Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase-like 2

Gene

PPIL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).1 PublicationBy similarity2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).1 PublicationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
  • ubiquitin protein ligase activity Source: MGI
  • ubiquitin-ubiquitin ligase activity Source: MGI

GO - Biological processi

  • leukocyte migration Source: Reactome
  • protein folding Source: InterPro
  • protein localization to plasma membrane Source: UniProtKB
  • protein polyubiquitination Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Ligase, Rotamase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:HS01952-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 2Curated (EC:5.2.1.81 PublicationBy similarity, EC:6.3.2.-1 Publication)
Short name:
PPIaseCurated
Alternative name(s):
CYC41 Publication
Cyclophilin-601 Publication
Short name:
Cyclophilin-like protein Cyp-601 Publication
Short name:
Cyp601 Publication
Short name:
hCyP-601 Publication
Rotamase PPIL2Curated
Gene namesi
Name:PPIL2Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9261. PPIL2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • Golgi lumen Source: Reactome
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23759.
OpenTargetsiENSG00000100023.
PharmGKBiPA33588.

Polymorphism and mutation databases

BioMutaiPPIL2.
DMDMi23813917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641711 – 520Peptidyl-prolyl cis-trans isomerase-like 2Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei470PhosphoserineCombined sources1
Modified residuei482N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ13356.
MaxQBiQ13356.
PaxDbiQ13356.
PeptideAtlasiQ13356.
PRIDEiQ13356.

PTM databases

iPTMnetiQ13356.
PhosphoSitePlusiQ13356.

Expressioni

Tissue specificityi

Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas.2 Publications

Gene expression databases

BgeeiENSG00000100023.
CleanExiHS_PPIL2.
ExpressionAtlasiQ13356. baseline and differential.
GenevisibleiQ13356. HS.

Organism-specific databases

HPAiHPA035344.
HPA055637.

Interactioni

Subunit structurei

Interacts with BSG. Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM23P364063EBI-7705988,EBI-740098
ZNF830Q96NB32EBI-7705988,EBI-3920997

Protein-protein interaction databases

BioGridi117260. 27 interactors.
IntActiQ13356. 15 interactors.
MINTiMINT-4654541.
STRINGi9606.ENSP00000390427.

Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi280 – 286Combined sources7
Beta strandi289 – 295Combined sources7
Turni297 – 299Combined sources3
Helixi301 – 312Combined sources12
Turni313 – 318Combined sources6
Beta strandi323 – 325Combined sources3
Turni326 – 328Combined sources3
Beta strandi329 – 332Combined sources4
Beta strandi337 – 340Combined sources4
Beta strandi365 – 368Combined sources4
Beta strandi380 – 385Combined sources6
Helixi388 – 390Combined sources3
Turni391 – 393Combined sources3
Beta strandi396 – 402Combined sources7
Helixi404 – 412Combined sources9
Turni417 – 419Combined sources3
Beta strandi422 – 424Combined sources3
Beta strandi427 – 435Combined sources9
Helixi439 – 455Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZKCX-ray1.65A/B280-457[»]
ProteinModelPortaliQ13356.
SMRiQ13356.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13356.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 108U-boxAdd BLAST74
Domaini278 – 433PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 217Sequence analysisAdd BLAST21

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 1 U-box domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0883. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000177172.
HOVERGENiHBG053655.
InParanoidiQ13356.
KOiK10598.
OMAiFEYPVCT.
OrthoDBiEOG091G05AW.
PhylomeDBiQ13356.
TreeFamiTF300854.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR003613. Ubox_domain.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00504. Ubox. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS51698. U_BOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q13356-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV
60 70 80 90 100
YPVCTPDGIV FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK
110 120 130 140 150
YHCPVLFTVF TNNTHIVAVR TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF
160 170 180 190 200
SRQDIITLQD PTNLDKFNVS NFYHVKNNMK IIDPDEEKAK QDPSYYLKNT
210 220 230 240 250
NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH YSTGKVSASF
260 270 280 290 300
TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT
310 320 330 340 350
PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF
360 370 380 390 400
KDEFRPNLSH TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV
410 420 430 440 450
VGGFDVLTAM ENVESDPKTD RPKEEIRIDA TTVFVDPYEE ADAQIAQERK
460 470 480 490 500
TQLKVAPETK VKSSQPQAGS QGPQTFRQGV GKYINPAATK RAAEEEPSTS
510 520
ATVPMSKKKP SRGFGDFSSW
Length:520
Mass (Da):58,823
Last modified:November 1, 1996 - v1
Checksum:i3FFA51C3D82F0957
GO
Isoform 2 (identifier: Q13356-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     490-520: KRAAEEEPSTSATVPMSKKKPSRGFGDFSSW → EQQRKSPQPVPLSPCPRRSPVGVLGTSAPGSSRLPDDH

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):59,458
Checksum:i9B494AE6D29EBAC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455V → I in AAH28385 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005182490 – 520KRAAE…DFSSW → EQQRKSPQPVPLSPCPRRSP VGVLGTSAPGSSRLPDDH in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37219 mRNA. Translation: AAC50376.1.
U37220 mRNA. Translation: AAC50377.1.
U37221 mRNA. Translation: AAC50378.1.
CR456548 mRNA. Translation: CAG30434.1.
BC028385 mRNA. Translation: AAH28385.1.
BC000022 mRNA. Translation: AAH00022.1.
CCDSiCCDS13793.1. [Q13356-1]
CCDS46670.1. [Q13356-2]
PIRiS64705.
RefSeqiNP_001304925.1. NM_001317996.1. [Q13356-1]
NP_055152.1. NM_014337.3. [Q13356-1]
NP_680480.1. NM_148175.2. [Q13356-1]
NP_680481.1. NM_148176.2. [Q13356-2]
XP_005261505.1. XM_005261448.3. [Q13356-1]
XP_011528348.1. XM_011530046.2. [Q13356-1]
XP_011528349.1. XM_011530047.2. [Q13356-1]
UniGeneiHs.438587.

Genome annotation databases

EnsembliENST00000335025; ENSP00000334553; ENSG00000100023. [Q13356-1]
ENST00000398831; ENSP00000381812; ENSG00000100023. [Q13356-1]
ENST00000406385; ENSP00000384299; ENSG00000100023. [Q13356-1]
ENST00000626352; ENSP00000486725; ENSG00000100023. [Q13356-2]
GeneIDi23759.
KEGGihsa:23759.
UCSCiuc002zvg.5. human. [Q13356-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37219 mRNA. Translation: AAC50376.1.
U37220 mRNA. Translation: AAC50377.1.
U37221 mRNA. Translation: AAC50378.1.
CR456548 mRNA. Translation: CAG30434.1.
BC028385 mRNA. Translation: AAH28385.1.
BC000022 mRNA. Translation: AAH00022.1.
CCDSiCCDS13793.1. [Q13356-1]
CCDS46670.1. [Q13356-2]
PIRiS64705.
RefSeqiNP_001304925.1. NM_001317996.1. [Q13356-1]
NP_055152.1. NM_014337.3. [Q13356-1]
NP_680480.1. NM_148175.2. [Q13356-1]
NP_680481.1. NM_148176.2. [Q13356-2]
XP_005261505.1. XM_005261448.3. [Q13356-1]
XP_011528348.1. XM_011530046.2. [Q13356-1]
XP_011528349.1. XM_011530047.2. [Q13356-1]
UniGeneiHs.438587.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZKCX-ray1.65A/B280-457[»]
ProteinModelPortaliQ13356.
SMRiQ13356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117260. 27 interactors.
IntActiQ13356. 15 interactors.
MINTiMINT-4654541.
STRINGi9606.ENSP00000390427.

PTM databases

iPTMnetiQ13356.
PhosphoSitePlusiQ13356.

Polymorphism and mutation databases

BioMutaiPPIL2.
DMDMi23813917.

Proteomic databases

EPDiQ13356.
MaxQBiQ13356.
PaxDbiQ13356.
PeptideAtlasiQ13356.
PRIDEiQ13356.

Protocols and materials databases

DNASUi23759.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335025; ENSP00000334553; ENSG00000100023. [Q13356-1]
ENST00000398831; ENSP00000381812; ENSG00000100023. [Q13356-1]
ENST00000406385; ENSP00000384299; ENSG00000100023. [Q13356-1]
ENST00000626352; ENSP00000486725; ENSG00000100023. [Q13356-2]
GeneIDi23759.
KEGGihsa:23759.
UCSCiuc002zvg.5. human. [Q13356-1]

Organism-specific databases

CTDi23759.
DisGeNETi23759.
GeneCardsiPPIL2.
HGNCiHGNC:9261. PPIL2.
HPAiHPA035344.
HPA055637.
MIMi607588. gene.
neXtProtiNX_Q13356.
OpenTargetsiENSG00000100023.
PharmGKBiPA33588.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0883. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000177172.
HOVERGENiHBG053655.
InParanoidiQ13356.
KOiK10598.
OMAiFEYPVCT.
OrthoDBiEOG091G05AW.
PhylomeDBiQ13356.
TreeFamiTF300854.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:HS01952-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.

Miscellaneous databases

ChiTaRSiPPIL2. human.
EvolutionaryTraceiQ13356.
GeneWikiiPPIL2.
GenomeRNAii23759.
PROiQ13356.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100023.
CleanExiHS_PPIL2.
ExpressionAtlasiQ13356. baseline and differential.
GenevisibleiQ13356. HS.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR003613. Ubox_domain.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00504. Ubox. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS51698. U_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIL2_HUMAN
AccessioniPrimary (citable) accession number: Q13356
Secondary accession number(s): Q13357, Q8TAH2, Q9BWR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.