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Q13325

- IFIT5_HUMAN

UniProt

Q13325 - IFIT5_HUMAN

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Protein

Interferon-induced protein with tetratricopeptide repeats 5

Gene

IFIT5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei33 – 331Interaction with PPP-RNA
Sitei37 – 371Interaction with PPP-RNA
Sitei41 – 411Interaction with PPP-RNA
Sitei150 – 1501Interaction with PPP-RNA
Sitei186 – 1861Interaction with PPP-RNA
Sitei250 – 2501Interaction with PPP-RNA
Sitei288 – 2881Interaction with the 5'-triphosphate group of PPP-RNA

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: UniProtKB
  3. single-stranded RNA binding Source: UniProtKB
  4. tRNA binding Source: UniProtKB

GO - Biological processi

  1. defense response to virus Source: UniProtKB
  2. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity

Keywords - Ligandi

RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 5
Short name:
IFIT-5
Alternative name(s):
Interferon-induced 58 kDa protein
Retinoic acid- and interferon-inducible 58 kDa protein
Short name:
P58
Gene namesi
Name:IFIT5
Synonyms:ISG58, RI58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:13328. IFIT5.

Subcellular locationi

Cell projectionruffle membrane 1 Publication
Note: Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. apical part of cell Source: UniProtKB
  3. ruffle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi33 – 331E → A: Reduced PPP-RNA-binding. 1 Publication
Mutagenesisi37 – 371T → V: Abolishes PPP-RNA-binding.
Mutagenesisi41 – 411Q → E: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi150 – 1501K → M: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi156 – 1561Y → F: Reduced PPP-RNA-binding. 1 Publication
Mutagenesisi186 – 1861R → H: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi250 – 2501Y → F: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi253 – 2531R → M: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi254 – 2541Y → F: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi260 – 2601R → E: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi287 – 2871H → A: Reduced PPP-RNA-binding. 1 Publication
Mutagenesisi288 – 2881Q → E: Abolishes PPP-RNA-binding. 1 Publication
Mutagenesisi291 – 2911L → A: Does not affect RNA-binding. 1 Publication
Mutagenesisi302 – 3021K → A: Reduced RNA-binding. 1 Publication
Mutagenesisi307 – 3071R → A: Reduced RNA-binding. 25 fold reduction in tRNA-binding. 1 Publication
Mutagenesisi309 – 3091K → A: Reduced RNA-binding. 1 Publication
Mutagenesisi337 – 3371F → A: Abolishes PPP-RNA-binding.
Mutagenesisi388 – 3892FH → AA: Reduced RNA-binding. 1 Publication
Mutagenesisi415 – 4151K → A: Reduced RNA-binding. 25 fold reduction in tRNA-binding. 1 Publication
Mutagenesisi422 – 4221K → A: Reduced RNA-binding. 1 Publication
Mutagenesisi426 – 4261K → A: Reduced RNA-binding. 5 fold reduction in tRNA-binding. 1 Publication

Organism-specific databases

PharmGKBiPA134988392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Interferon-induced protein with tetratricopeptide repeats 5PRO_0000106351Add
BLAST

Proteomic databases

MaxQBiQ13325.
PaxDbiQ13325.
PeptideAtlasiQ13325.
PRIDEiQ13325.

PTM databases

PhosphoSiteiQ13325.

Expressioni

Inductioni

By interferons (IFNs).

Gene expression databases

BgeeiQ13325.
CleanExiHS_IFIT5.
GenevestigatoriQ13325.

Organism-specific databases

HPAiHPA037957.

Interactioni

Subunit structurei

Monomer.2 Publications

Protein-protein interaction databases

BioGridi117289. 22 interactions.
IntActiQ13325. 13 interactions.
MINTiMINT-1395756.
STRINGi9606.ENSP00000360860.

