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Protein

MAGUK p55 subfamily member 3

Gene

MPP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • guanylate kinase activity Source: ProtInc

GO - Biological processi

  • signal transduction Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 3
Alternative name(s):
Discs large homolog 3
Protein MPP3
Gene namesi
Name:MPP3
Synonyms:DLG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161647.18
HGNCiHGNC:7221 MPP3
MIMi601114 gene
neXtProtiNX_Q13368

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161647
PharmGKBiPA30926

Polymorphism and mutation databases

BioMutaiMPP3
DMDMi150421601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945751 – 585MAGUK p55 subfamily member 3Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13368
PaxDbiQ13368
PeptideAtlasiQ13368
PRIDEiQ13368

PTM databases

iPTMnetiQ13368
PhosphoSitePlusiQ13368

Expressioni

Gene expression databases

BgeeiENSG00000161647
CleanExiHS_DLG3
HS_MPP3
ExpressionAtlasiQ13368 baseline and differential

Organism-specific databases

HPAiHPA021818
HPA024742

Interactioni

Subunit structurei

May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110496, 28 interactors
CORUMiQ13368
IntActiQ13368, 33 interactors
STRINGi9606.ENSP00000381425

Structurei

3D structure databases

ProteinModelPortaliQ13368
SMRiQ13368
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 60L27 1PROSITE-ProRule annotationAdd BLAST55
Domaini61 – 118L27 2PROSITE-ProRule annotationAdd BLAST58
Domaini137 – 212PDZPROSITE-ProRule annotationAdd BLAST76
Domaini226 – 296SH3PROSITE-ProRule annotationAdd BLAST71
Domaini385 – 570Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST186

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiQ13368
PhylomeDBiQ13368
TreeFamiTF314263

Family and domain databases

CDDicd12039 SH3_MPP3, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR035604 MPP3_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF02828 L27, 2 hits
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00569 L27, 2 hits
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS51022 L27, 2 hits
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q13368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH
60 70 80 90 100
EKLRYYERQS PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL
110 120 130 140 150
RAVLMVHDTV AQKNFDPVLP PLPDNIDEDF DEESVKIVRL VKNKEPLGAT
160 170 180 190 200
IRRDEHSGAV VVARIMRGGA ADRSGLVHVG DELREVNGIA VLHKRPDEIS
210 220 230 240 250
QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR EDRAIPCQEA
260 270 280 290 300
GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR
310 320 330 340 350
AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER
360 370 380 390 400
LGGSQEGKMS SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE
410 420 430 440 450
LKQKVVAENP QHFGVAVPHT TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK
460 470 480 490 500
FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL VDVEPEALKQ LRTSEFKPYI
510 520 530 540 550
IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF IDRHYGHLVD
560 570 580
AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR
Length:585
Mass (Da):66,152
Last modified:June 26, 2007 - v2
Checksum:i782DAE54096A4993
GO

Sequence cautioni

The sequence AAH47017 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37V → D in AAB36964 (PubMed:8824795).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050014585R → G. Corresponds to variant dbSNP:rs17742683Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37707 mRNA Translation: AAB36964.1
AM050144 mRNA Translation: CAJ18313.1
AM050145 mRNA Translation: CAJ18315.1
AK313045 mRNA Translation: BAG35877.1
CH471178 Genomic DNA Translation: EAW51664.1
CH471178 Genomic DNA Translation: EAW51665.1
BC047017 mRNA Translation: AAH47017.1 Different initiation.
BC056865 mRNA Translation: AAH56865.1
CCDSiCCDS42344.1
PIRiG02165
RefSeqiNP_001317162.1, NM_001330233.1
NP_001923.2, NM_001932.4
XP_006721978.1, XM_006721915.2
UniGeneiHs.396566

Genome annotation databases

EnsembliENST00000398389; ENSP00000381425; ENSG00000161647
GeneIDi4356
KEGGihsa:4356
UCSCiuc002iei.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMPP3_HUMAN
AccessioniPrimary (citable) accession number: Q13368
Secondary accession number(s): B2R7N0
, D3DX47, Q4GX05, Q6PGR3, Q86SV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: April 25, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health