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Q13349 (ITAD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-D
Alternative name(s):
ADB2
CD11 antigen-like family member D
Leukointegrin alpha D
CD_antigen=CD11d
Gene names
Name:ITGAD
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length1161 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Subunit structure

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

Sequence caution

The sequence AAB60634.1 differs from that shown. Reason:

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Magnesium
   Molecular functionIntegrin
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcell-cell adhesion

Non-traceable author statement. Source: UniProtKB

cell-matrix adhesion

Non-traceable author statement. Source: UniProtKB

immune response

Non-traceable author statement Ref.4. Source: UniProtKB

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegrin complex

Traceable author statement. Source: UniProtKB

   Molecular functionreceptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 11611144Integrin alpha-D
PRO_0000016296

Regions

Topological domain18 – 10991082Extracellular Potential
Transmembrane1100 – 112021Helical; Potential
Topological domain1121 – 116141Cytoplasmic Potential
Repeat19 – 7658FG-GAP 1
Repeat77 – 13660FG-GAP 2
Domain150 – 332183VWFA
Repeat339 – 39052FG-GAP 3
Repeat391 – 44454FG-GAP 4
Repeat445 – 50258FG-GAP 5
Repeat506 – 56459FG-GAP 6
Repeat569 – 62961FG-GAP 7
Calcium binding465 – 4739 Potential
Calcium binding529 – 5379 Potential
Calcium binding592 – 6009 Potential
Motif1126 – 11305GFFKR motif

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation6901N-linked (GlcNAc...) Potential
Glycosylation7321N-linked (GlcNAc...) Potential
Glycosylation8721N-linked (GlcNAc...) Potential
Glycosylation9561N-linked (GlcNAc...) Potential
Glycosylation10451N-linked (GlcNAc...) Potential
Disulfide bond67 ↔ 74 By similarity
Disulfide bond106 ↔ 124 By similarity
Disulfide bond654 ↔ 709 By similarity
Disulfide bond768 ↔ 774 By similarity
Disulfide bond845 ↔ 860 By similarity
Disulfide bond993 ↔ 1017 By similarity
Disulfide bond1022 ↔ 1027 By similarity

Experimental info

Sequence conflict4991G → GQ in AAB38547. Ref.1
Sequence conflict8241L → V in AAB60637. Ref.3
Sequence conflict9831V → A in AAB60638. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q13349 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 769D658010CE5823

FASTA1,161126,758
        10         20         30         40         50         60 
MTFGTVLLLS VLASYHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVG APLEVVAANQ 

        70         80         90        100        110        120 
TGRLYDCAAA TGMCQPIPLH IRPEAVNMSL GLTLAASTNG SRLLACGPTL HRVCGENSYS 

       130        140        150        160        170        180 
KGSCLLLGSR WEIIQTVPDA TPECPHQEMD IVFLIDGSGS IDQNDFNQMK GFVQAVMGQF 

       190        200        210        220        230        240 
EGTDTLFALM QYSNLLKIHF TFTQFRTSPS QQSLVDPIVQ LKGLTFTATG ILTVVTQLFH 

       250        260        270        280        290        300 
HKNGARKSAK KILIVITDGQ KYKDPLEYSD VIPQAEKAGI IRYAIGVGHA FQGPTARQEL 

       310        320        330        340        350        360 
NTISSAPPQD HVFKVDNFAA LGSIQKQLQE KIYAVEGTQS RASSSFQHEM SQEGFSTALT 

       370        380        390        400        410        420 
MDGLFLGAVG SFSWSGGAFL YPPNMSPTFI NMSQENVDMR DSYLGYSTEL ALWKGVQNLV 

       430        440        450        460        470        480 
LGAPRYQHTG KAVIFTQVSR QWRKKAEVTG TQIGSYFGAS LCSVDVDSDG STDLILIGAP 

       490        500        510        520        530        540 
HYYEQTRGGQ VSVCPLPRGR VQWQCDAVLR GEQGHPWGRF GAALTVLGDV NEDKLIDVAI 

       550        560        570        580        590        600 
GAPGEQENRG AVYLFHGASE SGISPSHSQR IASSQLSPRL QYFGQALSGG QDLTQDGLMD 

       610        620        630        640        650        660 
LAVGARGQVL LLRSLPVLKV GVAMRFSPVE VAKAVYRCWE EKPSALEAGD ATVCLTIQKS 

       670        680        690        700        710        720 
SLDQLGDIQS SVRFDLALDP GRLTSRAIFN ETKNPTLTRR KTLGLGIHCE TLKLLLPDCV 

