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Q13352

- CENPR_HUMAN

UniProt

Q13352 - CENPR_HUMAN

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Protein

Centromere protein R

Gene

ITGB3BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.5 Publications

GO - Molecular functioni

  1. protein C-terminus binding Source: ProtInc
  2. signal transducer activity Source: ProtInc

GO - Biological processi

  1. apoptotic signaling pathway Source: Reactome
  2. cell adhesion Source: ProtInc
  3. CENP-A containing nucleosome assembly Source: Reactome
  4. mitotic cell cycle Source: Reactome
  5. mitotic nuclear division Source: UniProtKB-KW
  6. neurotrophin TRK receptor signaling pathway Source: Reactome
  7. nucleosome assembly Source: Reactome
  8. positive regulation of apoptotic process Source: Reactome
  9. regulation of transcription, DNA-templated Source: UniProtKB-KW
  10. signal transduction Source: ProtInc
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_13643. NRIF signals cell death from the nucleus.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein R
Short name:
CENP-R
Alternative name(s):
Beta-3-endonexin
Integrin beta-3-binding protein
Nuclear receptor-interacting factor 3
Gene namesi
Name:ITGB3BP
Synonyms:CENPR, NRIF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6157. ITGB3BP.

Subcellular locationi

Isoform 3 : Nucleus. Cytoplasm
Note: Isoform 3 is predominantly nuclear and weakly cytoplasmic.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. cytosol Source: Reactome
  3. kinetochore Source: UniProtKB-KW
  4. membrane Source: ProtInc
  5. nucleoplasm Source: Reactome
  6. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91L → A: Decreased interaction with nuclear receptors. 1 Publication
Mutagenesisi28 – 281S → A: Loss of repressor function. 2 Publications
Mutagenesisi63 – 664Missing: Abolishes localization to nucleus. 1 Publication
Mutagenesisi63 – 653KRK → AAA: Abolishes localization to nucleus. 1 Publication
Mutagenesisi89 – 891L → R: Abolishes dimerization, but not interactions with nuclear receptors; when associated with R-96. 1 Publication
Mutagenesisi96 – 961L → R: Abolishes dimerization, but not interactions with nuclear receptors; when associated with R-89. 1 Publication
Mutagenesisi172 – 1765LKAIL → AKAAA: Abolishes interaction with nuclear receptors. 1 Publication

Organism-specific databases

PharmGKBiPA29956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Centromere protein RPRO_0000057949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171Phosphoserine2 Publications
Modified residuei28 – 281Phosphoserine1 Publication
Modified residuei71 – 711Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ13352.
PaxDbiQ13352.
PRIDEiQ13352.

PTM databases

PhosphoSiteiQ13352.

Expressioni

Tissue specificityi

Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes.2 Publications

Inductioni

By estrogen.1 Publication

Gene expression databases

BgeeiQ13352.
ExpressionAtlasiQ13352. baseline and differential.
GenevestigatoriQ13352.

Organism-specific databases

HPAiHPA028463.

Interactioni

Subunit structurei

Homodimer; mediated by the coiled coil domain. Isoform 3, but not other isoforms, interacts with the cytoplasmic tail of integrin ITGB3. The relevance of the interaction with ITGB3 is however uncertain, since isoform 3 is mainly nuclear. Interacts with CCNA2 and MTA1. Interacts with NFKB1 NF-kappa-B subunit. Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.7 Publications

Protein-protein interaction databases

BioGridi116992. 25 interactions.
IntActiQ13352. 31 interactions.
MINTiMINT-1378371.

Structurei

3D structure databases

ProteinModelPortaliQ13352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 5031DD1Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili83 – 11331Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 135LXXLL motif
Motifi63 – 664Nuclear localization signal
Motifi172 – 1765LXXIL motif

Domaini

The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis.1 Publication
Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known to be important for the association with nuclear receptors. Such motif, which is required for an efficient association with nuclear receptors, is however not essential.1 Publication
Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80433.
GeneTreeiENSGT00390000004336.
HOVERGENiHBG080553.
InParanoidiQ13352.
KOiK11510.
OMAiQMSPFAS.
OrthoDBiEOG7SR4P3.
PhylomeDBiQ13352.
TreeFamiTF336291.

Family and domain databases

InterProiIPR009601. CENP-R.
[Graphical view]
PANTHERiPTHR15581. PTHR15581. 1 hit.
PfamiPF06729. CENP-R. 1 hit.
[Graphical view]
PIRSFiPIRSF011860. NRIF3_coact_rcpt. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13352-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVKRSLKLD GLLEENSFDP SKITRKKSVI TYSPTTGTCQ MSLFASPTSS
60 70 80 90 100
EEQKHRNGLS NEKRKKLNHP SLTESKESTT KDNDEFMMLL SKVEKLSEEI
110 120 130 140 150
MEIMQNLSSI QALEGSRELE NLIGISCASH FLKREMQKTK ELMTKVNKQK
160 170
LFEKSTGLPH KASRHLDSYE FLKAILN
Length:177
Mass (Da):20,194
Last modified:July 19, 2004 - v2
Checksum:iC0A6FD5A56E98D43
GO
Isoform 2 (identifier: Q13352-2) [UniParc]FASTAAdd to Basket

Also known as: Long, EnL, En-L

The sequence of this isoform differs from the canonical sequence as follows:
     162-177: ASRHLDSYEFLKAILN → GQPQMSQPL

Show »
Length:170
Mass (Da):19,302
Checksum:i227EE95365D0AB5C
GO
Isoform 3 (identifier: Q13352-3) [UniParc]FASTAAdd to Basket

Also known as: Short, EnS, En-S

The sequence of this isoform differs from the canonical sequence as follows:
     112-177: Missing.

Show »
Length:111
Mass (Da):12,624
Checksum:i790E4D07D5CC09AF
GO
Isoform 4 (identifier: Q13352-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-177: Missing.

Show »
Length:62
Mass (Da):6,902
Checksum:iDB8074B62E359160
GO
Isoform 5 (identifier: Q13352-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MP → MPFAPVAQARVQWHDFRSLQHLLPAFKRFSCLSLGSSWDYS

Note: No experimental confirmation available.

Show »
Length:216
Mass (Da):24,729
Checksum:i1D131D450750DCF4
GO

Sequence cautioni

The sequence AAH14385.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301I → V.
Corresponds to variant rs1058057 [ dbSNP | Ensembl ].
VAR_048691

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 22MP → MPFAPVAQARVQWHDFRSLQ HLLPAFKRFSCLSLGSSWDY S in isoform 5. 1 PublicationVSP_010831
Alternative sequencei63 – 177115Missing in isoform 4. CuratedVSP_010832Add
BLAST
Alternative sequencei112 – 17766Missing in isoform 3. 1 PublicationVSP_010833Add
BLAST
Alternative sequencei162 – 17716ASRHL…KAILN → GQPQMSQPL in isoform 2. 1 PublicationVSP_010834Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37139 mRNA. Translation: AAC50295.1.
U37139 mRNA. Translation: AAC50294.1.
AF175306 mRNA. Translation: AAF00239.1.
AK312944 mRNA. Translation: BAG35785.1.
BX004807, AL592218 Genomic DNA. Translation: CAI15771.1.
BX004807, AL592218 Genomic DNA. Translation: CAI15772.1.
AL592218, BX004807 Genomic DNA. Translation: CAI18958.1.
AL592218, BX004807 Genomic DNA. Translation: CAI18959.1.
BC009929 mRNA. Translation: AAH09929.1.
BC014385 mRNA. Translation: AAH14385.1. Different initiation.
CCDSiCCDS30736.1. [Q13352-1]
CCDS55603.1. [Q13352-5]
PIRiA57277.
RefSeqiNP_001193668.1. NM_001206739.1. [Q13352-5]
NP_055103.3. NM_014288.4. [Q13352-1]
UniGeneiHs.166539.

Genome annotation databases

EnsembliENST00000271002; ENSP00000271002; ENSG00000142856. [Q13352-1]
ENST00000371092; ENSP00000360133; ENSG00000142856. [Q13352-5]
ENST00000489099; ENSP00000432904; ENSG00000142856. [Q13352-2]
GeneIDi23421.
KEGGihsa:23421.
UCSCiuc001dba.2. human. [Q13352-1]
uc001dbb.2. human. [Q13352-5]
uc009wak.1. human. [Q13352-2]

Polymorphism databases

DMDMi50400855.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37139 mRNA. Translation: AAC50295.1 .
U37139 mRNA. Translation: AAC50294.1 .
AF175306 mRNA. Translation: AAF00239.1 .
AK312944 mRNA. Translation: BAG35785.1 .
BX004807 , AL592218 Genomic DNA. Translation: CAI15771.1 .
BX004807 , AL592218 Genomic DNA. Translation: CAI15772.1 .
AL592218 , BX004807 Genomic DNA. Translation: CAI18958.1 .
AL592218 , BX004807 Genomic DNA. Translation: CAI18959.1 .
BC009929 mRNA. Translation: AAH09929.1 .
BC014385 mRNA. Translation: AAH14385.1 . Different initiation.
CCDSi CCDS30736.1. [Q13352-1 ]
CCDS55603.1. [Q13352-5 ]
PIRi A57277.
RefSeqi NP_001193668.1. NM_001206739.1. [Q13352-5 ]
NP_055103.3. NM_014288.4. [Q13352-1 ]
UniGenei Hs.166539.

3D structure databases

ProteinModelPortali Q13352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116992. 25 interactions.
IntActi Q13352. 31 interactions.
MINTi MINT-1378371.

PTM databases

PhosphoSitei Q13352.

Polymorphism databases

DMDMi 50400855.

Proteomic databases

MaxQBi Q13352.
PaxDbi Q13352.
PRIDEi Q13352.

