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Protein

Integrin alpha-D

Gene

ITGAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi465 – 4739Sequence analysis
Calcium bindingi529 – 5379Sequence analysis
Calcium bindingi592 – 6009Sequence analysis

GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: Reactome
  • heterotypic cell-cell adhesion Source: UniProtKB
  • immune response Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-D
Alternative name(s):
ADB2
CD11 antigen-like family member D
Leukointegrin alpha D
CD_antigen: CD11d
Gene namesi
Name:ITGAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:6146. ITGAD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 10991082ExtracellularSequence analysisAdd
BLAST
Transmembranei1100 – 112021HelicalSequence analysisAdd
BLAST
Topological domaini1121 – 116141CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integrin complex Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29946.

Polymorphism and mutation databases

BioMutaiITGAD.
DMDMi296434544.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 11611144Integrin alpha-DPRO_0000016296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi67 ↔ 74By similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi106 ↔ 124By similarity
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi654 ↔ 709By similarity
Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence analysis
Glycosylationi732 – 7321N-linked (GlcNAc...)Sequence analysis
Disulfide bondi768 ↔ 774By similarity
Disulfide bondi845 ↔ 860By similarity
Glycosylationi872 – 8721N-linked (GlcNAc...)Sequence analysis
Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi993 ↔ 1017By similarity
Disulfide bondi1022 ↔ 1027By similarity
Glycosylationi1045 – 10451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ13349.
PaxDbiQ13349.
PeptideAtlasiQ13349.
PRIDEiQ13349.

PTM databases

iPTMnetiQ13349.
PhosphoSiteiQ13349.

Expressioni

Tissue specificityi

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Gene expression databases

BgeeiENSG00000156886.
CleanExiHS_ITGAD.
GenevisibleiQ13349. HS.

Organism-specific databases

HPAiHPA026786.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.

Protein-protein interaction databases

BioGridi109887. 5 interactions.
STRINGi9606.ENSP00000373854.

Structurei

3D structure databases

ProteinModelPortaliQ13349.
SMRiQ13349. Positions 150-330, 339-1094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 7658FG-GAP 1PROSITE-ProRule annotationAdd
BLAST
Repeati77 – 13660FG-GAP 2PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 332183VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati339 – 39052FG-GAP 3PROSITE-ProRule annotationAdd
BLAST
Repeati391 – 44252FG-GAP 4PROSITE-ProRule annotationAdd
BLAST
Repeati443 – 50361FG-GAP 5PROSITE-ProRule annotationAdd
BLAST
Repeati506 – 56459FG-GAP 6PROSITE-ProRule annotationAdd
BLAST
Repeati569 – 62961FG-GAP 7PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1126 – 11305GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ13349.
KOiK06594.
OMAiPCVSERE.
OrthoDBiEOG091G01BZ.
PhylomeDBiQ13349.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q13349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFGTVLLLS VLASYHGFNL DVEEPTIFQE DAGGFGQSVV QFGGSRLVVG
60 70 80 90 100
APLEVVAANQ TGRLYDCAAA TGMCQPIPLH IRPEAVNMSL GLTLAASTNG
110 120 130 140 150
SRLLACGPTL HRVCGENSYS KGSCLLLGSR WEIIQTVPDA TPECPHQEMD
160 170 180 190 200
IVFLIDGSGS IDQNDFNQMK GFVQAVMGQF EGTDTLFALM QYSNLLKIHF
210 220 230 240 250
TFTQFRTSPS QQSLVDPIVQ LKGLTFTATG ILTVVTQLFH HKNGARKSAK
260 270 280 290 300
KILIVITDGQ KYKDPLEYSD VIPQAEKAGI IRYAIGVGHA FQGPTARQEL
310 320 330 340 350
NTISSAPPQD HVFKVDNFAA LGSIQKQLQE KIYAVEGTQS RASSSFQHEM
360 370 380 390 400
SQEGFSTALT MDGLFLGAVG SFSWSGGAFL YPPNMSPTFI NMSQENVDMR
410 420 430 440 450
DSYLGYSTEL ALWKGVQNLV LGAPRYQHTG KAVIFTQVSR QWRKKAEVTG
460 470 480 490 500
TQIGSYFGAS LCSVDVDSDG STDLILIGAP HYYEQTRGGQ VSVCPLPRGR
510 520 530 540 550
VQWQCDAVLR GEQGHPWGRF GAALTVLGDV NEDKLIDVAI GAPGEQENRG
560 570 580 590 600
AVYLFHGASE SGISPSHSQR IASSQLSPRL QYFGQALSGG QDLTQDGLMD
610 620 630 640 650
LAVGARGQVL LLRSLPVLKV GVAMRFSPVE VAKAVYRCWE EKPSALEAGD
660 670 680 690 700
ATVCLTIQKS SLDQLGDIQS SVRFDLALDP GRLTSRAIFN ETKNPTLTRR
710 720 730 740 750
KTLGLGIHCE TLKLLLPDCV EDVVSPIILH LNFSLVREPI PSPQNLRPVL
760 770 780 790 800
AVGSQDLFTA SLPFEKNCGQ DGLCEGDLGV TLSFSGLQTL TVGSSLELNV
810 820 830 840 850
IVTVWNAGED SYGTVVSLYY PAGLSHRRVS GAQKQPHQSA LRLACETVPT
860 870 880 890 900
EDEGLRSSRC SVNHPIFHEG SNGTFIVTFD VSYKATLGDR MLMRASASSE
910 920 930 940 950
NNKASSSKAT FQLELPVKYA VYTMISRQEE STKYFNFATS DEKKMKEAEH
960 970 980 990 1000
RYRVNNLSQR DLAISINFWV PVLLNGVAVW DVVMEAPSQS LPCVSERKPP
1010 1020 1030 1040 1050
QHSDFLTQIS RSPMLDCSIA DCLQFRCDVP SFSVQEELDF TLKGNLSFGW
1060 1070 1080 1090 1100
VRETLQKKVL VVSVAEITFD TSVYSQLPGQ EAFMRAQMEM VLEEDEVYNA
1110 1120 1130 1140 1150
IPIIMGSSVG ALLLLALITA TLYKLGFFKR HYKEMLEDKP EDTATFSGDD
1160
FSCVAPNVPL S
Length:1,161
Mass (Da):126,758
Last modified:May 18, 2010 - v2
Checksum:i769D658010CE5823
GO

Sequence cautioni

The sequence AAB60634 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti499 – 4991G → GQ in AAB38547 (PubMed:8777714).Curated
Sequence conflicti824 – 8241L → V in AAB60637 (PubMed:8666289).Curated
Sequence conflicti983 – 9831V → A in AAB60638 (PubMed:8666289).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37028 mRNA. Translation: AAB38547.1.
AF187881 Genomic DNA. Translation: AAF62875.1.
U40274 Genomic DNA. Translation: AAB60634.1. Sequence problems.
U40275 Genomic DNA. Translation: AAB60635.1.
U40276 Genomic DNA. Translation: AAB60636.1.
U40277 Genomic DNA. Translation: AAB60637.1.
U40279, U40278 Genomic DNA. Translation: AAB60638.1.
CCDSiCCDS32438.1.
RefSeqiNP_001305114.1. NM_001318185.1.
NP_005344.2. NM_005353.2.
UniGeneiHs.679163.

Genome annotation databases

EnsembliENST00000389202; ENSP00000373854; ENSG00000156886.
GeneIDi3681.
KEGGihsa:3681.
UCSCiuc002ebv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37028 mRNA. Translation: AAB38547.1.
AF187881 Genomic DNA. Translation: AAF62875.1.
U40274 Genomic DNA. Translation: AAB60634.1. Sequence problems.
U40275 Genomic DNA. Translation: AAB60635.1.
U40276 Genomic DNA. Translation: AAB60636.1.
U40277 Genomic DNA. Translation: AAB60637.1.
U40279, U40278 Genomic DNA. Translation: AAB60638.1.
CCDSiCCDS32438.1.
RefSeqiNP_001305114.1. NM_001318185.1.
NP_005344.2. NM_005353.2.
UniGeneiHs.679163.

3D structure databases

ProteinModelPortaliQ13349.
SMRiQ13349. Positions 150-330, 339-1094.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109887. 5 interactions.
STRINGi9606.ENSP00000373854.

PTM databases

iPTMnetiQ13349.
PhosphoSiteiQ13349.

Polymorphism and mutation databases

BioMutaiITGAD.
DMDMi296434544.

Proteomic databases

EPDiQ13349.
PaxDbiQ13349.
PeptideAtlasiQ13349.
PRIDEiQ13349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389202; ENSP00000373854; ENSG00000156886.
GeneIDi3681.
KEGGihsa:3681.
UCSCiuc002ebv.1. human.

Organism-specific databases

CTDi3681.
GeneCardsiITGAD.
H-InvDBHIX0012989.
HIX0134372.
HGNCiHGNC:6146. ITGAD.
HPAiHPA026786.
MIMi602453. gene.
neXtProtiNX_Q13349.
PharmGKBiPA29946.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
InParanoidiQ13349.
KOiK06594.
OMAiPCVSERE.
OrthoDBiEOG091G01BZ.
PhylomeDBiQ13349.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-HSA-216083. Integrin cell surface interactions.

Miscellaneous databases

GeneWikiiITGAD.
GenomeRNAii3681.
PROiQ13349.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156886.
CleanExiHS_ITGAD.
GenevisibleiQ13349. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITAD_HUMAN
AccessioniPrimary (citable) accession number: Q13349
Secondary accession number(s): Q15575, Q15576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.