Structurei

Secondary structure

1
482
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1513Combined sources
Helixi19 – 213Combined sources
Helixi26 – 283Combined sources
Helixi31 – 4414Combined sources
Beta strandi46 – 483Combined sources
Helixi50 – 6314Combined sources
Helixi67 – 8418Combined sources
Helixi86 – 883Combined sources
Helixi91 – 933Combined sources
Helixi94 – 10613Combined sources
Helixi110 – 12617Combined sources
Beta strandi130 – 1334Combined sources
Helixi138 – 15013Combined sources
Helixi153 – 1553Combined sources
Helixi156 – 16914Combined sources
Helixi174 – 18916Combined sources
Beta strandi193 – 1953Combined sources
Helixi201 – 21010Combined sources
Helixi215 – 22713Combined sources
Helixi231 – 24414Combined sources
Helixi249 – 26113Combined sources
Helixi265 – 27814Combined sources
Helixi283 – 30321Combined sources
Turni304 – 3063Combined sources
Helixi310 – 33324Combined sources
Helixi338 – 35013Combined sources
Helixi354 – 36512Combined sources
Helixi372 – 38817Combined sources
Helixi393 – 40614Combined sources
Beta strandi408 – 4103Combined sources
Helixi413 – 43018Combined sources
Helixi435 – 44713Combined sources
Helixi451 – 46414Combined sources
Helixi469 – 48012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZGQX-ray2.20A1-482[»]
4HOQX-ray2.07A1-482[»]
4HORX-ray1.86A1-482[»]
4HOSX-ray2.00A1-482[»]
4HOTX-ray2.50A1-482[»]
4J0UX-ray1.97A1-482[»]
ProteinModelPortaliQ13325.
SMRiQ13325. Positions 1-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 8434TPR 1Add
BLAST
Repeati94 – 12734TPR 2Add
BLAST
Repeati138 – 17336TPR 3Add
BLAST
Repeati181 – 21434TPR 4Add
BLAST
Repeati249 – 28234TPR 5Add
BLAST
Repeati338 – 37134TPR 6Add
BLAST
Repeati376 – 41035TPR 7Add
BLAST
Repeati435 – 46834TPR 8Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 2607Interaction with the 5'-triphosphate group of PPP-RNA

Domaini

RNA recognition is mediated by a convoluted intramolecular fold of the TPR repeats (TPR eddy), which scaffolds unique additional helices that form an RNA binding cleft (PubMed:23317505 and PubMed:23334420). Undergoes a conformational change upon RNA-binding: unliganded exists in a more open conformation, facilitating RNA entry (PubMed:23334420).1 Publication

Sequence similaritiesi

Belongs to the IFIT family.Curated
Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG311487.
GeneTreeiENSGT00390000013876.
HOGENOMiHOG000001558.
HOVERGENiHBG066330.
InParanoidiQ13325.
OMAiNTAIHHY.
OrthoDBiEOG71K62V.
PhylomeDBiQ13325.
TreeFamiTF342671.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR024125. Interferon_induced_IFIT5.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10271:SF5. PTHR10271:SF5. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
PF07719. TPR_2. 2 hits.
[Graphical view]
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q13325-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEIRKDTLK AILLELECHF TWNLLKEDID LFEVEDTIGQ QLEFLTTKSR
60 70 80 90 100
LALYNLLAYV KHLKGQNKDA LECLEQAEEI IQQEHSDKEE VRSLVTWGNY
110 120 130 140 150
AWVYYHMDQL EEAQKYTGKI GNVCKKLSSP SNYKLECPET DCEKGWALLK
160 170 180 190 200
FGGKYYQKAK AAFEKALEVE PDNPEFNIGY AITVYRLDDS DREGSVKSFS
210 220 230 240 250
LGPLRKAVTL NPDNSYIKVF LALKLQDVHA EAEGEKYIEE ILDQISSQPY
260 270 280 290 300
VLRYAAKFYR RKNSWNKALE LLKKALEVTP TSSFLHHQMG LCYRAQMIQI
310 320 330 340 350
KKATHNRPKG KDKLKVDELI SSAIFHFKAA MERDSMFAFA YTDLANMYAE
360 370 380 390 400
GGQYSNAEDI FRKALRLENI TDDHKHQIHY HYGRFQEFHR KSENTAIHHY
410 420 430 440 450
LEALKVKDRS PLRTKLTSAL KKLSTKRLCH NALDVQSLSA LGFVYKLEGE
460 470 480
KRQAAEYYEK AQKIDPENAE FLTALCELRL SI
Length:482
Mass (Da):55,847
Last modified:November 1, 1996 - v1
Checksum:i8045BC100384BE05
GO
Isoform 2 (identifier: Q13325-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-205: Missing.

Note: No experimental confirmation available.

Show »
Length:434
Mass (Da):50,520
Checksum:i6CA739D6614569C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti215 – 2151S → N in CAG33312. 1 PublicationCurated
Sequence conflicti449 – 4491G → R in BAG35276. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 20548Missing in isoform 2. 1 PublicationVSP_056412Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34605 mRNA. Translation: AAA84934.1.
AK293346 mRNA. Translation: BAG56862.1.
AK312358 mRNA. Translation: BAG35276.1.
CR457031 mRNA. Translation: CAG33312.1.
AL353146 Genomic DNA. Translation: CAI12381.1.
CH471066 Genomic DNA. Translation: EAW50135.1.
BC025786 mRNA. Translation: AAH25786.1.
CCDSiCCDS7403.1. [Q13325-1]
PIRiG02058.
RefSeqiNP_036552.1. NM_012420.2. [Q13325-1]
UniGeneiHs.252839.

Genome annotation databases

EnsembliENST00000371795; ENSP00000360860; ENSG00000152778. [Q13325-1]
GeneIDi24138.
KEGGihsa:24138.
UCSCiuc010qnh.2. human. [Q13325-1]

Polymorphism databases

DMDMi6831571.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34605 mRNA. Translation: AAA84934.1 .
AK293346 mRNA. Translation: BAG56862.1 .
AK312358 mRNA. Translation: BAG35276.1 .
CR457031 mRNA. Translation: CAG33312.1 .
AL353146 Genomic DNA. Translation: CAI12381.1 .
CH471066 Genomic DNA. Translation: EAW50135.1 .
BC025786 mRNA. Translation: AAH25786.1 .
CCDSi CCDS7403.1. [Q13325-1 ]
PIRi G02058.
RefSeqi NP_036552.1. NM_012420.2. [Q13325-1 ]
UniGenei Hs.252839.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZGQ X-ray 2.20 A 1-482 [» ]
4HOQ X-ray 2.07 A 1-482 [» ]
4HOR X-ray 1.86 A 1-482 [» ]
4HOS X-ray 2.00 A 1-482 [» ]
4HOT X-ray 2.50 A 1-482 [» ]
4J0U X-ray 1.97 A 1-482 [» ]
ProteinModelPortali Q13325.
SMRi Q13325. Positions 1-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117289. 22 interactions.
IntActi Q13325. 13 interactions.
MINTi MINT-1395756.
STRINGi 9606.ENSP00000360860.

PTM databases

PhosphoSitei Q13325.

Polymorphism databases

DMDMi 6831571.

Proteomic databases

MaxQBi Q13325.
PaxDbi Q13325.
PeptideAtlasi Q13325.
PRIDEi Q13325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371795 ; ENSP00000360860 ; ENSG00000152778 . [Q13325-1 ]
GeneIDi 24138.
KEGGi hsa:24138.
UCSCi uc010qnh.2. human. [Q13325-1 ]

Organism-specific databases

CTDi 24138.
GeneCardsi GC10P091164.
HGNCi HGNC:13328. IFIT5.
HPAi HPA037957.
neXtProti NX_Q13325.
PharmGKBi PA134988392.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311487.
GeneTreei ENSGT00390000013876.
HOGENOMi HOG000001558.
HOVERGENi HBG066330.
InParanoidi Q13325.
OMAi NTAIHHY.
OrthoDBi EOG71K62V.
PhylomeDBi Q13325.
TreeFami TF342671.

Miscellaneous databases

GenomeRNAii 24138.
NextBioi 35467534.
PROi Q13325.

Gene expression databases

Bgeei Q13325.
CleanExi HS_IFIT5.
Genevestigatori Q13325.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR024125. Interferon_induced_IFIT5.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10271:SF5. PTHR10271:SF5. 1 hit.
Pfami PF00515. TPR_1. 1 hit.
PF07719. TPR_2. 2 hits.
[Graphical view ]
SMARTi SM00028. TPR. 5 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel interferon-inducible gene expressed during myeloid differentiation."
    Niikura T., Hirata R., Weil S.C.
    Blood Cells Mol. Dis. 23:337-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas and Spleen.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: REVIEW.
  9. Cited for: RNA-BINDING.
  10. "tRNA binding, structure, and localization of the human interferon-induced protein IFIT5."
    Katibah G.E., Lee H.J., Huizar J.P., Vogan J.M., Alber T., Collins K.
    Mol. Cell 49:743-750(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), FUNCTION, RNA-BINDING, SUBCELLULAR LOCATION, SUBUNIT, MUTAGENESIS OF LEU-291; LYS-302; ARG-307; LYS-309; 388-PHE-HIS-389; LYS-415; LYS-422 AND LYS-426.
  11. "Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins."
    Abbas Y.M., Pichlmair A., Gorna M.W., Superti-Furga G., Nagar B.
    Nature 494:60-64(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH PPP-RNA, FUNCTION, RNA-BINDING, MUTAGENESIS OF GLU-33; GLN-41; LYS-150; TYR-156; ARG-186; TYR-250; ARG-253; TYR-254; ARG-260; HIS-287 AND GLN-288.

Entry informationi

Entry nameiIFIT5_HUMAN
AccessioniPrimary (citable) accession number: Q13325
Secondary accession number(s): B2R5X9
, B4DDV1, Q5T7I9, Q6IAX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3