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Q13361

- MFAP5_HUMAN

UniProt

Q13361 - MFAP5_HUMAN

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Protein
Microfibrillar-associated protein 5
Gene
MFAP5, MAGP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the elastin-associated microfibrils.

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: ProtInc

GO - Biological processi

  1. extracellular fibril organization Source: Ensembl
  2. extracellular matrix organization Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
SignaLinkiQ13361.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 5
Short name:
MFAP-5
Alternative name(s):
MP25
Microfibril-associated glycoprotein 2
Short name:
MAGP-2
Gene namesi
Name:MFAP5
Synonyms:MAGP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29673. MFAP5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. microfibril Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 173152Microfibrillar-associated protein 5
PRO_0000018685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541O-linked (GalNAc...)1 Publication
Glycosylationi79 – 791N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycan heterogeneity at Thr-54: HexHexNAc (major) and HexHexNAc + sulfate (minor).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ13361.
PRIDEiQ13361.

PTM databases

PhosphoSiteiQ13361.

Expressioni

Gene expression databases

ArrayExpressiQ13361.
BgeeiQ13361.
CleanExiHS_MFAP5.
GenevestigatoriQ13361.

Organism-specific databases

HPAiHPA010553.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000352455.

Structurei

3D structure databases

ProteinModelPortaliQ13361.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 323Cell attachment site Reviewed prediction

Sequence similaritiesi

Belongs to the MFAP family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39121.
HOGENOMiHOG000034641.
HOVERGENiHBG052464.
InParanoidiQ13361.
OMAiKNTTAEC.
PhylomeDBiQ13361.
TreeFamiTF333418.

Family and domain databases

InterProiIPR008673. MAGP.
[Graphical view]
PANTHERiPTHR16485. PTHR16485. 1 hit.
PfamiPF05507. MAGP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13361-1 [UniParc]FASTAAdd to Basket

« Hide

MSLLGPKVLL FLAAFIITSD WIPLGVNSQR GDDVTQATPE TFTEDPNLVN    50
DPATDETVLA VLADIAPSTD DLASLSEKNT TAECWDEKFT CTRLYSVHRP 100
VKQCIHQLCF TSLRRMYIVN KEICSRLVCK EHEAMKDELC RQMAGLPPRR 150
LRRSNYFRLP PCENVDLQRP NGL 173
Length:173
Mass (Da):19,612
Last modified:November 1, 1997 - v1
Checksum:i70CE35B303C710A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611V → D in a breast cancer sample; somatic mutation. 1 Publication
VAR_036430

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37283 mRNA. Translation: AAA96752.1.
AF084927
, AF084919, AF084920, AF084921, AF084922, AF084923, AF084924, AF084925, AF084926 Genomic DNA. Translation: AAC83942.1.
AK315807 mRNA. Translation: BAF98698.1.
CH471116 Genomic DNA. Translation: EAW88613.1.
CH471116 Genomic DNA. Translation: EAW88614.1.
BC005901 mRNA. Translation: AAH05901.1.
CCDSiCCDS8595.1.
RefSeqiNP_003471.1. NM_003480.2.
UniGeneiHs.512842.

Genome annotation databases

EnsembliENST00000359478; ENSP00000352455; ENSG00000197614.
GeneIDi8076.
KEGGihsa:8076.
UCSCiuc001qut.1. human.

Polymorphism databases

DMDMi2498553.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37283 mRNA. Translation: AAA96752.1 .
AF084927
, AF084919 , AF084920 , AF084921 , AF084922 , AF084923 , AF084924 , AF084925 , AF084926 Genomic DNA. Translation: AAC83942.1 .
AK315807 mRNA. Translation: BAF98698.1 .
CH471116 Genomic DNA. Translation: EAW88613.1 .
CH471116 Genomic DNA. Translation: EAW88614.1 .
BC005901 mRNA. Translation: AAH05901.1 .
CCDSi CCDS8595.1.
RefSeqi NP_003471.1. NM_003480.2.
UniGenei Hs.512842.

3D structure databases

ProteinModelPortali Q13361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000352455.

PTM databases

PhosphoSitei Q13361.

Polymorphism databases

DMDMi 2498553.

Proteomic databases

PaxDbi Q13361.
PRIDEi Q13361.

Protocols and materials databases

DNASUi 8076.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359478 ; ENSP00000352455 ; ENSG00000197614 .
GeneIDi 8076.
KEGGi hsa:8076.
UCSCi uc001qut.1. human.

Organism-specific databases

CTDi 8076.
GeneCardsi GC12M008798.
HGNCi HGNC:29673. MFAP5.
HPAi HPA010553.
MIMi 601103. gene.
neXtProti NX_Q13361.
PharmGKBi PA134915148.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39121.
HOGENOMi HOG000034641.
HOVERGENi HBG052464.
InParanoidi Q13361.
OMAi KNTTAEC.
PhylomeDBi Q13361.
TreeFami TF333418.

Enzyme and pathway databases

Reactomei REACT_150331. Molecules associated with elastic fibres.
REACT_150366. Elastic fibre formation.
SignaLinki Q13361.

Miscellaneous databases

GeneWikii MFAP5.
GenomeRNAii 8076.
NextBioi 30683.
PROi Q13361.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q13361.
Bgeei Q13361.
CleanExi HS_MFAP5.
Genevestigatori Q13361.

Family and domain databases

InterProi IPR008673. MAGP.
[Graphical view ]
PANTHERi PTHR16485. PTHR16485. 1 hit.
Pfami PF05507. MAGP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)."
    Gibson M.A., Hatzinikolas G., Kumaratilake J.S., Sandberg L.B., Nicholl J.K., Sutherland G.R., Cleary E.G.
    J. Biol. Chem. 271:1096-1103(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region."
    Hatzinikolas G., Gibson M.A.
    J. Biol. Chem. 273:29309-29314(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79.
    Tissue: Liver.
  7. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
    Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-54, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-61.

Entry informationi

Entry nameiMFAP5_HUMAN
AccessioniPrimary (citable) accession number: Q13361
Secondary accession number(s): B0AZL6, D3DUV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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