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Q13332

- PTPRS_HUMAN

UniProt

Q13332 - PTPRS_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase S

Gene

PTPRS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Interacts with LAR-interacting protein LIP.1.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei1197 – 11982CleavageBy similarity
    Binding sitei1557 – 15571SubstrateBy similarity
    Active sitei1589 – 15891Phosphocysteine intermediateBy similarity
    Binding sitei1633 – 16331SubstrateBy similarity
    Active sitei1880 – 18801Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cerebellum development Source: Ensembl
    3. cerebral cortex development Source: Ensembl
    4. corpus callosum development Source: Ensembl
    5. extracellular matrix organization Source: Reactome
    6. hippocampus development Source: Ensembl
    7. peptidyl-tyrosine dephosphorylation Source: GOC
    8. spinal cord development Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_163906. ECM proteoglycans.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.48)
    Short name:
    R-PTP-S
    Alternative name(s):
    Receptor-type tyrosine-protein phosphatase sigma
    Short name:
    R-PTP-sigma
    Gene namesi
    Name:PTPRS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9681. PTPRS.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 19481919Receptor-type tyrosine-protein phosphatase SPRO_0000025462Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi156 ↔ 216PROSITE-ProRule annotation
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi266 ↔ 311PROSITE-ProRule annotation
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi733 – 7331N-linked (GlcNAc...)3 Publications
    Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ13332.
    PaxDbiQ13332.
    PRIDEiQ13332.

    PTM databases

    PhosphoSiteiQ13332.

    Expressioni

    Tissue specificityi

    Detected in all tissues tested except for placenta and liver.

    Gene expression databases

    ArrayExpressiQ13332.
    BgeeiQ13332.
    CleanExiHS_PTPRS.
    GenevestigatoriQ13332.

    Organism-specific databases

    HPAiHPA054747.

    Interactioni

    Subunit structurei

    Interacts with PPFIA1, PPFIA2 and PPFIA3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PTPRNQ168495EBI-711536,EBI-728153

    Protein-protein interaction databases

    BioGridi111766. 22 interactions.
    IntActiQ13332. 16 interactions.
    MINTiMINT-1349588.
    STRINGi9606.ENSP00000349932.

    Structurei

    Secondary structure

    1
    1948
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi31 – 377
    Beta strandi42 – 454
    Beta strandi50 – 6011
    Beta strandi63 – 686
    Beta strandi75 – 839
    Helixi84 – 863
    Beta strandi88 – 936
    Turni98 – 1014
    Beta strandi103 – 1119
    Beta strandi114 – 12512
    Helixi127 – 1293
    Beta strandi136 – 1394
    Beta strandi144 – 1474
    Beta strandi152 – 1543
    Beta strandi157 – 1593
    Beta strandi165 – 1706
    Helixi177 – 1793
    Turni180 – 1823
    Beta strandi183 – 1864
    Beta strandi201 – 2055
    Helixi208 – 2103
    Beta strandi212 – 2209
    Beta strandi223 – 2264
    Beta strandi230 – 2356
    Beta strandi243 – 2497
    Beta strandi262 – 27211
    Beta strandi275 – 2806
    Beta strandi288 – 2903
    Beta strandi293 – 3008
    Beta strandi307 – 3159
    Beta strandi318 – 32710
    Helixi1375 – 13773
    Helixi1378 – 139821
    Helixi1409 – 14124
    Turni1414 – 14163
    Helixi1417 – 14193
    Helixi1429 – 14313
    Beta strandi1432 – 14343
    Turni1442 – 14454
    Beta strandi1446 – 14549
    Beta strandi1457 – 14648
    Helixi1469 – 14713
    Helixi1472 – 148110
    Beta strandi1486 – 14894
    Beta strandi1493 – 14953
    Beta strandi1507 – 15137
    Beta strandi1516 – 152510
    Beta strandi1527 – 153812
    Beta strandi1545 – 15528
    Beta strandi1557 – 15604
    Beta strandi1562 – 15643
    Helixi1565 – 157713
    Beta strandi1585 – 159410
    Helixi1595 – 161218
    Helixi1617 – 16259
    Helixi1635 – 165016
    Helixi1658 – 16603
    Helixi1661 – 16688
    Beta strandi1676 – 16783
    Helixi1679 – 16857
    Helixi1698 – 17014
    Turni1703 – 17053
    Helixi1706 – 17083
    Turni1718 – 17203
    Turni1728 – 17303
    Turni1731 – 17344
    Beta strandi1737 – 17415
    Beta strandi1744 – 17463
    Beta strandi1750 – 17534
    Helixi1758 – 17603
    Helixi1761 – 177010
    Beta strandi1775 – 17784
    Beta strandi1782 – 17843
    Beta strandi1796 – 17983
    Beta strandi1800 – 18023
    Beta strandi1805 – 181410
    Beta strandi1816 – 182712
    Turni1828 – 18303
    Beta strandi1833 – 18419
    Beta strandi1846 – 18483
    Helixi1854 – 186916
    Beta strandi1876 – 18849
    Helixi1885 – 190319
    Beta strandi1904 – 19063
    Helixi1908 – 19158
    Turni1916 – 19183
    Helixi1926 – 194116

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FH7X-ray2.00A1365-1948[»]
    2YD2X-ray2.55A30-244[»]
    2YD3X-ray2.30A30-235[»]
    2YD9X-ray2.60A30-334[»]
    4BPCX-ray2.10A1367-1948[»]
    ProteinModelPortaliQ13332.
    SMRiQ13332. Positions 29-327, 330-523, 1367-1942.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ13332.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 12821253ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1304 – 1948645CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1283 – 130321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 12391Ig-like C2-type 1Add
    BLAST
    Domaini135 – 23399Ig-like C2-type 2Add
    BLAST
    Domaini245 – 32783Ig-like C2-type 3Add
    BLAST
    Domaini334 – 42491Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini429 – 52395Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini527 – 61690Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini621 – 71898Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini723 – 831109Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini832 – 93099Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini931 – 1033103Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1036 – 112085Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1393 – 1648256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1680 – 1939260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1589 – 15957Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi641 – 6444Poly-Pro

    Sequence similaritiesi

    Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000010250.
    HOVERGENiHBG053758.
    InParanoidiQ13332.
    KOiK06778.
    OrthoDBiEOG7M98FB.
    PhylomeDBiQ13332.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q13332-1) [UniParc]FASTAAdd to Basket

    Also known as: PTPS

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA     50
    SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR 100
    DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR 150
    TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA 200
    LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL 250
    PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL 300
    TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI 350
    TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI 400
    WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP 450
    VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR 500
    VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ 550
    ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ 600
    GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA 650
    LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT 700
    EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH 750
    GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ 800
    PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA 850
    RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT 900
    YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW 950
    LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL 1000
    KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV 1050
    LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT 1100
    NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP 1150
    VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR 1200
    QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL 1250
    QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV 1300
    IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD 1350
    SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI 1400
    DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN 1450
    YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK 1500
    CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF 1550
    QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI 1600
    VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG 1650
    CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA 1700
    NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY 1750
    IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA 1800
    RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP 1850
    KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM 1900
    RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT 1948
    Length:1,948
    Mass (Da):217,041
    Last modified:January 11, 2011 - v3
    Checksum:iE8BFA76CA410C457
    GO
    Isoform PTPS-MEA (identifier: Q13332-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         190-198: Missing.

    Show »
    Length:1,939
    Mass (Da):215,980
    Checksum:i3EE7153FDA494FD9
    GO
    Isoform PTPS-MEB (identifier: Q13332-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         236-239: Missing.
         1350-1365: Missing.
         1366-1366: S → G

    Show »
    Length:1,928
    Mass (Da):214,658
    Checksum:i6A3B149EF382D202
    GO
    Isoform PTPS-MEC (identifier: Q13332-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         784-792: Missing.

    Show »
    Length:1,939
    Mass (Da):215,930
    Checksum:i63119FAC3E811F31
    GO
    Isoform PTPS-F4-7 (identifier: Q13332-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         617-1034: Missing.
         1035-1035: V → I

    Show »
    Length:1,530
    Mass (Da):171,838
    Checksum:i91EF6825A0AEE9F9
    GO
    Isoform 2 (identifier: Q13332-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         190-198: Missing.
         236-239: Missing.
         784-792: Missing.
         1350-1365: Missing.
         1366-1366: S → G

    Show »
    Length:1,910
    Mass (Da):212,486
    Checksum:i578E617EC9255E5C
    GO
    Isoform 3 (identifier: Q13332-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         190-198: Missing.
         236-239: Missing.
         617-1034: Missing.
         1035-1035: V → I
         1350-1365: Missing.
         1366-1366: S → G

    Show »
    Length:1,501
    Mass (Da):168,394
    Checksum:i8505BCDE81596910
    GO

    Sequence cautioni

    The sequence AAC50567.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481G → R in AAC50567. (PubMed:8992885)Curated
    Sequence conflicti428 – 4292SA → RP in AAC50567. (PubMed:8992885)Curated
    Sequence conflicti742 – 7454RSPA → LGPV in AAC50299. (PubMed:8524829)Curated
    Sequence conflicti765 – 7662GA → RR in AAC50567. (PubMed:8992885)Curated
    Sequence conflicti768 – 7681A → G in AAC50299. (PubMed:8524829)Curated
    Sequence conflicti910 – 9101R → P in AAC50567. (PubMed:8992885)Curated
    Sequence conflicti995 – 9951L → V in AAC50299. (PubMed:8524829)Curated
    Sequence conflicti1195 – 11962SL → TV in AAC50299. (PubMed:8524829)Curated
    Sequence conflicti1310 – 13134Missing in AAC62834. (PubMed:15057824)Curated
    Sequence conflicti1431 – 14311S → F in AAC50299. (PubMed:8524829)Curated
    Sequence conflicti1546 – 15461E → D in AAB21146. (PubMed:1370651)Curated
    Sequence conflicti1587 – 15871V → A in AAB21146. (PubMed:1370651)Curated
    Sequence conflicti1705 – 17051N → K in AAC50567. (PubMed:8992885)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti996 – 9961T → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035649
    Natural varianti1457 – 14571C → R.4 Publications
    Corresponds to variant rs4807697 [ dbSNP | Ensembl ].
    VAR_047277

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei190 – 1989Missing in isoform PTPS-MEA, isoform 2 and isoform 3. 2 PublicationsVSP_050021
    Alternative sequencei236 – 2394Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsVSP_050022
    Alternative sequencei617 – 1034418Missing in isoform PTPS-F4-7 and isoform 3. 1 PublicationVSP_050023Add
    BLAST
    Alternative sequencei784 – 7929Missing in isoform PTPS-MEC and isoform 2. 1 PublicationVSP_050024
    Alternative sequencei1035 – 10351V → I in isoform PTPS-F4-7 and isoform 3. 1 PublicationVSP_050025
    Alternative sequencei1350 – 136516Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsVSP_050026Add
    BLAST
    Alternative sequencei1366 – 13661S → G in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsVSP_050027

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35234 mRNA. Translation: AAC50299.1.
    U40317 mRNA. Translation: AAC50567.1. Frameshift.
    AC005335 Genomic DNA. No translation available.
    AC005790 Genomic DNA. Translation: AAC62832.1.
    AC005338 Genomic DNA. Translation: AAC27825.1.
    AC005788 Genomic DNA. Translation: AAC62834.1.
    AC118535 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69176.1.
    BC104812 mRNA. Translation: AAI04813.1.
    BC143287 mRNA. Translation: AAI43288.1.
    S78080 mRNA. Translation: AAB21146.2.
    CCDSiCCDS12139.1. [Q13332-7]
    CCDS12140.1. [Q13332-6]
    CCDS45930.1. [Q13332-1]
    RefSeqiNP_002841.3. NM_002850.3. [Q13332-1]
    NP_570923.2. NM_130853.2. [Q13332-7]
    NP_570924.2. NM_130854.2. [Q13332-6]
    NP_570925.2. NM_130855.2.
    XP_005259663.1. XM_005259606.1. [Q13332-6]
    XP_005259666.1. XM_005259609.1. [Q13332-7]
    XP_006722877.1. XM_006722814.1. [Q13332-3]
    UniGeneiHs.744928.

    Genome annotation databases

    EnsembliENST00000348075; ENSP00000269907; ENSG00000105426. [Q13332-6]
    ENST00000353284; ENSP00000327313; ENSG00000105426. [Q13332-7]
    ENST00000357368; ENSP00000349932; ENSG00000105426. [Q13332-1]
    ENST00000587303; ENSP00000467537; ENSG00000105426. [Q13332-1]
    ENST00000588012; ENSP00000465443; ENSG00000105426. [Q13332-6]
    ENST00000592099; ENSP00000467398; ENSG00000105426. [Q13332-7]
    GeneIDi5802.
    KEGGihsa:5802.
    UCSCiuc002mbv.3. human. [Q13332-1]
    uc002mbw.3. human. [Q13332-6]
    uc002mbx.3. human. [Q13332-7]

    Polymorphism databases

    DMDMi317373519.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35234 mRNA. Translation: AAC50299.1 .
    U40317 mRNA. Translation: AAC50567.1 . Frameshift.
    AC005335 Genomic DNA. No translation available.
    AC005790 Genomic DNA. Translation: AAC62832.1 .
    AC005338 Genomic DNA. Translation: AAC27825.1 .
    AC005788 Genomic DNA. Translation: AAC62834.1 .
    AC118535 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69176.1 .
    BC104812 mRNA. Translation: AAI04813.1 .
    BC143287 mRNA. Translation: AAI43288.1 .
    S78080 mRNA. Translation: AAB21146.2 .
    CCDSi CCDS12139.1. [Q13332-7 ]
    CCDS12140.1. [Q13332-6 ]
    CCDS45930.1. [Q13332-1 ]
    RefSeqi NP_002841.3. NM_002850.3. [Q13332-1 ]
    NP_570923.2. NM_130853.2. [Q13332-7 ]
    NP_570924.2. NM_130854.2. [Q13332-6 ]
    NP_570925.2. NM_130855.2.
    XP_005259663.1. XM_005259606.1. [Q13332-6 ]
    XP_005259666.1. XM_005259609.1. [Q13332-7 ]
    XP_006722877.1. XM_006722814.1. [Q13332-3 ]
    UniGenei Hs.744928.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FH7 X-ray 2.00 A 1365-1948 [» ]
    2YD2 X-ray 2.55 A 30-244 [» ]
    2YD3 X-ray 2.30 A 30-235 [» ]
    2YD9 X-ray 2.60 A 30-334 [» ]
    4BPC X-ray 2.10 A 1367-1948 [» ]
    ProteinModelPortali Q13332.
    SMRi Q13332. Positions 29-327, 330-523, 1367-1942.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111766. 22 interactions.
    IntActi Q13332. 16 interactions.
    MINTi MINT-1349588.
    STRINGi 9606.ENSP00000349932.

    Chemistry

    ChEMBLi CHEMBL2396508.

    PTM databases

    PhosphoSitei Q13332.

    Polymorphism databases

    DMDMi 317373519.

    Proteomic databases

    MaxQBi Q13332.
    PaxDbi Q13332.
    PRIDEi Q13332.

    Protocols and materials databases

    DNASUi 5802.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000348075 ; ENSP00000269907 ; ENSG00000105426 . [Q13332-6 ]
    ENST00000353284 ; ENSP00000327313 ; ENSG00000105426 . [Q13332-7 ]
    ENST00000357368 ; ENSP00000349932 ; ENSG00000105426 . [Q13332-1 ]
    ENST00000587303 ; ENSP00000467537 ; ENSG00000105426 . [Q13332-1 ]
    ENST00000588012 ; ENSP00000465443 ; ENSG00000105426 . [Q13332-6 ]
    ENST00000592099 ; ENSP00000467398 ; ENSG00000105426 . [Q13332-7 ]
    GeneIDi 5802.
    KEGGi hsa:5802.
    UCSCi uc002mbv.3. human. [Q13332-1 ]
    uc002mbw.3. human. [Q13332-6 ]
    uc002mbx.3. human. [Q13332-7 ]

    Organism-specific databases

    CTDi 5802.
    GeneCardsi GC19M005157.
    HGNCi HGNC:9681. PTPRS.
    HPAi HPA054747.
    MIMi 601576. gene.
    neXtProti NX_Q13332.
    PharmGKBi PA34026.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000010250.
    HOVERGENi HBG053758.
    InParanoidi Q13332.
    KOi K06778.
    OrthoDBi EOG7M98FB.
    PhylomeDBi Q13332.
    TreeFami TF312900.

    Enzyme and pathway databases

    Reactomei REACT_163906. ECM proteoglycans.

    Miscellaneous databases

    EvolutionaryTracei Q13332.
    GeneWikii PTPRS.
    GenomeRNAii 5802.
    NextBioi 22612.
    PROi Q13332.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q13332.
    Bgeei Q13332.
    CleanExi HS_PTPRS.
    Genevestigatori Q13332.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1."
      Pulido R., Serra-Pages C., Tang M., Streuli M.
      Proc. Natl. Acad. Sci. U.S.A. 92:11686-11690(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT ARG-1457.
      Tissue: Fetal brain.
    2. "Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates."
      Endo N., Rutledge S.J., Opas E.E., Vogel R., Rodan G.A., Schmidt A.
      J. Bone Miner. Res. 11:535-543(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, VARIANT ARG-1457.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-1457.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-1457.
      Tissue: Brain.
    6. "Protein-tyrosine phosphatase expression in pre-B cell NALM-6."
      Adachi M., Sekiya M., Arimura Y., Takekawa M., Itoh F., Hinoda Y., Imai K., Yachi A.
      Cancer Res. 52:737-740(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1503-1589.
    7. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
      Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
      J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PPFIA1; PPFIA2 AND PPFIA3.
    8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
      Tissue: Plasma.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
      Tissue: Liver.
    10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
      Tissue: Leukemic T-cell.
    11. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1365-1948.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-996.

    Entry informationi

    Entry nameiPTPRS_HUMAN
    AccessioniPrimary (citable) accession number: Q13332
    Secondary accession number(s): O75255
    , O75870, Q15718, Q16341, Q2M3R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 146 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3