       730        740        750        760        770        780 
EDVVSPIILH LNFSLVREPI PSPQNLRPVL AVGSQDLFTA SLPFEKNCGQ DGLCEGDLGV 

       790        800        810        820        830        840 
TLSFSGLQTL TVGSSLELNV IVTVWNAGED SYGTVVSLYY PAGLSHRRVS GAQKQPHQSA 

       850        860        870        880        890        900 
LRLACETVPT EDEGLRSSRC SVNHPIFHEG SNGTFIVTFD VSYKATLGDR MLMRASASSE 

       910        920        930        940        950        960 
NNKASSSKAT FQLELPVKYA VYTMISRQEE STKYFNFATS DEKKMKEAEH RYRVNNLSQR 

       970        980        990       1000       1010       1020 
DLAISINFWV PVLLNGVAVW DVVMEAPSQS LPCVSERKPP QHSDFLTQIS RSPMLDCSIA 

      1030       1040       1050       1060       1070       1080 
DCLQFRCDVP SFSVQEELDF TLKGNLSFGW VRETLQKKVL VVSVAEITFD TSVYSQLPGQ 

      1090       1100       1110       1120       1130       1140 
EAFMRAQMEM VLEEDEVYNA IPIIMGSSVG ALLLLALITA TLYKLGFFKR HYKEMLEDKP 

      1150       1160 
EDTATFSGDD FSCVAPNVPL S

« Hide

References

[1]"A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3."
Van der Vieren M., Le Trong H., Wood C.L., Moore P.F., St John T., Staunton D.E., Gallatin W.M.
Immunity 3:683-690(1995) [PubMed: 8777714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3."
Noti J.D., Johnson A.K., Dillon J.D.
J. Biol. Chem. 275:8959-8969(2000) [PubMed: 10722744] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-235.
[3]"Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit."
Wong D.A., Davis E.M., LeBeau M., Springer T.A.
Gene 171:291-294(1996) [PubMed: 8666289] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 467-536; 570-601; 632-665; 787-833 AND 909-1124.
[4]"Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)."
Grayson M.H., Van der Vieren M., Sterbinsky S.A., Michael Gallatin W., Hoffman P.A., Staunton D.E., Bochner B.S.
J. Exp. Med. 188:2187-2191(1998) [PubMed: 9841932] [Abstract]
Cited for: INTERACTION WITH VCAM1.
[5]"The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1."
Van der Vieren M., Crowe D.T., Hoekstra D., Vazeux R., Hoffman P.A., Grayson M.H., Bochner B.S., Gallatin W.M., Staunton D.E.
J. Immunol. 163:1984-1990(1999) [PubMed: 10438935] [Abstract]
Cited for: INTERACTION WITH VCAM1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U37028 mRNA. Translation: AAB38547.1.
AF187881 Genomic DNA. Translation: AAF62875.1.
U40274 Genomic DNA. Translation: AAB60634.1. Sequence problems.
U40275 Genomic DNA. Translation: AAB60635.1.
U40276 Genomic DNA. Translation: AAB60636.1.
U40277 Genomic DNA. Translation: AAB60637.1.
U40279, U40278 Genomic DNA. Translation: AAB60638.1.
IPIIPI00968161.
RefSeqNP_005344.2. NM_005353.2.
UniGeneHs.679163.

3D structure databases

ProteinModelPortalQ13349.
SMRQ13349. Positions 150-330, 339-1141.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ13349.

Polymorphism databases

DMDM296434544.

Proteomic databases

PRIDEQ13349.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268297; ENSP00000268297; ENSG00000156886.
GeneID3681.
KEGGhsa:3681.
UCSCuc010cap.1. human.

Organism-specific databases

CTD3681.
GeneCardsGC16P031405.
H-InvDBHIX0012989.
HIX0134372.
HGNCHGNC:6146. ITGAD.
HPAHPA026786.
MIM602453. gene.
neXtProtNX_Q13349.
PharmGKBPA29946.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10985.
GeneTreeENSGT00600000084082.
HOVERGENHBG100530.
InParanoidQ13349.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ13349.
CleanExHS_ITGAD.
GenevestigatorQ13349.
GermOnlineENSG00000156886. Homo sapiens.

Family and domain databases

InterProIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
KOK06594.
PfamPF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameITAD_HUMAN
AccessionPrimary (citable) accession number: Q13349
Secondary accession number(s): Q15575, Q15576
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: January 25, 2012
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents