Receptor-type tyrosine-protein phosphatase S precursor

Names and origin

Protein names

Recommended name:
    Receptor-type tyrosine-protein phosphatase S
      Short name=R-PTP-S
    EC=3.1.3.48
Alternative name(s):
    Receptor-type tyrosine-protein phosphatase sigma
      Short name=R-PTP-sigma

Gene names

Name:

PTPRS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1948 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Interacts with LAR-interacting protein LIP.1.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subunit structure	Interacts with PPFIA1, PPFIA2 and PPFIA3. Ref.5
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Detected in all tissues tested except for placenta and liver.
Post-translational modification	A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. Contains 8 fibronectin type-III domains. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 tyrosine-protein phosphatase domains.

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Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct transmembrane receptor protein tyrosine phosphatase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF4A2	Q14240	1	EBI-711536,EBI-73473
PTPRN	Q16849	3	EBI-711536,EBI-728153

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Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist.

Isoform PTPS (identifier: Q13332-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform PTPS-MEA (identifier: Q13332-2) The sequence of this isoform differs from the canonical sequence as follows: 190-198: Missing.

Isoform PTPS-MEB (identifier: Q13332-3) The sequence of this isoform differs from the canonical sequence as follows: 236-239: Missing. 1350-1365: Missing. 1366-1366: S → G

Isoform PTPS-MEC (identifier: Q13332-4) The sequence of this isoform differs from the canonical sequence as follows: 784-792: Missing.

Isoform PTPS-F4-7 (identifier: Q13332-5) The sequence of this isoform differs from the canonical sequence as follows: 617-1034: Missing. 1035-1035: V → I

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Potential

Chain

30 – 1948

1919

Receptor-type tyrosine-protein phosphatase S

PRO_0000025462

Regions

Topological domain

30 – 1282

1253

Extracellular Potential

Transmembrane

1283 – 1303

21

Potential

Topological domain

1304 – 1948

645

Cytoplasmic Potential

Domain

33 – 123

91

Ig-like C2-type 1

Domain

135 – 233

99

Ig-like C2-type 2

Domain

245 – 327

83

Ig-like C2-type 3

Domain

332 – 420

89

Fibronectin type-III 1

Domain

426 – 520

95

Fibronectin type-III 2

Domain

525 – 614

90

Fibronectin type-III 3

Domain

618 – 715

98

Fibronectin type-III 4

Domain

720 – 828

109

Fibronectin type-III 5

Domain

836 – 923

88

Fibronectin type-III 6

Domain

928 – 1031

104

Fibronectin type-III 7

Domain

1033 – 1117

85

Fibronectin type-III 8

Domain

1393 – 1648

256

Tyrosine-protein phosphatase 1

Domain

1680 – 1939

260

Tyrosine-protein phosphatase 2

Compositional bias

641 – 644

4

Poly-Pro

Sites

Active site

1589

1

Phosphocysteine intermediate By similarity

Active site

1880

1

Phosphocysteine intermediate By similarity

Site

1197 – 1198

2

Cleavage By similarity

Amino acid modifications

Glycosylation

263

1

N-linked (GlcNAc...) Potential

Glycosylation

308

1

N-linked (GlcNAc...) Potential

Glycosylation

733

1

N-linked (GlcNAc...) Ref.6

Glycosylation

940

1

N-linked (GlcNAc...) Potential

Disulfide bond

54 ↔ 107

Potential

Disulfide bond

156 ↔ 216

Potential

Disulfide bond

266 ↔ 311

Potential

Natural variations

Alternative sequence

190 – 198

9

Missing in isoform PTPS-MEA.

VSP_050021

Alternative sequence

236 – 239

4

Missing in isoform PTPS-MEB.

VSP_050022

Alternative sequence

617 – 1034

418

Missing in isoform PTPS-F4-7.

VSP_050023

Alternative sequence

784 – 792

9

Missing in isoform PTPS-MEC.

VSP_050024

Alternative sequence

1035

1

V → I in isoform PTPS-F4-7.

VSP_050025

Alternative sequence

1350 – 1365

16

Missing in isoform PTPS-MEB.

VSP_050026

Alternative sequence

1366

1

S → G in isoform PTPS-MEB.

VSP_050027

Natural variant

996

1

T → M in a colorectal cancer sample; somatic mutation. Ref.8

VAR_035649

Natural variant

1457

1

R → C: dbSNP rs4807697. Ref.1 Ref.3

VAR_047277

Experimental info

Sequence conflict

48

1

G → R in AAC50567. Ref.2

Sequence conflict

310

1

T → HP in AAC50567. Ref.2

Sequence conflict

428 – 429

2

SA → RP in AAC50567. Ref.2

Sequence conflict

742 – 745

4

RSPA → LGPV in AAC50299. Ref.1

Sequence conflict

765 – 766

2

GA → RR in AAC50567. Ref.2

Sequence conflict

768

1

A → G in AAC50299. Ref.1

Sequence conflict

771 – 773

3

PPR → RRS in AAC50567. Ref.2

Sequence conflict

910

1

R → P in AAC50567. Ref.2

Sequence conflict

986 – 994

9

AAEPGAENA → GRLSRARRT in AAC50567. Ref.2

Sequence conflict

995

1

L → V in AAC50299. Ref.1

Sequence conflict

1195 – 1196

2

SL → TV in AAC50299. Ref.1

Sequence conflict

1310 – 1313

4

Missing in AAC62834. Ref.3

Sequence conflict

1431

1

S → F in AAC50299. Ref.1

Sequence conflict

1546

1

E → D in AAB21146. Ref.4

Sequence conflict

1587

1

V → A in AAB21146. Ref.4

Sequence conflict

1705

1

N → K in AAC50567. Ref.2

Secondary structure

1

.

1948

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform PTPS [UniParc]. Last modified July 19, 2004. Version 2. Checksum: D3D211B18B3866DD Show »	FASTA	1,948	217,094
10 20 30 40 50 60 MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 70 80 90 100 110 120 KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 130 140 150 160 170 180 KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 190 200 210 220 230 240 NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV 250 260 270 280 290 300 RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL 310 320 330 340 350 360 TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV 370 380 390 400 410 420 SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR 430 440 450 460 470 480 TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV 490 500 510 520 530 540 DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS 550 560 570 580 590 600 ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ 610 620 630 640 650 660 GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP 670 680 690 700 710 720 LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP 730 740 750 760 770 780 SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA 790 800 810 820 830 840 DAQWETDDTA EYEMVITNLQ PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV 850 860 870 880 890 900 QQTPEGSLLA RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT 910 920 930 940 950 960 YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW LPPVPAERNG 970 980 990 1000 1010 1020 AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL KPDTAYDLQV RAHTRRGPGP 1030 1040 1050 1060 1070 1080 FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR 1090 1100 1110 1120 1130 1140 TTKKLITHLK PHTFYNFVLT NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV 1150 1160 1170 1180 1190 1200 YLPDGQSPVP VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR 1210 1220 1230 1240 1250 1260 QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL QKSEPTFAAS 1270 1280 1290 1300 1310 1320 PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV IAILLYKNKP DSKRKDSEPR 1330 1340 1350 1360 1370 1380 TKCLLNNADL APHHPKDPVE MRRINFQTPD SGLRSPLREP GFHFESMLSH PPIPIADMAE 1390 1400 1410 1420 1430 1440 HTERLKANDS LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG 1450 1460 1470 1480 1490 1500 IMGSDYINAN YVDGYRRQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK 1510 1520 1530 1540 1550 1560 CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV 1570 1580 1590 1600 1610 1620 PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH 1630 1640 1650 1660 1670 1680 VTLMRSQRNY MVQTEDQYSF IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM 1690 1700 1710 1720 1730 1740 ELEFKRLANS KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF 1750 1760 1770 1780 1790 1800 IDGYRQQKAY IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA 1810 1820 1830 1840 1850 1860 RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI 1870 1880 1890 1900 1910 1920 GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP 1930 1940 AMVQTEDEYQ FCYQAALEYL GSFDHYAT « Hide
Isoform PTPS-MEA. Checksum: 058AA3E2F561ED53 Show »	FASTA	1,939	216,033
10 20 30 40 50 60 MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 70 80 90 100 110 120 KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 130 140 150 160 170 180 KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 190 200 210 220 230 240 NGRIKQLRSG ALQIESSEET DQGKYECVAT NSAGVRYSSP ANLYVRELRE VRRVAPRFSI 250 260 270 280 290 300 LPMSHEIMPG GNVNITCVAV GSPMPYVKWM QGAEDLTPED DMPVGRNVLE LTDVKDSANY 310 320 330 340 350 360 TCVAMSSLGV IEAVAQITVK SLPKAPGTPM VTENTATSIT ITWDSGNPDP VSYYVIEYKS 370 380 390 400 410 420 KSQDGPYQIK EDITTTRYSI GGLSPNSEYE IWVSAVNSIG QGPPSESVVT RTGEQAPASA 430 440 450 460 470 480 PRNVQARMLS ATTMIVQWEE PVEPNGLIRG YRVYYTMEPE HPVGNWQKHN VDDSLLTTVG 490 500 510 520 530 540 SLLEDETYTV RVLAFTSVGD GPLSDPIQVK TQQGVPGQPM NLRAEARSET SITLSWSPPR 550 560 570 580 590 600 QESIIKYELL FREGDHGREV GRTFDPTTSY VVEDLKPNTE YAFRLAARSP QGLGAFTPVV 610 620 630 640 650 660 RQRTLQSKPS APPQDVKCVS VRSTAILVSW RPPPPETHNG ALVGYSVRYR PLGSEDPEPK 670 680 690 700 710 720 EVNGIPPTTT QILLEALEKW TQYRITTVAH TEVGPGPESS PVVVRTDEDV PSAPPRKVEA 730 740 750 760 770 780 EALNATAIRV LWRSPAPGRQ HGQIRGYQVH YVRMEGAEAR GPPRIKDVML ADAQWETDDT 790 800 810 820 830 840 AEYEMVITNL QPETAYSITV AAYTMKGDGA RSKPKVVVTK GAVLGRPTLS VQQTPEGSLL 850 860 870 880 890 900 ARWEPPAGTA EDQVLGYRLQ FGREDSTPLA TLEFPPSEDR YTASGVHKGA TYVFRLAARS 910 920 930 940 950 960 RGGLGEEAAE VLSIPEDTPR GHPQILEAAG NASAGTVLLR WLPPVPAERN GAIVKYTVAV 970 980 990 1000 1010 1020 REAGALGPAR ETELPAAAEP GAENALTLQG LKPDTAYDLQ VRAHTRRGPG PFSPPVRYRT 1030 1040 1050 1060 1070 1080 FLRDQVSPKN FKVKMIMKTS VLLSWEFPDN YNSPTPYKIQ YNGLTLDVDG RTTKKLITHL 1090 1100 1110 1120 1130 1140 KPHTFYNFVL TNRGSSLGGL QQTVTAWTAF NLLNGKPSVA PKPDADGFIM VYLPDGQSPV 1150 1160 1170 1180 1190 1200 PVQSYFIVMV PLRKSRGGQF LTPLGSPEDM DLEELIQDIS RLQRRSLRHS RQLEVPRPYI 1210 1220 1230 1240 1250 1260 AARFSVLPPT FHPGDQKQYG GFDNRGLEPG HRYVLFVLAV LQKSEPTFAA SPFSDPFQLD 1270 1280 1290 1300 1310 1320 NPDPQPIVDG EEGLIWVIGP VLAVVFIICI VIAILLYKNK PDSKRKDSEP RTKCLLNNAD 1330 1340 1350 1360 1370 1380 LAPHHPKDPV EMRRINFQTP DSGLRSPLRE PGFHFESMLS HPPIPIADMA EHTERLKAND 1390 1400 1410 1420 1430 1440 SLKLSQEYES IDPGQQFTWE HSNLEVNKPK NRYANVIAYD HSRVILQPIE GIMGSDYINA 1450 1460 1470 1480 1490 1500 NYVDGYRRQN AYIATQGPLP ETFGDFWRMV WEQRSATIVM MTRLEEKSRI KCDQYWPNRG 1510 1520 1530 1540 1550 1560 TETYGFIQVT LLDTIELATF CVRTFSLHKN GSSEKREVRQ FQFTAWPDHG VPEYPTPFLA 1570 1580 1590 1600 1610 1620 FLRRVKTCNP PDAGPIVVHC SAGVGRTGCF IVIDAMLERI KPEKTVDVYG HVTLMRSQRN 1630 1640 1650 1660 1670 1680 YMVQTEDQYS FIHEALLEAV GCGNTEVPAR SLYAYIQKLA QVEPGEHVTG MELEFKRLAN 1690 1700 1710 1720 1730 1740 SKAHTSRFIS ANLPCNKFKN RLVNIMPYES TRVCLQPIRG VEGSDYINAS FIDGYRQQKA 1750 1760 1770 1780 1790 1800 YIATQGPLAE TTEDFWRMLW ENNSTIVVML TKLREMGREK CHQYWPAERS ARYQYFVVDP 1810 1820 1830 1840 1850 1860 MAEYNMPQYI LREFKVTDAR DGQSRTVRQF QFTDWPEQGV PKSGEGFIDF IGQVHKTKEQ 1870 1880 1890 1900 1910 1920 FGQDGPISVH CSAGVGRTGV FITLSIVLER MRYEGVVDIF QTVKMLRTQR PAMVQTEDEY 1930 QFCYQAALEY LGSFDHYAT « Hide
Isoform PTPS-MEB. Checksum: 5156A243DCAA7088 Show »	FASTA	1,928	214,711
10 20 30 40 50 60 MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 70 80 90 100 110 120 KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 130 140 150 160 170 180 KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 190 200 210 220 230 240 NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRVRRVA 250 260 270 280 290 300 PRFSILPMSH EIMPGGNVNI TCVAVGSPMP YVKWMQGAED LTPEDDMPVG RNVLELTDVK 310 320 330 340 350 360 DSANYTCVAM SSLGVIEAVA QITVKSLPKA PGTPMVTENT ATSITITWDS GNPDPVSYYV 370 380 390 400 410 420 IEYKSKSQDG PYQIKEDITT TRYSIGGLSP NSEYEIWVSA VNSIGQGPPS ESVVTRTGEQ 430 440 450 460 470 480 APASAPRNVQ ARMLSATTMI VQWEEPVEPN GLIRGYRVYY TMEPEHPVGN WQKHNVDDSL 490 500 510 520 530 540 LTTVGSLLED ETYTVRVLAF TSVGDGPLSD PIQVKTQQGV PGQPMNLRAE ARSETSITLS 550 560 570 580 590 600 WSPPRQESII KYELLFREGD HGREVGRTFD PTTSYVVEDL KPNTEYAFRL AARSPQGLGA 610 620 630 640 650 660 FTPVVRQRTL QSKPSAPPQD VKCVSVRSTA ILVSWRPPPP ETHNGALVGY SVRYRPLGSE 670 680 690 700 710 720 DPEPKEVNGI PPTTTQILLE ALEKWTQYRI TTVAHTEVGP GPESSPVVVR TDEDVPSAPP 730 740 750 760 770 780 RKVEAEALNA TAIRVLWRSP APGRQHGQIR GYQVHYVRME GAEARGPPRI KDVMLADAQW 790 800 810 820 830 840 ETDDTAEYEM VITNLQPETA YSITVAAYTM KGDGARSKPK VVVTKGAVLG RPTLSVQQTP 850 860 870 880 890 900 EGSLLARWEP PAGTAEDQVL GYRLQFGRED STPLATLEFP PSEDRYTASG VHKGATYVFR 910 920 930 940 950 960 LAARSRGGLG EEAAEVLSIP EDTPRGHPQI LEAAGNASAG TVLLRWLPPV PAERNGAIVK 970 980 990 1000 1010 1020 YTVAVREAGA LGPARETELP AAAEPGAENA LTLQGLKPDT AYDLQVRAHT RRGPGPFSPP 1030 1040 1050 1060 1070 1080 VRYRTFLRDQ VSPKNFKVKM IMKTSVLLSW EFPDNYNSPT PYKIQYNGLT LDVDGRTTKK 1090 1100 1110 1120 1130 1140 LITHLKPHTF YNFVLTNRGS SLGGLQQTVT AWTAFNLLNG KPSVAPKPDA DGFIMVYLPD 1150 1160 1170 1180 1190 1200 GQSPVPVQSY FIVMVPLRKS RGGQFLTPLG SPEDMDLEEL IQDISRLQRR SLRHSRQLEV 1210 1220 1230 1240 1250 1260 PRPYIAARFS VLPPTFHPGD QKQYGGFDNR GLEPGHRYVL FVLAVLQKSE PTFAASPFSD 1270 1280 1290 1300 1310 1320 PFQLDNPDPQ PIVDGEEGLI WVIGPVLAVV FIICIVIAIL LYKNKPDSKR KDSEPRTKCL 1330 1340 1350 1360 1370 1380 LNNADLAPHH PKDPVEMRRI NFQTPGMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI 1390 1400 1410 1420 1430 1440 DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN YVDGYRRQNA 1450 1460 1470 1480 1490 1500 YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK CDQYWPNRGT ETYGFIQVTL 1510 1520 1530 1540 1550 1560 LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP 1570 1580 1590 1600 1610 1620 DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF 1630 1640 1650 1660 1670 1680 IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA 1690 1700 1710 1720 1730 1740 NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY IATQGPLAET 1750 1760 1770 1780 1790 1800 TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA RYQYFVVDPM AEYNMPQYIL 1810 1820 1830 1840 1850 1860 REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI GQVHKTKEQF GQDGPISVHC 1870 1880 1890 1900 1910 1920 SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT « Hide
Isoform PTPS-MEC. Checksum: 587C297111A9BDBB Show »	FASTA	1,939	215,983
10 20 30 40 50 60 MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 70 80 90 100 110 120 KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 130 140 150 160 170 180 KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 190 200 210 220 230 240 NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV 250 260 270 280 290 300 RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL 310 320 330 340 350 360 TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV 370 380 390 400 410 420 SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR 430 440 450 460 470 480 TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV 490 500 510 520 530 540 DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS 550 560 570 580 590 600 ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ 610 620 630 640 650 660 GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP 670 680 690 700 710 720 LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP 730 740 750 760 770 780 SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA 790 800 810 820 830 840 DAQEMVITNL QPETAYSITV AAYTMKGDGA RSKPKVVVTK GAVLGRPTLS VQQTPEGSLL 850 860 870 880 890 900 ARWEPPAGTA EDQVLGYRLQ FGREDSTPLA TLEFPPSEDR YTASGVHKGA TYVFRLAARS 910 920 930 940 950 960 RGGLGEEAAE VLSIPEDTPR GHPQILEAAG NASAGTVLLR WLPPVPAERN GAIVKYTVAV 970 980 990 1000 1010 1020 REAGALGPAR ETELPAAAEP GAENALTLQG LKPDTAYDLQ VRAHTRRGPG PFSPPVRYRT 1030 1040 1050 1060 1070 1080 FLRDQVSPKN FKVKMIMKTS VLLSWEFPDN YNSPTPYKIQ YNGLTLDVDG RTTKKLITHL 1090 1100 1110 1120 1130 1140 KPHTFYNFVL TNRGSSLGGL QQTVTAWTAF NLLNGKPSVA PKPDADGFIM VYLPDGQSPV 1150 1160 1170 1180 1190 1200 PVQSYFIVMV PLRKSRGGQF LTPLGSPEDM DLEELIQDIS RLQRRSLRHS RQLEVPRPYI 1210 1220 1230 1240 1250 1260 AARFSVLPPT FHPGDQKQYG GFDNRGLEPG HRYVLFVLAV LQKSEPTFAA SPFSDPFQLD 1270 1280 1290 1300 1310 1320 NPDPQPIVDG EEGLIWVIGP VLAVVFIICI VIAILLYKNK PDSKRKDSEP RTKCLLNNAD 1330 1340 1350 1360 1370 1380 LAPHHPKDPV EMRRINFQTP DSGLRSPLRE PGFHFESMLS HPPIPIADMA EHTERLKAND 1390 1400 1410 1420 1430 1440 SLKLSQEYES IDPGQQFTWE HSNLEVNKPK NRYANVIAYD HSRVILQPIE GIMGSDYINA 1450 1460 1470 1480 1490 1500 NYVDGYRRQN AYIATQGPLP ETFGDFWRMV WEQRSATIVM MTRLEEKSRI KCDQYWPNRG 1510 1520 1530 1540 1550 1560 TETYGFIQVT LLDTIELATF CVRTFSLHKN GSSEKREVRQ FQFTAWPDHG VPEYPTPFLA 1570 1580 1590 1600 1610 1620 FLRRVKTCNP PDAGPIVVHC SAGVGRTGCF IVIDAMLERI KPEKTVDVYG HVTLMRSQRN 1630 1640 1650 1660 1670 1680 YMVQTEDQYS FIHEALLEAV GCGNTEVPAR SLYAYIQKLA QVEPGEHVTG MELEFKRLAN 1690 1700 1710 1720 1730 1740 SKAHTSRFIS ANLPCNKFKN RLVNIMPYES TRVCLQPIRG VEGSDYINAS FIDGYRQQKA 1750 1760 1770 1780 1790 1800 YIATQGPLAE TTEDFWRMLW ENNSTIVVML TKLREMGREK CHQYWPAERS ARYQYFVVDP 1810 1820 1830 1840 1850 1860 MAEYNMPQYI LREFKVTDAR DGQSRTVRQF QFTDWPEQGV PKSGEGFIDF IGQVHKTKEQ 1870 1880 1890 1900 1910 1920 FGQDGPISVH CSAGVGRTGV FITLSIVLER MRYEGVVDIF QTVKMLRTQR PAMVQTEDEY 1930 QFCYQAALEY LGSFDHYAT « Hide
Isoform PTPS-F4-7. Checksum: AA82DEF88F864B73 Show »	FASTA	1,530	171,891
10 20 30 40 50 60 MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 70 80 90 100 110 120 KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 130 140 150 160 170 180 KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 190 200 210 220 230 240 NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV 250 260 270 280 290 300 RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL 310 320 330 340 350 360 TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV 370 380 390 400 410 420 SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR 430 440 450 460 470 480 TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV 490 500 510 520 530 540 DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS 550 560 570 580 590 600 ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ 610 620 630 640 650 660 GLGAFTPVVR QRTLQSISPK NFKVKMIMKT SVLLSWEFPD NYNSPTPYKI QYNGLTLDVD 670 680 690 700 710 720 GRTTKKLITH LKPHTFYNFV LTNRGSSLGG LQQTVTAWTA FNLLNGKPSV APKPDADGFI 730 740 750 760 770 780 MVYLPDGQSP VPVQSYFIVM VPLRKSRGGQ FLTPLGSPED MDLEELIQDI SRLQRRSLRH 790 800 810 820 830 840 SRQLEVPRPY IAARFSVLPP TFHPGDQKQY GGFDNRGLEP GHRYVLFVLA VLQKSEPTFA 850 860 870 880 890 900 ASPFSDPFQL DNPDPQPIVD GEEGLIWVIG PVLAVVFIIC IVIAILLYKN KPDSKRKDSE 910 920 930 940 950 960 PRTKCLLNNA DLAPHHPKDP VEMRRINFQT PDSGLRSPLR EPGFHFESML SHPPIPIADM 970 980 990 1000 1010 1020 AEHTERLKAN DSLKLSQEYE SIDPGQQFTW EHSNLEVNKP KNRYANVIAY DHSRVILQPI 1030 1040 1050 1060 1070 1080 EGIMGSDYIN ANYVDGYRRQ NAYIATQGPL PETFGDFWRM VWEQRSATIV MMTRLEEKSR 1090 1100 1110 1120 1130 1140 IKCDQYWPNR GTETYGFIQV TLLDTIELAT FCVRTFSLHK NGSSEKREVR QFQFTAWPDH 1150 1160 1170 1180 1190 1200 GVPEYPTPFL AFLRRVKTCN PPDAGPIVVH CSAGVGRTGC FIVIDAMLER IKPEKTVDVY 1210 1220 1230 1240 1250 1260 GHVTLMRSQR NYMVQTEDQY SFIHEALLEA VGCGNTEVPA RSLYAYIQKL AQVEPGEHVT 1270 1280 1290 1300 1310 1320 GMELEFKRLA NSKAHTSRFI SANLPCNKFK NRLVNIMPYE STRVCLQPIR GVEGSDYINA 1330 1340 1350 1360 1370 1380 SFIDGYRQQK AYIATQGPLA ETTEDFWRML WENNSTIVVM LTKLREMGRE KCHQYWPAER 1390 1400 1410 1420 1430 1440 SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ FQFTDWPEQG VPKSGEGFID 1450 1460 1470 1480 1490 1500 FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE RMRYEGVVDI FQTVKMLRTQ 1510 1520 1530 RPAMVQTEDE YQFCYQAALE YLGSFDHYAT « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1." Pulido R., Serra-Pages C., Tang M., Streuli M. Proc. Natl. Acad. Sci. U.S.A. 92:11686-11690(1995) [PubMed: 8524829] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-1457. Tissue: Fetal brain.
[2]	"Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates." Endo N., Rutledge S.J., Opas E.E., Vogel R., Rodan G.A., Schmidt A. J. Bone Miner. Res. 11:535-543(1996) [PubMed: 8992885] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT CYS-1457.
[4]	"Protein-tyrosine phosphatase expression in pre-B cell NALM-6." Adachi M., Sekiya M., Arimura Y., Takekawa M., Itoh F., Hinoda Y., Imai K., Yachi A. Cancer Res. 52:737-740(1992) [PubMed: 1370651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1503-1589.
[5]	"Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins." Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M. J. Biol. Chem. 273:15611-15620(1998) [PubMed: 9624153] [Abstract] Cited for: INTERACTION WITH PPFIA1; PPFIA2 AND PPFIA3.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733, MASS SPECTROMETRY. Tissue: Liver.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-996.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

U35234 mRNA. Translation: AAC50299.1.
U40317 mRNA. Translation: AAC50567.1.
AC005335 Genomic DNA. No translation available.
AC005790 Genomic DNA. Translation: AAC62832.1.
AC005338 Genomic DNA. Translation: AAC27825.1.
AC005788 Genomic DNA. Translation: AAC62834.1.
AC118535 Genomic DNA. No translation available.
S78080 mRNA. Translation: AAB21146.2.

IPI

IPI00289831.
IPI00299590.
IPI00332271.
IPI00332272.
IPI00332273.

UniGene

Hs.712625

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FH7	X-ray	2.00	A	1365-1948	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q13332. 17 interactions.

Proteomic databases

PRIDE

Q13332.

Genome annotation databases

Ensembl

ENSG00000105426. Homo sapiens. [Contig view]

Organism-specific databases

GeneCards

GC19M005157.

HGNC

HGNC:9681. PTPRS.

MIM

601576. gene.

PharmGKB

PA34026.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q13332.

HOVERGEN

Q13332.

Enzyme and pathway databases

BRENDA

3.1.3.48. 247.

Gene expression databases

ArrayExpress

Q13332.

Bgee

Q13332.

CleanEx

HS_PTPRS.

GermOnline

ENSG00000105426. Homo sapiens.

Family and domain databases

InterPro

IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003962. FnIII_subd.
IPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000387. Tyr_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Gene3D

G3DSA:2.60.40.30. FN_III-like. 7 hits.
G3DSA:2.60.40.10. Ig-like_fold. 3 hits.

Pfam

PF00041. fn3. 8 hits.
PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]

PRINTS

PR00014. FNTYPEIII.
PR00700. PRTYPHPHTASE.

SMART

SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]

PROSITE

PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

SOURCE

Search...

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Entry information

Entry name

PTPRS_HUMAN

Accession

Primary (citable) accession number: Q13332
Secondary accession number(s): O75255

Q16341

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	July 19, 2004
Last modified:	May 5, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents