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Protein

Receptor-type tyrosine-protein phosphatase S

Gene

PTPRS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with LAR-interacting protein LIP.1.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1557SubstrateBy similarity1
Active sitei1589Phosphocysteine intermediateBy similarity1
Binding sitei1633SubstrateBy similarity1
Active sitei1880Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:HS02737-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-3000178. ECM proteoglycans.
R-HSA-8849932. SALM protein interactions at the synapses.
SIGNORiQ13332.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.48)
Short name:
R-PTP-S
Alternative name(s):
Receptor-type tyrosine-protein phosphatase sigma
Short name:
R-PTP-sigma
Gene namesi
Name:PTPRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9681. PTPRS.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 1282ExtracellularSequence analysisAdd BLAST1253
Transmembranei1283 – 1303HelicalSequence analysisAdd BLAST21
Topological domaini1304 – 1948CytoplasmicSequence analysisAdd BLAST645

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5802.
OpenTargetsiENSG00000105426.
PharmGKBiPA34026.

Chemistry databases

ChEMBLiCHEMBL2396508.
DrugBankiDB00630. Alendronate.
DB01077. Etidronic acid.
GuidetoPHARMACOLOGYi1866.

Polymorphism and mutation databases

BioMutaiPTPRS.
DMDMi317373519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002546230 – 1948Receptor-type tyrosine-protein phosphatase SAdd BLAST1919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Disulfide bondi156 ↔ 216PROSITE-ProRule annotation
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266 ↔ 311PROSITE-ProRule annotation
Glycosylationi308N-linked (GlcNAc...)Sequence analysis1
Glycosylationi733N-linked (GlcNAc...)3 Publications1
Glycosylationi940N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1197 – 1198CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13332.
PaxDbiQ13332.
PeptideAtlasiQ13332.
PRIDEiQ13332.

PTM databases

DEPODiQ13332.
iPTMnetiQ13332.
PhosphoSitePlusiQ13332.

Expressioni

Tissue specificityi

Detected in all tissues tested except for placenta and liver.

Gene expression databases

BgeeiENSG00000105426.
CleanExiHS_PTPRS.
ExpressionAtlasiQ13332. baseline and differential.
GenevisibleiQ13332. HS.

Organism-specific databases

HPAiHPA054747.

Interactioni

Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRNQ168495EBI-711536,EBI-728153

Protein-protein interaction databases

BioGridi111766. 49 interactors.
IntActiQ13332. 17 interactors.
MINTiMINT-1349588.
STRINGi9606.ENSP00000349932.

Chemistry databases

BindingDBiQ13332.

Structurei

Secondary structure

11948
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 37Combined sources7
Beta strandi42 – 45Combined sources4
Beta strandi50 – 60Combined sources11
Beta strandi63 – 68Combined sources6
Turni69 – 71Combined sources3
Beta strandi75 – 83Combined sources9
Helixi84 – 86Combined sources3
Beta strandi88 – 93Combined sources6
Turni98 – 101Combined sources4
Beta strandi103 – 111Combined sources9
Beta strandi114 – 125Combined sources12
Helixi127 – 129Combined sources3
Beta strandi136 – 139Combined sources4
Beta strandi144 – 147Combined sources4
Beta strandi152 – 154Combined sources3
Beta strandi157 – 159Combined sources3
Beta strandi165 – 170Combined sources6
Helixi177 – 179Combined sources3
Turni180 – 182Combined sources3
Beta strandi183 – 186Combined sources4
Beta strandi201 – 205Combined sources5
Helixi208 – 210Combined sources3
Beta strandi212 – 220Combined sources9
Beta strandi223 – 226Combined sources4
Beta strandi230 – 235Combined sources6
Beta strandi243 – 249Combined sources7
Beta strandi254 – 256Combined sources3
Beta strandi262 – 272Combined sources11
Beta strandi275 – 280Combined sources6
Beta strandi288 – 290Combined sources3
Beta strandi293 – 300Combined sources8
Beta strandi307 – 315Combined sources9
Beta strandi318 – 327Combined sources10
Beta strandi339 – 343Combined sources5
Beta strandi348 – 351Combined sources4
Beta strandi361 – 370Combined sources10
Beta strandi377 – 382Combined sources6
Beta strandi384 – 389Combined sources6
Beta strandi397 – 405Combined sources9
Beta strandi410 – 413Combined sources4
Beta strandi417 – 420Combined sources4
Beta strandi431 – 441Combined sources11
Beta strandi443 – 448Combined sources6
Beta strandi457 – 466Combined sources10
Helixi472 – 474Combined sources3
Beta strandi475 – 479Combined sources5
Beta strandi482 – 488Combined sources7
Beta strandi496 – 507Combined sources12
Beta strandi516 – 524Combined sources9
Beta strandi529 – 537Combined sources9
Beta strandi540 – 546Combined sources7
Beta strandi554 – 562Combined sources9
Turni563 – 565Combined sources3
Beta strandi569 – 573Combined sources5
Beta strandi577 – 581Combined sources5
Beta strandi589 – 598Combined sources10
Beta strandi601 – 605Combined sources5
Beta strandi609 – 612Combined sources4
Helixi1375 – 1377Combined sources3
Helixi1378 – 1398Combined sources21
Helixi1409 – 1412Combined sources4
Turni1414 – 1416Combined sources3
Helixi1417 – 1419Combined sources3
Helixi1429 – 1431Combined sources3
Beta strandi1432 – 1434Combined sources3
Turni1442 – 1445Combined sources4
Beta strandi1446 – 1454Combined sources9
Beta strandi1457 – 1464Combined sources8
Helixi1469 – 1471Combined sources3
Helixi1472 – 1481Combined sources10
Beta strandi1486 – 1489Combined sources4
Beta strandi1493 – 1495Combined sources3
Beta strandi1507 – 1513Combined sources7
Beta strandi1516 – 1525Combined sources10
Beta strandi1527 – 1538Combined sources12
Beta strandi1545 – 1552Combined sources8
Beta strandi1557 – 1560Combined sources4
Beta strandi1562 – 1564Combined sources3
Helixi1565 – 1577Combined sources13
Beta strandi1585 – 1594Combined sources10
Helixi1595 – 1612Combined sources18
Helixi1617 – 1625Combined sources9
Helixi1635 – 1650Combined sources16
Helixi1658 – 1660Combined sources3
Helixi1661 – 1668Combined sources8
Beta strandi1676 – 1678Combined sources3
Helixi1679 – 1685Combined sources7
Helixi1698 – 1701Combined sources4
Turni1703 – 1705Combined sources3
Helixi1706 – 1708Combined sources3
Turni1718 – 1720Combined sources3
Turni1728 – 1730Combined sources3
Turni1731 – 1734Combined sources4
Beta strandi1737 – 1741Combined sources5
Beta strandi1744 – 1746Combined sources3
Beta strandi1750 – 1753Combined sources4
Helixi1758 – 1760Combined sources3
Helixi1761 – 1770Combined sources10
Beta strandi1775 – 1778Combined sources4
Beta strandi1782 – 1784Combined sources3
Beta strandi1796 – 1798Combined sources3
Beta strandi1800 – 1802Combined sources3
Beta strandi1805 – 1814Combined sources10
Beta strandi1816 – 1827Combined sources12
Turni1828 – 1830Combined sources3
Beta strandi1833 – 1841Combined sources9
Beta strandi1846 – 1848Combined sources3
Helixi1854 – 1869Combined sources16
Beta strandi1876 – 1884Combined sources9
Helixi1885 – 1903Combined sources19
Beta strandi1904 – 1906Combined sources3
Helixi1908 – 1915Combined sources8
Turni1916 – 1918Combined sources3
Helixi1926 – 1941Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH7X-ray2.00A1365-1948[»]
2YD2X-ray2.55A30-244[»]
2YD3X-ray2.30A30-235[»]
2YD9X-ray2.60A30-334[»]
4BPCX-ray2.10A1367-1948[»]
4PBXX-ray3.15A30-614[»]
ProteinModelPortaliQ13332.
SMRiQ13332.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13332.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 123Ig-like C2-type 1Add BLAST91
Domaini135 – 233Ig-like C2-type 2Add BLAST99
Domaini245 – 327Ig-like C2-type 3Add BLAST83
Domaini334 – 424Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini429 – 523Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini527 – 616Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini621 – 718Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini723 – 831Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini832 – 930Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini931 – 1033Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST103
Domaini1036 – 1120Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST85
Domaini1393 – 1648Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1680 – 1939Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1589 – 1595Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi641 – 644Poly-Pro4

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiQ13332.
KOiK06778.
OMAiGGTERCG.
OrthoDBiEOG091G11WG.
PhylomeDBiQ13332.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q13332-1) [UniParc]FASTAAdd to basket
Also known as: PTPS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA
60 70 80 90 100
SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR
110 120 130 140 150
DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR
160 170 180 190 200
TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA
210 220 230 240 250
LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL
260 270 280 290 300
PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL
310 320 330 340 350
TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI
360 370 380 390 400
TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI
410 420 430 440 450
WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP
460 470 480 490 500
VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR
510 520 530 540 550
VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ
560 570 580 590 600
ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ
610 620 630 640 650
GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA
660 670 680 690 700
LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT
710 720 730 740 750
EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH
760 770 780 790 800
GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ
810 820 830 840 850
PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA
860 870 880 890 900
RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT
910 920 930 940 950
YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW
960 970 980 990 1000
LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL
1010 1020 1030 1040 1050
KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV
1060 1070 1080 1090 1100
LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT
1110 1120 1130 1140 1150
NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP
1160 1170 1180 1190 1200
VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR
1210 1220 1230 1240 1250
QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL
1260 1270 1280 1290 1300
QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV
1310 1320 1330 1340 1350
IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD
1360 1370 1380 1390 1400
SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI
1410 1420 1430 1440 1450
DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN
1460 1470 1480 1490 1500
YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK
1510 1520 1530 1540 1550
CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF
1560 1570 1580 1590 1600
QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI
1610 1620 1630 1640 1650
VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG
1660 1670 1680 1690 1700
CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA
1710 1720 1730 1740 1750
NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY
1760 1770 1780 1790 1800
IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA
1810 1820 1830 1840 1850
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP
1860 1870 1880 1890 1900
KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM
1910 1920 1930 1940
RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT
Length:1,948
Mass (Da):217,041
Last modified:January 11, 2011 - v3
Checksum:iE8BFA76CA410C457
GO
Isoform PTPS-MEA (identifier: Q13332-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.

Show »
Length:1,939
Mass (Da):215,980
Checksum:i3EE7153FDA494FD9
GO
Isoform PTPS-MEB (identifier: Q13332-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-239: Missing.
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,928
Mass (Da):214,658
Checksum:i6A3B149EF382D202
GO
Isoform PTPS-MEC (identifier: Q13332-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-792: Missing.

Show »
Length:1,939
Mass (Da):215,930
Checksum:i63119FAC3E811F31
GO
Isoform PTPS-F4-7 (identifier: Q13332-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-1034: Missing.
     1035-1035: V → I

Show »
Length:1,530
Mass (Da):171,838
Checksum:i91EF6825A0AEE9F9
GO
Isoform 2 (identifier: Q13332-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     784-792: Missing.
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,910
Mass (Da):212,486
Checksum:i578E617EC9255E5C
GO
Isoform 3 (identifier: Q13332-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     617-1034: Missing.
     1035-1035: V → I
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,501
Mass (Da):168,394
Checksum:i8505BCDE81596910
GO

Sequence cautioni

The sequence AAC50567 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48G → R in AAC50567 (PubMed:8992885).Curated1
Sequence conflicti428 – 429SA → RP in AAC50567 (PubMed:8992885).Curated2
Sequence conflicti742 – 745RSPA → LGPV in AAC50299 (PubMed:8524829).Curated4
Sequence conflicti765 – 766GA → RR in AAC50567 (PubMed:8992885).Curated2
Sequence conflicti768A → G in AAC50299 (PubMed:8524829).Curated1
Sequence conflicti910R → P in AAC50567 (PubMed:8992885).Curated1
Sequence conflicti995L → V in AAC50299 (PubMed:8524829).Curated1
Sequence conflicti1195 – 1196SL → TV in AAC50299 (PubMed:8524829).Curated2
Sequence conflicti1310 – 1313Missing in AAC62834 (PubMed:15057824).Curated4
Sequence conflicti1431S → F in AAC50299 (PubMed:8524829).Curated1
Sequence conflicti1546E → D in AAB21146 (PubMed:1370651).Curated1
Sequence conflicti1587V → A in AAB21146 (PubMed:1370651).Curated1
Sequence conflicti1705N → K in AAC50567 (PubMed:8992885).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035649996T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs775778266dbSNPEnsembl.1
Natural variantiVAR_0472771457C → R.4 PublicationsCorresponds to variant rs4807697dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_050021190 – 198Missing in isoform PTPS-MEA, isoform 2 and isoform 3. 2 Publications9
Alternative sequenceiVSP_050022236 – 239Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 Publications4
Alternative sequenceiVSP_050023617 – 1034Missing in isoform PTPS-F4-7 and isoform 3. 1 PublicationAdd BLAST418
Alternative sequenceiVSP_050024784 – 792Missing in isoform PTPS-MEC and isoform 2. 1 Publication9
Alternative sequenceiVSP_0500251035V → I in isoform PTPS-F4-7 and isoform 3. 1 Publication1
Alternative sequenceiVSP_0500261350 – 1365Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500271366S → G in isoform PTPS-MEB, isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35234 mRNA. Translation: AAC50299.1.
U40317 mRNA. Translation: AAC50567.1. Frameshift.
AC005335 Genomic DNA. No translation available.
AC005790 Genomic DNA. Translation: AAC62832.1.
AC005338 Genomic DNA. Translation: AAC27825.1.
AC005788 Genomic DNA. Translation: AAC62834.1.
AC118535 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69176.1.
BC104812 mRNA. Translation: AAI04813.1.
BC143287 mRNA. Translation: AAI43288.1.
S78080 mRNA. Translation: AAB21146.2.
CCDSiCCDS12139.1. [Q13332-7]
CCDS12140.1. [Q13332-6]
CCDS45930.1. [Q13332-1]
RefSeqiNP_002841.3. NM_002850.3. [Q13332-1]
NP_570923.2. NM_130853.2. [Q13332-7]
NP_570924.2. NM_130854.2. [Q13332-6]
NP_570925.2. NM_130855.2.
XP_005259663.1. XM_005259606.2. [Q13332-6]
XP_005259666.1. XM_005259609.1. [Q13332-7]
XP_016882554.1. XM_017027065.1. [Q13332-2]
XP_016882555.1. XM_017027066.1. [Q13332-2]
XP_016882556.1. XM_017027067.1. [Q13332-2]
UniGeneiHs.744928.

Genome annotation databases

EnsembliENST00000587303; ENSP00000467537; ENSG00000105426. [Q13332-1]
ENST00000588012; ENSP00000465443; ENSG00000105426. [Q13332-6]
ENST00000592099; ENSP00000467398; ENSG00000105426. [Q13332-7]
GeneIDi5802.
KEGGihsa:5802.
UCSCiuc002mbv.3. human. [Q13332-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35234 mRNA. Translation: AAC50299.1.
U40317 mRNA. Translation: AAC50567.1. Frameshift.
AC005335 Genomic DNA. No translation available.
AC005790 Genomic DNA. Translation: AAC62832.1.
AC005338 Genomic DNA. Translation: AAC27825.1.
AC005788 Genomic DNA. Translation: AAC62834.1.
AC118535 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69176.1.
BC104812 mRNA. Translation: AAI04813.1.
BC143287 mRNA. Translation: AAI43288.1.
S78080 mRNA. Translation: AAB21146.2.
CCDSiCCDS12139.1. [Q13332-7]
CCDS12140.1. [Q13332-6]
CCDS45930.1. [Q13332-1]
RefSeqiNP_002841.3. NM_002850.3. [Q13332-1]
NP_570923.2. NM_130853.2. [Q13332-7]
NP_570924.2. NM_130854.2. [Q13332-6]
NP_570925.2. NM_130855.2.
XP_005259663.1. XM_005259606.2. [Q13332-6]
XP_005259666.1. XM_005259609.1. [Q13332-7]
XP_016882554.1. XM_017027065.1. [Q13332-2]
XP_016882555.1. XM_017027066.1. [Q13332-2]
XP_016882556.1. XM_017027067.1. [Q13332-2]
UniGeneiHs.744928.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH7X-ray2.00A1365-1948[»]
2YD2X-ray2.55A30-244[»]
2YD3X-ray2.30A30-235[»]
2YD9X-ray2.60A30-334[»]
4BPCX-ray2.10A1367-1948[»]
4PBXX-ray3.15A30-614[»]
ProteinModelPortaliQ13332.
SMRiQ13332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111766. 49 interactors.
IntActiQ13332. 17 interactors.
MINTiMINT-1349588.
STRINGi9606.ENSP00000349932.

Chemistry databases

BindingDBiQ13332.
ChEMBLiCHEMBL2396508.
DrugBankiDB00630. Alendronate.
DB01077. Etidronic acid.
GuidetoPHARMACOLOGYi1866.

PTM databases

DEPODiQ13332.
iPTMnetiQ13332.
PhosphoSitePlusiQ13332.

Polymorphism and mutation databases

BioMutaiPTPRS.
DMDMi317373519.

Proteomic databases

MaxQBiQ13332.
PaxDbiQ13332.
PeptideAtlasiQ13332.
PRIDEiQ13332.

Protocols and materials databases

DNASUi5802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587303; ENSP00000467537; ENSG00000105426. [Q13332-1]
ENST00000588012; ENSP00000465443; ENSG00000105426. [Q13332-6]
ENST00000592099; ENSP00000467398; ENSG00000105426. [Q13332-7]
GeneIDi5802.
KEGGihsa:5802.
UCSCiuc002mbv.3. human. [Q13332-1]

Organism-specific databases

CTDi5802.
DisGeNETi5802.
GeneCardsiPTPRS.
HGNCiHGNC:9681. PTPRS.
HPAiHPA054747.
MIMi601576. gene.
neXtProtiNX_Q13332.
OpenTargetsiENSG00000105426.
PharmGKBiPA34026.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiQ13332.
KOiK06778.
OMAiGGTERCG.
OrthoDBiEOG091G11WG.
PhylomeDBiQ13332.
TreeFamiTF312900.

Enzyme and pathway databases

BioCyciZFISH:HS02737-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-3000178. ECM proteoglycans.
R-HSA-8849932. SALM protein interactions at the synapses.
SIGNORiQ13332.

Miscellaneous databases

ChiTaRSiPTPRS. human.
EvolutionaryTraceiQ13332.
GeneWikiiPTPRS.
GenomeRNAii5802.
PROiQ13332.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105426.
CleanExiHS_PTPRS.
ExpressionAtlasiQ13332. baseline and differential.
GenevisibleiQ13332. HS.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRS_HUMAN
AccessioniPrimary (citable) accession number: Q13332
Secondary accession number(s): O75255
, O75870, Q15718, Q16341, Q2M3R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.