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Protein

MAGUK p55 subfamily member 3

Gene

MPP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • guanylate kinase activity Source: ProtInc

GO - Biological processi

  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161647-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 3
Alternative name(s):
Discs large homolog 3
Protein MPP3
Gene namesi
Name:MPP3
Synonyms:DLG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7221. MPP3.

Subcellular locationi

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4356.
OpenTargetsiENSG00000161647.
PharmGKBiPA30926.

Polymorphism and mutation databases

BioMutaiMPP3.
DMDMi150421601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945751 – 585MAGUK p55 subfamily member 3Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13368.
PaxDbiQ13368.
PeptideAtlasiQ13368.
PRIDEiQ13368.

PTM databases

iPTMnetiQ13368.
PhosphoSitePlusiQ13368.

Expressioni

Gene expression databases

BgeeiENSG00000161647.
CleanExiHS_DLG3.
HS_MPP3.
ExpressionAtlasiQ13368. baseline and differential.

Organism-specific databases

HPAiHPA021818.
HPA024742.

Interactioni

Subunit structurei

May interact with HTR2A (By similarity). Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LIN7AO149104EBI-716157,EBI-2513988
LIN7BQ9HAP64EBI-716157,EBI-821335

Protein-protein interaction databases

BioGridi110496. 27 interactors.
IntActiQ13368. 32 interactors.
MINTiMINT-1377781.
STRINGi9606.ENSP00000381425.

Structurei

3D structure databases

ProteinModelPortaliQ13368.
SMRiQ13368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 60L27 1PROSITE-ProRule annotationAdd BLAST55
Domaini61 – 118L27 2PROSITE-ProRule annotationAdd BLAST58
Domaini137 – 212PDZPROSITE-ProRule annotationAdd BLAST76
Domaini226 – 296SH3PROSITE-ProRule annotationAdd BLAST71
Domaini385 – 570Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST186

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ13368.
PhylomeDBiQ13368.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q13368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH
60 70 80 90 100
EKLRYYERQS PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL
110 120 130 140 150
RAVLMVHDTV AQKNFDPVLP PLPDNIDEDF DEESVKIVRL VKNKEPLGAT
160 170 180 190 200
IRRDEHSGAV VVARIMRGGA ADRSGLVHVG DELREVNGIA VLHKRPDEIS
210 220 230 240 250
QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR EDRAIPCQEA
260 270 280 290 300
GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR
310 320 330 340 350
AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER
360 370 380 390 400
LGGSQEGKMS SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE
410 420 430 440 450
LKQKVVAENP QHFGVAVPHT TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK
460 470 480 490 500
FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL VDVEPEALKQ LRTSEFKPYI
510 520 530 540 550
IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF IDRHYGHLVD
560 570 580
AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR
Length:585
Mass (Da):66,152
Last modified:June 26, 2007 - v2
Checksum:i782DAE54096A4993
GO

Sequence cautioni

The sequence AAH47017 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37V → D in AAB36964 (PubMed:8824795).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050014585R → G.Corresponds to variant rs17742683dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37707 mRNA. Translation: AAB36964.1.
AM050144 mRNA. Translation: CAJ18313.1.
AM050145 mRNA. Translation: CAJ18315.1.
AK313045 mRNA. Translation: BAG35877.1.
CH471178 Genomic DNA. Translation: EAW51664.1.
CH471178 Genomic DNA. Translation: EAW51665.1.
BC047017 mRNA. Translation: AAH47017.1. Different initiation.
BC056865 mRNA. Translation: AAH56865.1.
CCDSiCCDS42344.1.
PIRiG02165.
RefSeqiNP_001317162.1. NM_001330233.1.
NP_001923.2. NM_001932.4.
XP_006721978.1. XM_006721915.2.
UniGeneiHs.396566.

Genome annotation databases

EnsembliENST00000398389; ENSP00000381425; ENSG00000161647.
GeneIDi4356.
KEGGihsa:4356.
UCSCiuc002iei.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37707 mRNA. Translation: AAB36964.1.
AM050144 mRNA. Translation: CAJ18313.1.
AM050145 mRNA. Translation: CAJ18315.1.
AK313045 mRNA. Translation: BAG35877.1.
CH471178 Genomic DNA. Translation: EAW51664.1.
CH471178 Genomic DNA. Translation: EAW51665.1.
BC047017 mRNA. Translation: AAH47017.1. Different initiation.
BC056865 mRNA. Translation: AAH56865.1.
CCDSiCCDS42344.1.
PIRiG02165.
RefSeqiNP_001317162.1. NM_001330233.1.
NP_001923.2. NM_001932.4.
XP_006721978.1. XM_006721915.2.
UniGeneiHs.396566.

3D structure databases

ProteinModelPortaliQ13368.
SMRiQ13368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110496. 27 interactors.
IntActiQ13368. 32 interactors.
MINTiMINT-1377781.
STRINGi9606.ENSP00000381425.

PTM databases

iPTMnetiQ13368.
PhosphoSitePlusiQ13368.

Polymorphism and mutation databases

BioMutaiMPP3.
DMDMi150421601.

Proteomic databases

MaxQBiQ13368.
PaxDbiQ13368.
PeptideAtlasiQ13368.
PRIDEiQ13368.

Protocols and materials databases

DNASUi4356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398389; ENSP00000381425; ENSG00000161647.
GeneIDi4356.
KEGGihsa:4356.
UCSCiuc002iei.5. human.

Organism-specific databases

CTDi4356.
DisGeNETi4356.
GeneCardsiMPP3.
HGNCiHGNC:7221. MPP3.
HPAiHPA021818.
HPA024742.
MIMi601114. gene.
neXtProtiNX_Q13368.
OpenTargetsiENSG00000161647.
PharmGKBiPA30926.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ13368.
PhylomeDBiQ13368.
TreeFamiTF314263.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161647-MONOMER.

Miscellaneous databases

GenomeRNAii4356.
PROiQ13368.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161647.
CleanExiHS_DLG3.
HS_MPP3.
ExpressionAtlasiQ13368. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPP3_HUMAN
AccessioniPrimary (citable) accession number: Q13368
Secondary accession number(s): B2R7N0
, D3DX47, Q4GX05, Q6PGR3, Q86SV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.