178 Genomic DNA. Translation: EAW51664.1 .
    CH471178 Genomic DNA. Translation: EAW51665.1 .
    BC047017 mRNA. Translation: AAH47017.1 . Different initiation.
    BC056865 mRNA. Translation: AAH56865.1 .
    CCDSi CCDS42344.1.
    PIRi G02165.
    RefSeqi NP_001923.2. NM_001932.4.
    XP_006721978.1. XM_006721915.1.
    UniGenei Hs.396566.

    3D structure databases

    ProteinModelPortali Q13368.
    SMRi Q13368. Positions 7-116, 134-217, 229-580.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110496. 22 interactions.
    IntActi Q13368. 28 interactions.
    MINTi MINT-1377781.
    STRINGi 9606.ENSP00000381425.

    PTM databases

    PhosphoSitei Q13368.

    Polymorphism databases

    DMDMi 150421601.

    Proteomic databases

    PaxDbi Q13368.
    PRIDEi Q13368.

    Protocols and materials databases

    DNASUi 4356.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398389 ; ENSP00000381425 ; ENSG00000161647 .
    ENST00000496503 ; ENSP00000465486 ; ENSG00000161647 .
    GeneIDi 4356.
    KEGGi hsa:4356.
    UCSCi uc002iei.4. human.

    Organism-specific databases

    CTDi 4356.
    GeneCardsi GC17M041888.
    HGNCi HGNC:7221. MPP3.
    HPAi HPA021818.
    HPA024742.
    MIMi 601114. gene.
    neXtProti NX_Q13368.
    PharmGKBi PA30926.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0194.
    HOGENOMi HOG000233034.
    HOVERGENi HBG001858.
    InParanoidi Q13368.
    PhylomeDBi Q13368.
    TreeFami TF314263.

    Miscellaneous databases

    GenomeRNAii 4356.
    NextBioi 17138.
    PROi Q13368.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13368.
    Bgeei Q13368.
    CleanExi HS_DLG3.
    HS_MPP3.
    Genevestigatori Q13368.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 2 hits.
    PF00595. PDZ. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21."
      Smith S.A., Holik P., Stevens J., Mazoyer S., Melis R., Williams B., White R., Albertsen H.
      Genomics 31:145-150(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human retinal membrane palmitoylated protein 3 (mpp3): molecular cloning and characterization."
      Kantardzhieva A., Alexeeva S., Versteeg I., de Jong P.T.V.M., Wijnholds J.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Pancreas.
    6. "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
      Fukuhara H., Masuda M., Yageta M., Fukami T., Kuramochi M., Maruyama T., Kitamura T., Murakami Y.
      Oncogene 22:6160-6165(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CADM1.

    Entry informationi

    Entry nameiMPP3_HUMAN
    AccessioniPrimary (citable) accession number: Q13368
    Secondary accession number(s): B2R7N0
    , D3DX47, Q4GX05, Q6PGR3, Q86SV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3