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Q13361

- MFAP5_HUMAN

UniProt

Q13361 - MFAP5_HUMAN

Protein

Microfibrillar-associated protein 5

Gene

MFAP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Component of the elastin-associated microfibrils.

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: ProtInc

    GO - Biological processi

    1. extracellular fibril organization Source: Ensembl
    2. extracellular matrix organization Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_150331. Molecules associated with elastic fibres.
    REACT_150366. Elastic fibre formation.
    SignaLinkiQ13361.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microfibrillar-associated protein 5
    Short name:
    MFAP-5
    Alternative name(s):
    MP25
    Microfibril-associated glycoprotein 2
    Short name:
    MAGP-2
    Gene namesi
    Name:MFAP5
    Synonyms:MAGP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29673. MFAP5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. microfibril Source: InterPro

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134915148.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 173152Microfibrillar-associated protein 5PRO_0000018685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541O-linked (GalNAc...)1 Publication
    Glycosylationi79 – 791N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.
    N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycan heterogeneity at Thr-54: HexHexNAc (major) and HexHexNAc + sulfate (minor).2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ13361.
    PRIDEiQ13361.

    PTM databases

    PhosphoSiteiQ13361.

    Expressioni

    Gene expression databases

    ArrayExpressiQ13361.
    BgeeiQ13361.
    CleanExiHS_MFAP5.
    GenevestigatoriQ13361.

    Organism-specific databases

    HPAiHPA010553.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000352455.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi30 – 323Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the MFAP family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39121.
    HOGENOMiHOG000034641.
    HOVERGENiHBG052464.
    InParanoidiQ13361.
    OMAiKNTTAEC.
    PhylomeDBiQ13361.
    TreeFamiTF333418.

    Family and domain databases

    InterProiIPR008673. MAGP.
    [Graphical view]
    PANTHERiPTHR16485. PTHR16485. 1 hit.
    PfamiPF05507. MAGP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q13361-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLLGPKVLL FLAAFIITSD WIPLGVNSQR GDDVTQATPE TFTEDPNLVN    50
    DPATDETVLA VLADIAPSTD DLASLSEKNT TAECWDEKFT CTRLYSVHRP 100
    VKQCIHQLCF TSLRRMYIVN KEICSRLVCK EHEAMKDELC RQMAGLPPRR 150
    LRRSNYFRLP PCENVDLQRP NGL 173
    Length:173
    Mass (Da):19,612
    Last modified:November 1, 1997 - v1
    Checksum:i70CE35B303C710A0
    GO
    Isoform 2 (identifier: Q13361-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-82: Missing.

    Show »
    Length:163
    Mass (Da):18,608
    Checksum:iC9EE4E1165E7CE0E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611V → D in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036430

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei73 – 8210Missing in isoform 2. 2 PublicationsVSP_056618

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37283 mRNA. Translation: AAA96752.1.
    AF084927
    , AF084919, AF084920, AF084921, AF084922, AF084923, AF084924, AF084925, AF084926 Genomic DNA. Translation: AAC83942.1.
    AY339060 mRNA. Translation: AAQ18021.1.
    AK299475 mRNA. Translation: BAG61439.1.
    AK315807 mRNA. Translation: BAF98698.1.
    AC092184 Genomic DNA. No translation available.
    AC092490 Genomic DNA. No translation available.
    CH471116 Genomic DNA. Translation: EAW88613.1.
    CH471116 Genomic DNA. Translation: EAW88614.1.
    BC005901 mRNA. Translation: AAH05901.1.
    CCDSiCCDS8595.1.
    RefSeqiNP_003471.1. NM_003480.2.
    XP_005253542.1. XM_005253485.2.
    UniGeneiHs.512842.

    Genome annotation databases

    EnsembliENST00000359478; ENSP00000352455; ENSG00000197614.
    ENST00000396549; ENSP00000379798; ENSG00000197614.
    GeneIDi8076.
    KEGGihsa:8076.
    UCSCiuc001qut.1. human.

    Polymorphism databases

    DMDMi2498553.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37283 mRNA. Translation: AAA96752.1 .
    AF084927
    , AF084919 , AF084920 , AF084921 , AF084922 , AF084923 , AF084924 , AF084925 , AF084926 Genomic DNA. Translation: AAC83942.1 .
    AY339060 mRNA. Translation: AAQ18021.1 .
    AK299475 mRNA. Translation: BAG61439.1 .
    AK315807 mRNA. Translation: BAF98698.1 .
    AC092184 Genomic DNA. No translation available.
    AC092490 Genomic DNA. No translation available.
    CH471116 Genomic DNA. Translation: EAW88613.1 .
    CH471116 Genomic DNA. Translation: EAW88614.1 .
    BC005901 mRNA. Translation: AAH05901.1 .
    CCDSi CCDS8595.1.
    RefSeqi NP_003471.1. NM_003480.2.
    XP_005253542.1. XM_005253485.2.
    UniGenei Hs.512842.

    3D structure databases

    ProteinModelPortali Q13361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000352455.

    PTM databases

    PhosphoSitei Q13361.

    Polymorphism databases

    DMDMi 2498553.

    Proteomic databases

    PaxDbi Q13361.
    PRIDEi Q13361.

    Protocols and materials databases

    DNASUi 8076.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359478 ; ENSP00000352455 ; ENSG00000197614 .
    ENST00000396549 ; ENSP00000379798 ; ENSG00000197614 .
    GeneIDi 8076.
    KEGGi hsa:8076.
    UCSCi uc001qut.1. human.

    Organism-specific databases

    CTDi 8076.
    GeneCardsi GC12M008798.
    HGNCi HGNC:29673. MFAP5.
    HPAi HPA010553.
    MIMi 601103. gene.
    neXtProti NX_Q13361.
    PharmGKBi PA134915148.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39121.
    HOGENOMi HOG000034641.
    HOVERGENi HBG052464.
    InParanoidi Q13361.
    OMAi KNTTAEC.
    PhylomeDBi Q13361.
    TreeFami TF333418.

    Enzyme and pathway databases

    Reactomei REACT_150331. Molecules associated with elastic fibres.
    REACT_150366. Elastic fibre formation.
    SignaLinki Q13361.

    Miscellaneous databases

    GeneWikii MFAP5.
    GenomeRNAii 8076.
    NextBioi 30683.
    PROi Q13361.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13361.
    Bgeei Q13361.
    CleanExi HS_MFAP5.
    Genevestigatori Q13361.

    Family and domain databases

    InterProi IPR008673. MAGP.
    [Graphical view ]
    PANTHERi PTHR16485. PTHR16485. 1 hit.
    Pfami PF05507. MAGP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)."
      Gibson M.A., Hatzinikolas G., Kumaratilake J.S., Sandberg L.B., Nicholl J.K., Sutherland G.R., Cleary E.G.
      J. Biol. Chem. 271:1096-1103(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region."
      Hatzinikolas G., Gibson M.A.
      J. Biol. Chem. 273:29309-29314(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. Li H., Cao L., Zhou G., Shen C., Zhong G., Yu R., Lin L., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Tongue.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79.
      Tissue: Liver.
    9. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
      Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT THR-54, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-61.

    Entry informationi

    Entry nameiMFAP5_HUMAN
    AccessioniPrimary (citable) accession number: Q13361
    Secondary accession number(s): B0AZL6, D3DUV1, Q7Z490
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3