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Protein

Zinc finger protein 177

Gene

ZNF177

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri176 – 198C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 177
Gene namesi
Name:ZNF177
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188629.11
HGNCiHGNC:12966 ZNF177
MIMi601276 gene
neXtProtiNX_Q13360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7730
OpenTargetsiENSG00000188629
ENSG00000270011
PharmGKBiPA37548

Polymorphism and mutation databases

BioMutaiZNF177
DMDMi425906076

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474411 – 481Zinc finger protein 177Add BLAST481

Proteomic databases

EPDiQ13360
MaxQBiQ13360
PaxDbiQ13360
PeptideAtlasiQ13360
PRIDEiQ13360

PTM databases

iPTMnetiQ13360
PhosphoSitePlusiQ13360

Expressioni

Gene expression databases

BgeeiENSG00000188629
CleanExiHS_ZNF177
ExpressionAtlasiQ13360 baseline and differential
GenevisibleiQ13360 HS

Organism-specific databases

HPAiHPA003141

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGAP21J3JSM93EBI-3921570,EBI-10178656

Protein-protein interaction databases

BioGridi1135194 interactors.
IntActiQ13360 4 interactors.
STRINGi9606.ENSP00000415070

Structurei

3D structure databases

ProteinModelPortaliQ13360
SMRiQ13360
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 170C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri176 – 198C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129830
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ13360
KOiK09228
OMAiPLSVHTK
OrthoDBiEOG091G02KC
PhylomeDBiQ13360

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13360-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGWLTTWS QNSVTFQEVA VDFSQEEWAL LDPAQKNLYK DVMLENFRNL
60 70 80 90 100
ASVGYQLCRH SLISKVDQEQ LKTDERGILQ GDCADWETQL KPKDTIAMQN
110 120 130 140 150
IPGGKTSNGI NTAENQPGEH SLECNHCGKF RKNTRFICTR YCKGEKCYKY
160 170 180 190 200
IKYSKVFNHP STLRSHVSIH IGEKTLEFTD CRKAFNQESS LRKHLRTPTG
210 220 230 240 250
QKFQEYEQCD MSFSLHSSCS VREQIPTGEK GDECSDYGKI SPLSVHTKTG
260 270 280 290 300
SVEEGLECNE HEKTFTDPLS LQNCVRTHSG EMPYECSDCG KAFIFQSSLK
310 320 330 340 350
KHMRSHTGEK PYECDHCGKS FSQSSHLNVH KRTHTGEKPY DCKECGKAFT
360 370 380 390 400
VPSSLQKHVR THTGEKPYEC SDCGKAFIDQ SSLKKHTRSH TGEKPYECNQ
410 420 430 440 450
CGKSFSTGSY LIVHKRTHTG EKTYECKECG KAFRNSSCLR VHVRTHTGEK
460 470 480
PYKCIQCEKA FSTSTNLIMH KRIHNGQKLH E
Length:481
Mass (Da):54,782
Last modified:November 28, 2012 - v4
Checksum:iECC43A8D975F6F90
GO
Isoform 2 (identifier: Q13360-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-272: Missing.

Show »
Length:321
Mass (Da):36,409
Checksum:i62BE3432F37067D9
GO
Isoform 3 (identifier: Q13360-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-120: AENQPGEH → NPHGREFL
     121-481: Missing.

Show »
Length:120
Mass (Da):13,572
Checksum:i99F27784198CC0F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29A → G in U37251 (PubMed:11549323).Curated1
Sequence conflicti470H → P in AAH12012 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03169294D → G. Corresponds to variant dbSNP:rs2230750Ensembl.1
Natural variantiVAR_031693112T → M3 PublicationsCorresponds to variant dbSNP:rs2217652Ensembl.1
Natural variantiVAR_057401455I → F2 PublicationsCorresponds to variant dbSNP:rs2230752Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044461113 – 272Missing in isoform 2. 2 PublicationsAdd BLAST160
Alternative sequenceiVSP_045841113 – 120AENQPGEH → NPHGREFL in isoform 3. 1 Publication8
Alternative sequenceiVSP_045842121 – 481Missing in isoform 3. 1 PublicationAdd BLAST361

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37263 mRNA Translation: AAB09749.1
U37251 mRNA No translation available.
AK302274 mRNA Translation: BAG63619.1
AC011451 Genomic DNA No translation available.
BC012012 mRNA Translation: AAH12012.1
CCDSiCCDS12212.1 [Q13360-2]
CCDS54214.1 [Q13360-1]
CCDS56081.1 [Q13360-3]
RefSeqiNP_001166121.1, NM_001172650.2 [Q13360-2]
NP_001166122.1, NM_001172651.1 [Q13360-1]
NP_001189354.1, NM_001202425.1 [Q13360-3]
NP_003442.2, NM_003451.2 [Q13360-2]
UniGeneiHs.728944

Genome annotation databases

EnsembliENST00000343499; ENSP00000341497; ENSG00000188629 [Q13360-2]
ENST00000589262; ENSP00000468531; ENSG00000188629 [Q13360-1]
GeneIDi100529215
7730
KEGGihsa:100529215
hsa:7730
UCSCiuc002mlk.4 human [Q13360-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN177_HUMAN
AccessioniPrimary (citable) accession number: Q13360
Secondary accession number(s): B4DY57
, E9PDG0, I3L0I4, Q96ER2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2012
Last modified: March 28, 2018
This is version 163 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome