Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q13332 (PTPRS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase S

Short name=R-PTP-S
EC=3.1.3.48
Alternative name(s):
Receptor-type tyrosine-protein phosphatase sigma
Short name=R-PTP-sigma
Gene names
Name:PTPRS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1948 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts with LAR-interacting protein LIP.1.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with PPFIA1, PPFIA2 and PPFIA3. Ref.7

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Detected in all tissues tested except for placenta and liver.

Post-translational modification

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

Contains 8 fibronectin type-III domains.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 tyrosine-protein phosphatase domains.

Sequence caution

The sequence AAC50567.1 differs from that shown. Reason: Frameshift at several positions.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PTPRNQ168495EBI-711536,EBI-728153

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q13332-1)

Also known as: PTPS;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PTPS-MEA (identifier: Q13332-2)

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
Isoform PTPS-MEB (identifier: Q13332-3)

The sequence of this isoform differs from the canonical sequence as follows:
     236-239: Missing.
     1350-1365: Missing.
     1366-1366: S → G
Isoform PTPS-MEC (identifier: Q13332-4)

The sequence of this isoform differs from the canonical sequence as follows:
     784-792: Missing.
Isoform PTPS-F4-7 (identifier: Q13332-5)

The sequence of this isoform differs from the canonical sequence as follows:
     617-1034: Missing.
     1035-1035: V → I
Isoform 2 (identifier: Q13332-6)

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     784-792: Missing.
     1350-1365: Missing.
     1366-1366: S → G
Isoform 3 (identifier: Q13332-7)

The sequence of this isoform differs from the canonical sequence as follows:
     190-198: Missing.
     236-239: Missing.
     617-1034: Missing.
     1035-1035: V → I
     1350-1365: Missing.
     1366-1366: S → G

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 19481919Receptor-type tyrosine-protein phosphatase S
PRO_0000025462

Regions

Topological domain30 – 12821253Extracellular Potential
Transmembrane1283 – 130321Helical; Potential
Topological domain1304 – 1948645Cytoplasmic Potential
Domain33 – 12391Ig-like C2-type 1
Domain135 – 23399Ig-like C2-type 2
Domain245 – 32783Ig-like C2-type 3
Domain334 – 42491Fibronectin type-III 1
Domain429 – 52395Fibronectin type-III 2
Domain527 – 61690Fibronectin type-III 3
Domain621 – 71898Fibronectin type-III 4
Domain723 – 831109Fibronectin type-III 5
Domain832 – 93099Fibronectin type-III 6
Domain931 – 1033103Fibronectin type-III 7
Domain1036 – 112085Fibronectin type-III 8
Domain1393 – 1648256Tyrosine-protein phosphatase 1
Domain1680 – 1939260Tyrosine-protein phosphatase 2
Region1589 – 15957Substrate binding By similarity
Compositional bias641 – 6444Poly-Pro

Sites

Active site15891Phosphocysteine intermediate By similarity
Active site18801Phosphocysteine intermediate By similarity
Binding site15571Substrate By similarity
Binding site16331Substrate By similarity
Site1197 – 11982Cleavage By similarity

Amino acid modifications

Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation3081N-linked (GlcNAc...) Potential
Glycosylation7331N-linked (GlcNAc...) Ref.8 Ref.9 Ref.10
Glycosylation9401N-linked (GlcNAc...) Potential
Disulfide bond54 ↔ 107 Potential
Disulfide bond156 ↔ 216 Potential
Disulfide bond266 ↔ 311 Potential

Natural variations

Alternative sequence190 – 1989Missing in isoform PTPS-MEA, isoform 2 and isoform 3.
VSP_050021
Alternative sequence236 – 2394Missing in isoform PTPS-MEB, isoform 2 and isoform 3.
VSP_050022
Alternative sequence617 – 1034418Missing in isoform PTPS-F4-7 and isoform 3.
VSP_050023
Alternative sequence784 – 7929Missing in isoform PTPS-MEC and isoform 2.
VSP_050024
Alternative sequence10351V → I in isoform PTPS-F4-7 and isoform 3.
VSP_050025
Alternative sequence1350 – 136516Missing in isoform PTPS-MEB, isoform 2 and isoform 3.
VSP_050026
Alternative sequence13661S → G in isoform PTPS-MEB, isoform 2 and isoform 3.
VSP_050027
Natural variant9961T → M in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035649
Natural variant14571C → R. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs4807697 [ dbSNP | Ensembl ].
VAR_047277

Experimental info

Sequence conflict481G → R in AAC50567. Ref.2
Sequence conflict428 – 4292SA → RP in AAC50567. Ref.2
Sequence conflict742 – 7454RSPA → LGPV in AAC50299. Ref.1
Sequence conflict765 – 7662GA → RR in AAC50567. Ref.2
Sequence conflict7681A → G in AAC50299. Ref.1
Sequence conflict9101R → P in AAC50567. Ref.2
Sequence conflict9951L → V in AAC50299. Ref.1
Sequence conflict1195 – 11962SL → TV in AAC50299. Ref.1
Sequence conflict1310 – 13134Missing in AAC62834. Ref.3
Sequence conflict14311S → F in AAC50299. Ref.1
Sequence conflict15461E → D in AAB21146. Ref.6
Sequence conflict15871V → A in AAB21146. Ref.6
Sequence conflict17051N → K in AAC50567. Ref.2

Secondary structure

............................................................................................................................................................ 1948
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (PTPS) [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: E8BFA76CA410C457

FASTA1,948217,041
        10         20         30         40         50         60 
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP 

        70         80         90        100        110        120 
KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA 

       130        140        150        160        170        180 
KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS 

       190        200        210        220        230        240 
NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV 

       250        260        270        280        290        300 
RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL 

       310        320        330        340        350        360 
TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV 

       370        380        390        400        410        420 
SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR 

       430        440        450        460        470        480 
TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV 

       490        500        510        520        530        540 
DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS 

       550        560        570        580        590        600 
ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ 

       610        620        630        640        650        660 
GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP 

       670        680        690        700        710        720 
LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP 

       730        740        750        760        770        780 
SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA 

       790        800        810        820        830        840 
DAQWETDDTA EYEMVITNLQ PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV 

       850        860        870        880        890        900 
QQTPEGSLLA RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT 

       910        920        930        940        950        960 
YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW LPPVPAERNG 

       970        980        990       1000       1010       1020 
AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL KPDTAYDLQV RAHTRRGPGP 

      1030       1040       1050       1060       1070       1080 
FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR 

      1090       1100       1110       1120       1130       1140 
TTKKLITHLK PHTFYNFVLT NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV 

      1150       1160       1170       1180       1190       1200 
YLPDGQSPVP VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR 

      1210       1220       1230       1240       1250       1260 
QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL QKSEPTFAAS 

      1270       1280       1290       1300       1310       1320 
PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV IAILLYKNKP DSKRKDSEPR 

      1330       1340       1350       1360       1370       1380 
TKCLLNNADL APHHPKDPVE MRRINFQTPD SGLRSPLREP GFHFESMLSH PPIPIADMAE 

      1390       1400       1410       1420       1430       1440 
HTERLKANDS LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG 

      1450       1460       1470       1480       1490       1500 
IMGSDYINAN YVDGYRCQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK 

      1510       1520       1530       1540       1550       1560 
CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV 

      1570       1580       1590       1600       1610       1620 
PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH 

      1630       1640       1650       1660       1670       1680 
VTLMRSQRNY MVQTEDQYSF IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM 

      1690       1700       1710       1720       1730       1740 
ELEFKRLANS KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF 

      1750       1760       1770       1780       1790       1800 
IDGYRQQKAY IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA 

      1810       1820       1830       1840       1850       1860 
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI 

      1870       1880       1890       1900       1910       1920 
GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP 

      1930       1940 
AMVQTEDEYQ FCYQAALEYL GSFDHYAT 

« Hide

Isoform PTPS-MEA [UniParc].

Checksum: 3EE7153FDA494FD9
Show »

FASTA1,939215,980
Isoform PTPS-MEB [UniParc].

Checksum: 6A3B149EF382D202
Show »

FASTA1,928214,658
Isoform PTPS-MEC [UniParc].

Checksum: 63119FAC3E811F31
Show »

FASTA1,939215,930
Isoform PTPS-F4-7 [UniParc].

Checksum: 91EF6825A0AEE9F9
Show »

FASTA1,530171,838
Isoform 2 [UniParc].

Checksum: 578E617EC9255E5C
Show »

FASTA1,910212,486
Isoform 3 [UniParc].

Checksum: 8505BCDE81596910
Show »

FASTA1,501168,394

References

« Hide 'large scale' references
[1]"The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1."
Pulido R., Serra-Pages C., Tang M., Streuli M.
Proc. Natl. Acad. Sci. U.S.A. 92:11686-11690(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANT ARG-1457.
Tissue: Fetal brain.
[2]"Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates."
Endo N., Rutledge S.J., Opas E.E., Vogel R., Rodan G.A., Schmidt A.
J. Bone Miner. Res. 11:535-543(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, VARIANT ARG-1457.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-1457.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ARG-1457.
Tissue: Brain.
[6]"Protein-tyrosine phosphatase expression in pre-B cell NALM-6."
Adachi M., Sekiya M., Arimura Y., Takekawa M., Itoh F., Hinoda Y., Imai K., Yachi A.
Cancer Res. 52:737-740(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1503-1589.
[7]"Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins."
Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.
J. Biol. Chem. 273:15611-15620(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PPFIA1; PPFIA2 AND PPFIA3.
[8]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
Tissue: Plasma.
[9]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
Tissue: Liver.
[10]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-733.
Tissue: Leukemic T-cell.
[11]"Structural genomics of protein phosphatases."
Almo S.C., Bonanno J.B., Sauder J.M., Emtage S., Dilorenzo T.P., Malashkevich V., Wasserman S.R., Swaminathan S., Eswaramoorthy S., Agarwal R., Kumaran D., Madegowda M., Ragumani S., Patskovsky Y., Alvarado J., Ramagopal U.A., Faber-Barata J., Chance M.R. expand/collapse author list , Sali A., Fiser A., Zhang Z.Y., Lawrence D.S., Burley S.K.
J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1365-1948.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-996.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U35234 mRNA. Translation: AAC50299.1.
U40317 mRNA. Translation: AAC50567.1. Frameshift.
AC005335 Genomic DNA. No translation available.
AC005790 Genomic DNA. Translation: AAC62832.1.
AC005338 Genomic DNA. Translation: AAC27825.1.
AC005788 Genomic DNA. Translation: AAC62834.1.
AC118535 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69176.1.
BC104812 mRNA. Translation: AAI04813.1.
BC143287 mRNA. Translation: AAI43288.1.
S78080 mRNA. Translation: AAB21146.2.
RefSeqNP_002841.3. NM_002850.3.
NP_570923.2. NM_130853.2.
NP_570924.2. NM_130854.2.
NP_570925.2. NM_130855.2.
XP_005259663.1. XM_005259606.1.
XP_005259666.1. XM_005259609.1.
UniGeneHs.744928.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FH7X-ray2.00A1365-1948[»]
2YD2X-ray2.55A30-231[»]
2YD3X-ray2.30A30-228[»]
2YD9X-ray2.60A30-321[»]
4BPCX-ray2.10A1367-1948[»]
ProteinModelPortalQ13332.
SMRQ13332. Positions 29-327, 330-523, 1367-1942.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111766. 22 interactions.
IntActQ13332. 16 interactions.
MINTMINT-1349588.
STRING9606.ENSP00000349932.

PTM databases

PhosphoSiteQ13332.

Polymorphism databases

DMDM317373519.

Proteomic databases

PaxDbQ13332.
PRIDEQ13332.

Protocols and materials databases

DNASU5802.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000348075; ENSP00000269907; ENSG00000105426. [Q13332-6]
ENST00000353284; ENSP00000327313; ENSG00000105426. [Q13332-7]
ENST00000357368; ENSP00000349932; ENSG00000105426. [Q13332-1]
ENST00000587303; ENSP00000467537; ENSG00000105426. [Q13332-1]
ENST00000588012; ENSP00000465443; ENSG00000105426. [Q13332-6]
ENST00000592099; ENSP00000467398; ENSG00000105426. [Q13332-7]
GeneID5802.
KEGGhsa:5802.
UCSCuc002mbv.3. human. [Q13332-1]
uc002mbw.3. human. [Q13332-6]
uc002mbx.3. human. [Q13332-7]

Organism-specific databases

CTD5802.
GeneCardsGC19M005157.
HGNCHGNC:9681. PTPRS.
HPAHPA054747.
MIM601576. gene.
neXtProtNX_Q13332.
PharmGKBPA34026.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000010250.
HOVERGENHBG053758.
InParanoidQ13332.
KOK06778.
OrthoDBEOG7M98FB.
PhylomeDBQ13332.
TreeFamTF312900.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

ArrayExpressQ13332.
BgeeQ13332.
CleanExHS_PTPRS.
GenevestigatorQ13332.

Family and domain databases

Gene3D2.60.40.10. 11 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 5 hits.
PROSITEPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ13332.
GeneWikiPTPRS.
GenomeRNAi5802.
NextBio22612.
PROQ13332.
SOURCESearch...

Entry information

Entry namePTPRS_HUMAN
AccessionPrimary (citable) accession number: Q13332
Secondary accession number(s): O75255 expand/collapse secondary AC list , O75870, Q15718, Q16341, Q2M3R7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM