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Protein

Zinc finger protein 177

Gene

ZNF177

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 17026C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 177
Gene namesi
Name:ZNF177
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12966. ZNF177.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37548.

Polymorphism and mutation databases

BioMutaiZNF177.
DMDMi425906076.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Zinc finger protein 177PRO_0000047441Add
BLAST

Proteomic databases

EPDiQ13360.
PaxDbiQ13360.
PeptideAtlasiQ13360.
PRIDEiQ13360.

PTM databases

iPTMnetiQ13360.

Expressioni

Gene expression databases

BgeeiQ13360.
CleanExiHS_ZNF177.
ExpressionAtlasiQ13360. baseline and differential.
GenevisibleiQ13360. HS.

Organism-specific databases

HPAiHPA003141.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGAP21J3JSM93EBI-3921570,EBI-10178656

Protein-protein interaction databases

BioGridi113519. 4 interactions.
IntActiQ13360. 3 interactions.
STRINGi9606.ENSP00000415070.

Structurei

3D structure databases

ProteinModelPortaliQ13360.
SMRiQ13360. Positions 12-62, 124-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8471KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 17026C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ13360.
KOiK09228.
OMAiPLSVHTK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ13360.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13360-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGWLTTWS QNSVTFQEVA VDFSQEEWAL LDPAQKNLYK DVMLENFRNL
60 70 80 90 100
ASVGYQLCRH SLISKVDQEQ LKTDERGILQ GDCADWETQL KPKDTIAMQN
110 120 130 140 150
IPGGKTSNGI NTAENQPGEH SLECNHCGKF RKNTRFICTR YCKGEKCYKY
160 170 180 190 200
IKYSKVFNHP STLRSHVSIH IGEKTLEFTD CRKAFNQESS LRKHLRTPTG
210 220 230 240 250
QKFQEYEQCD MSFSLHSSCS VREQIPTGEK GDECSDYGKI SPLSVHTKTG
260 270 280 290 300
SVEEGLECNE HEKTFTDPLS LQNCVRTHSG EMPYECSDCG KAFIFQSSLK
310 320 330 340 350
KHMRSHTGEK PYECDHCGKS FSQSSHLNVH KRTHTGEKPY DCKECGKAFT
360 370 380 390 400
VPSSLQKHVR THTGEKPYEC SDCGKAFIDQ SSLKKHTRSH TGEKPYECNQ
410 420 430 440 450
CGKSFSTGSY LIVHKRTHTG EKTYECKECG KAFRNSSCLR VHVRTHTGEK
460 470 480
PYKCIQCEKA FSTSTNLIMH KRIHNGQKLH E
Length:481
Mass (Da):54,782
Last modified:November 28, 2012 - v4
Checksum:iECC43A8D975F6F90
GO
Isoform 2 (identifier: Q13360-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-272: Missing.

Show »
Length:321
Mass (Da):36,409
Checksum:i62BE3432F37067D9
GO
Isoform 3 (identifier: Q13360-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-120: AENQPGEH → NPHGREFL
     121-481: Missing.

Show »
Length:120
Mass (Da):13,572
Checksum:i99F27784198CC0F3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291A → G in U37251 (PubMed:11549323).Curated
Sequence conflicti470 – 4701H → P in AAH12012 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti94 – 941D → G.
Corresponds to variant rs2230750 [ dbSNP | Ensembl ].
VAR_031692
Natural varianti112 – 1121T → M.3 Publications
Corresponds to variant rs2217652 [ dbSNP | Ensembl ].
VAR_031693
Natural varianti455 – 4551I → F.2 Publications
Corresponds to variant rs2230752 [ dbSNP | Ensembl ].
VAR_057401

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 272160Missing in isoform 2. 2 PublicationsVSP_044461Add
BLAST
Alternative sequencei113 – 1208AENQPGEH → NPHGREFL in isoform 3. 1 PublicationVSP_045841
Alternative sequencei121 – 481361Missing in isoform 3. 1 PublicationVSP_045842Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37263 mRNA. Translation: AAB09749.1.
U37251 mRNA. No translation available.
AK302274 mRNA. Translation: BAG63619.1.
AC011451 Genomic DNA. No translation available.
BC012012 mRNA. Translation: AAH12012.1.
CCDSiCCDS12212.1. [Q13360-2]
CCDS54214.1. [Q13360-1]
CCDS56081.1. [Q13360-3]
RefSeqiNP_001166121.1. NM_001172650.2. [Q13360-2]
NP_001166122.1. NM_001172651.1. [Q13360-1]
NP_001189354.1. NM_001202425.1. [Q13360-3]
NP_003442.2. NM_003451.2. [Q13360-2]
UniGeneiHs.728944.

Genome annotation databases

EnsembliENST00000343499; ENSP00000341497; ENSG00000188629. [Q13360-2]
ENST00000589262; ENSP00000468531; ENSG00000188629. [Q13360-1]
GeneIDi100529215.
7730.
KEGGihsa:100529215.
hsa:7730.
UCSCiuc002mlk.4. human. [Q13360-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37263 mRNA. Translation: AAB09749.1.
U37251 mRNA. No translation available.
AK302274 mRNA. Translation: BAG63619.1.
AC011451 Genomic DNA. No translation available.
BC012012 mRNA. Translation: AAH12012.1.
CCDSiCCDS12212.1. [Q13360-2]
CCDS54214.1. [Q13360-1]
CCDS56081.1. [Q13360-3]
RefSeqiNP_001166121.1. NM_001172650.2. [Q13360-2]
NP_001166122.1. NM_001172651.1. [Q13360-1]
NP_001189354.1. NM_001202425.1. [Q13360-3]
NP_003442.2. NM_003451.2. [Q13360-2]
UniGeneiHs.728944.

3D structure databases

ProteinModelPortaliQ13360.
SMRiQ13360. Positions 12-62, 124-474.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113519. 4 interactions.
IntActiQ13360. 3 interactions.
STRINGi9606.ENSP00000415070.

PTM databases

iPTMnetiQ13360.

Polymorphism and mutation databases

BioMutaiZNF177.
DMDMi425906076.

Proteomic databases

EPDiQ13360.
PaxDbiQ13360.
PeptideAtlasiQ13360.
PRIDEiQ13360.

Protocols and materials databases

DNASUi7730.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343499; ENSP00000341497; ENSG00000188629. [Q13360-2]
ENST00000589262; ENSP00000468531; ENSG00000188629. [Q13360-1]
GeneIDi100529215.
7730.
KEGGihsa:100529215.
hsa:7730.
UCSCiuc002mlk.4. human. [Q13360-1]

Organism-specific databases

CTDi100529215.
7730.
GeneCardsiZNF177.
ZNF559-ZNF177.
HGNCiHGNC:12966. ZNF177.
HPAiHPA003141.
MIMi601276. gene.
neXtProtiNX_Q13360.
PharmGKBiPA37548.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ13360.
KOiK09228.
OMAiPLSVHTK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ13360.

Miscellaneous databases

PROiQ13360.
SOURCEiSearch...

Gene expression databases

BgeeiQ13360.
CleanExiHS_ZNF177.
ExpressionAtlasiQ13360. baseline and differential.
GenevisibleiQ13360. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments."
    Baban S., Freeman J.D., Mager D.L.
    Genomics 33:463-472(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS MET-112 AND PHE-455.
  2. "Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency."
    Landry J.R., Medstrand P., Mager D.L.
    Genomics 76:110-116(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT MET-112.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS MET-112 AND PHE-455.
    Tissue: Testis.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiZN177_HUMAN
AccessioniPrimary (citable) accession number: Q13360
Secondary accession number(s): B4DY57
, E9PDG0, I3L0I4, Q96ER2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2012
Last modified: July 6, 2016
This is version 148 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.