Protocols and materials databases

DNASUi 23421.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271002 ; ENSP00000271002 ; ENSG00000142856 . [Q13352-1 ]
ENST00000371092 ; ENSP00000360133 ; ENSG00000142856 . [Q13352-5 ]
ENST00000489099 ; ENSP00000432904 ; ENSG00000142856 . [Q13352-2 ]
GeneIDi 23421.
KEGGi hsa:23421.
UCSCi uc001dba.2. human. [Q13352-1 ]
uc001dbb.2. human. [Q13352-5 ]
uc009wak.1. human. [Q13352-2 ]

Organism-specific databases

CTDi 23421.
GeneCardsi GC01M063906.
H-InvDB HIX0019635.
HGNCi HGNC:6157. ITGB3BP.
HPAi HPA028463.
MIMi 605494. gene.
neXtProti NX_Q13352.
PharmGKBi PA29956.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80433.
GeneTreei ENSGT00390000004336.
HOVERGENi HBG080553.
InParanoidi Q13352.
KOi K11510.
OMAi QMSPFAS.
OrthoDBi EOG7SR4P3.
PhylomeDBi Q13352.
TreeFami TF336291.

Enzyme and pathway databases

Reactomei REACT_13643. NRIF signals cell death from the nucleus.
REACT_150425. Resolution of Sister Chromatid Cohesion.
REACT_150471. Separation of Sister Chromatids.
REACT_22186. Deposition of new CENPA-containing nucleosomes at the centromere.
REACT_682. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSi ITGB3BP. human.
GeneWikii ITGB3BP.
GenomeRNAii 23421.
NextBioi 45639.
PROi Q13352.
SOURCEi Search...

Gene expression databases

Bgeei Q13352.
ExpressionAtlasi Q13352. baseline and differential.
Genevestigatori Q13352.

Family and domain databases

InterProi IPR009601. CENP-R.
[Graphical view ]
PANTHERi PTHR15581. PTHR15581. 1 hit.
Pfami PF06729. CENP-R. 1 hit.
[Graphical view ]
PIRSFi PIRSF011860. NRIF3_coact_rcpt. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit."
    Shattil S.J., O'Toole T.E., Eigenthaler M.J., Thon V., Williams M.J., Babior B.M., Ginsberg M.H.
    J. Cell Biol. 131:807-816(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), TISSUE SPECIFICITY, INTERACTION WITH ITGB3.
    Tissue: B-cell.
  2. "NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors."
    Li D., Desai-Yajnik V., Lo E., Schapira M., Abagyan R., Samuels H.H.
    Mol. Cell. Biol. 19:7191-7202(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), COACTIVATOR FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RXRA AND THRA, MUTAGENESIS OF LEU-9 AND 172-LEU--LEU-176.
    Tissue: Cervix carcinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Bone marrow and Placenta.
  6. "Novel alternatively spliced form of beta(3)-endonexin."
    Fujimoto T.-T., Katsutani S., Shimomura T., Fujimura K.
    Thromb. Res. 105:63-70(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORM 4), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 63-LYS--LYS-65.
  7. "Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail."
    Kashiwagi H., Schwartz M.A., Eigenthaler M., Davis K.A., Ginsberg M.H., Shattil S.J.
    J. Cell Biol. 137:1433-1443(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. Cited for: INTERACTION WITH CCNA2.
  9. "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation."
    Li D., Wang F., Samuels H.H.
    Mol. Cell. Biol. 21:8371-8384(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A COREPRESSOR, SUBCELLULAR LOCATION, HOMODIMERIZATION, PHOSPHORYLATION, MUTAGENESIS OF SER-28; LEU-89 AND LEU-96.
  10. "Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor."
    Besta F., Massberg S., Brand K., Mueller E., Page S., Gruener S., Lorenz M., Sadoul K., Kolanus W., Lengyel E., Gawaz M.
    J. Cell Sci. 115:3879-3888(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A COREPRESSOR, SUBCELLULAR LOCATION, INTERACTION WITH NFKB1, MUTAGENESIS OF 63-LYS--LYS-66.
  11. "The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells."
    Li D., Das S., Yamada T., Samuels H.H.
    Mol. Cell. Biol. 24:3838-3848(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, MUTAGENESIS OF SER-28.
  12. "Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator."
    Talukder A.H., Gururaj A., Mishra S.K., Vadlamudi R.K., Kumar R.
    Mol. Cell. Biol. 24:6581-6591(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, INTERACTION WITH MTA1.
  13. "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres."
    Okada M., Cheeseman I.M., Hori T., Okawa K., McLeod I.X., Yates J.R. III, Desai A., Fukagawa T.
    Nat. Cell Biol. 8:446-457(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH CENPH; CENPI; CENPK; CENPN; CENPO; CENPP; CENPQ AND CENPU, FUNCTION, SUBCELLULAR LOCATION.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPK; CENPL; CENPO; CENPP; CENPQ AND CENPS.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-71, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCENPR_HUMAN
AccessioniPrimary (citable) accession number: Q13352
Secondary accession number(s): B2R7D8
, Q13353, Q5RJ42, Q5RJ44, Q5RJ45, Q7KYX2, Q96CD5, Q9UKB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

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