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Q13325 (IFIT5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon-induced protein with tetratricopeptide repeats 5
Short name=IFIT-5
Alternative name(s):
Retinoic acid- and interferon-inducible 58 kDa protein
Gene names
Name:IFIT5
Synonyms:RI58
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Induction

By interferons.

Sequence similarities

Belongs to the IFIT family.

Contains 8 TPR repeats.

Ontologies

Keywords
   DomainRepeat
TPR repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functionbinding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482Interferon-induced protein with tetratricopeptide repeats 5
PRO_0000106351

Regions

Repeat51 – 8434TPR 1
Repeat94 – 12734TPR 2
Repeat138 – 17336TPR 3
Repeat181 – 21434TPR 4
Repeat249 – 28234TPR 5
Repeat338 – 37134TPR 6
Repeat376 – 41035TPR 7
Repeat435 – 46834TPR 8

Sequences

Sequence LengthMass (Da)Tools
Q13325 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8045BC100384BE05

FASTA48255,847
        10         20         30         40         50         60 
MSEIRKDTLK AILLELECHF TWNLLKEDID LFEVEDTIGQ QLEFLTTKSR LALYNLLAYV 

        70         80         90        100        110        120 
KHLKGQNKDA LECLEQAEEI IQQEHSDKEE VRSLVTWGNY AWVYYHMDQL EEAQKYTGKI 

       130        140        150        160        170        180 
GNVCKKLSSP SNYKLECPET DCEKGWALLK FGGKYYQKAK AAFEKALEVE PDNPEFNIGY 

       190        200        210        220        230        240 
AITVYRLDDS DREGSVKSFS LGPLRKAVTL NPDNSYIKVF LALKLQDVHA EAEGEKYIEE 

       250        260        270        280        290        300 
ILDQISSQPY VLRYAAKFYR RKNSWNKALE LLKKALEVTP TSSFLHHQMG LCYRAQMIQI 

       310        320        330        340        350        360 
KKATHNRPKG KDKLKVDELI SSAIFHFKAA MERDSMFAFA YTDLANMYAE GGQYSNAEDI 

       370        380        390        400        410        420 
FRKALRLENI TDDHKHQIHY HYGRFQEFHR KSENTAIHHY LEALKVKDRS PLRTKLTSAL 

       430        440        450        460        470        480 
KKLSTKRLCH NALDVQSLSA LGFVYKLEGE KRQAAEYYEK AQKIDPENAE FLTALCELRL 


SI

« Hide

References

« Hide 'large scale' references
[1]"A novel interferon-inducible gene expressed during myeloid differentiation."
Niikura T., Hirata R., Weil S.C.
Blood Cells Mol. Dis. 23:337-349(1997) [PubMed: 9398535] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Spleen.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U34605 mRNA. Translation: AAA84934.1.
AL353146 Genomic DNA. Translation: CAI12381.1.
CH471066 Genomic DNA. Translation: EAW50135.1.
BC025786 mRNA. Translation: AAH25786.1.
IPIIPI00012756.
PIRG02058.
RefSeqNP_036552.1. NM_012420.2.
UniGeneHs.252839.

3D structure databases

ProteinModelPortalQ13325.
SMRQ13325. Positions 53-410, 431-468.
ModBaseSearch...

Protein-protein interaction databases

IntActQ13325. 11 interactions.
MINTMINT-1395756.
STRINGQ13325.

PTM databases

PhosphoSiteQ13325.

Polymorphism databases

DMDM6831571.

Proteomic databases

PeptideAtlasQ13325.
PRIDEQ13325.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371795; ENSP00000360860; ENSG00000152778.
GeneID24138.
KEGGhsa:24138.
UCSCuc001kgk.1. human.

Organism-specific databases

CTD24138.
GeneCardsGC10P091164.
H-InvDBHIX0009023.
HGNCHGNC:13328. IFIT5.
HPAHPA037957.
neXtProtNX_Q13325.
PharmGKBPA134988392.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG14796.
HOGENOMHBG447196.
HOVERGENHBG066330.
InParanoidQ13325.
OMAQPYVLRY.
OrthoDBEOG4V6ZGT.
PhylomeDBQ13325.

Gene expression databases

ArrayExpressQ13325.
BgeeQ13325.
CleanExHS_IFIT5.
GenevestigatorQ13325.
GermOnlineENSG00000152778. Homo sapiens.

Family and domain databases

InterProIPR024125. Interferon_induced_IFIT5.
IPR001440. TPR-1.
IPR013026. TPR-contain.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 2 hits.
PANTHERPTHR10271:SF5. PTHR10271:SF5. 1 hit.
PfamPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 5 hits.
[Graphical view]
PROSITEPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio46805.

Entry information

Entry nameIFIT5_HUMAN
AccessionPrimary (citable) accession number: Q13325
Secondary accession number(s): Q5T7I9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents