Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q13368 (MPP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MAGUK p55 subfamily member 3
Alternative name(s):
Discs large homolog 3
Protein MPP3
Gene names
Name:MPP3
Synonyms:DLG3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

May interact with HTR2A By similarity. Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 By similarity. Ref.6

Sequence similarities

Belongs to the MAGUK family.

Contains 1 guanylate kinase-like domain.

Contains 2 L27 domains.

Contains 1 PDZ (DHR) domain.

Contains 1 SH3 domain.

Sequence caution

The sequence AAH47017.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
SH3 domain
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionguanylate kinase activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585MAGUK p55 subfamily member 3
PRO_0000094575

Regions

Domain6 – 6055L27 1
Domain61 – 11858L27 2
Domain137 – 21276PDZ
Domain226 – 29671SH3
Domain385 – 570186Guanylate kinase-like

Natural variations

Natural variant5851R → G.
Corresponds to variant rs17742683 [ dbSNP | Ensembl ].
VAR_050014

Experimental info

Sequence conflict371V → D in AAB36964. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q13368 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 782DAE54096A4993

FASTA58566,152
        10         20         30         40         50         60 
MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH EKLRYYERQS 

        70         80         90        100        110        120 
PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL RAVLMVHDTV AQKNFDPVLP 

       130        140        150        160        170        180 
PLPDNIDEDF DEESVKIVRL VKNKEPLGAT IRRDEHSGAV VVARIMRGGA ADRSGLVHVG 

       190        200        210        220        230        240 
DELREVNGIA VLHKRPDEIS QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR 

       250        260        270        280        290        300 
EDRAIPCQEA GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR 

       310        320        330        340        350        360 
AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER LGGSQEGKMS 

       370        380        390        400        410        420 
SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE LKQKVVAENP QHFGVAVPHT 

       430        440        450        460        470        480 
TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL 

       490        500        510        520        530        540 
VDVEPEALKQ LRTSEFKPYI IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF 

       550        560        570        580 
IDRHYGHLVD AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21."
Smith S.A., Holik P., Stevens J., Mazoyer S., Melis R., Williams B., White R., Albertsen H.
Genomics 31:145-150(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human retinal membrane palmitoylated protein 3 (mpp3): molecular cloning and characterization."
Kantardzhieva A., Alexeeva S., Versteeg I., de Jong P.T.V.M., Wijnholds J.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Pancreas.
[6]"Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
Fukuhara H., Masuda M., Yageta M., Fukami T., Kuramochi M., Maruyama T., Kitamura T., Murakami Y.
Oncogene 22:6160-6165(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CADM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U37707 mRNA. Translation: AAB36964.1.
AM050144 mRNA. Translation: CAJ18313.1.
AM050145 mRNA. Translation: CAJ18315.1.
AK313045 mRNA. Translation: BAG35877.1.
CH471178 Genomic DNA. Translation: EAW51664.1.
CH471178 Genomic DNA. Translation: EAW51665.1.
BC047017 mRNA. Translation: AAH47017.1. Different initiation.
BC056865 mRNA. Translation: AAH56865.1.
PIRG02165.
RefSeqNP_001923.2. NM_001932.4.
UniGeneHs.396566.

3D structure databases

ProteinModelPortalQ13368.
SMRQ13368. Positions 7-116, 134-582.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110496. 22 interactions.
IntActQ13368. 28 interactions.
MINTMINT-1377781.
STRING9606.ENSP00000381425.

PTM databases

PhosphoSiteQ13368.

Polymorphism databases

DMDM150421601.

Proteomic databases

PaxDbQ13368.
PRIDEQ13368.

Protocols and materials databases

DNASU4356.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398389; ENSP00000381425; ENSG00000161647.
ENST00000496503; ENSP00000465486; ENSG00000161647.
GeneID4356.
KEGGhsa:4356.
UCSCuc002iei.4. human.

Organism-specific databases

CTD4356.
GeneCardsGC17M041888.
HGNCHGNC:7221. MPP3.
HPAHPA021818.
HPA024742.
MIM601114. gene.
neXtProtNX_Q13368.
PharmGKBPA30926.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000233034.
HOVERGENHBG001858.
InParanoidQ13368.
TreeFamTF314263.

Gene expression databases

ArrayExpressQ13368.
BgeeQ13368.
CleanExHS_DLG3.
HS_MPP3.
GenevestigatorQ13368.

Family and domain databases

InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4356.
NextBio17138.
PROQ13368.
SOURCESearch...

Entry information

Entry nameMPP3_HUMAN
AccessionPrimary (citable) accession number: Q13368
Secondary accession number(s): B2R7N0 expand/collapse secondary AC list , D3DX47, Q4GX05, Q6PGR3, Q86SV1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: March 19, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM