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Q13332

- PTPRS_HUMAN

UniProt

Q13332 - PTPRS_HUMAN

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Protein

Receptor-type tyrosine-protein phosphatase S

Gene

PTPRS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Interacts with LAR-interacting protein LIP.1.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1197 – 11982CleavageBy similarity
Binding sitei1557 – 15571SubstrateBy similarity
Active sitei1589 – 15891Phosphocysteine intermediateBy similarity
Binding sitei1633 – 16331SubstrateBy similarity
Active sitei1880 – 18801Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cerebellum development Source: Ensembl
  3. cerebral cortex development Source: Ensembl
  4. corpus callosum development Source: Ensembl
  5. extracellular matrix organization Source: Reactome
  6. hippocampus development Source: Ensembl
  7. peptidyl-tyrosine dephosphorylation Source: GOC
  8. spinal cord development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_163906. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase S (EC:3.1.3.48)
Short name:
R-PTP-S
Alternative name(s):
Receptor-type tyrosine-protein phosphatase sigma
Short name:
R-PTP-sigma
Gene namesi
Name:PTPRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9681. PTPRS.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 19481919Receptor-type tyrosine-protein phosphatase SPRO_0000025462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Disulfide bondi156 ↔ 216PROSITE-ProRule annotation
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 ↔ 311PROSITE-ProRule annotation
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi733 – 7331N-linked (GlcNAc...)3 Publications
Glycosylationi940 – 9401N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ13332.
PaxDbiQ13332.
PRIDEiQ13332.

PTM databases

PhosphoSiteiQ13332.

Expressioni

Tissue specificityi

Detected in all tissues tested except for placenta and liver.

Gene expression databases

BgeeiQ13332.
CleanExiHS_PTPRS.
ExpressionAtlasiQ13332. baseline and differential.
GenevestigatoriQ13332.

Organism-specific databases

HPAiHPA054747.

Interactioni

Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPRNQ168495EBI-711536,EBI-728153

Protein-protein interaction databases

BioGridi111766. 30 interactions.
IntActiQ13332. 16 interactions.
MINTiMINT-1349588.
STRINGi9606.ENSP00000349932.

Structurei

Secondary structure

1
1948
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 377
Beta strandi42 – 454
Beta strandi50 – 6011
Beta strandi63 – 686
Beta strandi75 – 839
Helixi84 – 863
Beta strandi88 – 936
Turni98 – 1014
Beta strandi103 – 1119
Beta strandi114 – 12512
Helixi127 – 1293
Beta strandi136 – 1394
Beta strandi144 – 1474
Beta strandi152 – 1543
Beta strandi157 – 1593
Beta strandi165 – 1706
Helixi177 – 1793
Turni180 – 1823
Beta strandi183 – 1864
Beta strandi201 – 2055
Helixi208 – 2103
Beta strandi212 – 2209
Beta strandi223 – 2264
Beta strandi230 – 2356
Beta strandi243 – 2497
Beta strandi262 – 27211
Beta strandi275 – 2806
Beta strandi288 – 2903
Beta strandi293 – 3008
Beta strandi307 – 3159
Beta strandi318 – 32710
Helixi1375 – 13773
Helixi1378 – 139821
Helixi1409 – 14124
Turni1414 – 14163
Helixi1417 – 14193
Helixi1429 – 14313
Beta strandi1432 – 14343
Turni1442 – 14454
Beta strandi1446 – 14549
Beta strandi1457 – 14648
Helixi1469 – 14713
Helixi1472 – 148110
Beta strandi1486 – 14894
Beta strandi1493 – 14953
Beta strandi1507 – 15137
Beta strandi1516 – 152510
Beta strandi1527 – 153812
Beta strandi1545 – 15528
Beta strandi1557 – 15604
Beta strandi1562 – 15643
Helixi1565 – 157713
Beta strandi1585 – 159410
Helixi1595 – 161218
Helixi1617 – 16259
Helixi1635 – 165016
Helixi1658 – 16603
Helixi1661 – 16688
Beta strandi1676 – 16783
Helixi1679 – 16857
Helixi1698 – 17014
Turni1703 – 17053
Helixi1706 – 17083
Turni1718 – 17203
Turni1728 – 17303
Turni1731 – 17344
Beta strandi1737 – 17415
Beta strandi1744 – 17463
Beta strandi1750 – 17534
Helixi1758 – 17603
Helixi1761 – 177010
Beta strandi1775 – 17784
Beta strandi1782 – 17843
Beta strandi1796 – 17983
Beta strandi1800 – 18023
Beta strandi1805 – 181410
Beta strandi1816 – 182712
Turni1828 – 18303
Beta strandi1833 – 18419
Beta strandi1846 – 18483
Helixi1854 – 186916
Beta strandi1876 – 18849
Helixi1885 – 190319
Beta strandi1904 – 19063
Helixi1908 – 19158
Turni1916 – 19183
Helixi1926 – 194116

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FH7X-ray2.00A1365-1948[»]
2YD2X-ray2.55A30-244[»]
2YD3X-ray2.30A30-235[»]
2YD9X-ray2.60A30-334[»]
4BPCX-ray2.10A1367-1948[»]
ProteinModelPortaliQ13332.
SMRiQ13332. Positions 29-327, 330-523, 1367-1942.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ13332.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 12821253ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1304 – 1948645CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1283 – 130321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12391Ig-like C2-type 1Add
BLAST
Domaini135 – 23399Ig-like C2-type 2Add
BLAST
Domaini245 – 32783Ig-like C2-type 3Add
BLAST
Domaini334 – 42491Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 52395Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini527 – 61690Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini621 – 71898Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini723 – 831109Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini832 – 93099Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini931 – 1033103Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1036 – 112085Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1393 – 1648256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1680 – 1939260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1589 – 15957Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi641 – 6444Poly-Pro

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiQ13332.
KOiK06778.
OrthoDBiEOG7M98FB.
PhylomeDBiQ13332.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q13332-1) [UniParc]FASTAAdd to Basket

Also known as: PTPS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA
60 70 80 90 100
SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR
110 120 130 140 150
DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR
160 170 180 190 200
TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA
210 220 230 240 250
LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL
260 270 280 290 300
PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL
310 320 330 340 350
TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI
360 370 380 390 400
TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI
410 420 430 440 450
WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP
460 470 480 490 500
VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR
510 520 530 540 550
VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ
560 570 580 590 600
ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ
610 620 630 640 650
GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA
660 670 680 690 700
LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT
710 720 730 740 750
EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH
760 770 780 790 800
GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ
810 820 830 840 850
PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA
860 870 880 890 900
RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT
910 920 930 940 950
YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW
960 970 980 990 1000
LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL
1010 1020 1030 1040 1050
KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV
1060 1070 1080 1090 1100
LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT
1110 1120 1130 1140 1150
NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP
1160 1170 1180 1190 1200
VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR
1210 1220 1230 1240 1250
QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL
1260 1270 1280 1290 1300
QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV
1310 1320 1330 1340 1350
IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD
1360 1370 1380 1390 1400
SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI
1410 1420 1430 1440 1450
DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN
1460 1470 1480 1490 1500
YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK
1510 1520 1530 1540 1550
CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF
1560 1570 1580 1590 1600
QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI
1610 1620 1630 1640 1650
VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG
1660 1670 1680 1690 1700
CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA
1710 1720 1730 1740 1750
NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY
1760 1770 1780 1790 1800
IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA
1810 1820 1830 1840 1850
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP
1860 1870 1880 1890 1900
KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM
1910 1920 1930 1940
RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT
Length:1,948
Mass (Da):217,041
Last modified:January 11, 2011 - v3
Checksum:iE8BFA76CA410C457
GO
Isoform PTPS-MEA (identifier: Q13332-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.

Show »
Length:1,939
Mass (Da):215,980
Checksum:i3EE7153FDA494FD9
GO
Isoform PTPS-MEB (identifier: Q13332-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-239: Missing.
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,928
Mass (Da):214,658
Checksum:i6A3B149EF382D202
GO
Isoform PTPS-MEC (identifier: Q13332-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-792: Missing.

Show »
Length:1,939
Mass (Da):215,930
Checksum:i63119FAC3E811F31
GO
Isoform PTPS-F4-7 (identifier: Q13332-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-1034: Missing.
     1035-1035: V → I

Show »
Length:1,530
Mass (Da):171,838
Checksum:i91EF6825A0AEE9F9
GO
Isoform 2 (identifier: Q13332-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     784-792: Missing.
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,910
Mass (Da):212,486
Checksum:i578E617EC9255E5C
GO
Isoform 3 (identifier: Q13332-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     617-1034: Missing.
     1035-1035: V → I
     1350-1365: Missing.
     1366-1366: S → G

Show »
Length:1,501
Mass (Da):168,394
Checksum:i8505BCDE81596910
GO

Sequence cautioni

The sequence AAC50567.1 differs from that shown. Reason: Frameshift at several positions.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481G → R in AAC50567. (PubMed:8992885)Curated
Sequence conflicti428 – 4292SA → RP in AAC50567. (PubMed:8992885)Curated
Sequence conflicti742 – 7454RSPA → LGPV in AAC50299. (PubMed:8524829)Curated
Sequence conflicti765 – 7662GA → RR in AAC50567. (PubMed:8992885)Curated
Sequence conflicti768 – 7681A → G in AAC50299. (PubMed:8524829)Curated
Sequence conflicti910 – 9101R → P in AAC50567. (PubMed:8992885)Curated
Sequence conflicti995 – 9951L → V in AAC50299. (PubMed:8524829)Curated
Sequence conflicti1195 – 11962SL → TV in AAC50299. (PubMed:8524829)Curated
Sequence conflicti1310 – 13134Missing in AAC62834. (PubMed:15057824)Curated
Sequence conflicti1431 – 14311S → F in AAC50299. (PubMed:8524829)Curated
Sequence conflicti1546 – 15461E → D in AAB21146. (PubMed:1370651)Curated
Sequence conflicti1587 – 15871V → A in AAB21146. (PubMed:1370651)Curated
Sequence conflicti1705 – 17051N → K in AAC50567. (PubMed:8992885)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti996 – 9961T → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035649
Natural varianti1457 – 14571C → R.4 Publications
Corresponds to variant rs4807697 [ dbSNP | Ensembl ].
VAR_047277

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei190 – 1989Missing in isoform PTPS-MEA, isoform 2 and isoform 3. 2 PublicationsVSP_050021
Alternative sequencei236 – 2394Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsVSP_050022
Alternative sequencei617 – 1034418Missing in isoform PTPS-F4-7 and isoform 3. 1 PublicationVSP_050023Add
BLAST
Alternative sequencei784 – 7929Missing in isoform PTPS-MEC and isoform 2. 1 PublicationVSP_050024
Alternative sequencei1035 – 10351V → I in isoform PTPS-F4-7 and isoform 3. 1 PublicationVSP_050025
Alternative sequencei1350 – 136516Missing in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsVSP_050026Add
BLAST
Alternative sequencei1366 – 13661S → G in isoform PTPS-MEB, isoform 2 and isoform 3. 2 PublicationsVSP_050027

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35234 mRNA. Translation: AAC50299.1.
U40317 mRNA. Translation: AAC50567.1. Frameshift.
AC005335 Genomic DNA. No translation available.
AC005790 Genomic DNA. Translation: AAC62832.1.
AC005338 Genomic DNA. Translation: AAC27825.1.
AC005788 Genomic DNA. Translation: AAC62834.1.
AC118535 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69176.1.
BC104812 mRNA. Translation: AAI04813.1.
BC143287 mRNA. Translation: AAI43288.1.
S78080 mRNA. Translation: AAB21146.2.
CCDSiCCDS12139.1. [Q13332-7]
CCDS12140.1. [Q13332-6]
CCDS45930.1. [Q13332-1]
RefSeqiNP_002841.3. NM_002850.3. [Q13332-1]
NP_570923.2. NM_130853.2. [Q13332-7]
NP_570924.2. NM_130854.2. [Q13332-6]
NP_570925.2. NM_130855.2.
XP_005259663.1. XM_005259606.1. [Q13332-6]
XP_005259666.1. XM_005259609.1. [Q13332-7]
XP_006722877.1. XM_006722814.1. [Q13332-3]
UniGeneiHs.744928.

Genome annotation databases

EnsembliENST00000348075; ENSP00000269907; ENSG00000105426. [Q13332-6]
ENST00000357368; ENSP00000349932; ENSG00000105426. [Q13332-1]
ENST00000587303; ENSP00000467537; ENSG00000105426. [Q13332-1]
ENST00000588012; ENSP00000465443; ENSG00000105426. [Q13332-6]
ENST00000592099; ENSP00000467398; ENSG00000105426. [Q13332-7]
GeneIDi5802.
KEGGihsa:5802.
UCSCiuc002mbv.3. human. [Q13332-1]
uc002mbw.3. human. [Q13332-6]
uc002mbx.3. human. [Q13332-7]

Polymorphism databases

DMDMi317373519.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35234 mRNA. Translation: AAC50299.1 .
U40317 mRNA. Translation: AAC50567.1 . Frameshift.
AC005335 Genomic DNA. No translation available.
AC005790 Genomic DNA. Translation: AAC62832.1 .
AC005338 Genomic DNA. Translation: AAC27825.1 .
AC005788 Genomic DNA. Translation: AAC62834.1 .
AC118535 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69176.1 .
BC104812 mRNA. Translation: AAI04813.1 .
BC143287 mRNA. Translation: AAI43288.1 .
S78080 mRNA. Translation: AAB21146.2 .
CCDSi CCDS12139.1. [Q13332-7 ]
CCDS12140.1. [Q13332-6 ]
CCDS45930.1. [Q13332-1 ]
RefSeqi NP_002841.3. NM_002850.3. [Q13332-1 ]
NP_570923.2. NM_130853.2. [Q13332-7 ]
NP_570924.2. NM_130854.2. [Q13332-6 ]
NP_570925.2. NM_130855.2.
XP_005259663.1. XM_005259606.1. [Q13332-6 ]
XP_005259666.1. XM_005259609.1. [Q13332-7 ]
XP_006722877.1. XM_006722814.1. [Q13332-3 ]
UniGenei Hs.744928.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FH7 X-ray 2.00 A 1365-1948 [» ]
2YD2 X-ray 2.55 A 30-244 [» ]
2YD3 X-ray 2.30 A 30-235 [» ]
2YD9 X-ray 2.60 A 30-334 [» ]
4BPC X-ray 2.10 A 1367-1948 [» ]
ProteinModelPortali Q13332.
SMRi Q13332. Positions 29-327, 330-523, 1367-1942.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111766. 30 interactions.
IntActi Q13332. 16 interactions.
MINTi MINT-1349588.
STRINGi 9606.ENSP00000349932.

Chemistry

ChEMBLi CHEMBL2396508.
DrugBanki DB00630. Alendronate.
DB01077. Etidronic acid.

PTM databases

PhosphoSitei Q13332.

Polymorphism databases

DMDMi 317373519.

Proteomic databases

MaxQBi Q13332.
PaxDbi Q13332.
PRIDEi Q13332.

Protocols and materials databases

DNASUi 5802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000348075 ; ENSP00000269907 ; ENSG00000105426 . [Q13332-6 ]
ENST00000357368 ; ENSP00000349932 ; ENSG00000105426 . [Q13332-1 ]
ENST00000587303 ; ENSP00000467537 ; ENSG00000105426 . [Q13332-1 ]
ENST00000588012 ; ENSP00000465443 ; ENSG00000105426 . [Q13332-6 ]
ENST00000592099 ; ENSP00000467398 ; ENSG00000105426 . [Q13332-7 ]
GeneIDi 5802.
KEGGi hsa:5802.
UCSCi uc002mbv.3. human. [Q13332-1 ]
uc002mbw.3. human. [Q13332-6 ]
uc002mbx.3. human. [Q13332-7 ]

Organism-specific databases

CTDi 5802.
GeneCardsi GC19M005157.
HGNCi HGNC:9681. PTPRS.
HPAi HPA054747.
MIMi 601576. gene.
neXtProti NX_Q13332.
PharmGKBi PA34026.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000010250.
HOVERGENi HBG053758.
InParanoidi Q13332.
KOi K06778.
OrthoDBi EOG7M98FB.
PhylomeDBi Q13332.
TreeFami TF312900.

Enzyme and pathway databases

Reactomei REACT_163906. ECM proteoglycans.

Miscellaneous databases

EvolutionaryTracei Q13332.
GeneWikii PTPRS.
GenomeRNAii 5802.
NextBioi 22612.
PROi Q13332.
SOURCEi Search...

Gene expression databases

Bgeei Q13332.
CleanExi HS_PTPRS.
ExpressionAtlasi Q13332. baseline and differential.
Genevestigatori Q13332.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1."
    Pulido R., Serra-Pages C., Tang M., Streuli M.
    Proc. Natl. Acad. Sci. U.S.A. 92:11686-11690(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT ARG-1457.
    Tissue: Fetal brain.
  2. "Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates."
    Endo N., Rutledge S.J., Opas E.E., Vogel R., Rodan G.A., Schmidt A.
    J. Bone Miner. Res. 11:535-543(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, VARIANT ARG-1457.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-1457.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-1457.
    Tissue: Brain.
  6. "Protein-tyrosine phosphatase expression in pre-B cell NALM-6."
    Adachi M., Sekiya M., Arimura Y., Takekawa M., Itoh F., Hinoda Y., Imai K., Yachi A.
    Cancer Res. 52:737-740(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1503-1589.
  7. "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
    Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
    J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPFIA1; PPFIA2 AND PPFIA3.
  8. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
    Tissue: Plasma.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
    Tissue: Liver.
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
    Tissue: Leukemic T-cell.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1365-1948.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-996.

Entry informationi

Entry nameiPTPRS_HUMAN
AccessioniPrimary (citable) accession number: Q13332
Secondary accession number(s): O75255
, O75870, Q15718, Q16341, Q2M3R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3