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Reviewed, UniProtKB/Swiss-Prot Q13330 (MTA1_HUMAN)

Last modified November 25, 2008. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Metastasis-associated protein MTA1
Gene names
Name: MTA1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in the regulation of gene expression by covalent modification of histone proteins. The long isoform is a corepressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.

Subunit structure

Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR.

Subcellular location

Isoform Short: Cytoplasm.

Isoform Long: Nucleus.

Tissue specificity

Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual.

Developmental stage

Highly expressed in metastatic cells.

Miscellaneous

The short isoform contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif).

Sequence similarities

Contains 1 BAH domain.

Contains 1 ELM2 domain.

Contains 1 GATA-type zinc finger.

Contains 1 SANT domain.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q13330-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q13330-2)

Also known as: MTA1S;

The sequence of this isoform differs from the canonical sequence as follows:
     398-430: TTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGL → MSSLRILLDILEEIWWLENANPVRWREARTKPQ
     431-715: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 715715Metastasis-associated protein MTA1
PRO_0000083493

Regions

Domain1 – 164164BAH
Domain165 – 276112ELM2
Domain283 – 33553SANT
Zinc finger393 – 42028GATA-type; atypical
Motif545 – 5528SH3-binding Potential
Motif696 – 70510SH3-binding Potential
Compositional bias697 – 7059Poly-Pro

Amino acid modifications

Modified residue3861Phosphoserine
Modified residue4491Phosphoserine
Modified residue4671Phosphothreonine
Modified residue5221Phosphoserine
Modified residue5641Phosphothreonine
Modified residue5761Phosphoserine

Natural variations

Alternative sequence398 – 43033TTQSY…KYGGL → MSSLRILLDILEEIWWLENA NPVRWREARTKPQ in isoform Short.
VSP_001601
Alternative sequence431 – 715285Missing in isoform Short.
VSP_001602

Experimental info

Sequence conflict4981N → H in AAH09443. Ref.4
Sequence conflict6551G → D in AAH09443. Ref.4
Sequence conflict661 – 6622PK → AT in AAH09443. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C5D4E20A125F820F

FASTA71580,788
        10         20         30         40         50         60 
MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTANGNVEA KVVCFYRRRD ISSTLIALAD 

        70         80         90        100        110        120 
KHATLSVCYK AGPGADNGEE GEIEEEMENP EMVDLPEKLK HQLRHRELFL SRQLESLPAT 

       130        140        150        160        170        180 
HIRGKCSVTL LNETESLKSY LEREDFFFYS LVYDPQQKTL LADKGEIRVG NRYQADITDL 

       190        200        210        220        230        240 
LKEGEEDGRD QSRLETQVWE AHNPLTDKQI DQFLVVARSV GTFARALDCS SSVRQPSLHM 

       250        260        270        280        290        300 
SAAAASRDIT LFHAMDTLHK NIYDISKAIS ALVPQGGPVL CRDEMEEWSA SEANLFEEAL 

       310        320        330        340        350        360 
EKYGKDFTDI QQDFLPWKSL TSIIEYYYMW KTTDRYVQQK RLKAAEAESK LKQVYIPNYN 

       370        380        390        400        410        420 
KPNPNQISVN NVKAGVVNGT GAPGQSPGAG RACESCYTTQ SYQWYSWGPP NMQCRLCASC 

       430        440        450        460        470        480 
WTYWKKYGGL KMPTRLDGER PGPNRSNMSP HGLPARSSGS PKFAMKTRQA FYLHTTKLTR 

       490        500        510        520        530        540 
IARRLCREIL RPWHAARNPY LPINSAAIKA ECTARLPEAS QSPLVLKQAV RKPLEAVLRY 

       550        560        570        580        590        600 
LETHPRPPKP DPVKSVSSVL SSLTPAKVAP VINNGSPTIL GKRSYEQHNG VDGNMKKRLL 

       610        620        630        640        650        660 
MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPGDVFYM 

       670        680        690        700        710 
PKEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP PPPAPVNDEP IVIED

« Hide

Isoform Short (MTA1S) [UniParc].

Checksum: DE4B752E9476C6CE
Show »

43049,017

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References

« Hide 'large scale' references
[1]"A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses."
Toh Y., Pencil S.D., Nicolson G.L.
J. Biol. Chem. 269:22958-22963(1994) [PubMed: 8083195] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[2]"Analysis of the complete sequence of the novel metastasis-associated candidate gene, mta1, differentially expressed in mammary adenocarcinoma and breast cancer cell lines."
Toh Y., Pencil S.D., Nicolson G.L.
Gene 159:97-104(1995) [PubMed: 7607577] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[3]"A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm."
Kumar R., Wang R.-A., Mazumdar A., Talukder A.H., Mandal M., Yang Z., Bagheri-Yarmand R., Sahin A., Hortobagyi G., Adam L., Barnes C.J., Vadlamudi R.K.
Nature 418:654-657(2002) [PubMed: 12167865] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), SUBCELLULAR LOCATION.
Tissue: Mammary gland.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 453-715.
Tissue: Brain.
[5]"NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities."
Xue Y., Wong J., Moreno G.T., Young M.K., Cote J., Wang W.
Mol. Cell 2:851-861(1998) [PubMed: 9885572] [Abstract]
Cited for: IDENTIFICATION IN NURD COMPLEX.
[6]"Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator."
Talukder A.H., Gururaj A., Mishra S.K., Vadlamudi R.K., Kumar R.
Mol. Cell. Biol. 24:6581-6591(2004) [PubMed: 15254226] [Abstract]
Cited for: INTERACTION WITH ITGB3BP.
[7]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576, MASS SPECTROMETRY.
Tissue: Epithelium.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-467, MASS SPECTROMETRY.
Tissue: Epithelium.
[9]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386 AND THR-564, MASS SPECTROMETRY.
Tissue: Epithelium.
[10]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-564, MASS SPECTROMETRY.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-449; SER-522; THR-564 AND SER-576, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U35113 mRNA. Translation: AAA78935.1.
AF508978 mRNA. Translation: AAN01613.1.
BC009443 mRNA. Translation: AAH09443.2.
RefSeqNP_004680.2.
UniGeneHs.525629

3D structure databases

SMRQ13330. Positions 285-341.
ModBaseSearch...

Protein-protein interaction databases

IntActQ13330.

PTM databases

PhosphoSiteQ13330.

Genome annotation databases

EnsemblENSG00000182979. Homo sapiens. [Contig view]
GeneID9112.
KEGGhsa:9112.

Organism-specific databases

H-InvDBHIX0018922.
HGNCHGNC:7410. MTA1.
HPACAB004508.
HPA005544.
MIM603526. gene.
PharmGKBPA38688.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ13330.
HOVERGENQ13330.

Gene expression databases

ArrayExpressQ13330.
CleanExHS_MTA1.
GermOnlineENSG00000182979. Homo sapiens.

Family and domain databases

InterProIPR001025. BAH.
IPR000949. ELM2.
IPR014778. Myb_DNA-bd.
IPR001005. SANT_DNA-bd.
IPR000679. Znf_GATA.
[Graphical view]
PfamPF01426. BAH. 1 hit.
PF01448. ELM2. 1 hit.
PF00320. GATA. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTSM00439. BAH. 1 hit.
SM00717. SANT. 1 hit.
SM00401. ZnF_GATA. 1 hit.
[Graphical view]
PROSITEPS51038. BAH. 1 hit.
PS51156. ELM2. 1 hit.
PS00344. GATA_ZN_FINGER_1. False negative.
PS50114. GATA_ZN_FINGER_2. False negative.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio34153.
SOURCESearch...

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Entry information

Entry nameMTA1_HUMAN
AccessionPrimary (citable) accession number: Q13330
Secondary accession number(s): Q8NFI8, Q96GI8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents